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									365 330 General Pathology

Introduction
Darunee Jintakanon
Department of Pathology Faculty of Medicine, KKU

• Pathology คือ อะไร? • ทาไมต้องเรียน? • เรียนอย่างไร? • ต้องการพื้นฐานความรู้ใดบ้าง • จะได้ใช้วิชานี้เมื่อไร? อย่างไร?

Pathology คือ อะไร?
Pathology = Pathos + Logos Suffering Study

พยาธิวิทยา

Study of Disease

•ทาไมต้องเรียน?

•จะได้ใช้วิชานีเมื่อไร? ้

di ag no sis

= STUDY ABNORMAL STATE OF BODY PARTICULAR IN MORPHOLOGICAL & FUNCTIONAL CHANGES OF ORGAN, TISSUE CELLS.

Abnormal stage of body  Disease

•Disorderly function (show off as abnormal sign and symptom) of organ system of body (cell, tissue, organ)

• Sign = objective symptom of disease •Ascites, cachexia, cough, dysphagia, fever, gynecomastia, hemoptysis, hepatomegaly, splenomegaly, icterus, lymphadenopathy, palmar erythema • Symptom = subjective sign of disease •Chest pain, dizziness, loss of appetite, weakness, numbness, headache, toothache

The concept of disease
Change with adaptation Hypertrophy /hyperplasia Atrophy Metaplasia
Structural change
Signs
Functional change

Environmental factors
Cell Tissue Organ

Lesion

Inability to adapt

Injury Death

Genetic factors

Symptoms

The general main causes of disease
i ii Inflammation:

Congenital Diseases
appendicitis, TB

Acquired Diseases

Genetic
Inherited :
cystic fibrosis

Non genetic
Environmental :
rubella assoc mal-

Hemodynamic Growth disorder : shock, MI disorders Injury, disordered repair: Neoplasia: lung CA fracture, aspirin induced PU Non neoplastic: BPH

Metabolic disorders: DM
osteoarthritis

Immune disorder:

AIDS, Graves’ disease

Spontaneous :
Down’s syndrome

Accidental : cerebral
palsy ~ birth hypoxia

Degeneration:

* Familial diseases * Abnormal Growth & Development
Cushing’s syndrome ~ X steroids

Iatrogenic disease

Aplastic anemia ~ chloramphenicol

Scope of Pathology
Anatomical Pathology Clinical Pathology
•surgical pathology •cytopathology •forensic pathology •Oral and maxillofacial pathology Pathologists •clinical chemistry •clinical hematology/blood banking •clinical microbiology
~ medical technologists

Veterinary pathology is concerned with animal disease Phytopathology is the study of plant diseases.

A combination both anatomical and clinical pathology is known as general pathology

General pathology
• also called investigative pathology, experimental pathology or theoretical pathology • is a broad and complex scientific field which seeks to understand the mechanisms of injury to cells and tissues, as well as the body's means of responding to and repairing injury

เรียนอย่างไร?

THEORETICAL STUDY

Main object is to know the nature of DISEASE by study as the following :-

1. Etiology ( causes of diseases ) 2. Pathogenesis (mechanism of diseases) 3. Pathological changes : structural change  Lesion

THEORETICAL STUDY

4. Clinical feature : functional & structural changes  symptoms & signs of patients

5. Complication
6. Prognosis ( prediction the future of victim)

Etiology
Pathogenesis

S.aureus

Smoking , Polycyclic AHC

HBV

Acute inflammation

Genetic mutation

Immuneinfected Increased renin to virus reaction production cells

Morphological and functional features Complications & sequelae

Boil

Lung cancer

Cirrhosis

High BP

Septicemia

Metastasis

Liver failure

Cerebral hemorrhage

เรียนอย่างไร?

TACTICAL STUDY

“เปรียบเทียบ” ระหว่างสิ่งปกติ กับ สิ่งซึ่งผิดปกติไปจากธรรมชาติของมนุษย์
ศึกษาโดย

เปรียบเทียบสิ่งเดียวกัน ชนิดเดียวกันในเรื่อง

โครงสร้าง และ หน้าที่การทางาน ของ อวัยวะ เนื้อเยื่อ และเซลล์ นั้น

ตัวอย่างการเปรียบเทียบ
Structure
Normal squamous cell VS abnormal squamous cell

Function of organ, tissue, cell

Normal blood sugar VS abnormal blood sugar

ตัวอย่างการเปรียบเทียบ

ตัวอย่างการเปรียบเทียบ

Techniques of Pathology

Biochemical Microbiological Hematological Cell/ tissue culture

Learning objective
1. The meaning of pathology and scope of pathology.
2. How to study the pathology? 3. Techniques of Pathology 4. The general main causes of disease

REFERENCES
1. General and systematic Pathology, 4th edition, edited by J.C.E.Underwood, “Introduction to Pathology” 2. Concise Pathology, 3rd edition, edited by P. Chandrasoma ; C.R. Taylor, Introduction : The Discipline of Pathology, pp xiii – xiv 3. Robbins and Cotran Pathologic Basis of Disease, 7th edition, edited by Kumar; Abbas; Fausto; “Introduction to Pathology” pp 4


								
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