IBS 604 Cell Signaling by hcj


									IBS 604 Cell Signaling


Spring 2008

Instructors: Tim McClintock (Course Director), Ms585 Medical Science Building, Ph. 323-1083; mcclint@uky.edu; Office hours: by appointment Doug Andres, 179 BBSR Building, Ph. 257-6775; dandres@uky.edu Olivier Thibault, MS320 Medical Science Building, 323-4863, othibau@uky.edu Jonathan Satin, MS503 Medical Science Building, 323-5356, jonathan.satin@uky.edu Ming Gong, 509 Charles T Wethington Building, 323-4933 x81361, ming.gong@uky.edu Mariana Nikolova-Karakashian, MS571 Medical Science, 323-8210, mnikolo@uky.edu Anthony Sinai, MN352 Medical Sciences Building, 323-6680, sinai@uky.edu Carol Pickett, MN374 Medical Science Building, 323-5313, cpicket@uky.edu Steve Post, 501 Wethington Building, 323-4933 x81371, spost@uky.edu Charlotte Kaetzel, 124D Combs Building, 257-6573, charlotte.kaetzel@uky.edu Robert Geraghty, MS439 Medical Science Building, 257-5147, rgeragh@uky.edu Room, Date, and Time: HSLC 115, MWF, 9-9:50 am. Evening Exams: Exams are listed in the Schedule. Note times and dates to avoid conflicts. Description: This is a 3 credit course that focuses on inter- and intracellular communication, from the generation of signaling molecules through the cellular responses. It teaches concepts central to understanding cellular signaling mechanisms. It covers the major signaling pathways and several emerging pathways. Explanations of cellular and molecular techniques that are important to understanding key advances in this area are integrated into the material presented. Class sessions will include didactic lectures and group discussions of problem sets or reading assignments. Objectives: To convey an understanding of key concepts about cellular signaling mechanisms, about the major signaling pathways identified to date, and about the methods used to study these pathways. Textbook: None required. A recommended reference text is: Molecular Biology of the Cell, Third Edition, by Alberts, Bray, Lewis, Raff, Roberts, and Watson. Garland Publishing. Supplementary Materials: A limited number of reviews and primary articles will be assigned. Most will be available via the electronic journals page of the Medical Center Library website (http://www.mc.uky.edu/medlibrary/resources/ejournals.htm). Please note that you will need to access this site from a computer with a UK IP address. Course Website via Blackboard. You will have password-level access to selected course material via the Blackboard server. Assignments will be posted there and we will also make use of some of the communication features. Most instructors will post their lecture files (ppt or pdf format) to this site. Responsibility for generating a hard copy of a lecture files rests with the students. Examinations and Grading: There will be four closed book examinations. Each exam will be worth 20% of the final grade. The remaining 20% of the grade will be drawn from problem set assignments. There will be no comprehensive final examination. The fourth examination will be given at the time announced for the final exam in the Schedule of Classes. Final grade assignments will be the better of the two scales shown below. A = 90% of total points or one standard deviation above the mean class grade. B = 80% of total points or between one standard deviation above and one standard

deviation below the mean class grade. C = 70% of total points or between one standard deviation and two standard deviations below the mean class grade. E = 60% of total points or less than two standard deviations below the mean class grade. For graduate students, there is no "D" grade. Regrading Examinations: Students who believe that a mistake was made in the grading of an hour examination should re-submit the examination and a signed note to the course director that describes briefly which problem they want to have re-graded and why the grading was in error. Requests for re-grading of a particular hour examination must be submitted before the next hour examination or in the case of the final exam, within 3 weeks of the final exam. The examinations will be re-evaluated and returned with the subsequent hour examination, or mailed to the student in the case of the final exam. Rescheduling Examinations: Make-up exams will be given only in rare instances. Requests for make-up exams due to illness must be made in writing to the course director and must include a statement signed by the treating physician. Approval for make-up exams due to scientific responsibilities out of state (presentation at a conference, for example) must be obtained in advance by providing to the course director documentation that proves that the student’s absence is required (presenting author is an acceptable reason, attending a conference is not). Missing a scheduled exam for any other reason (such as going home early duing finals week) will result in a score of zero for the exam. Discussion Session problem sets: Answers must be machine printed and submitted by the beginning of class. Late submission of answers will result in at least a 20% penalty. These take home questions will be slightly more difficult than the typical exam question. You may discuss them with anyone, including your classmates. However, you must write your answers in your own words. You may not share your written answers with classmates. You are responsible for understanding that copying or close paraphrasing of an answer from a classmate or a previous student in the course is plagiarism, as is copying or close paraphrasing without citation any published source. Academic honesty. No form of dishonesty will be tolerated. Students are encouraged to read the Student Rights and Responsibilities with regard to cheating and plagiarism (http://www.uky.edu/StudentAffairs/Code/part2-6.html). The minimum punishment for cheating on an exam or plagiarism on an assignment is an E for the course.

IBS 604, CELL SIGNALING, LECTURE SCHEDULE: JAN. 9. Introduction to signaling JAN. 11. Receptors and ligands I JAN. 14. Receptors and ligands II JAN. 16. Discussion I JAN. 18. G-protein coupled receptors (GPCRs) JAN. 21. MARTIN LUTHER KING BIRTHDAY JAN. 23. GPCRs: heterotrimeric G-proteins JAN. 25 GPCRs: effectors I JAN. 28. GPCRs: effectors II JAN. 30. Gasous messengers: NO and CO FEB. 1 Discussion II FEB. 1 Exam I; Hospital Auditorium FEB. 4. Wnt and Hedgehog Signaling FEB. 6. Notch/Delta signaling FEB. 8. Discussion III FEB. 11. Tyrosine kinase receptors FEB. 13. Cytokine receptors FEB. 15. Src kinases FEB. 18. ras/MAPK pathways I FEB. 20. ras/MAPK pathways II FEB. 22. Mitogenic signaling FEB. 25. Discussion IV FEB. 27. Focal adhesion signaling FEB. 28. Exam II; Hospital Auditorium Feb. 29. Rac/rho and the cytoskeleton MAR. 3. Pattern recognition receptors MAR. 5. Discussion V MAR. 7. Ion Channels I MAR. 10 -14. UK SPRING BREAK MAR. 17. Ion Channels II MAR. 19. Ion Channels III MAR. 21. Ion Channels IV MAR. 24. Discussion VI MAR. 26. TGF beta signaling MAR. 28. Lipid signaling I MAR. 31. Lipid signaling II APR. 2 Lipid signaling III APR. 4. Discussion VII APR. 7. Calcium homeostasis APR. 9. Calcium signaling APR. 9. Exam III; Hospital Auditorium APR. 11. Kinases and phosphatases APR. 14. Calcium imaging and quantification APR. 16. Discussion VIII APR. 18. Signaling and Toxins APR. 21. Bacterial pathogens and signaling APR. 23. Protozoan parasites APR. 25. Viral pathogens and signaling APR. 30. FINAL EXAM; Hospital Auditorium

McClintock Post Post Post/McClintock McClintock McClintock McClintock McClintock McClintock McClintock 6-8pm McClintock Andres McClintock/Andres Andres Andres Andres Andres Andres Andres Andres Gong 6-8pm Gong Kaetzel Gong /Kaetzel Satin Satin Satin Satin Satin Karakashian Karakashian Karakashian Karakashian Karakashian Thibault Thibault 6-8pm Thibault Thibault Thibault Pickett Sinai Sinai Geraghty 10:30a-12:20p

Exam I I I I I I I I I I I II II II II II II II II II II III III III III III III III III III III III III III III Final Final Final Final Final Final Final Final Final

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