POSTDOCTORAL RESEARCH ASSOCIATE IN MUSCLE
RANDALL DIVISION OF CELL & MOLECULAR BIOPHYSICS
SCHOOL OF BIOMEDICAL & HEALTH SCIENCES
REFERENCE NUMBER W6/JKA/466/09-DB
1. Explanatory notes, including application procedure
2. Further particulars, including:
a. information about the King‟s College London
b. job description and person specification
c. summary of the terms and conditions of service
3. Application form
4. Equal opportunities monitoring form
EXPLANATORY NOTES - please read carefully before completing the application form
Thank you for your enquiry regarding a post at King‟s College London. Enclosed is an application
form and a set of further particulars for this post. These comprise: a job description and person
specification; general information about the College, School and Department, as well as the main
terms and conditions of the post.
Should you wish to apply for this position, please send a completed application form to:
(You may include a CV as well, but not in place of the application form)
Human Resources department
4th Floor Capital House
42 Weston Street
Tel: + 44 (0) 020 7 848 4755
Please ensure you quote reference number W6/JKA/466/09-DB on all correspondence
For an informal discussion of the post please contact Prof. Malcolm Irving, e-mail:
Closing date: 25th January 2010
King‟s College London is committed to promoting and developing equality of opportunity in all
areas of its work. In order to achieve this aim, the College will seek to:
ensure that prospective and current students, job applicants and members of staff are
treated solely on the basis of their merits, abilities and potential without any unjustified
discrimination on grounds of age, sex, disability, family circumstances, race, colour,
nationality, citizenship, ethnic origin, social and economic status, religious belief, sexual
orientation, marital status or other irrelevant distinction;
promote good relations between individuals from different groups;
recognise and develop the diversity of skills and talent within both its current and potential
staff and student body;
foster a culture based on trust and mutual respect;
undertake a programme of action to make equality policies effective;
monitor progress towards achieving equality of opportunity on a regular basis;
communicate to staff, students, associates and others the promotion of equal opportunities
and College procedures to sustain it.
Applicants with disabilities
King‟s College London is keen to increase the number of disabled people it employs. We therefore
encourage applications from individuals with a disability who are able to carry out the duties of the
post. If you have special needs in relation to your application please contact the HR Advisor
responsible for the administration of the post.
The College normally reimburses reasonable travel costs to and from interview within the United
Kingdom. Reasonable travel costs include travelling by second class rail, underground and bus.
Regrettably, only limited contribution to travel costs for applicants from outside the UK may be
available. Please contact the Human Resource Services Department before making your
We very much regret that due to limited resources and the large number of applications we
currently receive, we are only able to inform short listed candidates of the outcome of their
If you do not hear from us within four weeks of the closing date, please assume that you have been
unsuccessful on this occasion. We would like to assure you, however, that every application we
receive is considered in detail and a shortlist only drawn up after careful reference to a detailed
If therefore, your application is not successful, we hope that you will not be discouraged and will
still apply for other suitable vacancies at King‟s College London as and when they are advertised.
Thank you for your interest in King‟s College London.
King's College London is one of the top 25 universities in the world (Times Higher Education 2009)
and the fourth oldest in England. A research-led university based in the heart of London, King's
has more than 21,000 students from nearly 140 countries, and more than 5,700 employees. King's
is in the second phase of a £1 billion redevelopment programme which is transforming its estate.
King's has an outstanding reputation for providing world-class teaching and cutting-edge research.
In the 2008 Research Assessment Exercise for British universities, 23 departments were ranked in
the top quartile of British universities; over half of our academic staff work in departments that are
in the top 10 per cent in the UK in their field and can thus be classed as world leading. The College
is in the top seven UK universities for research earnings and has an overall annual income of
nearly £450 million.
There are nine Schools of Study:
Arts & Humanities
Biomedical & Health Sciences
Institute of Psychiatry
Nursing & Midwifery
Physical Sciences & Engineering
Social Science & Public Policy
King's has a particularly distinguished reputation in the humanities, law, the sciences (including a
wide range of health areas such as psychiatry, medicine and dentistry) and social sciences
including international affairs. It has played a major role in many of the advances that have shaped
modern life, such as the discovery of the structure of DNA and research that led to the
development of radio, television, mobile phones and radar. It is the largest centre for the education
of healthcare professionals in Europe; no university has more Medical Research Council Centres.
King's College London and Guy's and St Thomas', King's College Hospital and South London and
Maudsley NHS Foundation Trusts are part of King's Health Partners. King's Health Partners
Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the
world's leading research-led universities and three of London's most successful NHS Foundation
Trusts, including leading teaching hospitals and comprehensive mental health services. For more
information, visit: www.kingshealthpartners.org.
THE SCHOOL OF BIOMEDICAL AND HEALTH SCIENCES
The School of Biomedical and Health Sciences (see appendix 1) is one of the largest Schools of
King‟s College London, with a turnover in excess of £50 million per annum. It has approximately
200 academic staff, 400 research and support staff, 450 postgraduate students and the School
teaches approximately 2500 undergraduate students on a range of biomedical, life sciences,
medical, dental and other health-related programmes.
The School is based primarily at the Guy‟s (London Bridge) and Waterloo Campuses, although
significant activity is also located at St Thomas‟ which, along with Guy‟s, provides an important
clinical interface for research. All three campuses are located in proximity to each other on the
vibrant South Bank, and to the Strand. The facilities for teaching and research at the Guy‟s and
Waterloo Campuses have been greatly enhanced since 1998 through a capital investment
programme of approximately £200 million, which has provided state of the art laboratories and a
high quality learning environment.
Within the School, research divisions provide the focus for the organisation of research activity.
The research divisions build on the success at the 2001 Research Assessment Exercise (RAE),
with ratings of 5* for The MRC Centre for Developmental Neurobiology (UoA 6, Anatomy), 5 in Pre-
Clinical studies (UoA 5), 5 in Biological Sciences (UoA 14), 5 in Pharmacy (UoA 9), 5 (Nutrition and
Dietetics) and 4 (Applied Biomedical Research) in Other Studies and Professions Allied to
Medicine (UoA 11). Teaching is delivered by discipline-based departments, and all teaching
activity in the School has achieved excellent ratings from Quality Assurance Agency assessors.
The Randall Division of Cell and Molecular Biophysics continues the tradition of Biophysics at
King‟s established by Sir John Randall, which produced the famous studies of the structure of DNA
by Rosalind Franklin and Maurice Wilkins. Much of this early work was supported by the Medical
Research Council, who still provide a large part of our research funding.
Research in „the Randall‟ has a strong interdisciplinary flavour, and we have joint appointments
and extensive collaborations with the Asthma, Allergy and Lung Biology, Cancer Studies,
Cardiovascular, and Developmental Neurobiology Divisions. We contribute expertise in molecular
and cell biology, molecular structure, and molecular cell imaging to these and other areas of
research in the Health Schools at King‟s. Many of our research groups operate at the interface
between the health, biomedical and physical sciences, developing new techniques for application
in biology and medicine.
The Division occupies new laboratories on the third floor of New Hunt‟s House on the Guy‟s
Campus. About 120 staff and students work here, in six research groups. There are many cross-
group collaborations and shared facilities.
The Post is funded by an MRC Project Grant: „Molecular mechanism of the myosin motor in skeletal
muscle‟ to Professor Malcolm Irving (King‟s College London) and Professor Bernhard Brenner
(Hannover Medical School).
The project will use a novel fluorescence-based technique to measure the conformation of the
myosin lever arm, the key structural parameter in current models of muscle contraction, in isolated
muscle cells. Thus it aims to answer some longstanding fundamental questions about the
mechanism of muscle contraction, and to underpin a wide range of physiological and pathological
studies on skeletal, cardiac and smooth muscle, for example on the molecular basis of
cardiomyopathies, and on the many non-muscle myosins with diverse cellular functions and their
We are looking for a Postdoctoral Research Associate with experience in muscle cell physiology or
biophysics to carry out the biophysical measurements on isolated demembranated muscle fibres.
The RA will prepare the fibres, replace the endogenous regulatory light chain (RLC) component of
the myosin lever arms with fluorescently-labelled RLCs prepared by other members of the group,
and determine the orientation of the myosin lever arms within the fibres by polarised fluorescence
measurements. Lever arm conformations will be measured when myosin is bound to actin in the
absence of ATP, and in the presence of nucleotide analogues that mimic either weak actin-binding
or force-generating states of the myosin motor. The results will elucidate the transitions between
conformational and biochemical states of myosin that drive muscle contraction.
Post Title: Research Associate
Department/Division/Directorate: Randall Division
Responsible to: Professor Malcolm Irving
Reports to: Professor Malcolm Irving
The overall purpose of the job will be to conduct original and high quality research to
elucidate the molecular mechanism of muscle contraction
ROLE OUTLINE – MAIN RESPONSIBILITIES
Develop and undertake research of high quality consistent with making a full active
research contribution to help achieve the objectives of the research project.
Manage specific pieces of activity to an agreed timeline and within a specific budget
including literature reviews, data collection and analysis, report writing.
Attend and, as appropriate, present research findings and papers at internal academic
meetings and external professional conferences.
Work as a conscientious and committed member of the team in order to achieve the aims
of the project.
Undertake any additional specialist training as required by the project.
To be committed to your own personal career development.
Liaise with the administrative team for the support of the project
Contribute to publications arising from this project
Undertake any other reasonable duties that may be relevant to the role outline.
Communication & Networking:
Deal with routine communication using a range of media
Communicate complex information orally and in writing
Communicate material of a specialist or highly technical nature
Present progress reports to the principal investigators and lab group
Presenting and attending seminars to the research group and the Randall Division, and at
Liaise with colleagues and students
Build internal and external contacts, share information and form relationships for future
Decision Making, Planning and Problem Solving:
Use new research techniques and methods
Identify areas for research, develop new research methods and extend the research
Contribute to collaborative decision making with colleagues in area of research
Provide expert advice about muscle physiology and biophysics
Analysis & Research:
Develop research objectives and proposals for own or joint research.
Conduct individual and collaborative research projects
Write up research work for publication
Continually update knowledge and understanding in field
Translate knowledge of advances in muscle physiology and biophysics into research
Analyse and interpret research data and draw conclusions on the outcomes
To prepare isolated demembranated muscle fibres from psoas muscle of rabbit and
replace the endogenous regulatory light chain (RLC) component of the myosin lever arms
with fluorescently-labelled RLCs
To determine the orientation of the myosin lever arms within the muscle fibres by polarised
Team Work, Teaching & Learning Support:
Work with colleagues on joint projects as required
Collaborate with academic colleagues on areas of shared research interest
Attend and contribute to relevant meetings
Share of general laboratory routines
Help with the day-to-day supervision of undergraduate and PhD projects.
Sensory/Physical Demands & Work Environment:
Adhere to any COSHH and Risk Assessment requirements and safe working practices.
Be well organised and keep own work areas tidy
Show consideration to others
Professor Malcolm Irving
Head of Division
Randall Division of Cell &
Professor Malcolm Irving
(Lead Principal 25 x Division PIs Division management staff
Lab members of the Irving
and Brenner groups
You will be required to work irregular hours in accordance with the needs of the role
Information of a confidential nature must be kept strictly confidential and should never be
disclosed either inside or outside work. It should be noted that breach of confidentiality is a
serious offence which may lead to dismissal.
This appointment is subject to Occupational Health clearance. Should you be offered this post
you will be sent an Occupational Health Questionnaire along with your contract of
employment. When the Occupational Health Department have evaluated your questionnaire
and declared that you are fit for appointment, your appointment will be formally confirmed.
All staff are expected to adhere to King‟s policies and procedures.
Date: 22 December 2009
This job description reflects the core activities of the role and as the College and the post-holder
develop there will inevitably be changes in the emphasis of duties. It is expected that the post-
holder recognise this and adopt a flexible approach to work and be willing to participate in training.
If changes to the job become significant, the job description should be reviewed formally by the
post-holder and line manger. The Human Resources department should then be consulted as to
the implications of the proposed changes.
Eligibility to Work in the United Kingdom
International applications will be considered for this position. If you do not have permission to
enter, remain and work in the United Kingdom you will need to pass a points-based immigration
assessment. Before you apply for this job you must ascertain whether you have sufficient points to
qualify under Tier 1 and/or Tier 21 schemes. If you do not have sufficient points please do not apply
as you will not be granted permission to enter the United Kingdom. Click on the following link to the
Border & Immigration Agency | Points-based calculator
At the interview you will be asked to furnish the panel with the details of the route (Tier 1 and/or
Tier 2) you would be eligible to follow. Please note that should you have sufficient points this does
not mean your application will be successful. In the event your application is successful there is no
guarantee that your application for a visa will be granted, in which event the offer will be withdrawn.
CRITERIA E D HOW IDENTIFIED
S E AND ASSESSED
AP = application
N R AS = assessment
T A I = interview
A L P = presentation
L E R = references
Education/qualification and training
PhD in a relevant field X AP
Broad knowledge of muscle physiology and structure X AP & I
Quantitative skills in data analysis X AP & I
Knowledge of instrumentation for experimental data acquisition X AP & I
Expertise in quantitative measurements on isolated cells X AP & I
Laboratory-based experience in a relevant research field X AP & I
Relevant post-doctoral research experience X AP & I
Personal characteristics/other requirements
Ability to communicate findings with others X I&R
Motivated, hard-working and adaptable X R
Willingness to help and collaborate with other staff and students X I&R
Ability to work independently and with minimal supervision X I&R
Well informed and up-to-date with literature in the field of interest X I
Reliable and conscientious approach to duties X I&R
Willing to undertake share of group tasks and maintenance of X I
Willingness to work occasionally outside normal working hours X I
Enthusiasm about own projects and collaborative projects X I
There are two classifications – highly skilled migrant and sponsored migrant. Highly skilled migrants are
encouraged to apply under the Tier 1 (General Migrant) route. If you do not qualify under the Tier 1 (General
Migrant) route, you may qualify under the Tier 2 (Skilled Worker-General) route, however this is dependent on
King‟s College London at its sole discretion issuing you with a Certificate of Sponsorship.
SUMMARY OF TERMS AND CONDITIONS OF SERVICE
This appointment is made under the King‟s College London Terms and Conditions of Service for Non-
Academic staff. A copy of which is available from the Human Resources Department on request.
Period of appointment Three years
Probation 6 months
Salary £30,747 - £36,715 plus £2323 London Allowance
Annual leave 27 working days
Staff are entitled to four additional closure days. Notification as to how these days are taken is
circulated at the start of the academic year.
This appointment is superannuable under the USS pension scheme, the employee's contribution
normally being 6.35% of salary. Staff already superannuated under the NHS Superannuation
Scheme may opt to remain in that scheme provided an application to do so is received by the NHS
scheme trustees within three months of appointment to King‟s College London. Alternatively staff
may opt to participate in SERPS or take out a personal pension. Please note that the College
does not provide an employer's contribution towards a private pension plan.
The College operates PensionsPlus by which individuals increase their take home pay by reducing
their NI contributions. For staff who join either USS or SAUL pension schemes, you will automatically
be entered into PensionsPlus (provided you would benefit from doing so). As a result your salary will
be reduced so that you receive the PensionsPlus salary and a payment is made into your pension
NB - NHS Superannuation Scheme: Medical Schools are classed as “Direction Employers” and
some benefits of the NHS Scheme are not available to Direction members.
For further information please contact Ms Pauline Job, Payroll & Pension Manager, King‟s College
London, James Clerk Maxwell Building, 57 Waterloo Road, London SE1 8WA.
All appointments to King‟s are subject to Occupational Health clearance. Should you be offered
this post you will be sent an Occupational Health Questionnaire along with your contract of
employment. When the Occupational Health Department have evaluated your questionnaire and
declared that you are fit for appointment, your appointment will be formally confirmed.
In the course of your work you may have access to personal or confidential information which must
not be disclosed or made available to any other person unless in the performance of your duties or
with specific permission from your Head of School/Department/Division. (In particular if your work
involves the handling of clinical samples and/or patient data, NHS policies for the maintenance of
security and confidentiality of NHS systems and data must be observed). Breaches in
confidentiality may lead to disciplinary action.
Training and Education
King‟s College London recognises the importance of training in achieving its objective of pursuing
excellence in teaching, research and clinical practice through the activities of its staff. We are
committed to providing training for all members of staff so that they can perform their jobs
effectively and offering them opportunities for further development. Most training and development
will occur "on the job" and formal training opportunities are also available within King‟s College
London associated hospitals trusts and through other external organisations.
All members of staff with teaching responsibilities are encouraged to obtain formal recognition of
their professional expertise in teaching. It is the normal expectation that staff new to teaching in
higher education will register for the Post Graduate Certificate in Academic Practice (PGCAP)
unless they already possess a teaching qualification in higher education. The PGCAP is taught
and managed by the King's Learning Institute (KLI); information about the certificate and other
programmes run by KLI can be found on their web site – www.kcl.ac.uk/learningteaching
No Smoking Policy
King‟s College London is committed to maintaining a healthy environment for staff, students and
visitors. Therefore, please note that smoking is not permitted in any of the College buildings or in
College vehicles. Smoking is also not permitted immediately outside the entrances to College
buildings or near to windows and air intake units. Staff working at associated NHS trust sites or
other premises should adhere to whatever policy is in place at these locations.
It is important that you type or write legibly using black ink when completing the form as it
will be photocopied. You may supply additional material if relevant but unfortunately it is not
sufficient to only send a copy of your Curriculum Vitae. Receipt of application will be
acknowledged only upon receipt of a stamped self-addressed envelope. Applications
should be returned to the address provided in the job details.
* Please refer to job details Closing date: *
Job Ref: *
Post applied for: *
Where did you first see the post advertised? Date of Publication:
Surname: Title (Prof/Dr/Mr/Mrs/Miss/Ms):
Home Address (including postcode):
Tel no: Mobile no:
Work Address (including postcode):
Tel no: Email (work):
May we contact you by telephone or email at work? (please indicate as appropriate)
Period of notice in present post: Are you over 16 and under 65?: Yes No
National Insurance no: Work Permit Needed: Yes No
Are you in good health? Yes No If not, please state the reason(s):
How many days sickness absence have you taken in the last two years?
If an offer of employment is made, you may be required to complete a medical questionnaire which would be sent direct to our
occupational health department.
Have you applied to/been employed by King‟s College before? If so, please give details/dates:
Please give your present/last annual salary and details of any additional benefits/allowances:
Please note: salary details of appointee may be verified.
EDUCATION AND QUALIFICATIONS
University/College Subject From (mth/yr) To (mth/yr)
Technical, professional, commercial or relevant in-house training
College/Institute Type of training From (mth/yr) To (mth/yr) Results
Membership of professional bodies / Professional registration
Secondary School Examinations passed From (mth/yr) To (mth/yr) Grades
Please provide the names and addresses of two referees (one of whom should normally be your manager/supervisor at your current
workplace). For recent graduates your personal tutor could also be appropriate. Relatives may not be given as referees.
Tel no: Tel no:
Fax no: Fax no:
Email address: Email address:
Job title of referee: Job title of referee:
Relationship to you: Relationship to you:
If you are shortlisted, references may be taken up prior to interview. Please indicate if you do not wish us to contact your current
employer prior to interview.
CURRENT AND PREVIOUS APPOINTMENTS (please start with most recent)
From (mth/yr) Reason for
Employer's name, address and type of business Positions held (briefly describe duties)
To (mth/yr) leaving
Please state below why you are interested in applying for the post and indicate how your skills, past achievements, qualifications,
experience and personal qualities make you suited for this job and what contribution you would expect to make if appointed. For
academic and research posts please list publications, grants and distinctions. (Please use additional sheets if necessary).
DATA PROTECTION STATEMENT
Access to this information will be restricted to a limited number of authorised College Staff. The information may also be used for
the purposes of compiling employee statistics and equal opportunities monitoring.
For those staff who hold honorary contracts with the NHS, the data may be shared with your honorary employer.
I give my consent to this information being processed and stored (by means of a computer database or otherwise) as described
above, for the duration of my contract of employment and to fulfil the statutory, or recommended, retention periods when I am no
longer an employee at King‟s College London.
I confirm that all the information given on this form is complete and correct by signing below.
Signature: ........................................................................................... Date: ............................................................
Please note that failure to disclose relevant details or a deliberate attempt to falsify information may lead to dismissal.
KING'S COLLEGE LONDON
EQUAL OPPORTUNITIES IN EMPLOYMENT
EQUAL OPPORTUNITIES STATEMENT
King‟s College London is committed to promoting and developing equality of opportunity in all areas of its work. In
order to achieve this aim, the College will seek to:
ensure that prospective and current students, job applicants and members of staff are treated solely on
the basis of their merits, abilities and potential without any unjustified discrimination on grounds of age,
sex, disability, family circumstances, race, colour, nationality, citizenship, ethnic origin, social and
economic status, religious belief, sexual orientation, marital status or other irrelevant distinction
promote good relations between individuals from different groups
recognise and develop the diversity of skills and talent within both its current and potential staff and
foster a culture based on trust and mutual respect
undertake a programme of action to make equality policies effective
monitor progress towards achieving equality of opportunity on a regular basis
communicate to staff, students, associates and others the promotion of equal opportunities and College
procedures to sustain it
To ensure that the College's equal opportunities policy is effective, detailed monitoring of applications will be
carried out. This necessitates the collection of information regarding applicants' gender, marital status, age,
ethnic origin, nationality and disability. This monitoring slip is detached prior to shortlisting and is not seen by staff
involved in making shortlisting decisions. The contents of the slip is treated in strict confidence by the Human
Resources department. The information provided will form a confidential statistical record/database which will be
used for analysis of the College's Equal Opportunities policy.
Please indicate the option which most closely describes you.
I am: Female
I am: Married Divorced With partner
Single Widowed Separated
DATE OF BIRTH:
Have you ever been convicted of a criminal offence, other than that of a spent conviction under the Rehabilitation
of Offenders Act 1974?
Having a current conviction will not necessarily bar you from employment with the College. This will depend on
the nature of the work and the circumstance and background to the offence(s).
If Yes, please give details:
The following ethnic categories meet the current recommendations of the Commission for Racial Equality as well
as the requirements of the Higher Education Statistics Agency (HESA):
Other White background (please complete)
White & Black Caribbean
White & Black African
White & Asian
Other mixed background (please complete)
c: Asian or Asian British
Other Asian background (please complete)
d: Black or Black British
Other Black background (please complete)
e: Chinese or Chinese British or Other ethnic group
Any other ethnic background (please complete)
or, Information refused
DISABILITY DISCRIMINATION ACT 1995
King's College London wishes to ensure that disabled people are not discriminated against, either directly or
indirectly, both in recruitment/selection and in employment. If you are selected for interview and you consider
yourself to be disabled, we may contact you to find out if there are any particular arrangements you may need for
the interview. You are not obliged to answer the following question or to give details.
As defined by the act - a disability is "a physical or mental impairment which has a substantial and long-term
adverse effect on a person's ability to carry out normal day-to-day activities". Do you consider yourself to be
If appropriate, please describe any requirements which may be necessary for an interview: