Physiological Science 111C Foundations in Physiological Science

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					               Physiological Science 111C: Foundations in Physiological Science

                      Transport, Endocrine and Reproductive Physiology

Fall Quarter, 2009

Instructors:

        Professor Barney A. Schlinger
        Department of Physiological Science
        Life Sciences 5802
        825-5716
        Office Hours: Tuesday 10:30-12:00 PM (Oct. 27 - Dec. 1, only)

        Professor Nasser A. Farahbakhsh
        Department of Physiological Science
        Life Sciences 4817
        206-4343
        Office Hours: MWF 10:00 – 11:00 AM (Sep. 25 - Oct. 19, only)


Textbook: Human Physiology, by L. Sherwood
Students will have the option of purchasing lecture notes for transport physiology or downloading them
from the class website. They will be required to purchase from APS a set of readings for the discussion
sections in the second module.

Midterms: There will be three midterms: October 19 and November 13, during lecture and the third
during Final Exam week. The midterms will last one hour and twenty minutes each and will each comprise
25% of the final grade. Note there will be no breaks during the 80 min exams. The first midterm will cover
the material in the first 10 lectures (Transport Physiology); the second midterm will cover the endocrine
physiology (10 lectures); the third midterm will cover all the material on reproductive physiology (10
lectures).

THERE WILL BE NO MAKE-UP EXAMS. STUDENTS WILL NOT BE PERMITTED TO TAKE
THESE EXAMS EARLY OR LATE.

Ethics: Any form of cheating will not be tolerated. Students suspected of cheating will be reported to
the Dean of Academic Affairs.

Discussion Section (Lab): Attendance in Discussion Sections is required (20 points). Active participation
in discussions is also required (30 points). Students will sign up for these sections on the first day of class.
The grade for the discussion section will constitute 25% of the final grade.

Quizzes and Readings: The remaining 50 points of the grade for the discussion section will be composed
of the grade from quizzes, to be given at the beginning of each discussion session based on the following
assigned articles and additional articles to be determined at a later date. There will not be any assigned
article for Transport Physiology. However, students are expected to read the Supplemental Material
(i.e. the material in the notes, but not covered in the lectures), on their own and discuss them, along with
the material covered in lectures, with their TAs, during these sessions.
Week Due

Oct. 26-30      Marx, J. (2003) "Cellular Warriors at the Battle of the Bulge".
                Science 299: 846- 849

Nov. 2-6        Weekes, N. et al. (1998) "Examination stress as an ecological inducer of cortisol
                and psychological responses to stress in undergraduate students". Stress 8: 199-
                206.

Nov. 16-20      Grinspoon, S. and E. Seely eds. 2006. "Hot topics in pituitary tumor management".
                Endocrine News 31: 16-21.

Nov. 23-27      Aitken et al., 2008 "As the world grows: contraception in the 21st century". J. Clin.
                Invest. 118: 1330-1343.


                   SCHEDULE OF LECTURES on Physiology of Transport

Dates                                  TOPICS

Sep. 25         Anatomy of Epithelia. (Supplemental Material: Diffusion of Non-electrolytes and
                      ions; Osmosis and the Diffusion of Water; The Donnan Equilibrium).

Sep. 28, 30     Facilitated Diffusion and Coupled Transport; Symports and Antiports; Active
Oct. 2                  Transport; Polarity and Vectorial Transport; Mechanism of Water Transport.

Oct. 5-9        Mechanism of Water Secretion and Salivary Gland; Secretion by the Gastric
                      Mucosa of the Stomach; Digestion and Absorption in the Small Intestine;
                      The Kidney: Stucture and Function.

Oct. 12-16      The Kidney: The Counter-current Mechanism and Regulation of Osmolality; Acid-
                       Base Balance. Review.

Oct. 19         First Midterm.


              SCHEDULE OF LECTURES on Endocrinology and Reproductive Physiology

Dates                            TOPICS

Oct. 21-23      Gen'l Introduction: Anatomy of the Endocrine System, Types of Hormones; Hormones and
                        homeostasis: feedback; Regulation of Hormonal Secretion; Mechanism of Hormone
                        Action: Hormonal Receptors;

Oct. 26–30      Hormone Signal Transduction: G-proteins; Neuroendocrinology: Anatomy of the Endocrine
                     Hypothalamus and limbic system; Anatomy of the Pituitary; Hormones of the
                     Anterior Pituitary: Feedback Regulation of Secretion
Nov. 2-6       Mechanism of Action; Evolution of Pituitary Hormones. Hormonal Regulation of
                     Metabolism: Thyroid Hormones; Regulation of Secretion; Transport; Mechanisms
                     of action.

Nov. 9-13      Pancreatic islet hormones; Regulation of glucose transport and utilization.
                      Second Midterm

Nov. 16-20     Posterior Pituitary Hormones; General Introduction to Hormones and Reproduction-
                       Biochemistry of steroid hormones;

Nov. 23-25     Male Reproductive Physiology: Anatomy of the male reproductive system; Testicular
Nov. 30              function; Sertoli and Leydig cells; Spermatogenesis; Spermiogenesis; Hormonal
                     control of behavior;

Dec. 2-4       Female Reproductive Physiology: Anatomy of the female reproductive system; Ovarian
                      Function; Hormones and the Ovulatory Cycle; Mechanism of Ovulationl Hormones
                     in pregnancy; Hormonal control of behavior.


Physiological Science Honors Program

Students who wish to take Physiological Science 111C as a part of their Honors Program must contract for
the course no later than the second week of the quarter. To obtain honors credit for 111C, a student must
complete all of the normal requirements for the course and in addition complete the following assignment.
A 8-10 page double-spaced paper must be turned in to Professor Schlinger (Articles 1 & 2 or approved
article) or to Professor Farahbakhsh (Article 3) no later than 5:00 PM of the last day of classes. This paper
must present a detailed analysis of one article:

1.     Johnson, J. et al. 2005 Oocyte generation in adult mammalian ovaries by putative germ cells in
       bone marrow and peripheral blood. Cell 122: 303-315 and Vogel, G. 2005. Controversial Study
       finds an unexpected source of oocytes. This Week NEWS in Science 309: 678-9.

2.     Ohlsson, C., Bengtsson, B.-A., Isaksson, O. G. P., Andtreassen, T. T. and Slootweg, M. C.
       (1998) Growth hormone and bone. Endocrine Reviews 19:55-79.

3.     Wall, S. M. and Pech, V. The interaction of pendrin and the epithelial sodium channel in
       blood pressure regulation. Curr. Opin. Nephrol. Hypertens. 17:18-24, 2008. [Here]