History of Genetics in Evolution

History of Genetics in Evolution Joe Felsenstein GENOME 453, Autumn 2007 History of Genetics in Evolution – p.1/39 The Great Chain of Being (1600’s onward) Deity Angels Man Mammals Birds Reptiles Amphibians Fish Insects Worms Protists Issues: placement of birds, insects not obvious. A scale of complexity? Or what? History of Genetics in Evolution – p.2/39 Karl Linné (Carolus Linnaeus) (1707-1778) History of Genetics in Evolution – p.3/39 Monophyly Monophyletic: having a common ancestor which is not the ancestor of any of the other species being discussed. (This definition works for cases where there are fossil forms being included, and those where they are not, and works whether we are discussing only a fixed set of species or all species descended from some ancestor.) History of Genetics in Evolution – p.4/39 Mammals Birds Crocodilians Snakes, Lizards Turtles Frogs Salamanders Lungfish Coelacanth Most fishes Sharks, Rays Lamprey Hagfish Amphioxus History of Genetics in Evolution – p.5/39 A phylogeny of the living Craniata Mammals Birds Crocodilians Snakes, Lizards Turtles Frogs Salamanders Lungfish Coelacanth Most fishes Sharks, Rays Lamprey Hagfish Amphioxus History of Genetics in Evolution – p.6/39 Vertebrates are a monophyletic group The vertebrates Mammals Birds Crocodilians Snakes, Lizards Turtles Frogs Salamanders Lungfish Coelacanth Most fishes Sharks, Rays Lamprey Hagfish Amphioxus Reptiles Reptiles and fishes are paraphyletic groups Osteichtyes History of Genetics in Evolution – p.7/39 An American in Paris (2005) Wandering east of the Panthéon on the Left Bank of Paris, you begin to notice unusual street names: ... which is only hints at a little-known story. History of Genetics in Evolution – p.8/39 Buffon George-Louis Leclerc, Comte de Buffon (1707-1788) History of Genetics in Evolution – p.9/39 Statue of Buffon at the Jardin des Plantes History of Genetics in Evolution – p.10/39 Buffon, honored Rue Buffon, next to the Jardin des Plantes (with plastic mastodon, Golden Arches, traffic ticket) History of Genetics in Evolution – p.11/39 Lamarck Jean Baptiste Pierre Antoine de Monet, Chevalier de Lamarck (1744-1829) History of Genetics in Evolution – p.12/39 Lamarck’s mechanism for evolution In Philosophie Zoologique, 1809. Organisms’ characters are altered by the effects of use and disuse. These changes are passed on to descendants by inheritance of acquired characters. Note that Lamarck did not originate “Lamarckian inheritance": it was something everyone believed in at that time. History of Genetics in Evolution – p.13/39 Old displays in the Museum of Natural History, Paris History of Genetics in Evolution – p.14/39 Statue of Lamarck in the Jardin des Plantes, Paris History of Genetics in Evolution – p.15/39 Lamarck’s works listed History of Genetics in Evolution – p.16/39 “My father, you will be vindicated” History of Genetics in Evolution – p.17/39 Buffon’s (and Lamarck’s) house next to the Museum History of Genetics in Evolution – p.18/39 Plaque on house commemorating Buffon History of Genetics in Evolution – p.19/39 Plaque on house commemorating Lamarck History of Genetics in Evolution – p.20/39 Geoffroy versus Cuvier Etienne Geoffroy St. Hilaire (1772-1844) Georges Lèopole Chrètien Frèdèric Dagobert, Baron Cuvier (1769-1832) History of Genetics in Evolution – p.21/39 Memorials in Paris Fountain on corner of Rue Linné and Rue Cuvier (“A GEORGES CUVIER”) Rue Cuvier, along side of fountain and side of Jardin des Plantes History of Genetics in Evolution – p.22/39 Allee Cuvier, within the Jardin History of Genetics in Evolution – p.23/39 Rue Geoffroy St. Hilaire History of Genetics in Evolution – p.24/39 Paris: Rue Lamarck and Rue Darwin History of Genetics in Evolution – p.25/39 Johann Wolfgang von Goethe (1749-1832) History of Genetics in Evolution – p.26/39 The Naturphilosophen The Naturphilosophen and Evolutionary views Ape Monkey Mouse Reptile Amphibian Fish Ape Monkey Mouse Reptile Amphibian Fish evolutionary tree common developmental pathway Note − The picture here is very much a Great Chain of Being History of Genetics in Evolution – p.27/39 Charles Darwin (1809-1882) History of Genetics in Evolution – p.28/39 Wallace Alfred Russel Wallace (1823-1913) in 1869 History of Genetics in Evolution – p.29/39 Lamarck’s theory versus Darwin’s Genetic variation important? Differential survival or reproduction? Mutations are in what direction? Phenotypic changes inherited? Lamarck No No adaptive Yes Darwin/Wallace Yes Yes random maybe History of Genetics in Evolution – p.30/39 Fleeming Jenkin Fleeming Jenkin (1833-1885) Fleeming Jenkin Building University of Edinburgh History of Genetics in Evolution – p.31/39 Blending inheritance and selection 10 8 4 2 0 0 10 20 30 40 Value of character History of Genetics in Evolution – p.32/39 The Biometricians Francis Galton (1822-1911) Karl Pearson (1857-1936) History of Genetics in Evolution – p.33/39 Gregor Mendel (1822-1884) History of Genetics in Evolution – p.34/39 Mendel in his school The faculty of Mendel’s monastery school (Mendel is top center-right with flower) History of Genetics in Evolution – p.35/39 Rediscoverers of Mendel Carl Correns Erich von Tschermak-Seysenegg Hugo De Vries History of Genetics in Evolution – p.36/39 Founders of theoretical population genetics R. A. Fisher J. B. S. Haldane Sewall Wright History of Genetics in Evolution – p.37/39 Developers and popularizers of the Neodarwinian Synthesis Ernst Mayr George Gaylord Simpson Sir Julian Huxley G. Ledyard Stebbins Theodosius Dobzhansky History of Genetics in Evolution – p.38/39 How it was done This projection produced using the prosper style in LaTeX, using Latex to make a .dvi file, using dvips to turn this into a Postscript file, using ps2pdf to make a PDF file, and displaying the slides in Adobe Acrobat Reader. Result: nice slides using freeware. History of Genetics in Evolution – p.39/39