Tomographic Ultrasound Imaging by smapdi62


									                                                                                                                                                                      w w w. g e h e a l t h c a r e . c o m

2007 / 1st edition No. 16
                                            technical development and medical research –
                                                                      NEWS and FACTS.

                    Contrast Enhanced                                                    Benefits of Volume                                                      Breakthroughs in
                    Ultrasound in Cancer                                                 Ultrasound Imaging                                                      DXA Densitometry
                    Diagnosis &Treatment
                                                          2                              in the Scrotum
                                                                                                                             3                                   Technology

Abdominal Applications of                                                                                                             applying gray maps. Each
                                                                                                                                      of these slices will then be
                                                                                                                                                                        4. Providing concentrated
                                                                                                                                                                           evaluation of the scan

                                                                                                                                      filtered and processed. A            area by allowing the us-
                                                                                                                                      single bitmap image will be          er to define the distance
                                                                                                                                      generated that consists of           between the slices
                                                                                                                                      all of the slices displayed       5. Allowing for a compre-

Ultrasound Imaging
                                                                                                                                      per the chosen format. An            hensive review of anato-
                                                                                                                                      orthogonal scout image               my with a “virtual rescan”
                                                                                                                                      will indicate where each             of the volumetric data
                                                                                                                                      frame is located in the vol-         that can be obtained in
                                                                                                                                      ume.                                 any plane
                                                                                                                                      Once the algorithm de-            6. Using the raw data to
Introduction                       TUI and present a series of     readily evaluated. Display-      to the other. The 2D slices       termines the num-
Tomographic Ultrasound             cases demonstrating the         ing multiple slices at one       can then be viewed either         ber of slices separat-
Imaging (TUI) is a new tech-       clinical benefits in abdom-     time allows quicker and          as separate images or to-         ed by the slice dis-
nology that allows for a           inal applications.              easier viewing of volume         gether when projected on          tance, the application
comprehensive sequential                                           information, as well as a        a volumetric cube. The ac-        then allows for view-
analysis of the desired anat-      Technology                      more intuitive way to view       quired frames in the volume       ing between two par-
omy. There are reports of          TUI is a feature of Volume      Volume Ultrasound images.        are oblique in shape along        ticular slices. The user
TUI’s clinical benefits in ob-     Ultrasound imaging which        Using mechanical volume-         the probe sweep curvature.        can      choose      the
stetrical studies, but to our      displays multiple parallel      tric 3D/4D transducers, vol-     The spatial separation be-        image displayed by
knowledge there are no             slices within a volume data     ume data is acquired by cap-     tween each frame is at an         adjusting the slice
clinical reports of different      set. Since the user adjusts     turing frames that are sep-      angle.                            position control.         B
applications using TUI in          the orientation and spac-       arated by a regular time         Frames are processed
radiology. This article will       ing of the slices, a specific   interval, as the transducer      using normalization vec-          Clinical Benefits
explain the concept behind         region of interest can be       head sweeps from one end         tors, which convert them in-      Ultrasound has tradi-
                                                                                                    to a set of frames that are       tionally been a modal-
                      EDITORIAL:                                                                    parallel to each other. The       ity driven by images
                                                                                                    angle between two frames          taken in non-volume-
                                   for many applications. With     display of ultrasound im-        will be translated to a dis-      tric 2D planes.
                                   the introduction of GE's        ages in a “sliced” way just as   tance between each frame.         As technologies have
                                   Volume Ultrasound imaging       with CT and MR, or Contrast      The volume angle of the           advanced, it has now C
                                   technology, our business        Enhanced Ultrasound (CEUS),      sweep will determine how          become possible to
                       Heinz       fulfills these requirements     an important imaging mo-         many frames fit inside a          collect volumetric da-
                       GLOOR       even better.                    dality for oncology diag-        data set. A higher quality is     ta. With TruScan™ ar-
Vice President / General Manager   Since GE introduced this        nosis.                           achieved when the frames          chitecture, the user
GE Healthcare Technologies         state-of-the-art ultrasound     Volume Ultrasound can be         are spaced closer together.       can obtain data in a
Ultrasound & PCD
Europe, Middle East & Africa
                                   technology, a fast growing      an advantage for you, the        The algorithm will compute        volume and manipu-
                                   number of radiologists apply    physician, and your patient.     the number of slices and          late the raw data
                                   and appreciate this precise,    It also demonstrates GE's        the distance between each         after the images have
Dear Readers,                      easy-to-use and very econ-      commitment to improve            slice.                            been obtained.               Figure A-C
                                   omic imaging technology.        healthcare with new, inno-       Using the center slice as an      Tomographic Ultra-
                                                                                                                                                                   TUI with slice spacing set at 0.5 mm
                                                                                                                                                                   intervals. Complex ascites and in-
   Economic circumstances          The advantages in terms of      vative technology.
                                                                                                    index, the location of each       sound Imaging (TUI)          creased thickness of the small bowel
and personnel availability         diagnostic confidence and                                                                                                       wall was detected suggesting ische-
                                                                                                    slice in the volume is            provides numerous            mic bowel.
are two main drivers re-           workflow efficiency of Vol-     With this I wish you enjoy-
                                                                                                    determined by the follow-         clinical benefits to the
quiring us to increase pro-        ume Ultrasound to physi-        able reading about the
                                                                                                    ing equation:                     user.
ductivity and to achieve           cians and patients are mani-    latest   scientific  studies
                                                                                                    Slice(n) = Slice(center) +        1. Dramatically decreasing           conduct a side-by-side
more economical use of the         fold.                           associated with Volume
available resources.               Volume Ultrasound data sets     Ultrasound applications and
                                                                                                    n*D; where the value of n            the scan time for the so-         comparison from prior
Ultrasound is meeting this         contain all of the necessary    their advantages written         ranges from –(Number of              nographer as the entire           studies
demanding challenge. Being         information from the ROI,       by renowned specialists in       Slices)/2 to +(Number of             area of interest is imag- 7. Systematically displaying
easily transportable, non-         thus in real-time as well as    this issue of Ultrasound         Slices)/2                            ed by one volumetric              images of normal and
invasive and providing un-         off-line anytime and any-       Post.                            The user will also specify           sweep                             abnormal anatomy, and
ique and relevant diagnostic       where.                                                           how many of these slices          2. Capturing images in planes        allowing the reviewer to
features, ultrasound be-           Volume Ultrasound offers        Yours                            appear on the screen using           that were not possible            have the familiarity of
came an essential diag-            even more imaging modes                                          the display format. Raw              with conventional ultra-          conventional images ob-
nostic tool in screening and       such as Tomographic Ultra-                                       data, which is located at a          sound                             tained from volumetric
diagnosis and is today an          sound Imaging (TUI), which                                       particular slice index, will be   3. Displaying individual im-         data sets in multiple or-
imaging method of choice           enables the analysis and        Heinz Gloor                      loaded and interpolated by           ages at any angle                 thogonal planes

w w w. g e h e a l t h c a r e . c o m                                                                                                                                                            -1-
ultrasoundpost NEWS and FACTS 2007 / 1st edition

Conclusion                           presents a new, faster, and       Michael LEDWIDGE,         A                                            B                                          C
                                                                       BS, RDMS, RVT,
TUI ushers in the next gen-          more flexible approach to         CNMT Department
eration of ultrasound imag-          clinical ultrasound challeng-     of Radiology, Sono-
                                                                       graphy Section, Uni-
ing through volumetric da-           es, increasing diagnostic         versity of Wisconsin
tasets, which when manipu-           confidence through access         Hospital and Clinics
lated and displayed in a sys-        to multiplanar views unob-        Jorge SARMIENTO,
tematic format, allow for            tainable in traditional scan-     M.D., Clinical Special-
                                                                       ist, Ultrasound, GE
better imaging capabilities.         ning, as well as an intuitive     Healthcare
The outcome of using this            display of the volume. Cor-       Cindy A. OWEN,
                                                                                                     Figure A-C
technology will ultimately           roborated clinical studies        RDMS, RVT,
                                                                                                     Using TUI a single volumetric sweep of the liver in this immunosuppressed patient demonstrated multiple hypoechoic masses.
                                                                       GE Healthcare, Con-
reduce scan time and ben-            will be conducted to confirm      sultant Baptist Mem-
                                                                                                     The ability to acquire all relevant diagnostic information with a single volumetric sweep improved efficiency. Biopsy results
                                                                                                     were positive for fungal infection.
efit patient care. TUI re-           our exciting initial findings.    orial Hospital

Prof. Tranquart at the International Anti Cancer Treatment Conference in Paris

                      Contrast Enhanced Ultrasound
                      in Cancer Diagnosis & Treatment
    Prof. François Tranquart         Prof. TRANQUART                  confidence in CEUS?                     including both radiologists sound companies play in                              this objective, the availability
is the Head of “Centre d’In-         Worldwide ultrasound is                                                  and      gastroenterologists, spreading CEUS?                                    of both volume and quan-
novations Technologiques             considered the first imag- Prof. TRANQUART                               established the first Euro-                                                      tification packages on and
Ultrasons” at the CHRU               ing modality for screening The usage of CEUS undoubt- pean guidelines for the Prof. TRANQUART                                                             offline is essential for the
Bretonneau in Tours. Always          focal liver lesions in cancer edly faced some uncertain- usage of CEUS in the study Their role is becoming in-                                            workflow in guiding clini-
at the center of new re-             staging or for any abdom- ties in the first few years. of FLL. The work promoted creasingly important. All of                                             cians in treatment planning.
search in ultrasound, such           inal symptoms.                   The first CEUS, requiring by EFSUMB had the aim of these companies have de-
as elastography, contrast            However, because of a few high MI, were a little bit introducing some recom- veloped new features and                                                     ULTRASOUND POST
enhanced ultrasound and              technical limitations, funda- tough due to the fact that mendations in their clinical waves to increase the ratio                                         So, what do you feel is the
volume imaging, his team             mental ultrasound sensi- they entailed lengthy pro- use. These guidelines were signal/noise and provide                                                   role of Volume Ultrasound
handles important research           tivity is lower than that of cedures which were far re- quite successful and were more useful information to                                              and how it will change?
in ultrasound with focus on          MRI & CT in detection and moved from the daily clini- presented by the AIUM so- clinicians. Easier and reli-
abdominal, vascular and              very poor in the character- cal usage of ultrasound.                     ciety to the FDA to support able procedures have been                            Prof. TRANQUART
breast imaging.                      ization of the lesions, which Low repeatability along the introduction of CEUS in developed and numerous                                                  Volume CEUS will continue
                                     is the next step after de- with high user and patient USA. It was really a big investments have been                                                      to be important because it
Appointed as one of the              tection. So, for many years dependency made it tough deal! The success of these made in educational pro-                                                  can effectively change the
centers involved in the              the accuracy of MRI                                                                                                                                       workflow related to patient
French STIC 2006 program,            and CT with contrast                                                                                                                                      management. The render-
which aims to evaluate the           agents has been the                                                                                                                                       ed vascular architecture of
pharmaco-economical im-              gold standard in the                                                                                                                                      the vessels feeding a le-
pact of CEUS in daily prac-          study of liver lesions,                                                                                                                                   sion, or clear information
tice, the CIT in Tours is one        mainly because the vas-                                                                                                                                   about the relation of the le-
the most renowned French             cular specific patterns                                                                                                                                   sion to surrounding tissues
institutes concerning itself         are clearly detectable.                                                                                                                                   can help surgeons choose
with the use of contrast             The introduction of                                                                                                                                       the best way to treat a
enhanced ultrasound in               low MI contrast agents                                                                                                                                    patient, thus changing the
clinical practice. Among the         (SonoVue 2001, Bracco)                                                                                                                                    way in which they act and
machines the center pos-             combined with the                                                                                                                                         enabling them to better
sesses, we are proud to              developments of new                                                                                                                                       perform follow-up exams.
count a brand new Voluson            ultrasound technolo-         Volume calculation of a selected area in a kidney          “Time Intensity Curve” quantification in a kidney                 Acquiring a contrast vol-
E8, and a LOGIQ 9 BT07,              gies changed the way                                                                                                                                      ume data set and repre-
along with a valuable part-          we handle these patients, to gain acceptance from a guidelines, printed in more grams in cooperation with                                                 senting it in many rendering
nership in the development           enabling a much clear de- broader audience.                              than 20,000 copies and the pharmaceutical com-                                   modes, obtaining re-slices
of products and marketing            tection of the liver lesions The introduction of the new translated into 4 languages, panies. Last year, technical                                        or calculating volumes of a
collateral.                          and a further character- agents in 2001 had a great necessitated further revi- developments undoubtedly                                                   lesion over the time are all
                                     ization thanks to the same impact: they were easy to sion, which is now complete. precipitated further changes                                            new aspects.
We recently met in Paris,            vascular patterns. These use, well accepted and fol- A broader European com- in the importance of CEUS,                                                   Now, with the latest im-
where Prof. Tranquart was            days the sensitivity of CEUS lowed a standard live scan- mittee met recently in Rot- as demonstrated by Vol-                                              provements, we have re-
a speaker at the GE Sympo-           is truly comparable to CT & ning protocol and they in- terdam to extend the guide- ume Ultrasound and re-                                                 producible access to the
sium at the ICACT (Interna-          MRI with contrast agents, troduced clear vascular lines to additional areas liable quantification pack-                                                   total volume, necrotic vol-
tional Anti Cancer Treatment)        resulting in lower costs and patterns associated with such as the pancreas, liver, ages available on the                                                  ume, vascular architecture,
Conference on Contrast Ul-           an easier patient handling the work on lesions along kidneys, etc. and to more LOGIQ 9 BT07.                                                              relationship with the en-
trasound. Prof. Tranquart            for several kinds of lesions, with clear guidelines. All of procedures, including some Nowadays, the effective-                                           vironment and precise
agreed to meet Ultrasound            both malignant & benign these factors have contrib- technical recommendations ness of new targeted treat-                                                 quantification of enhance-
Post to discuss his vision of        (metastases, HCC or aden- uted to the increased con- (studied with the US com- ments for oncology pa-                                                     ment. This is more than
contrast enhanced ultra-             omas) with less costs and fidence in CEUS.                               panies) for the proper use tients needs to be evaluated                          other modalities can pro-
sound and summarize his              less discomfort for the                                                  of CEUS. These new guide- at an earlier stage. Thus,                             vide with a single injection
experience with GE Health-           patient.                         ULTRASOUND POST                         lines will probably be issued because of its accuracy,                           with any available imaging
care.                                                                 Which guidelines are you by mid 2007. That’s a real non invasiveness and lower                                           method.
                                     ULTRASOUND POST                  referring to?                           achievement for the use of cost, CEUS is becoming the                            It’s a great challenge and I
ULTRASOUND POST                      We have been talking                                                     CEUS in our daily routine.          technology of choice for fre-                am excited about these
Prof. Tranquart, what role           about CEUS since the late Prof. TRANQUART                                                                    quent monitoring of tumor                    new possibilities and ready
does ultrasound play in              ‘90s, but where are we In 2004, a European com- ULTRASOUND POST                                              volume and the changes in                    to explore the topic in
imaging liver lesions?               now with regard to the mittee of clinical experts, What role do the ultra- its feeding vasculature. In                                                    greater depth.

   -2-                                                                                                                                                                               w w w. g e h e a l t h c a r e . c o m
                                                                                                                                                                              ultrasoundpost NEWS and FACTS 2007 / 1st edition

    A Pictorial Review

    Benefits of Volume Ultrasound
    Imaging in the Scrotum
    Introduction                       study is dependent on the             lustrate the benefits of vol-         The number of
                                                                                                                                             A                                                          Figure 3
    Two-dimensional (2D) ul-           experience, skills and train-         ume data sets in scrotal ul-          slices and dis-                                                                      Cystic appendix epidid-
    trasound imaging has long          ing of the sonographer. In            trasound. The images pre-             tance between                                                                        ymis in a 53 year old
    been the imaging method            many ultrasound depart-               sented were obtained with             slices can be                                                                        male with diabetes and
                                                                                                                                                                                                        left scrotal pain.
    of choice for evaluation of        ments, the request for scro-          either a volumetric trans-            easily adjusted.                                                                     Conventional 2D imag-
    the scrotum. It has advan-         tal sonography occurs with            ducer (4D16L or 4D10L), or            In scrotal ultra-                                                                    ing (A) demonstrated a
    tages of being readily avail-      much less frequency than              a Matrix Array transducer             sound, a volume                                                                      cystic mass slightly
                                                                                                                                                                                                        superior and lateral to
    able for emergency exams,          other ultrasound exams.               (M12) on the LOGIQ 9 ultra-           data set is ac-                                                                      the right testis. The left
    comparatively inexpensive          This lengthens the learning           sound system (GE Health-              quired with an au-                                                                   testis was unremark-
                                                                                                                                                                                                        able. The etiology of
    and does not involve ioniz-        curve for student and new             care, Wauwatosa, WI).                 tomated sweep
                                                                                                                                                                                                        the cyst was not deter-
    ing radiation. Technological       sonographers.                                                               through the testis                                                                   mined. The patient was
    advancements including             Furthermore, scrotal exams            Volume Ultrasound                     with the volumet-                                                                    rescanned with the
                                                                                                                                                                                                        4D16L transducer and
    CrossXBeam™ imaging, SRI           are often ordered through             Volume ultrasound is a meth-          ric transducer.                                                                      a 3D volume was ob-
    (Speckle Reduction Imaging)        the emergency room and                od of acquiring an anatom-            The sweep is ob-                                                                     tained.
    and Coded Harmonics Im-            may be performed after re-            ical volume data set either           tained within a                                                                      Sectional planes with a
                                                                                                                                                                                                        surface rendering (B -
    aging have resulted in ex-         gular hours, when less-skil-          through an automated 3D               few seconds and                                                                      lower right image) de-
    quisitely detailed images of       led or more recently trained          sweep using a volumetric              a series of equidis-                                                                 monstrated         smooth
    the scrotal contents (Fig 1).      staff is on duty (and exper-          transducer or through a               tant parallel slic-                                                                  walls and confirmed
                                                                                                                                                                                                        the extratesticular lo-
    Yet compared to other im-          ienced staff unavailable for          freehand sweep with a con-            es are displayed                                                                     cation of the cyst near
    aging modalities such as MR        consultation). This can re-           ventional 2D transducer.              on the monitor                                                                       the epididymal head.
    and CT, ultrasound exams           sult in equivocal exams, non-         Each volume data set can              similar to com-                                                                      The corona plane im-
                                                                                                                                                                                                        age (B lower left image)
    remain time-consuming              diagnostic exams or force             be manipulated to display             puted tomogra-                                                                       demonstrated a stalk
    and operator dependent. A          the recall of patients for ad-        many individual B-mode                phy (CT) or mag-                                                                     connecting the cyst to
                                                                                                                                                                                                        the epididymal head.
                                                                                                                                                                                                        The 3D Visualization
                                                                                                                                                                                                        was then changed to
                                                           Figure 1                                                                          C                                                          TUI of the coronal plane
                                                           Cross sectional ultrasound image of the testis and epididymal head in                                                                        (C).
                                                           a patient with torsion of the spermatic cord demonstrates the fine                                                                           The distance between
                                                           anatomical detail obtainable with the bundling of advanced imaging                                                                           the slices was set to
                                                           features. A high frequency matrix array transducer (M12) that pro-                                                                           0.6mm with the number
                                                           duces a very thin slice improves visualization of such small anatomical                                                                      of slices at 19 with a
                                                           features as the edematous tubules in the epididymis (arrow). The clar-                                                                       2x2 display to enlarge
                                                           ity of the hydrocele is a result of improved contrast resolution asso-                                                                       the image. This allowed
                                                           ciated with Coded Harmonics Imaging. By combining multiple images                                                                            for translation through
                                                           fired at different angles into a single displayed image, CrossXBeam                                                                          the epididymal head at
                                                           enhanced the boundary definition between the epididymis, testis and                                                                          very fine intervals. This
                                                           surrounding tissue.                                                                                                                          improved       diagnostic
                                                           Finally, the abnormal texture within the epididymis is easily recogni-                                                                       confidence of a pedun-
                                                           zed because the inherent overlying speckle artifact has been removed                                                                         culated cystic appendix
                                                           with SRI.                                                                                                                                    epididymis.

A                                                      B                                                       C                                                         D

    Figure 2                                                                                                       was then manipulated to better demonstrate the tail of the epididymis and visualization was changed to
    Right epididymitis in a 25 year old male with right testicular pain. Color Doppler imaging demonstrated        TUI in the coronal plane (slightly off axis of the coronal plane). Multiple slices through the inferior aspect
    hyperemic flow within the epididymis and testis consistent with epididymo orchitis (A). Standard 2D            of the hemiscrotum show the enlarged epididymal tail (globus minor). (D) The globus minor is often
    imaging was not performed. Volume Ultrasound was performed with the 4D16L transducer. Sectional                difficult to identify sonographically, however the volume data set can be manipulated by adjusting the X,
    planes on the right show enlargement of the right epididymis throughout its length (B). The rendered           Y and Z planes to lay out the epididymis as it curves around the inferior aspect of the testis and then
    image clearly demonstrates the enlarged epididymis, testis and surrounding hydrocele (C). The data set         slice through the volume until the desired image is obtained.

    sonographer typically fol-         ditional images, delaying             images in an infinite num-            netic resonance (MR).                of interest is detected, an            Rendering can be applied
    lows a laboratory protocol         necessary intervention. New           ber of imaging planes. The            The “A” plane is displayed           axis point can be set on that          to the volume to produce
    requiring numerous static          tools available for Volume            volume image visualization            by default and represents            anatomy, and with the 3D               images of startling realistic
    images obtained through-           Ultrasound imaging can                is user selectable between            the plane in which the vol-          visualization changed to               quality. These images are
    out the length and width           reduce operator depend-               Sectional, Render, VCI (Vol-          ume was acquired. A refer-           Sectional, three orthogonal            particularly helpful when
    of each hemiscrotum.               ence, add anatomic informa-           ume Contrast Imaging), and            ence image is shown in the           views will be displayed.               discussing the anatomy or
    Color Doppler images of            tion and increase diagnos-            TUI. Tomographic Ultrasound           upper left corner of the dis-        The volume data set can                pathology with the patient
    each testis and epididymis,        tic confidence through visu-          Imaging (TUI) is a volume             play. To display images of           be reconstructed at any                and referring physician.
    as well as spectral Doppler        alization of the anatomy in           imaging tool that allows              the testis in the B and C            time to show an infinite               Cindy A. OWEN, RDMS, RVT
    waveforms of the intrates-         imaging planes not available          rapid and automated dis-              planes, the user chooses             number of planes to better             Craig LIPMAN, M.D., Mid-South
                                                                                                                                                                                               Imaging & Therapeutics,
    ticular vessels are obtained.      with standard 2D imaging.             play of the volume into               the view from a touch pan-           display anatomical relation-           P.A., Baptist Memorial Hospital,
    The resulting quality of the       This pictorial review will il-        parallel slices in any plane.         el. When a particular area           ships.                                 Memphis, TN

    w w w. g e h e a l t h c a r e . c o m                                                                                                                                                                                 -3-
ultrasoundpost NEWS and FACTS 2007 / 1st edition

Breakthroughs in                                                                                                                                                                      due to its excellent pre-
                                                                                                                                                                                      cision. In addition, the en-
                                                                                                                                                                                      hanced image quality al-

DXA Densitometry Technology
                                                                                                                                                                                      lows for a more accurate
                                                                                                                                                                                      bone edge detection and
                                                                                                                                                                                      vertebral fracture assess-
                                                                                                                                                                                      ment, helping physicians
                                                                                                                                                                                      to better diagnose osteo-
    Healthcare is a wonder-          meter is a prime example             is anticipating trends, lis-          excellent image quality           iDXA™ also supports re-             porosis.” David Ergun, Vice
ful industry and GE Health-          of GE Healthcare’s break-            tening to the customer’s              at low dose.                      mote access (MudbA),                President Global Technolo-
care is dedicated to helping         through strategy, with em-           needs and understanding               The Dual-energy X-ray             automated custom re-                gy – Lunar Densitometry.
patients, clinicians and re-         phasis on image quality,             the disease. Launched in              source, with proprietary          porting (Composer) and
searchers by providing in-           precision, innovative appli-         Europe at Medica 2005                 Performa X-ray tube               paperless .PDF report-              Visit our booth at ECR
novative technologies and            cations and ease of use.             [Düsseldorf (D) November              and k-edge filtration,            ing (TeleDensitometry).             2007 (GE Healthcare #202)
strategies that help save                                                 2005], I am very proud                delivers a reliable X-ray         The optional InSite 2.0             for a demonstration of our
lives.                               “Key to the clinical suc-            that the Lunar iDXA™ in-              flux optimizing bone, fat         establishes a secured               densitometry equipment.
The Lunar iDXA™ densito-             cess of a new technology,            troduction is an incredible           and lean tissue attenu-           electronic link to Lunar            GE Healthcare - Lunar Den-
                                                                          success with market up-               ation.                            Densitometry’s Online               sitometry, the #1 densito-
                                                                          take at key clinical and              The enCORE 2007 soft-             Support Center, enabling            metry partner worldwide, de-
                                                                          research sites throughout             ware platform offers              proactive     monitoring            livers annual breakthroughs
                                                                          Europe, … and with excel-             extensive clinical and            and maintenance as well             dedicated to bone health
                                                                          lent customer satisfac-               research applications,            as upgrade functionality.           and beyond, enabling clini-
                                                                          tion.” Jef Van Dam, Interna-          such as: Adult and pe-        “Osteoporosis may be suc-               cians and researchers to
                                                                          tional Director - Lunar Den-          diatric AP Spine and          cessfully prevented and                 help save lives. Lunar Den-
                                                                          sitometry.                            DualFemur; Advanced           treated, when doctors can               sitometry Re-Imagined.
                                                                          Equipped       with    Lunar          Hip Assessment (AHA);         detect and intervene ear-
                                                                                                                                                                                      Gitte ANDREASEN, Global Marketing
                                                                          iDXA™ clinicians and re-              Dual-energy Vertebral         ly. Lunar iDXA™ enables                 Manager – Lunar Densitometry
                                                                          searchers benefit from                Assessment (DVA); Adult       physicians to monitor bone              Pascal SITTER, EMEA Product
                                                                          breakthroughs dedicated               and pediatric Total Body      changes in a short interval             Manager – Lunar Densitometry
                                                                          to bone health and beyond             BMD and Body Compo-
                                                                          such as:                              sition; and peripheral, or-   GE Ultrasound Offices Have Moved
                                                                              High Definition Direct-           thopedic and small ani-
                                                                                                                                              Please notice that some of our European GE Ultrasound
                                                                              Digital CZT detector: GE          mal BMD functionality.
                                                                                                                                              offices have moved. You will find the new addresses of the
                                                                              Healthcare’s patented             In addition to RIS/HIS
                                                                                                                                              Netherlands, Italy, Finland & Estonia and GE's Lunar office
                                                                              detector enables diag-            connectivity (such as         in France below.
                                                                              nostic confidence and             DICOM and HL7), Lunar

                                                                                                                                              GE ULTRASOUND OFFICE ADDRESSES:

  International Academy of Medical Ultrasound DATES for 2007
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                                                                                                                                              GE Medical Systems Ultrasound           Phone: (+47) 2202 0800
                                                                                                                                              Eagle Building, Kouterveldstraat 20
  TVI, STRAIN & MYOCARDIAL                          G.R. Sutherland MD PhD                  Berlin, Germany              19 - 20 April        1831 DIEGEM                             NORWAY
                                                                                                                                              Phone: (+32) 2 719 7204                 GE Medical Systems Ultrasound
  DEFORMATION                                                                                                                                 Fax: (+32) 2 719 7205                   Strandpromenaden 45,
                                                                                                                                                                                      P.O. Box 141, 3191 Horten
                                                                                                                                              CZECH REPUBLIC                          Phone: (+47) 33 02 11 16
  4D & MULTIDIMENSIONAL IMAGING                      J. D. Kasprzak MD PhD                  Berlin, Germany              27 - 28 April        GE Medical Systems Ultrasound
                                                                                                                                              Vyskocilova 1422/1a                     POLAND
                                                                                                                                              140 28 Praha                            GE Medical Systems Ultrasound
  ADVANCED COURSE IN                                         Prof. S. Bianchi          Noordwijk, Netherlands                4 - 5 May                                                Al. Wilanowska 372
                                                                                                                                              DENMARK                                 02-665 Warszawa
  MUSCULOSKELETAL ULTRASOUND                                Prof. C. Martinoli                                                                GE Medical Systems Ultrasound           Phone: (+48) 330 83 00
                                                                                                                                              Park Allé 295, 2605 Brondby
                                                                                                                                              Phone: (+45) 43295 400                  PORTUGAL
  VISUS 3D/4D                                           Prof. A. Kratochwil                  Vienna, Austria              21 - 24 May         Fax: (+45) 43295 399                    General Electric Portuguesa,
                                                                                                                                                                                      SA. Avenida do Forte, n° 4,
                                                                                                                                              FINLAND & ESTONIA                       Fraccao F
  MAMMASONOGRAPHY                                           Dr. C. Weismann                 Salzburg, Austria            21 - 23 June         GE Medical Systems                      2795-502 Carnaxide,
                                                                                                                                              Kuortaneenkatu 2, 000510 Helsinki       Phone: (+351) 21 425 1309
                                                                                                                                              P.O.Box 330, 00031 GE Finland           Fax: (+351) 21 425 1343
  ADVANCED VISUS COURSE                                 Prof. Rabih Chaoui                  Berlin, Germany                  6 - 7 July       Phone: (+358) 10 39 48 220
                                                                                                                                              Fax: (+358) 10 39 48 221                REPUBLIC OF IRELAND
                                                                                                                                                                                      G.E. Healthcare
›› REGISTRATION:                   email:                   phone: +43-7682-3800-380              FRANCE
                                                                                                                                              GE Medical Systems Ultrasound
                                                                                                                                                                                      Unit F4, Centrepoint Business Park,
                                                                                                                                                                                      Oak Drive, Dublin 22
                                                                                                                                              and Primary Care Diagnostics France     Phone: 01 4605500
                                                                                                                                              F-78457 Velizy
                                                                                                                                              Fax: (+33) 13 44 95 202                 RUSSIA

                                                                                                                                                                                      GE Medical Systems Ultrasound
                                                                                                                                                 General Imaging
                                                                                                                                                                                      Kosmodamianskaya nab., 52
                                                                                                                                                 Phone: (+33) 13 449 52 43
                                                                                                                                                                                      113045 MOSCOW
                                                                                                                                                 Phone: (+33) 13 449 52 31            SPAIN
  TOPIC                                                                 LOCATION                                                  DATE           Luna
                                                                                                                                                                                      GE Medical Systems España
                                                                                                                                                                                      Avda. Europa 22
                                                                                                                                                 Phone: (+33) 13 449 53 65
                                                                                                                                                                                      (Parque Emp.La Moraleja)
  ESC                                                                    Vienna, A                                  1 - 5 September              8, Rue Paul Dautier
                                                                                                                                                                                      28108 Alcobendas-Madrid
                                                                                                                                                                                      Phone: (+34) 91 663 2500
                                                                                                                                                 F-78140 Velizy-Villacoublay          Fax: (+34) 91 663 2501
                                                                                                                                                 Phone: (+33) 1-69-18-54-02
  ISUOG 2007                                                            Florence, I                                   7 - 11 October             Fax: (+33) 1-64 46 32 48             SWEDEN
                                                                                                                                                                                      GE Medical Systems Ultrasound
                                                                                                                                              GERMANY                                 PO Box 314, 17175 Stockholm
  JFR                                                                     Paris, F                                   20 - 24 October          GE Medical Systems Ultrasound           Phone: (+46) 0855950010
                                                                                                                                              Beethovenstr. 239, 42655 Solingen
                                                                                                                                              Phone: (+49) 212 28 02-0                SWITZERLAND
  EUROSON / 3 LÄNDER TREFFEN                                             Leipzig, G                                  24 - 27 October          Fax: (+49) 212 28 02-47                 GE Medical Systems Ab
                                                                                                                                                                                      Europastrasse 31,
                                                                                                                                              GREECE                                  8152 Glattbrugg
  MEDICA                                                               Düsseldorf, G                              14 - 17 November            GE Medical Systems Hellas               Phone: (+41) 1 809 92 92
                                                                                                                                              156 Kyprou Av.& 91 Konstantinoupoleos   Fax: (+41) 1 809 92 22
                                                                                                                                              Str. Argyroupolis, 164 51 Athens
  EUROECHO 2007                                                          Lisbon, P                                   5 - 8 December           Phone: (+30) 210 9690990
                                                                                                                                              Fax: (+30) 210 9625931
                                                                                                                                                                                      GE Healthcare Holding
                                                                                                                                                                                                                            Printed in Austria - 300-07-U004E

                                                                                                                                                                                      Suite 1101, 11th Floor City Tower 2
                                                                                                                                              ITALY                                   Sheik Zayed Rd. Dubai,
                                                                                                                                              GE Medical Systems Italia spa           U.A.E
IMPRINT:                                                                                                                                      Via Galeno, 36, 20126 Milano
                                                                                                                                              Phone: (+39) 02 2600 1111
                                                                                                                                                                                      Phone: (+971) 4 3131 207
                                                                                                                                                                                      Fax: (+971) 4 3321802
                                                                                                                                              Fax: (+39) 02 2600 1599
Publishers:                           Editor–in-chief:                    Concept and Production:            Printing:                                                                UNITED KINGDOM
GE Healthcare                         Pierre Radzikowski                  ICS Media GmbH                     Kroiss & Bichler GmbH & CoKG     NETHERLANDS                             GE Medical Systems Ultrasound
Marketing Department Europe                    A-4860 Lenzing, Austria            Römerweg 1                       De Wel 18 B, 3871 MV Hoevelaken         2, Napier Road
                                                                                                                                              PO Box 22, 3870 CA Hoevelaken           Bedford MK41 0JW
Beethovenstraße 239                   Tel: +48 2275 14103                 E-mail:        A-4844 Regau                     Phone: (+31) 33 254 1290                Phone: (+44) 1234 340881
42655 Solingen                                                                                                   Fax: (+31) 33 254 1292                  Fax: (+44) 1234 266261

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