Leeds Teaching Hospitals NHS Trust and the University of by klutzfu45


									Leeds Institute of Molecular Medicine

                          Leeds Teaching Hospitals NHS Trust and the University of Leeds
                                       Clinical Biochemist (KTP Associate)

Leeds Teaching Hospitals NHS Trust (the Trust), is the largest healthcare Trust in the UK providing secondary healthcare
services for Leeds, tertiary services and regional speciality centres for services such as cancer, within West Yorkshire
and beyond, to upwards of 3 million people. The Trust has a very exciting opportunity for a recently registered or about
to be registered Clinical Biochemist to “fast track” their career by leading a high profile and strategically important
project to a successful conclusion.

The Trust has recently established a Knowledge Transfer Partnership (KTP) with the University of Leeds. The aim of this
partnership is to enable the transfer of state of the art knowledge of biomarker development, using proteomic
technologies, into the Trust Clinical Biochemistry and Immunology Department by means of a specific research project
aimed at the development of biomarkers for neurological disease.


The KTP Associate will be based in the Trust Clinical Biochemistry and Immunology Department and in the University of
Leeds Clinical Proteomics Research Laboratory at St James’s University Hospital and will be employed by the University
of Leeds for the duration of the 3 year project. The Leeds Institute for Molecular Medicine, which is part of the Faculty of
Medicine and Health, will provide academic and technical support to the Associate.

Throughout the KTP you will;

    •   Receive a competitive salary
    •   Gain excellent experience managing a high profile project
    •   Receive formal management training and work towards a qualification
    •   Potentially gain a higher degree
    •   Have both opportunities and a budget for personal and professional development
    •   Continue training towards MRCPath


    •   Applicants must have a good first degree in a relevant biological science and preferably also have a PhD. You
        should be HPC registered and you may also have Part I MRC Path.
    •   You must have had significant experience of working in a Clinical Biochemistry laboratory and be able to function
        as a Clinical Biochemist in routine duties without close supervision. You are also likely to have some research
    •   You should be hard-working, enthusiastic, meticulous, practical, self-motivated and able to work independently as
        well as part of a team in order to ensure a successful outcome to the project. Additionally you should have good
        communication and inter-personal skills.

Shortlisted candidates will be expected to be able to attend for interview within 1 month of the closing date for

Salary: circa £28,000 - £37,000 (dependent upon qualifications and experience)
Job Ref: 214227                                                                   Closing Date: 12 December 2008
Informal enquiries related to this post may be made to Professor Roz Banks on 0113 2064927 (e-mail
r.banks@leeds.ac.uk) or Dr D Thompson on 0113 3926503 (e-mail Douglas.Thompson@leedsth.nhs.uk).

For further information and to apply online visit http://www.keyworth.leeds.ac.uk/jobs/ web site. Alternatively application
forms can also be obtained by contacting the Keyworth Institute on 0113 343 3518 or e-mail keyworthjobs@leeds.ac.uk

The University of Leeds promotes an Equal Opportunities Policy


Leeds Teaching Hospitals NHS Trust (the Trust), is the largest healthcare Trust in the UK providing secondary healthcare
services for Leeds, tertiary services and regional speciality centres for services such as cancer, within West Yorkshire
and beyond, to upwards of 3 million people. The Department of Clinical Biochemistry and Immunology which is the
biggest in the country provides comprehensive clinical biochemistry and immunology services to this Trust , Bradford
Hospitals Trust and local Primary Care Trusts. In addition it provides a number of highly specialised services on a
regional and national basis, also advising scientific professionals in laboratories across the country.

The fact that there are inadequate biomarkers for many diseases, whether for diagnosis, prognosis, treatment selection or
monitoring, - part of “personalised medicine” - is widely acknowledged as being a major problem in medicine. Ideally,
biomarker discovery and evaluation programmes would be pursued within hospital Clinical Biochemistry departments,
with their expertise in routine biomarker analysis. However with service pressures and the expense of research
technology acquisition, this is becoming increasingly difficult and the research is increasingly pursued by a small number
of academic research groups, often without the capability to translate the findings into clinical practice. The Clinical
Proteomics Research Laboratory under the guidance of Professors Roz Banks and Peter Selby has become one of the
focal points of biomarker discovery and evaluation in the UK using a number of state of the art proteomic technologies.
This KTP is focused on enabling the transfer of such capability into Clinical Biochemistry Laboratories in the Trust. The
Neurology Department will be the clinical focus of the work and Multiple Sclerosis (MS) will be the principal disease model
for the KTP.

Job Description

The Associate will divide their time between Trust and University laboratories in the fulfilment of the KTP role but will in
addition be expected to maintain their personal development as a Clinical Biochemist and time will be made available to
do this.

The role of the KTP Associate in the Trust/University of Leeds Knowledge Transfer Partnership is to lead the
development and application of specific proteomic technologies (available within the University) through to their use in
research by the Trust. This will potentially enable the discovery and translation into clinical practice of novel biomarkers
for MS (although equally applicable to other diseases in the future).

Specific plans and their embedded outputs:

    •   Training in and development of skills in critical literature appraisal and a review of current biomarker research in
        MS, for publication and to underpin project planning.

    •   Expansion of existing clinical sample banks/data from patients with MS (with the Consultant in Neurology) –
        ethical approval is in place for this.

    •   Development and evaluation of sample preparation methodology for cerebrospinal fluid (CSF) and blood

    •   Training of the Associate in state of the art proteomic technologies and application to specific biomarker discovery

    •   Confirmation of the validity of potential markers using parallel techniques with subsequent development and
        validation of research grade assays to analyse larger sample numbers

    •   Protection of IP and liaison with commercial diagnostics companies to plan subsequent potential implementation
        in routine service

    •   Initiation of a pilot scale clinical trial of new markers in the Trust and planning of approaches for future multicentre
        trials of selected biomarkers.

    •   Appraisal and reporting of the feasibility of future adoption of such proteomic technologies within the Trust for
        research purposes, including cost implications, training needs, space implications and potential outcomes.

    •   Training of Clinical Biochemists in proteomic technologies and processes
    •   Dissemination of findings by publication, conference presentations and feasibility reports internally and widely e.g.
        ACB newsletter.

In order to maintain their development as a Clinical Biochemist the associate will spend some time working as part of a
team of Clinical Scientists in the Department of Clinical Biochemistry and Immunology to help provide a comprehensive
scientific service (scientific and advisory) .

The work may include some of the following tasks

            •    To contribute to the provision of the Clinical Biochemistry and Immunology service to nationally accepted

            •    To contribute to the development of policies and protocols, ensuring that these are implemented within
                 the work area

            •    To contribute to the testing and selection of analytical equipment including those requiring OJEC

            •    To attend and contribute to departmental meetings related to management, service development and
                 policy development.

            •    To provide clinical and scientific leadership and training of staff in specific areas.

            •    To implement policies and procedures within the work area

            •    To provide advice to service users as required on all aspects of the provision of pathology service.

            •    To provide clinical advice to medical staff in charge of patient management, if necessary challenging that
                 management and advising an alternative approach or treatment.

            •    To participate in the Duty Officer rota to answer clinical queries within the department providing advice
                 and interpretation to all clinical specialities and dealing with all clinical or laboratory problems that arise

            •    The associate must respect patient confidentiality at all times and not divulge patient information unless
                 sanctioned by the requirements of the role

Person Specification


•   A good first degree in a relevant biological science. You should be HPC registered.
•   Significant experience of working in a Clinical Biochemistry lab and able to function as a Clinical Biochemist in routine
    duties without close supervision.
•   Personal qualities of being hard-working, enthusiastic, meticulous, practical, and self-motivated.
•   Able to work independently as well as part of a team in order to ensure a successful outcome to the project.
•   Good communication and inter-personal skills.
•   Good writing and computing skills


•   Have obtained a PhD
•   Have obtained Part 1 MRCPath
•   Research experience


The KTP Associate will be employed by the University of Leeds for 3 years based in the Trust Clinical Biochemistry
laboratory and the Clinical Proteomics Research Laboratory, Leeds Institute of Molecular Medicine and subject to both
their employment practices and conditions of work. Your work will be supervised both by the Trust and the University of
Leeds. You will receive an Honorary NHS contract.

On a day to day basis the Associate will be accountable to Dr D Thompson when working in the Trust Clinical
Biochemistry Laboratories and to Prof R Banks and Dr D Thompson whilst working in the Clinical Proteomics Research

Personal Development

In addition to the challenges of the post, the KTP Associate will be given the opportunity to register for a higher degree if
the successful candidate does not already hold one, to work towards a Diploma in Management from the Chartered
Management Institute and to work towards membership of The Royal College of Pathologists. The Associate will also be
required to attend various KTP training, management and personal development courses for which time is allocated. The
associate will be expected to ensure that Continuous Professional Development is a priority and HPC registration

How to Apply

We encourage all applicants to e-mail their completed application forms to us and to complete the equal
opportunities monitoring form on-line as this is the most efficient and environmentally friendly option

     Send Completed Applications to:                   Kimberley Matthews
     By:                                               14th Nov
     Quoting Job Reference number:                     214227

If you have any difficulties in e-mailing and completing electronic versions of these forms, we are very happy
to receive printed copies by post to Kimberley Matthews, Keyworth Institute, University of Leeds LS2 9JT.

Applications should include the following:
    •   A completed application form. If you wish to download an application form allowing you to e-mail
        your application back please visit http://www.leeds.ac.uk/hr/forms/index.htm#recruitment
    •   A Curriculum Vitae/information requested on page 2 of the application form.
    •   Equal Opportunities Monitoring form found online, please visit:

Replies will be treated in complete confidence.

If you are selected for interview you can expect to hear from the University not later than 4 weeks after the closing date.
If you are not selected for interview the University will not contact you again.

Please note that if you are appointed to this post you must be able to supply proof of the right to work in the UK. If you do
not have the right to work in the UK the University will apply to the Border and Immigration Agency (formerly known as the
Home Office) to obtain a Work Permit for you. We are obliged by European law to appoint people who are citizens of the
European Economic Area (EEA) where possible. A Work Permit will therefore only usually be granted by the Border and
Immigration Agency where there is a skills shortage for a particular post.

A Criminal Records Disclosure is required for this position               The post is exempt from Section 4(2) of the
Rehabilitation of Offenders Act 1974, by virtue of the Rehabilitation of Offenders Act 1974 (Exemptions) Order 1975. It
will therefore be necessary for a submission for Disclosure to be made to the Criminal Records Bureau to
check for any previous criminal convictions.

Disabled Applicants
Since the post holder will be expected to work in several Trust and University laboratories across a number of sites
he/she may wish to review access to the buildings concerned. Additional information may be sought from Disability
Services, e-mail disability@leeds.ac.uk or tel + 44 (0)113 343 3927.

Disabled applicants are not obliged to inform employers of their disability but will still be covered by the Disability
Discrimination Act once their disability becomes known.

Data Protection
The information you provide in your application will be used to consider your suitability for the post for which you have
applied. If your application is not successful the information will be disposed of confidentially after 9 months. If your
application is successful and you are appointed, your information and future data will be processed in accordance with
the University's Data Protection Code of Practice. A copy of this code can be obtained from either the University's Human
Resources Department or by visiting:

Health and Safety Responsibilities

You are required to adhere to and comply with the provisions of the Health and Safety at Work Act, related Regulations,
and act in accordance with the University’s Policy on Health and Safety which can be accessed via:
In addition you are also required to co-operate with regard to the implementation of the Health and Safety arrangements
and should not interfere with or misuse anything provided in the interest of Health, Safety and Welfare at Work.
Whilst working in Trust laboratories you will be expected to adhere to the Trust Health and Safety Management policy.

Equality and Diversity Statement

The University of Leeds is proud to be a multi-cultural community. We value diversity, and are determined to ensure:
    •   that we treat all individuals fairly, with dignity and respect;
    •   that the opportunities we provide are open to all;
    •   that we provide a safe, supportive and welcoming environment – for staff, for students and for visitors.

We recognise that we still have work to do to secure a truly inclusive community, and we are committed to a wide-ranging
plan of action to tackle discrimination and to promote diversity.

The Equality and Diversity Statement forms part of the University’s Equality and Diversity Policy, which applies to staff
and students alike and is available on the University’s website at: http://www.equality.leeds.ac.uk/ed/policy/

The University has published the following policy and code of practice which are linked to the Equality and Diversity
policy. They are also available on the University’s website:
    •   The Race Equality Policy,
    •   The Code of Practice on Harassment and Bullying

Further policies are being developed, and will be made available on the University’s website in due course.

Further information and advice are available from The Equality Service, Telephone: +44 (0)113 343 3927 or by email to

Terms and Conditions of Employment

The KTP associated will be employed by the University of Leeds, on University of Leeds Terms and Conditions, with the
following exceptions:

Hours of Work; The KTP associate will work 37.5 hours per week.

Holiday Entitlement; The KTP Associate Holiday entitlement is equivalent to annual leave determined by the NHS
Agenda for Change Terms; starting at 27 days per annum (pro-rata).


Employees will automatically be entered into the Pension Scheme, unless other wise stated. Pension payments will be
transferrable from the University system to the NHS system at the end of the project if the Associate is offered
employment by the Trust.

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