Transdermal Buspirone for Treatment of an Aggressive Cat by liwenting

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									Transdermal Buspirone for Treatment of an Aggressive Cat
Susan Davis Lisa Englert Randy Ferreter Catherine Fiola Richard Flege Dan Melzer

Case Presentation
11-year-old male cat showed aggressive behavior toward other cats and started urinary spraying
Owners tried buspirone 2.5 mg/ml flavored oral suspension, but too difficult to administer and cat vomited medication

Use of buspirone in animals
Nonbenzodiazepine anti-anxiety drug Used to treat various behavioral disorders in cats and dogs (chronic fears/anxiety, phobias, and aggression) Considered drug of choice in management of urine spraying and inappropriate urination in cats

Use of buspirone in animals
One week of therapy usually determines if the drug is going to be successful If successful, the buspirone is continued for 8 weeks, after which the dose is gradually reduced Only half of the cats treated resumed spraying when the drug was discontinued after 2 months of treatment

Before Treatment

Pharmaceutically challenging compounding problem:
How can we administer the much needed buspirone to an aggressive cat who cannot take the oral suspension?

Transdermal buspirone
Buspirone HCL 2.5 mg/0.1 mL PLO
Buspirone HCL 0.025 g PLO Gel QS 1 mL 1 cc syringes Apply 0.1 mL inside the tip of the cat’s ear twice daily

Pluronic Lecithin Organogel (PLO)
Made from Pluronic (poloxamer) gels Functions as a gelling agent in topical preparations (????)

PLO Gel
Lecithin and isopropyl palmitate liquid 20 mL
Soy lecithin, granular 10 g Isopropyl palmitate 10 g
Add the soy lecithin granules to the isopropyl palmitate liquid. Mix by rolling or gentle agitation. Do not shake. Allow to set overnight for complete dissolution.

Pluronic 20% Gel
Add 20 g Pluronic F-127 to sufficient cold water to make 100 mL

Pluronic 20% Gel
Used as emulsifying agents, solubilizing agents, and wetting agents Range in concentrations from 15% to 50% White, waxy, free-flowing granules that are practically odorless and tasteless Pluronic F-127 has low toxicity and good solubilizing capacity and optical properties

PLO Gel
Mix the lecithin:isopropyl palmitate liquid and the Pluronic 20% gel together well.
Plastic bags Two syringes with adapter Mortar and pestle

Minimize the incorporation of air.

Transdermal buspirone
Place 0.025 g buspirone HCL powder in mortar. Add PLO gel (QS to 1 mL), mix well. Run through mill. Draw up into syringes and cap. Beyond use date: 6 months.

Case Presentation
Owner applied 0.1 mL of transdermal buspirone 2.5 mg/0.1 mL PLO topically inside the tip of the ear twice a day Cat was too sleepy after the first dose, so it was decreased to 0.05 mL (1.25 mg of buspirone)

Case Presentation
Cat’s aggressive behavior has been controlled on the lower dose with few exceptions.
The owner is AMAZED at how easy it is to apply the medication!!!

After Treatment

1. Allen, L. The Art, Science, and Technology of Pharmaceutical Compounding. Washington, D.C.: American Pharmaceutical Association. 1998. 2. Allen, L. PLO Gel for Feline Hyperthyroidism. U.S. Pharmacist. Feb 2001. 3. Thompson, J. A Practical Guide to Contemporary Pharmacy Practice. Baltimore: Williams & Wilkins. 1998. 4. Transdermal Treatment for Aggressive Cat. Nebraska Veterinary and Biomedical Sciences Newsletter. University of NebraskaLincoln Cooperative Extension. 29(4): April 2000.


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