School of Medicine What is Radiopharmaceutics? Can YOU make this … Cl 11 MSc in Radiopharmaceutics and PET Radiochemistry Cl CH3 O N N OH O O HOOC HO OC S S Re S N H S CO OH O • Pure • Sterile • Free of toxins • Ready for injection into a patient …in 10 minutes flat? Probably not right now. Designing a complex synthesis of a radiolabelled molecule, when the half-life of the radiolabel is just a few minutes, is a challenge by any standards. But the job of the PET radiochemist is to come up with solutions to just this type of problem. With an MSc in Radiopharmaceutics and PET Radiochemistry, you can be a key player in the interdisciplinary team of chemists, physicists, pharmacists, engineers and clinicians, working together to help diagnose disease by PET and gamma camera imaging, and to treat cancer patients with targeted radioactive molecules. Radiopharmaceutics is an interdisciplinary science. Its aim is the use of radiolabelled drugs for the diagnosis and treatment of human disease. Its applications include imaging using short half-life gamma emitting and positron emitting radioisotopes, and cancer treatment using particle-emitting (beta and alpha) radioisotopes. Whether diagnostic or therapeutic, the radioisotopes are chemically attached to carrier molecules that deliver them selectively to the disease site. The science comprises: • Designing a targeting strategy (physiology and biochemistry) • Choosing and manufacturing the radionuclide (physics, radiobiology, chemistry and cyclotron engineering) • Designing and synthesising the radiopharmaceutical (chemistry) • Studying its transport and metabolism at the cellular and whole body level (pharmacology, cell biology, radiobiology) • Clinical evaluation (medicine) • Production and quality control of the radiopharmaceutical on demand (radiopharmacy) Your chemistry is the key, but you must be willing to learn and use the language and ideas of specialists in all these fields to ensure the success of the enterprise. The MSc in Radiopharmaceutics and PET Radiochemistry will help you to do this. C N O F β+ β+ β+ β+ Join the team. Your CHEMISTRY or PHARMACY expertise is in demand for • Medical imaging • Cancer treatment • PET Y β Tc γ Re β Cu β β,β+ In γ I β,γ At α Careers in radiopharmaceutics Your MSc in Radiopharmaceutics and PET Radiochemistry will prepare you for • Employment in a commercial/industrial cyclotron centre, producing radionuclides and radiopharmaceuticals for hospitals and the drug industry. This is a growing international industry facing a severe radiochemical skills shortage – you will be in demand. • Employment in NHS hospitals as a radiopharmacist or radiochemist, preparing radiopharmaceuticals for immediate patient use and taking responsibility for quality control and radiopharmacy management • Research and Development in the radiopharmaceutical industry or the conventional drug industry (which is adopting PET as a major drug development tool). • Academic research in any aspect of the field, leading to a PhD Course structure The course has a modular structure with options to suit different career options listed above. Semester 1 (Autumn Term) Module 1 (30 credits) Introduction to Radiopharmaceutics (approx. = current Radiopharmacy elective) Module 2 (30 credits) Radiopharmacology Semester 2 (Spring Term) Christmas vacation Module 3a (30 credits) <OR> Radiopharmaceutical chemistry Module 3b (30 credits) Module 4b (30 credits) Radiopharmaceuticals in practice Radiopharmaceutical design, formulation and manufacturing Module 4a (30 credits) <OR> Cyclotron engineering and nuclear chemistry Term 3 (Summer Term/break) Easter vacation Examinations Module 5 (60 credits) Research Project You can take the full MSc on a full time (1 year, two days per week) or part time (2 years, day release, one day per week during term time) basis. Individual modules (on day-release basis) will be offered with a Diploma level qualification. As an MSc student you will take five Modules: 1, 2, 3a OR 3b, 4a OR 4b, and 5. Module 1 provides general introduction, and module 2 provides introduction to biological aspects. Module 3a has the most detailed chemical content, while 3b is strong on regulatory and radiopharmacy topics. Module 4a provides the basis for cyclotron-based radiochemistry associated with PET or industrial radionuclide production, and 4b develops the principles established earlier for application to conventional radiopharmaceuticals. Both 4a and 4b will include a 2-week placement in either a cyclotron centre (4a) or a conventional radiopharmacy (4b). All MSc students do a research project (module 5), which will be either laboratory-based or literature-based. Laboratory-based projects will be on a placement basis in a PET centre, industry, radiopharmacy, or academic laboratory. Although most projects will involve direct work with radiochemicals, there is no necessity for the project to involve directly the handling of radioisotopes, provided the topic underpins radiopharmaceutical research (e.g. peptide synthesis or chelator synthesis). Studentships: Fully or partially funded studentships will be available to suitably qualified candidates Location: Kings College London, St Thomas’ Hospital Campus For more information please contact: Dr Tony Theobald or Prof Phil Blower at: Kings College London Imaging Sciences Division 5th Floor, Thomas Guy House Guy’s Campus LondonSE1 9RT email@example.com firstname.lastname@example.org Tel: +44(0)20 7848 5438 Application form/on-line application: http://www.kcl.ac.uk/pgp06/programme/443 Further information: http://www-pet.umds.ac.uk/ Sponsorship: The course is currently sponsored in the form of studentships or other support by: Cancer Research UK, GE Healthcare, Tyco Healthcare, Siemens Medical and EPSRC.