The sense of smell is mediated by a repertoire

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The sense of smell is mediated by a repertoire Powered By Docstoc
					Olfaction	Targeted
Peter Mombaerts
The Rockefeller University
    The sense of smell is mediated by a repertoire of ~1000 odorant receptor genes
in mice. Each olfactory sensory neuron is thought to express just one of these genes.
Its axon synapes with second-order neurons within a glomerulus in the olfactory
bulb. The axons of all neurons that express the same receptor gene converge to the
same glomeruli. The odorant receptor is a critical determinant of which glomerulus is
innervated. An olfactory sensory neuron thus faces two tasks during differentiation: to
choose one odorant receptor gene for expression, and to project its axon to a specific
glomerulus.