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					Breast Cancer Campaign grant funding information

Breast Cancer Campaign grant funding information

Thank you for your interest in Breast Cancer Campaign funding. Please use the following document, in conjunction with the „Guidelines for completing Breast Cancer Campaign application literature‟ when you are completing your application forms.

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Breast Cancer Campaign grant funding information

1. Introduction ........................................................................................ 4 2. Types of awards funded by Campaign ................................................. 5 2.1 General information ........................................................................ 5 2.2 Pilot grants .................................................................................... 5 2.2.1 General information ..................................................................... 5 2.2.2 Submission information ................................................................ 5 2.2.3 Costs ......................................................................................... 5 2.3 Project grants ................................................................................ 5 2.3.1 General information ..................................................................... 5 2.3.2 Submission information ................................................................ 6 2.3.3 Costs ......................................................................................... 6 2.3.4 Restrictions ................................................................................. 6 2.4 PhD studentships ........................................................................... 6 2.4.1 General information ..................................................................... 6 2.4.2 Submission information ................................................................. 6 2.4.3 Costs ......................................................................................... 7 2.4.4 Restrictions ................................................................................ 7 2.5 Scientific fellowships ..................................................................... 7 2.5.1 General information ...................................................................... 7 2.5.2 Submission information ................................................................. 8 2.5.3 Costs .......................................................................................... 8 2.6 Applications for ‘re-funding’ a current grant that is about to end .. 9 2.6.1 Submission information ................................................................ 9 2.7 Follow-on from a Campaign pilot grant ........................................... 9 2.7.1 Submission information ................................................................. 9 2.8 Applications for re-considering a grant that has been rejected in a previous grant round ............................................................................ 9 2.8.1 Invited resubmissions ................................................................... 9 2.8.2 Uninvited resubmissions ................................................................ 9 2.9 Travel .............................................................................................. 9 2.9.1 To conferences ............................................................................. 9 2.9.2 For recruitment .......................................................................... 10 2.10 Grant extensions ......................................................................... 10 2.10.1 Extensions up to three months ................................................... 10 2.10.2 Extensions of between three and twelve months .......................... 10 2.10.3 Underspend on the grant ........................................................... 11 2.10.4 Maternity leave ........................................................................ 11 2.10.5 Grant in abeyance .................................................................... 11 2.11 Applications for projects taking place within the NHS ................ 11 2.12 Applications which may fall out of Campaign’s funding remit .... 11 2.12.1 Animal licence costs ................................................................. 11 2.12.2 Equipment grants .................................................................... 11 2.12.3 Applications from abroad .......................................................... 11 2.12.4 Applications from a commercial entity ........................................ 11 2.12.5 Applications from those not employed by a University .................. 11 2.12.6 Applications for consumables costs only ...................................... 12 3. Application Procedure ....................................................................... 12 4. Deadlines .......................................................................................... 12 5. Peer review process .......................................................................... 13 6. Scientific Advisory Board meeting ...................................................... 13 7. Terms and conditions of award ......................................................... 13 7.1 Payment of grant .......................................................................... 13 7.2 Project management .................................................................... 14 7.2.1 General ..................................................................................... 14 7.2.2 Reports and Publications ............................................................. 14 7.2.3 Contact with the Media ............................................................... 15

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Breast Cancer Campaign grant funding information 7.2.4 7.2.5 7.2.6 7.2.7 7.2.8 7.2.9 Charity visits ............................................................................. 15 Peer review process .................................................................... 15 Intellectual Property ................................................................... 15 Scientific Fraud/Integrity ............................................................. 16 Experimental Animals ................................................................. 17 Patient involvement in research ................................................... 17

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Breast Cancer Campaign grant funding information 1. Introduction Each year around 46,000 people are diagnosed in the UK with breast cancer and 2,300 in Ireland. Each year almost 12,500 people will die from breast cancer in the UK and around 666 in the Republic. Breast Cancer Campaign (Campaign) believes that research is the only way forward if we are to make a difference to these figures. Campaign‟s mission is to beat breast cancer by funding innovative world-class research to understand how breast cancer develops, leading to improved diagnosis, treatment, prevention and cure. Our aim is to be the leading specialist in breast cancer research across the UK and the Republic of Ireland, making a significant impact on breast cancer for the benefit of patients. Scientific excellence and relevance to breast cancer are the key principles which guide Campaign‟s research. Key research objectives 1. Campaign will help to build the talent pool in breast cancer research as an assurance that the highest quality of research will continue to be done in the UK and the Republic of Ireland. 2. Campaign seeks to encourage scientific innovation. Campaign encourages scientific development and will continue to fund innovative projects that others might not support. 3. Campaign will continue to make every effort to engage in scientific and public dialogue and encourage scientists to communicate and collaborate with each other and ensure that the results are disseminated in an easy format to the general public. 4. Campaign will make every effort to ensure that research translates into benefits for patients as quickly and effectively as possible. This information will help you understand the kind of projects that Campaign funds, the peer review process and grant management procedures. The terms and conditions of awarded grants are also included. Completion of an application means full acceptance of these terms and conditions. The guidelines to completing the application form and the application literature itself can be downloaded from the apply for a grant page on our website www.breastcancercampaign.org/whatwedo/applyGrant/

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Breast Cancer Campaign grant funding information

2. Types of awards funded by Campaign 2.1 General information Awards are provided for pilot grants, project grants, PhD studentships and scientific fellowships in universities, medical schools/teaching hospitals and research institutes within the UK and Ireland. Grants will be made in support of the research project including salaries/stipends, minor equipment and consumables costs. Campaign will not directly employ scientific staff. Campaign will only undertake the funding of research that has been peer reviewed. Pilot grants will be peer reviewed internally by Campaign‟s Scientific Advisory Board. All other grant applications will be considered by at least two independent reviewers and Campaign‟s own Scientific Advisory Board. Applications for funding should be based on actual expenditure and all figures should be entered in GBP (£ Sterling). Invoices will be paid in GBP (£ Sterling) and converted to the currency of request by the bank at their exchange rate on the day the transfer or draft is actioned. Campaign is not responsible for losses incurred through fluctuations in exchange rates. 2.2 Pilot grants 2.2.1 General information Campaign pilot grants are available to allow established scientists to investigate and develop new ideas in the field of breast cancer research. Scientific innovation forms the framework for all Campaign research; pilot grants therefore will be awarded if they can be clearly demonstrated that support is for a new direction of research for researchers to test hypotheses for up to a year to provide sufficient data for a full application to Campaign. It is expected in general that a pilot grant will be used to fund a discrete piece of research that will not be supplemented from other sources. The applicant must have a proven track record in their own scientific field and be employed in a UK or Republic of Ireland research institute. 2.2.2 Submission information Please refer to Campaign‟s website for pilot grant application submission deadlines. Campaign‟s Scientific Advisory Board will review them internally and the final decision made within eight weeks of application. 2.2.3 Costs A maximum of £20,000 may be applied for. 2.3 Project grants 2.3.1 General information Campaign‟s projects grants are available to support innovative research in to breast cancer. Campaign will award project grants for a clear research proposal of relevance to breast cancer and is expected to lead to a significant advance of understanding of breast cancer and its impact. These awards will thereby expand the levels of knowledge and expertise in breast cancer research in the UK and Ireland. The applicants should have conducted independent research in the field of breast cancer or be an experienced researcher in a related field, and wish to build on their history and reputation in the breast cancer area, deepening their knowledge and experience.

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Breast Cancer Campaign grant funding information

Campaign is committed to supporting young investigators in breast cancer research and therefore would encourage applications from talented, new postdoctoral researchers. 2.3.2 Submission information Please refer to Campaign‟s website for project grant application submission deadlines. 2.3.3 Costs Project grants are awarded for up to three years. Costs covered are salary, consumables, small pieces of equipment and travel to conferences. Costs will not normally exceed £65,000 per annum. Consumables will not normally exceed £15,000 per annum, unless in exceptional circumstances, excluding animal and microarray costs. 2.3.4 Restrictions Campaign will not accept:  applications for consumables costs only  applications for PhD student stipend costs within a project grant

2.4 PhD studentships 2.4.1 General information Campaign PhD studentships are designed to capture new and highly qualified science graduates into a career of breast cancer research. In addition to the scientific merit of the proposed research and its relevance to the aims of the charity, particular attention will be paid the quality of the environment in which the award is to be held, and the support provided by the supervisor and the host institution to help develop the student's career in research. The application must be made by the potential supervisor who must be an experienced researcher in breast cancer, or a related field, Campaign will not accept applications from the potential students themselves. 2.4.2 Submission information Applications are requested once a year, please refer to Campaign‟s website for PhD studentship application submission deadlines. Campaign will hold one award session a year specifically to consider these applications.

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Breast Cancer Campaign grant funding information 2.4.3 Costs 2.4.3.1 Stipend The stipend awarded for PhD studentships are detailed below: Year 1 £15,120 £13,500* Year 2 £15,680 £14,000* Year 3 £16,240 £14,500*

London (Within the M25) Outside of London

* or equivalent in the Republic of Ireland.

2.4.3.2 Fees Fees are included, the value of which is dependent on the specific university policy at the time of application, but would not normally exceed £3,500 per annum. Exceptions are made for applications from Oxford and Cambridge whose PhD students are required to pay studentship and college fees. 2.4.3.3 Consumables Consumables are considered part of the PhD studentship award. No limit has been allocated to this, however the amount requested will be assessed by the board who will determine whether they are reasonable for the proposed study and will not normally exceed £12,000 per annum. This does not include animal or microarray costs. 2.4.4 Restrictions Campaign will not accept:  applications which request costs for stipends, fees or consumables only  applications requesting funding of the second or subsequent years of an already existing studentship  applications for part time studentships  applications for clinical fellowships 2.5 Scientific fellowships 2.5.1 General information Campaign scientific fellowships provide an excellent opportunity for post-doctoral scientists to become independent researchers specialising in the breast cancer field and to undertake research of the highest quality. These awards will thereby expand knowledge and expertise in breast cancer research internationally. Candidates will write their own application for support of an independent project. Applicants should have conducted independent research in the field of breast cancer and wish to build on their history and reputation in this arena, deepening their knowledge and experience. Candidates will be expected to have a significant publication record in their chosen field. Campaign recognises the importance of such individuals to the national research structure. Applicants should have at least three years post-doctoral experience, a solid track record in a relevant area and intend to maintain a long-term interest in breast cancer research. Each candidate should nominate a mentor who will be asked to carefully consider the appropriateness of the project to the candidate‟s career development and provide a responsible statement as to the candidate‟s prospects for gaining tenured position with the host institute, or indicate how they see the candidate‟s career developing outside the host institution.

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Breast Cancer Campaign grant funding information

In addition to the scientific merit of the proposed research, Campaign will also consider the potential of the candidate to become an independent and competitive researcher, the quality of the environment in which the award is to be held, and the support provided by the host institution to help develop the candidate's career in research. A successful fellow is expected to act as a representative and ambassador for Campaign, candidates‟ potential in this area will also be assessed. 2.5.2 Submission information Deadlines for fellowship applications are December each year, to be awarded in May the following year. Candidates will be short listed and invited to interview by a panel of Scientific Advisory Board and Campaign representatives. 2.5.3 Costs Campaign fellowships are awarded for five years. Costs covered are salary, consumables, core technical support, small pieces of equipment and travel to conferences. Campaign will support the salary for a full time technician for the duration of the fellowship if this is justified. Campaign will award up to £550,000 for each fellowship.

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Breast Cancer Campaign grant funding information

2.6 Applications for ‘re-funding’ a current grant that is about to end This kind of application arises when a grant holder applies for a new grant where the work is following on from successful, current Campaign grant that is coming to an end. 2.6.1 Submission information The application procedure asks for a two-page report outlining the initial aims of your previous project, how you have achieved these aims and how the new project builds on the previous work; to be submitted by the grantee with the application. A second report should be submitted prior to the Scientific Advisory Board meeting, as an update of developments since the application was written. The Campaign office will contact you six weeks in advance of the Scientific Advisory Board meeting for this information. 2.7 Follow-on from a Campaign pilot grant This kind of application arises when a grant holder submits an application based on the results obtained from a Campaign pilot grant. 2.7.1 Submission information The application procedure asks for a two-page report outlining the initial aims of your previous project, how you have achieved these aims and how the new project builds on the previous work; to be submitted by the grantee with the application. 2.8 Applications for re-considering a grant that has been rejected in a previous grant round Our policy is that all applications are reviewed and funded on their own merit. 2.8.1 Invited resubmissions If an unsuccessful applicant has been invited to re-submit their application subject to certain significant changes, then the Scientific Advisory Board will review it. This application will go out to independent referees as normal. 2.8.2 Uninvited resubmissions If the application was rejected without any invitation to re-submit, a resubmission of the same application will not be considered. A new application based on a rejected grant for the same award must be at least 50 per cent different and a covering letter submitted with the application must highlight the changes made. A new application based on a rejected grant, but for a different award does not need to be over 50 per cent different, but a covering letter must be submitted acknowledging the rejected grant, outlining the changes made and the reasons for applying for a different award. 2.9 Travel 2.9.1 To conferences In order to qualify for the travel award, the grantee (or preferably the researcher) must present work funded by Campaign, whether it is in the form of a poster or an oral presentation. These travel costs should not be included in the application form as they will automatically be added on to the grant should the application be funded.

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Breast Cancer Campaign grant funding information Campaign will pay costs only on receipt of invoice, and will require a short report on the outcomes of the conference. 2.9.1.1 Project grants and PhD studentships Campaign will provide £1000 for the costs of travel, registration and accommodation for one international conference and £300 per year for the costs of travel, registration and accommodation of national conferences. PhD students may also use the award for travel for training purposes in new techniques, for example. 2.9.1.2 Scientific fellowships Campaign will award a total of £4500 for travel: £3000 for the costs of travel, registration and accommodation for three international conferences and £1500 for the costs of travel, registration and accommodation for up to five national conferences. 2.9.1.3 Pilot grants No travel grants are awarded for pilot grants. 2.9.2 For recruitment Campaign does not cover the travel expenses for staff recruitment on the funded project. 2.10 Grant extensions Campaign will consider applications for grant extensions for up to twelve months at its discretion. Extensions will be considered for work proposed in the original application which has not been completed due to extenuating circumstances. Extensions will also be considered if it can be demonstrated that the additional time will be beneficial to the project in terms of further results for publication. As a general guideline, a one-month extension for each year of a project funded can be approved. All grant amendment requests must come from the grant holder only. Extension requests of over twelve months will not be considered. 2.10.1 Extensions up to three months For extensions of up to three months, please contact Natalie Anthony (nanthony@breastcancercampaign.org) for a grant extension request form, which should be submitted at least three months before the extension would start. Applications for extensions of up to three months with costs will be considered by the original Scientific Advisory Board sponsors; extensions of up to three months without costs will be considered by Campaign. 2.10.2 Extensions of between three and twelve months Under exceptional circumstances, Campaign will consider extensions of current grants for up to twelve months. A full application form should be completed by the grant holder not less than six months before their proposed extension will start. Extension requests must be received by the office at least two months before a Scientific Advisory Board meeting (held in May and November). The application will be reviewed by the original Scientific Advisory Board sponsors (where possible) and the applicant will be notified of the outcome after the trustee meeting.

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Breast Cancer Campaign grant funding information 2.10.3 Underspend on the grant If a project is coming to an end and there has been a substantial under spend, this may be used to fund up to three months extra research time. This must be approved by the Campaign office at least two months before the project end date. 2.10.4 Maternity leave Campaign will agree to put the grant into a period of abeyance while the researcher is on maternity leave. The length of time for maternity leave and the conditions on which the researcher will return must be discussed with Campaign in advance of the researcher going on leave. As Campaign does not employ the researcher, the charity is not responsible for covering any cost incurred for maternity leave, as we fully expect the University to assume responsibility for this. 2.10.5 Grant in abeyance If a researcher employed on a Campaign funded grant leaves, we will agree to put the grant into abeyance for a period of up to 12 months. If the position is not filled within this time funding may be withdrawn, and a request made for the grant to be resubmitted in a competitive grant round. A letter will be sent to the grant holder, and also the finance and research and development departments, requesting an update on the grant at three monthly intervals. Failure to respond to these letters will also risk withdrawal of funding. 2.11 Applications for projects taking place within the NHS The Scientific Advisory Board will consider applications for research that will take place within the NHS. Should the research become part of a NCRN clinical trial Campaign will fund the research but will not act as a sponsor. 2.12 Applications which fall out of Campaign’s funding remit 2.12.1 Animal licence costs Campaign will not fund animal licence costs. 2.12.2 Equipment grants The Scientific Advisory Board will not consider applications for equipment only. Under exceptional circumstances funding for large pieces of equipment may be considered within a project grant application where there is overwhelming evidence that Campaign funding was required, the project could not proceed without it being in place, and that the equipment would be solely used for breast cancer research. Full justification for the equipment request is required and must be included in the research proposal. 2.12.3 Applications from outside the UK and Ireland Campaign will not consider applications from outside the UK and Ireland. However, they would consider an application involving a non-UK/ Ireland collaboration provided that the main grant holder and researcher was UK or Ireland based and the research will be carried out in a UK or Ireland institution. 2.12.4 Applications from a commercial entity Campaign will not consider an application from a commercial entity. 2.12.5 Applications from those not employed by a University Campaign will not consider applications from an individual who is not employed by a University. In order to be able to qualify for a Campaign grant the applicant

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Breast Cancer Campaign grant funding information must have an honorary contract with the University of which written evidence must be supplied along with the grant application form. 2.12.6 Applications for consumables costs only The Scientific Advisory Board will not consider applications for project grants, PhD studentships or scientific fellowships which request funding for consumables only. 3. Application Procedure If you would like to apply for a Campaign grant, please download the application literature from the „apply for a grant‟ pages of Campaign‟s website at www.breastcancercampaign.org Submitting you application form: Please email a copy of the application form in Word format along with all supporting documents to rglover@breastcancercampaign.org When emailing your application, the subject of your email should read: Month & year (award meeting and year) PhD/project/fellowship/pilot and the applicant‟s name, for example; 2008NovPhD Smith. All application forms and supporting documents should be saved with a file name in the same format, for example; 2008Nov PhD Smith form A Please also submit three hard copies plus the signed original for project, PhD and scientific fellowship applications, only the signed original copy is required for pilot grant applications. Hard copies should be sent to the Campaign office at the address below. Please staple all the information together and do not use paper clips and plastic folders. Rebecca Glover Research Grants Officer Breast Cancer Campaign Clifton Centre 110 Clifton Street London EC2A 4HT Please note that only applications submitted using the most up to date Campaign application literature will be considered for review. If you have any suggestions for suitable referees who could review your application please provide all contact details in your covering letter. 4. Deadlines The Scientific Advisory Board meet twice a year in May and November Our current deadlines are: Award Scientific fellowships Project grants PhD studentships Pilot grants Deadline December January July September Award meeting May May November November

Please refer to the website for exact dates of upcoming submission deadlines.

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Breast Cancer Campaign grant funding information 5. Peer review process Your application will be sponsored by two members of our Scientific Advisory Board, who will each decide whether or not the application should continue through the peer review system. Those applications deemed unsuitable for Campaign support will not be sent out for external review and will therefore not be considered for funding. You will be notified of this decision within 10 weeks. Unsuccessful applicants will receive feedback from the Scientific Advisory Board. Applications that progress will be reviewed by at least two external referees except for pilot grant applications which are reviewed internally by the Scientific Advisory Board. If there is a scientist or clinical researcher with acknowledged experience and expertise in your speciality whom you would particularly like to nominate as a referee, please include their name and contact details in a covering letter when you submit your application. Campaign will take your suggestions into account but we do not guarantee these referees will be approached. We expect that these referees treat your application as confidential. Each referee responds scoring the proposal from 0 (not fundable) to 10 (where the funds are available, must be supported). This review process takes up to eight weeks. A second report should be submitted by the applicant prior to the Scientific Advisory Board meeting, as an update of what has happened since the application was written. The Campaign office will contact you six weeks in advance of the Board meeting for this information. 6. Scientific Advisory Board meeting All grants put forward for external review are reviewed with the referees‟ comments and the grants are then re-scored. The grants are then ranked from the highest to lowest, and those that the board deem to be funded are then recommended to the Trustees of Campaign who make the final decision as to whether or not the charity should fund the project. The Trustee‟s decision is final. The Trustees meeting normally happens within a month of the Scientific Advisory Board meeting. You will be informed after this meeting whether your application has been successful. Ifyou application is successful you will receive a formal letter along with Terms and Conditions of Award. Campaign will always aim to provide feedback to applicants and we are able to do this with the external referees‟ comments. For those applications which are reviewed by external referees, it must be emphasised that any decision whether to fund a grant or not is not based solely on these comments, as the applications are reviewed by the members of our board at the meeting and there may have been are other factors dictated by Campaign‟s own policies and priorities which may influence the outcomes of the meeting. Please note that the charity will not enter into any discussion regarding these comments and that the decision taken by the Scientific Advisory Board and the Trustees is final. The time from date of submission of your application to learning the outcome of the review process should take not longer than six months. 7. Terms and conditions of award 7.1 Payment of grant Grants will be paid quarterly in arrears, on the receipt of an invoice from the Finance Officer. Campaign is not liable as employer of any persons to whom support may have been given. Payment of invoices will not begin until a signed start date form has been received.

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Breast Cancer Campaign grant funding information Grant amounts agreed will not be increased or extended other than in exceptional circumstances and where funds are available. Applications should include in the application form expected cost of salary rises over the period of the grant. 7.2 Project management 7.2.1 General Project and scientific fellowship grants must start within nine months of the award letter being received. PhD studentships are awarded in November and must start by October of the following year. Pilot grants must begin within two months of the award letter being received. Campaign must received advance written notification of any changes to personnel. Any changes to the principal investigator must also be approved, in writing, by the researcher and any co-applicants. Changes to PhD supervision must be approved, in writing, by the new supervisor, the second supervisor and the student. Campaign must also approve any other changes to be made to the project itself. Full financial and performance monitoring of research grants will be undertaken by Campaign. The Grant holders are expected to be actively engaged in their project and will remain responsible for conduct throughout. Campaign requires to be given in writing the names, qualifications, career plans and tenure of all individuals working on the project. Failure to comply with any of the above may risk withdrawal of the grant from Campaign and may require the submission of a new application. 7.2.2 Reports and Publications Campaign will request a report on the progress of your grant at the end of each year. The details of what this should entail are outlined at the point of award and will be sent out again once the project start date has been finalised. Failure to submit such a report will jeopardise the continuation of support by Campaign. Final reports on all projects are also required and the final invoice will not be paid until this is received. The grant holder must notify Campaign, in advance of publication, of the acceptance of their abstract or paper for publication or presentation so that we can prepare a press release when appropriate. Acknowledgement of the support of Campaign is required in publications relating to the research including abstracts submitted to scientific meetings. If you wish to use our logo on any publications or presentations please contact the Campaign office for more information. Campaign maintains a library of all publications resulting for research funded by them. Electronic copies of abstracts and all published papers (acknowledging the support of Campaign) must be sent to Natalie Anthony at nanthony@breastcancercampaign.org. In the case of PhD studentships and fellowships the recipient agrees to itemise this award in his/her curriculum vitae and in any and all publications where the award is relevant.

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Breast Cancer Campaign grant funding information

7.2.3 Contact with the Media It is important for the charity to raise its profile where appropriate; Campaign supports and encourages the researcher to promote their Campaign funded work with the media but strictly in consultation with the charity‟s Communications department. Campaign Communications department will contact the researcher when appropriate to help respond to relevant media enquiries and PR initiatives about the charity‟s work. Campaign‟s communication department will press release the award to national and local media and, from time to time, may choose to press release any publications or presentations that arise from the award. Any media work undertaken by Campaign will be carried out with the full involvement of the grant holder. 7.2.4 Charity visits Campaign will expect the grant holder and researcher, if in post, to attend an induction day in London, which will take place within the eighteen months, for which travel expenses will be paid. Campaign will also invite grant holders and researchers to attend an annual parliamentary reception, and to present Campaign funded work at a scientific conference, both of which will be in London. All travel expenses will be paid. Campaign will undertake one or more site visits to grant holders laboratories during the course of the grant, to which the charity may invite the local MP, Campaign staff, trustees, Scientific Advisory Board, fundraisers, spokespeople and supporters. 7.2.5 Peer review process Campaign expects that grant holders respond to requests, within reason, to provide referee reports for applications submitted to Campaign. 7.2.6 Intellectual Property Campaign‟s aim is to exploit the outcome of its research so that the understanding, diagnosis and treatment of breast cancer and related diseases are maximised. Neither the host institute of Campaign (nor its agents) shall be under an obligation to protect intellectual property and materials where, in the parties reasonable opinion, there is insufficient commercial justification to do so. The host institute shall allow Campaign (or its agent) to visit, meet and discuss with Campaign grantees the results of their research and any potential for protection of such Intellectual Property Rights and for the commercial exploitation of their research. If, in the opinion of Campaign (or its agent), any results of Campaign -funded research are protect able or have a potential for commercial exploitation then Campaign (or its agent) will inform the host institute. The appropriate authority in the host institute and /or the grant holder is required to consider and inform Campaign (or its agent) of any results produced from or arising during the course of Campaign -funded research and any rights in those results, including any patents, design rights, copyright and other industrial and intellectual property rights, whether registrable or not and all scientifically useful or commercially exploitable material, know-how and data relating to any invention arising from Campaign-funded research (“Intellectual Property Rights”) which might be suitable for commercial exploitation. Publication or any other

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Breast Cancer Campaign grant funding information form of public presentation of the results should not occur until after that consideration and all necessary steps to protect any Intellectual Property Rights have been taken. However, there should be no unnecessary delay before publication. The host institute may elect to take all necessary steps to protect any Intellectual Property Rights, as may from time to time be identified by the host institute and /or Campaign (or its agent) and notified by each of them to the other. If the host institute decides not to protect any Intellectual Property Rights, Campaign (either itself or through its agent) may elect, but is not obliged, to take the necessary steps required to protect those Intellectual Property Rights. In this case, the host institute shall co-operate fully with Campaign (or its agent) and ensure that their employees, contractors and agents do the same and will, upon Campaign‟s (or its agent‟s) request, assign to Campaign (or its agent), at no cost (but without prejudice to paragraph 5), their respective whole right, title and interest in and to the results of any Intellectual Property Rights relating to those results. All revenues generated through the commercial exploitation of the Intellectual Property Rights arising from research funded by Campaign, shall following reimbursement of costs directly incurred in protecting the intellectual Property Rights and in carrying out the exploitation be divided equally between the host institute on the one hand and Campaign (or its agent) on the other regardless of which undertook the commercial exploitation. In the event that parties other than those funded by Campaign contribute to the generation of Intellectual Property Rights, the parties shall meet to agree who should assume responsibility for such action and a revenue share which reflects the relative contributions of all parties. Successful applicants must therefore advise Campaign of all other financial assistance to their projects. The host institute shall be solely responsible for rewarding the inventors and department in which the researchers are situated out of its share of the revenue net of the aforementioned costs. The prior written agreement of Campaign (or its agent) is required for any commercial exploitation of the research results and any Intellectual Property Rights, before the host institute or any individuals involved in Campaign -funded research enter into any agreement, accept any appointment or take any action, which involves agreeing with a third party to any restrictions on publication, or the early disclosure, of the results of their research. Campaign (or its agent) reserves the right to refuse such agreement or to grant agreement subject to such terms and conditions as Campaign (or its agent) may decide. For the avoidance of doubt, Campaign reserves the right to vary its policy from time to time regarding ownership and exploitation of the Intellectual Property Rights and to change these Conditions accordingly. 7.2.7 Scientific Fraud/Integrity In the event of fraud occurring, Campaign wishes to make it clear that it is the responsibility of the employing authority to investigate this. If a case of scientific fraud is suspected in the course of the research, then Campaign should be notified and kept informed of further developments. At the initial stages of the enquiry Campaign would not normally suspend the grant. However, if adequate steps are not taken to proceed with the investigation, Campaign will suspend the grant. If fraud is proven Campaign will terminate the grant immediately.

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Breast Cancer Campaign grant funding information 7.2.8 Experimental Animals Applications are expected where possible to adopt procedures and techniques which avoid the use of animals, and where this is not possible to use the minimum number of animals considered necessary to achieving a valid result in any experiment (this may involve the use of animals of higher quality). Grant holders are asked to ensure that any new procedure which reduces the number of live animals needed for research or testing is communicated through the usual media so that it becomes known to all who might make use of it. Where the work is subject to regulation by the Animals (Scientific Procedures) Act 1986, the provision of that act must be observed. Campaign‟s support for a particular project does not absolve the applicant from personal responsibility in this regard; application for all licenses and certificates required under the Act must be made to the Home Office direct through the host establishment‟s normal channels. Campaign does not insist that Home Office approval of any particular project be sought in advance of the application for funding, but any award made in response to such an application will be on the absolute condition that no work which is fees controlled by the Act will be begun until the necessary licenses and certificates have been obtained. Any levied under the Act are the responsibility of the host establishment and cannot be provided under the grant. 7.2.9 Patient involvement in research We require that patients be treated according to the World Medical Association Declaration of Helsinki and the Guidelines for Good Clinical Practice.

Completion of an application means full acceptance of the above terms and conditions.

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