Potential Ewing's Sarcoma Targeted Therapy Discovered by olliegoblue25

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									Lombardi



                                                                                                                                                                    Georgetown University
                                                                                                                                                 summer 2008




Potential Ewing’s Sarcoma Targeted
Therapy Discovered

T
           wo Lombardi scientists have found a small molecule                              ate a recombinant EWS-FLI fusion protein. This allowed them
           that could serve as the basis for a new treatment for                           to study the activity of the oncogene in depth, and the team dis-
           Ewing’s sarcoma. If further studies continue to                                      covered an important binding partner called RNA helicase
           show positive results, they believe the novel                                             A (RHA).
agent could be the first targeted therapy to treat the                                                      Through a series of partner proteins including
disease, which is a rare childhood cancer.                                                              RHA, EWS-FLI1 initiates and sustains the can-
    In the United States, about 500 patients are                                                        cer. In order to stop the continued proliferation of
diagnosed with Ewing’s sarcoma each year, and                                                             the tumors, Dr. Toretsky and his team knew they
they are treated with a combination of five differ-                                                         needed to disrupt the binding between the onco-
ent chemotherapy drugs. Between 60-70 percent                                                               genic protein and its partners. Focusing on RHA,
of patients survive over time, but many have long-term                                                they worked to identify the specific region on RHA
side effects that linger from the therapy.                                                      that stuck to EWS-FLI1. This painstaking work took over
    Over 95 percent of patients with Ewing’s sarcoma                                           ten years from idea to implementation. Throughout that time,
have the same mutation—called a translocation—                                                            The Children’s Cancer Foundation of Baltimore,
where the end of chromosome 22 becomes fused                                                                MD, supported Dr. Toretsky’s research, believing
to the end of chromosome 11. This very specific                                                               in the promise of his approach.
mutation fuses two normally unrelated proteins                                                                     In order to discover the binding patterns
into one oncogenic protein called EWS-FLI1.                                                                      of EWS-FLI1, the laboratory must produce
    Jeffrey Toretsky, MD, led the Lombardi                                                                         millions of copies of the RHA and EWS-
research to discover the potential new                                                                              FLI1 proteins. A generous gift from the
treatment. He has been at the fore-                                                                                Go4theGoal Foundation recently allowed
front of Ewing’s sarcoma research                                                                              Dr. Toretsky to purchase a new piece of equip-
for a number of years. Working                                                                             ment to purify the proteins. This ensures that
with Lombardi colleague Aykut                                                                          his team is able to push forward with their research,
Üren, MD, the Toretsky-Üren                                                                 including the testing of the new drug.
laboratory was the first to cre-                                                                Finally, collaborating with Milton Brown, MD, PhD, Director
                                                                                             of Georgetown’s Drug Discovery Program, the team searched
The small molecule in green binds to
the the purple structure on the eWs-FLi1                                                      for a molecule that would keep the two proteins separated. In
protein (continues off page). Dr. Toretsky                                                          other words, they sought an agent that would stick to
hopes the green molecule will serve as the                                                               EWS-FLI1 in the very place that RHA bound to
basis for new treatment for ewing’s sarcoma.                                                                                                 ConTinueD on pAge 4




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                   Deputy Director                    Lombardi                            Blood Test Predicts                 Appointment with       The Infinite
                   Named                              Gala                                Cancer’s Spread                     “El Doctor”            Power of One

                   Top of page: Detail from Yellow Townhouse, for Emily by Frank DiCicco on display in the Atrium in April, 2008.
    2



                                                 Dear Friends,
From the Director




                                                 I
                                                         am very excited to have the op- need support beyond their last treatment appointment. Aziza
                                                         portunity to lead the Lombardi Shad, MD, who directs a survivorship clinic for pediatric cancer
                                                         Comprehensive Cancer Center. I patients, has expanded her reach to patients throughout the
                                                         was attracted to this job for many world by publishing a handbook for pediatric cancer survi-
                                                   reasons, not least of which is the oppor- vors. The vivid pages of the guide provide invaluable advice to
                                                   tunity to work with so many wonderful patients as they cross the bridge to survivorship.
                        physicians and scientists here at Lombardi.                             I am proud that Georgetown is taking a leading role in cancer
                           My vision is for Lombardi’s research to reduce the burden research. As you know, Lombardi is the only NCI-designated
                        of human cancer through the development and early adoption comprehensive cancer center in the Washington metropolitan
                        of cutting-edge systems biology-based tools. The Cancer Center area. Because of this, we have a special set of opportunities
                        will be a world leader in designing                                                                and obligations to our neighbors.
                        and implementing a paradigm-                “My vision is for Lombardi’s research                  I believe we must reach out and
                        changing technology for cancer                                                                     address issues such as health dis-
                        research. Currently under devel-           to reduce the burden of human cancer                    parities and access to care here in
                        opment, the Georgetown Database              through the development and early                     our neighborhood.
                        of Cancer (G-DOC) will help us                                                                         Lombardi member Elmer
                        define the molecular features that            adoption of cutting-edge systems                     Huerta, MD, MPH, is at the fore-
                        underlie prognosis and respon-            biology-based tools. The Cancer Center                   front of efforts to educate the local
                        siveness to therapy in patients,                                                                   Latino population about cancer
                        providing a basis for personalized            will be a world leader in designing                  risks and prevention. His “Cancer
                        medicine and a tool for target            and implementing a paradigm-changing                     Preventorium” clinic, based out of
                        discovery and drug development.                                                                    the Washington Cancer Institute,
                        This enterprise will add an extra              technology for cancer research.”                    demonstrates the need for such
                        dimension to the outstanding                                                                       outreach programs. Dr. Huerta
                        research that we conduct at Lombardi.                                also serves an important role as President of the American
                           As you can see in this issue of Lombardi Magazine, the Cancer Society, the country’s largest health advocacy organiza-
                        Cancer Center is making a real impact on many different fronts. tion.
                        The cover story of this issue is particularly exciting. The col-        We are fortunate to have such strong collaborations with
                        laboration between Jeffrey Toretsky, MD, and Milton Brown, faculty members throughout the MedStar Health network, who
                        MD, PhD, has led to a promising targeted compound to treat truly enrich the Cancer Center. I look forward to updating you
                        Ewing’s sarcoma. Both Jeff and Milt were also recognized in on these collaborations and many other activities in the coming
                        the past months for their extraordinary talent with a presti- months.
                        gious Burroughs Welcome Foundation Clinical Scientist Award             All the best to you and your family.
                        and the Richard von Matsch Endowed Chair in Experimental
                        Therapeutics, respectively. I congratulate them both on these
                        most recent successes.
                           I believe that the growing number of cancer survivors is a
                        testament to cancer researchers around the globe. At Lombardi           Louis M. Weiner, MD
                        we celebrate this accomplishment, but we believe that patients          Director, Lombardi Comprehensive Cancer Center

                        louis m. Weiner, md, became director of the lombardi comprehensive cancer center on January 1, 2008. previously he served as the
                        chairman of medical oncology and vice president for translational research at Fox chase cancer center in philadelphia. a medical
                        oncologist specializing in the treatment of patients with gastrointestinal cancers, his research has emphasized the translation of new
                        ideas from the laboratory into clinical practice, with an emphasis on immunotherapy and targeted cancer therapy.



                            upcoming lombardi events
                                                                                             23rd Annual Lombardi Gala            Saturday, November 1, 2008
                        Doo Wop Concert for Cancer       september 6, 2008                   Hilton Washington
                        Hyundai Hope on Wheels           september 10, 2008                  1919 Connecticut Avenue, NW • Washington, DC, 20009
                        Gift of Life Breakfast           october 7, 2008                     6–8 pm    silent auction
                                                                                             8 pm      dinner, awards, raffle, live auction, and dancing
                        visit http://lombardi.georgetown.edu/events to learn more.



                    LombardiMagazine 4 Wui m T eerr 22000078
                                       s n m                                                   To find out more:    http://lombardi.georgetown.edu
                                                                                                                                                3



Lombardi Welcomes…




                                                                                                                                            Inside Lombardi
                      Katharine Brophy, MSB, CPA                                             Joanne Carper
                      Katharine Brophy, MSB, CPA, joined                                     Joanne Carper joined Lombardi in Decem-
                      Lombardi in October 2007 as Chief                                      ber 2007 as the new Clinic Administrator
                      Financial Officer for the cancer center. She                           for the adult hematology/oncology clinic.
                      comes to Georgetown from Johns Hopkins                                 Joanne has worked for MedStar Health
                      University where she most recently served                              hospitals for over 15 years, including
                      as assistant to the controller. Over her 17                            Washington Hospital Center, Georgetown’s
                      year career at Hopkins, Kathy held a num-                              sister hospital, and several years at the
                      ber of financial management positions in                               pre-certification department at Georgetown
                      the School of Public Health including the                              University Hospital. “I’ve found that all
Director of Financial Operations and the Director of Business         MedStar facilities have this union, almost like a family, that
Services, where she was responsible for financial forecasting and     made me want to come here,” she said. At Lombardi, Joanne
budget development for the School’s $300 million operation, as        oversees the day-to-day operations of the clinic. In addition
well as strategic planning and management of the bursur’s office.     to these administrative responsibilities, she’s spending time
“At Lombardi, I have the opportunity to work more closely with        listening to patients and their concerns to help make their visit
researchers, and really make a direct impact on the faculty,” she     easier and more relaxed. “It’s about making patients feel better
said. As CFO at Lombardi, Kathy has already begun to build a          on many levels, and it’s great to work in a place where our mis-
strong platform of administrative support for the cancer center’s     sion includes training residents and fellows, doing research, and
research activities.                                                  providing patient care.”




Peter Shields Appointed Deputy Director
new associate director for population sciences also named




L
           ombardi Director Louis M. Weiner, MD, has appointed        has led the Cancer Control Program since 1999. She is a nation-
           Peter G. Shields, MD, to the newly created position of     ally-recognized cancer control scientist with more than a decade
           Deputy Director. Dr. Shields, a                                                    of health services, health outcomes, can-
           member of the Cancer Center                                                        cer epidemiology, and cancer and aging
since 2000, has served as Associate Di-                                                       research experience. Her research focus-
rector for Population Sciences and Leader                                                     es on age, race, and ethnicity related dis-
of the Cancer Genetics and Epidemiology                                                       parities in cancer care and outcomes.
Program for the past seven years.                                                                 Dr. Weiner also appointed 4 new pro-
    Dr. Shields’ research focuses on gene-                                                    gram leaders to oversee the core research
environment interactions for cancer risk,                                                     areas in the cancer center. Christopher
with a strong emphasis on tobacco-related                                                     Loffredo, PhD, and Marc Schwartz, PhD,
harm and also separately on breast cancer.                                                    were promoted to primary program leaders
The laboratory component of his research Dr. shields                  Dr. mandelblatt
                                                                                              for the Cancer Genetics and Epidemiology
develops new biomarkers of cancer risk,                               and Cancer Control programs, respectively. Both had served as
while his epidemiological work studies special populations and        co-leaders for several years.
tests hypotheses related to determining the causes of cancer.             Eliot Rosen, MD, PhD, and C. Richard Schlegel, MD, PhD,
    In a letter to the Lombardi community, Dr. Weiner wrote,          have also been named to leadership positions. Dr. Rosen, a radi-
“Peter is an outstanding physician-scientist who has demonstrat-      ation oncologist and basic science researcher is now co-leader of
ed leadership and vision in executing his prior responsibilities...   the Radiation Biology and DNA Repair program. Dr. Rosen holds
In his new role, Peter will work with me to prioritize and oversee    the Gragnani Chair for Oncology and Radiation Biology. Dr.
Cancer Center operations on a strategic level.”                       Schlegel, academic chair of the Department of Pathology, is now
    Dr. Weiner has also appointed Jeanne Mandelblatt, MD, MPH,        co-leader for the Growth Regulation of Cancer program. He is
as Associate Director for Population Sciences. Dr. Mandelblatt        one of the inventors of the vaccine against cervical cancer. LM



Lombardi CancerLine:       (202) 444-4000                                                         summer 2008 4        LombardiMagazine
    4

                     ConTinueD From pAge 1
Inside Lombardi


                     the fusion molecule.                                                    that bound to EWS-FLI1 and chose to pursue one of them, which
                         Dr. Brown’s laboratory is able to screen thousands of com-          seemed the most promising.
                     pounds for their potential drug-like properties in a matter of min-        “We’ve taken this initial hit from the library and discovered
                     utes instead of days or weeks. Using the known crystal structures       the relationship between the small molecule and the EWS-FLI1
                     of proteins, Dr. Brown and his team match the 3-dimensional             protein,” said Dr. Brown. “This is very exciting because it pro-
                     structures of the target with a library of small molecules in silico,   vides us the opportunity to bridge the gap between basic science
                     or on the computer. This way, they can conduct a very rapid             and pre-clinical studies.”
                     assessment to find the best candidates for further testing in cells,       The drug discovery team is now working to make the com-
                     which is a much more time consuming and expensive process.              pound target the pocket more specifically in order to create
                         In this case, Dr. Toretsky was able to use a library of small       a better candidate drug. While several stages of the research
                     molecules loaned to Georgetown from the National Cancer                 process remain before the drug can move into the clinic, this
                     Institute. The team of investigators screened 3,000 compounds           could be the first targeted therapy to be developed for Ewing’s
                     for their potential to block the EWS-FLI1 interaction with RHA.         sarcoma.
                     Using a direct binding assay, the team found several molecules             Because of the relatively small number of patients diagnosed

                                                                       Drug Development Pipeline
                       tHe drug development pipeline




                     Dr. Toretsky’s candidate therapy is in the drug discovery and
                     translational studies stages of drug development.




                     Lombardi Physician-Scientist Receives Burroughs Wellcome Fund Award



                     J
                             effrey a. toretsky, md, a pediatric oncology physician          vides the freedom and flexibility to explore scientific ques-
                             and researcher at lombardi, received the prestigious            tions, apply the resulting knowledge at the bedside, and
                             clinical scientist award in translational research              bring insights from the clinical setting back to the labora-
                     from the burroughs Wellcome Fund (bWF). the $750,000                    tory for further study. ”
                     award, one of only 13 given in 2008, is designed                                        “We hope these awards will lead to better
                     to support established, independent physician-                                       understanding of the mechanisms of disease as
                     scientists who are dedicated to translational                                        well as new methods of diagnosing, treating and
                     research.                                                                                                 ”
                                                                                                          preventing disease, said burroughs Wellcome
                         dr. toretsky, whose research is featured on the                                  Fund president enriqueta c. bond, phd.
                     cover of this magazine, splits his time between                                         “bWF particularly is interested in supporting
                     the clinic and the laboratory. He is an active phy-                                  physician-scientists who bring novel ideas and
                     sician, treating pediatric patients with rare pedi-                                  new approaches to translational research. ”
                     atric hematology diseases and cancers including                                         dr. toretsky’s laboratory recently discovered
                     ewing’s sarcoma, osteosarcoma, and synovial                                          a small molecule that may be able to disrupt the
                     sarcoma. at the same time, dr. toretsky actively                                     cancer pathways in ewing’s sarcoma.
                     pursues research that will lead to new and more specific                   “this award will significantly aid us in advancing our
                     therapies for ewing’s sarcoma, a solid tumor in bone or soft                                                                ”
                                                                                             work in ewing’s sarcoma and i’m truly honored, said dr.
                     tissue that primarily occurs in children and young adults.              toretsky. “specifically, we’ll use the award to accelerate our
                         the clinical scientist award is a unique award that                 efforts in finding new treatments for this cancer by engaging
                     provides funds for physician-scientists who conduct trans-              a unique drug discovery laboratory at georgetown. LM  ”
                     lational research. according to the Fund, “the award pro-




                  LombardiMagazine 4 s u m m e r            2008                              To find out more:    http://lombardi.georgetown.edu
                                                                                                                                               5




                                                                                                                                           Inside Lombardi
with the disease each year, there has been little research invest-     “Ewing’s sarcoma is rare,” said Dr. Toretsky,
ment into new treatments. So-called “orphan” diseases such as
Ewing’s, garner little interest from pharmaceutical companies          “but our work has the potential to improve
who most often conduct drug development research. George-             treatment not only for patients with this dis-
town’s Drug Discovery Program provides an academic solution,
enabling basic laboratory research, like Dr. Toretsky’s, to prog-       ease but for others who have cancers with
ress to pre-clinical stages in the drug discovery pipeline.                   similar molecular characteristics.”
    “Ewing’s sarcoma is rare,” said Dr. Toretsky, “but our work
has the potential to improve treatment not only for patients with
this disease but for others who have cancers with similar molecu-    Toretsky and Brown has a different activity than other drugs that
lar characteristics.”                                                have been shown to work against fusion proteins. For example,
    This finding is also important for another reason—it demon-      Gleevac—which treats chronic myeloid leukemia formed by a
strates a proof of principle for a new method of designing drugs.    chromosome translocation—blocks the function of a single pro-
The notion long accepted among scientists is that it is not pos-     tein, not the binding of two proteins. Dr. Toretsky is hopeful that
sible to block protein-protein interactions given that the surface   this means that other fusion proteins, found in other sarcomas as
of these proteins is slippery, and much too flexible for a drug to   well as diverse disorders, can be successfully treated as well.
bind to.                                                                The findings were presented at the annual meeting of the
    “These are wiggly proteins, yet this study shows that inhibit-   American Association for Cancer Research (AACR) in San
ing protein-protein interactions with a small molecule is pos-       Diego by Hayriye Verda Erkizan, PhD, a postdoctoral researcher
sible,” said Dr. Toretsky.                                           in Dr. Toretsky’s lab. LM
    This is unique because the small molecule developed by Drs.




Milton Brown Awarded Richard von Matsch Endowed Chair
in Experimental Therapeutics



M
           ilton l. brown, md, phd, was named the inaug-                at the chair presentation ceremony, Howard J. Federoff,
           ural edwin H. richard and elisabeth richard von           md, phd, executive vice president of Health sciences at
           matsch endowed chair in experimental thera-               gumc and John J. degioia, phd, president of georgetown
peutics on January 17th, 2008. dr. brown leads george-               university, praised dr. brown for his commitment to com-
town university’s drug discovery program, which aims to              passionate medical research.
narrow the gap between the discovery of tools                                        “scientific understanding of disease has
that improve our knowledge of diseases and the                                                                          ”
                                                                                 increased dramatically in recent years, said dr.
number of new therapies “translated” to the bed-                                 Federoff. “but what we now need are the tools
side.                                                                            and resources to turn these basic discoveries
    the endowed chair is part of a $4.5 million                                                                      ”
                                                                                 into drugs that will help save lives.
gift from mrs. elisabeth richard von matsch and                                      dr. brown delivered an academic lecture
the richard family to support clinical and trans-                                titled, “engaging the Future of drug discovery, ”
lational research in drug discovery and develop-                                 which explored his journey as a scientist. dr.
ment at georgetown university medical center                                     brown was recruited by georgetown in 2006
(gumc). dr. brown has devoted his career to                                      from the university of virginia, where he tested
developing drugs to treat diseases ranging from                                  thousands of potential drug compounds, lead-
cancer to seizure disorders to hypertension. as chair, he            ing to a patent for a class of novel oral general anesthetics
will continue to lead georgetown’s thriving drug discovery           and more than 20 patents currently pending for various
program in its mission to develop lifesaving diagnostics             therapeutics including new anticonvulsants and non-addic-
and therapeutics.                                                    tive pain relieving drugs.
    “i am really grateful for the generous support of the               in addition to this work, dr. brown has several patents
richard family, said dr. brown, who is an associate profes-
                ”                                                    on small molecule angiogenesis inhibitors that are licensed
sor of oncology and neuroscience. “their generosity will             and in development for treating acute macular degenera-
help us solidify the foundation of one of the only academic          tion. He has also mentored many students and fellows who
drug discovery programs in the country, leading to the               have continued the tradition of drug discovery at leading
creation of many new compounds aimed at helping people               institutions throughout the world. LM
live healthier lives.”




Lombardi CancerLine:       (202) 444-4000                                                        summer 2008 4        LombardiMagazine
                         save tHe date | tHe 23rd annual lombardi gala | november 1, 20 08
    6



                      The 22nd Annual
Inside Lombardi




                                                                                    T
                                                                                                     he gala co-chairs Tina Alster, MD and The Hon. Paul Frazer,
                                                                                                     welcomed over 1200 attendees to the Hilton Washington for the
                                                                                                     much anticipated 22nd Annual Lombardi Gala on November 3rd,
                                                                                                     2008. Dr. Alster is a world-renowned lecturer and author on cos-
                                                                                         metic dermatology and laser surgery. She is the director of the Washington
                                                                                         Institute of Dermatologic Laser Surgery which she founded in 1990, and
                                                                                         clinical professor of dermatology at Georgetown. Mr. Frazer, Tina’s hus-
                                                                                         band, served as a career diplomat with the Canadian Foreign Service with
                                                                                         assignments encompassing national and international public policy issues
                                                                                         in Ottawa, Washington, DC and abroad.
                      The Hon. Frank Keating, Tony snow, Vincent T. Lombardi, ii,
                      Dr. Louis Weiner, president John J. Degioia
                                                                                             The evening began at the Exhibit Hall where hundreds of outstanding
                                                                                         silent auction items were on display. The “Items of Distinction” category
                                                                                                                    included a framed original handwritten play
                                                                                                                    penciled on the back of a manila folder by Coach
                                                                                                                    Vince Lombardi that was beautifully framed
                                                                                                                    and donated by the Lombardi Family; an Italian
                                                                                                                    Hand Tailored suit valued at $5,000 from
                                                                                                                    Ermenegildo Zenga; the opportunity to host your
                                                                                                                    own outdoor movie on a 25’ inflatable movie
                                                                                                                    screen from Executive 411, along with stunning
                                                                                                                    jewelry, fabulous trips, and coveted fine wine.
                                                                                                                        Guests moved to the International Ballroom
                                                                                                                    for an exceptional dinner by Chef Andre Coté
                      gala honorees Tony snow and                    the live auction included a 2008 lexus         accompanied by wine and champagne from
                      Ken Venturi                                    rX400h suv Hybrid from exclusive               Diageo, the official wine and champagne spon-
                                                                     automotive sponsor, the Washington             sor. The Live Auction was a resounding success,
                                                                     area lexus dealers; american airlines          and was followed by a special announcement from
                                                                     was the official airlines for a trip to        John J. DeGioia, PhD, President of Georgetown
                                                                     shanghai with a week’s stay at the
                                                                                                                    University. President DeGioia introduced
                                                                     portman ritz-carlton; and a cruise to
                                                                                                                    the new director of the Lombardi Comprehensive
                                                                     the galapagos islands from national
                                                                     geographic expeditions.
                                                                                                                    Cancer Center, Louis M. Weiner, MD.
                                                                                                                        Highlights of the evening included the
                                                                                                                    Lombardi honorees—Ken Venturi, U.S. Open
                                                                                         Champion and CBS Golf Analyst, and Tony Snow, news commentator and
                                                                                         former White House Press Secretary. Their humorous and inspirational
                      robyn redfield with gala co-chairs                                 messages demonstrated once again why we were all together—that most
                      The Hon. paul Frazer and Dr. Tina Alster
                                                                                         of us have been touched by cancer in some way; to raise funds for the fight
                                                                                         against cancer; and to support the remarkable research, education and
                                                                                         treatment efforts taking place at Lombardi that will benefit all of us. John
                           Ken and
                                                                                         Safer received the Margaret Hodges Leadership Award.
                  Kathleen Venturi                                                           Special guests that evening included Vincent T. Lombardi, II who
                    with long-time                                                       presented the Lombardi awards; noted author Tom Clancy and his
                  gala supporters                                                        wife, Alexandra, who were guests of the Gala Co-Chairs, and H.E. The
                   molly and mark                                                        Ambassador of Canada and Mrs. Wilson, guests of former Co-Chairs, The
                            Decker
                                                                                         Hon. Carol and Mr. Ronald Crawford. We are also grateful to Mr. Tom
                                                                                         Donohue and the U.S. Chamber of Commerce. LM


                                   We would like to thank several major supporters of the 22nd Annual Gala:
                                   4comcast                         4ermenegildo Zegna              4lancôme usa                     4united states chamber
                                   4liz and tom donohue             4georgetown pet/ct              4John and Joy safer               of commerce




                  LombardiMagazine 4 s u m m e r        2008                                     To find out more:     http://lombardi.georgetown.edu
                                                                                                                                                7



Lombardi Publishes Handbook for




                                                                                                                                            Inside Lombardi
Pediatric Cancer Survivors


W
                 ith more than 270,000 childhood cancer survi-            Some examples of late effects from treatment include heart
                 vors living in the United States, researchers have    disease after treatment with anthracycline chemotherapy or
                 turned their attention to the effects of cancer       high-dose chest radiation, learning disabilities in survivors
                 treatment that can occur years after therapy,         treated with radiation and/or chemotherapy to the brain, second
called late effects. At the Lombardi Comprehensive Cancer              cancers from chemotherapy drugs or radiation used to treat the
Center and Georgetown University Hospital, a team of oncolo-           original cancer, symptoms of post-traumatic stress syndrome in
gists, nurses, social workers and an art therapist have created the    survivors and their parents, and chronic pain and fatigue.
first survivorship book, tailored for each child treated for cancer.      “Thirty years ago, few children with cancer survived, but
The Next Step… Crossing the Bridge to Survivorship is an edu-          now almost 80 percent of all children and adolescents diag-
cational guide designed to                                             nosed with cancer are surviving more than 5 years and the
provide specific information                                           majority of them are cured,” explained Dr. Shad. “There is
related to long-term follow-up                                         much to celebrate in the field of childhood cancer. We hope this
and survivorship.                                                      book will help ease the transition for patients and families from
    “The end of cancer treat-                                          active treatment to follow-up care.”
ment is a time of strong emo-
tions for patients and fami-
lies,” said Aziza T. Shad, MD,                                         “There is much to celebrate in the field of
chief of the division of pedi-                                          childhood cancer. We hope this book will help
atric hematology oncology at
Lombardi, and author of the                                             ease the transition for patients and families
book. “Celebration is often                                             from active treatment to follow-up care.”
mixed with anxiety and loss
of security. Most families feel                                                                                        —aziza shad, md
overwhelmed and have many
questions about the future.” Dr. Shad, an internationally known           The book is customized for each patient to include informa-
pediatric oncologist, is the Amey Distinguished Professor of           tion about their cancer diagnosis and specific treatment. It
Neuro-oncology and Childhood Cancer at Georgetown University           combines the personal health record with an educational guide
Medical Center.                                                        about long-term effects. Also, the book promotes a “shared
    Many of those questions center on the future health                care” model, incorporating primary care providers as an inte-
of the child. Chemotherapy, radiation ther-                                   gral part of a survivor’s care.
apy, and surgery may all have late effects                                          “Primary care physicians and nurses can play
involving any organs or body systems.                                              a pivotal role in the monitoring of potential late
Some complications can be identified                                                effects and survivorship issues,” said Dr. Shad.
early during treatment and follow-up.                                                    At Lombardi, patients who are two years out
The majority of late effects, how-                                                   from treatment are automatically enrolled in the
ever, become apparent many years                                                     Childhood Cancer Survivorship Program directed
after treatment is finished.                                                         by Dr. Shad. The program, established in 2003,
    “Late effects are caused by                                                         is also open to all childhood cancer survivors,
injury to healthy cells as a result                                                       regardless of where they received treatment. LM
of cancer treatment. Just like
every person reacts differently to
treatment, late effects also vary from
                                                                                         The Next Step…Crossing the Bridge to
person to person and cancer to cancer,”
                                                                                         Survivorship is now available online.
Dr. Shad’s book explains. “A lot depends
                                                                                        Funding for the book was provided by
on the types of therapy and the doses used.                                            tracy’s Kids, a program of the prevent cancer
Chemotherapy and radiation therapy cause                                               Foundation. to learn more about lombardi’s
most of the late effects.”                                                             childhood cancer survivorship program and
                                                                                       to download chapters of the book, go to:
       The book is filled with images of survivors from
                                                                                       http://lombardi.georgetown.edu/survivorship.
   Dr. shad’s program at Lombardi, each individual a
                 testament to the program she runs.



Lombardi CancerLine:            (202) 444-4000                                                    summer 2008 4         LombardiMagazine
    8



                      Lombardi Research Reaches into Space
Research Update




                      W
                                     ith implications for long-duration space travel, a         the risks to astronauts from prolonged space travel. His work is
                                     study from the Lombardi Comprehensive Cancer               funded by a grant from NASA’s Radiation Research Program,
                                     Center demonstrates that the high-energy radia-            and this study was conducted in part at the Brookhaven National
                                     tion found in space may lead to premature aging            Laboratory on Long Island, NY.
                      and an increased risk of colon cancer for astronauts. The find-               “The major goal of the project is to develop a risk estimate
                      ings, presented at the 2008 American Association for Cancer               model to help NASA predict if space travel will increase the risk
                      Research annual meeting suggest that exposure to the high                 of developing colon cancer in astronauts and to develop strate-
                      linear energy transfer (LET) radiation found in space may need            gies to protect against increased carcinogenic risk following
                      to be addressed.                                                          space radiation,” he said.
                         “Radiation exposure, either intentional or accidental, is inev-            Current risk estimates for radiation exposure rely exclusively
                      itable during our lifetimes,” said Kamal Datta, MD, assistant             on the cumulative dose of radiation a person receives in his or
                      professor of oncology at Lombardi and the study’s lead author.            her lifetime. However, the Lombardi study suggests that a more
                      “But with plans for a mission to Mars, we need to understand              accurate risk assessment should include not only dose, but also
                      more about the nature of radiation in space. There is currently           the quality of radiation.
                      no conclusive information for estimating the risk that astronauts             Dr. Fornace added, “In the course of our studies, we have
                      may experience.”                                                          found that heavy particle radiation, found in space radiation,
                                                                                                              triggered degenerative changes and oxidative stress
                                                                                                              which are reminiscent of premature aging.”
                                                         “The major goal of the                                   To conduct the study, Dr. Fornace and his team
                                                                                                              measured the level of free radicals as well as the
                                                           project is to develop a risk                       expression of stress response genes in the cells of
                                                           estimate model to help                             mice exposed to high-LET radiation similar to that
                                                                                                              found in space. The researchers concluded that the
                                                           NASA predict if space                              cellular environment of the gastrointestinal tract
                                                           travel will increase the risk                      was highly oxidative—or full of free radicals—for
                                                                                                              prolonged periods of time, a state which is condu-
                                                           of developing colon cancer                         cive to cancer development.
                                                           in astronauts…”                                        In addition to the cellular damage from oxida-
                                                                                                              tive stress, the researchers also found that the
                                                                            —Albert J. Fornace, Jr, mD        mice exposed to the high-LET radiation showed
                                                                                                              some changes suggestive of accelerated aging. For
                                                                                                              example, Dr. Datta said the mice’s coats became
                                                                                                              prematurely grey, an observation the team plans
                         The kickoff of Project Constellation—the National Aeronautics to follow-up with MRI brain scans. For the study, the doses of
                      and Space Administration (NASA) program to return humans to radiation were much higher than the levels astronauts would
                      the moon and ultimately travel to Mars—has led to increased typically be exposed to, but the results help highlight the novel
                      scrutiny of radiation exposures during space travel. A 2004 aspects of space radiation.
                      report from the National Academies suggested that cancer inci-                High-LET radiation is found in space and is made up of high-
                      dence may be higher in the astronaut population as compared to energy protons, charged iron particles, and some gamma radia-
                      the general U.S. population. In March of this year, the National tion. The earth’s atmosphere blocks the majority of this radiation,
                      Research Council published a report recommending increased preventing exposure to these particles in normal life. High-LET
                      research into radiation exposures for astronauts during space radiation is known to cause a great deal of damage in a localized
                      travel and development of new radiation shielding technologies. area, whereas the impact of low-LET radiation—used in medical
                         That is where Lombardi’s research comes in. Albert J. imaging and more common here on earth—tends to be more dif-
                      Fornace, Jr, MD, is part of the national effort to better understand fuse within a tissue, causing much less severe damage. LM




                  LombardiMagazine 4 s ui m T eerr 22000078
                                     W n m                                                     To find out more:     http://lombardi.georgetown.edu
                                                                                                                                                 9



New Blood Test Identifies




                                                                                                                                             Research Update
Disease Progression Earlier


W
                ith the goal of tailoring cancer treatment for each   as the threshold. Dr.
                individual, Minetta Liu, MD, has found that a         Liu and her colleagues
                simple blood test might help doctors more reli-       observed a big difference
                ably assess treatment efficacy for patients with      between patients with CTC lev-
metastatic breast cancer. Dr. Liu, a breast oncologist and trans-     els of 5 and above compared to those below 5. Seventy-one per-
lational researcher at Lombardi, presented the find-                              cent of patients who had a CTC count greater than
ings at the annual meeting of the American Society                                or equal to five had disease progression, compared
of Clinical Oncology.                                                             to only 32 percent of patients with a CTC count of
    “It can take several weeks and sometimes months                               less than five.
to determine if a particular cancer treatment is                                     “A CTC count of five or greater at the time of
working because it can take that long to observe                                  restaging was associated with a 5.2 fold increase
any significant radiographic changes in tumor size                                in a patient’s chance of having disease progression
or appearance,” said Dr. Liu. “With this new blood                                compared to CTC counts of less than five,” explained
test, we have a tool that may allow us to determine                               Dr. Liu.
much sooner if a therapy is ineffective so that we can                               Additional data suggest that the CTC assay is a
                                                           Dr. Liu
change therapy earlier and potentially make more                                  more reliable means of assessing treatment response
significant improvements in survival.”                                than other traditional serum-based tumor markers currently in
    Using the FDA-approved CellSearch™ technology, Dr. Liu            use. Dr. Liu serves at the national principal investigator of clini-
and colleagues at Georgetown University Hospital and Franklin         cal study that will evaluate the CTC results within the framework
Square Hospital measured the number of circulating tumor cells        of a randomized clinical trial—eliminating possible variability
(CTC) in blood collected from women with metastatic breast can-       caused by treatments administered.
cer. The number of CTCs was correlated with disease response             “We have many treatment options for advanced breast cancer.
or progression as determined by standard radiology studies.           The key is to find the most effective therapy for each patient. It
    Based on previous research, a CTC count of five was used          shouldn’t take months to figure that out,” Dr. Liu concluded. LM




Sandra Swain Elected to ASCO Board


S
       andra m. swain, md, a member of lombardi’s                     insights in how to further mobilize the international effort
       breast cancer program and medical director of                  to bring more effective oncology treatment to under-
       the Washington cancer institute, was elected to                                                                ”
                                                                      resourced communities throughout the world, she wrote.
the board of the american society of clinical oncology                “i will advocate initiatives for the advancement of clinical
(asco). dr. swain will serve a three-year term                                   research, which include education of physicians
on the board, beginning June 3rd.                                                and patients both of whom are integral to the
   “asco is the pre-eminent professional oncol-                                  success of this goal. ”
ogy organization and is therefore uniquely posi-                                    asco is the world’s leading professional
tioned to impact the future direction of oncol-                                  organization representing physicians who treat
ogy, said dr. swain. “as a 22-year member of
    ”                                                                            people with cancer. asco’s members set the
asco, i have volunteered on many committees                                      standard for patient care worldwide and lead
and seen the tremendous growth that the orga-                                    the way in carrying out clinical research aimed
nization has experienced. ”                                                      at improving the prevention, diagnosis, and
   in her nomination statement, dr. swain noted                                  treatment of cancer. asco’s efforts are also
two upcoming challenges facing the organization: the                  directed toward advocating for policies that provide access
looming physician shortage and the low patient accrual                to high-quality care for all patients with cancer and at sup-
rates for federally-supported clinical trials.                        porting the increased funding for clinical and translational
   “success around these two initiatives will provide                 research. LM




Lombardi CancerLine:       (202) 444-4000                                                         summer 2008 4         LombardiMagazine
 10



                     Appointment with “El Doctor”
Research Update




                      I
                             n 1986, Elmer Huerta, MD, MPH, asked himself why                Knowing nothing about the mechanics of a show, Dr. Huerta
                             people who knew so much about soap opera plots and          relied on his bedside manner and his medical knowledge to
                             soccer statistics knew so little about mammograms or create the segments. He was a huge success, but he knew he
                             preventive health.                                          needed to do more.
                         “I was working in the triage unit of the National Cancer
                      Institute of Peru, and patients were coming to me with tumors Leading Cancer Advocacy
                      the size of baseballs, or even bigger,” he recalled. “When I Fast forward to 2008. Dr. Huerta runs the only Cancer
                      asked them why they didn’t come to see a doctor sooner, they Preventorium in the United States—a clinic for healthy people
                      said ‘Because it didn’t hurt.’”                                    who want to speak with a doctor about prevention. A member
                         And yet his patients could recite the latest entertainment of Lombardi Comprehensive Cancer Center (though based at
                      news and were predicting who would win the Copa Perú. To Washington Hospital Center’s Cancer Institute), he conducts
                      Dr. Huerta, the answer was                                                                              extensive research with
                      clear: media bombardment          “We are working with local communities to                             local Hispanic communi-
                      with entertainment and                                                                                  ties in the Washington, DC
                      sports news made it impos-      inject cancer research onto their radar screen.” area.
                      sible to ignore.                                                                                            Dr. Huerta, in associa-
                         He decided to contact the media himself and met with pro- tion with Jeanne Mandelblatt, MD, MPH, associate director
                      ducers and managers at local radio and TV stations in Lima. To for population sciences at Lombardi, has two grants from the
                      his surprise, they did not have a good understanding of health National Cancer Institute to bring cancer research into Hispanic
                      and prevention either.                                             community clinics.
                         “So I told them, let me produce shows for you to get my mes-        “We are working with local communities to inject cancer
                      sage across about health,” he recounted. “And I convinced the research onto their radar screen,” said Dr. Huerta. “Physicians
                      media to give me radio and TV segments.”                           see patients, but they don’t think about the benefits that come
                                                                                         from research. We learn so much and can provide the best care
                                                                                         with clinical trials, smoking cessation programs, and findings
                                                                                         about how to best communicate about cancer risks and treat-
                                                                                         ment options with these patients.”
                                                               Dr. Huerta educates the       Dr. Huerta is also busier than ever with his media outreach.
                                                               Latino population about   He has three daily radio shows and three weekly television
                                                               health and prevention     shows, including one on CNN en Español that is syndicated
                                                               through three daily radio throughout Latin America.
                                                               broadcasts.
                                                                                             On top of all this, Dr. Huerta currently serves as president
                                                                                         of the American Cancer Society (ACS), the largest cancer advo-
                                                                                         cacy organization in the United States, and one of the largest
                                                                                         medical associations in the world. While his term will only last
                                                                                         one year, he has big goals for the Society.
                                                                                             “There are two reasons why I wanted to be president of the
                                                                                         ACS,” he explained. “The first is that the ACS is a wonderful
                                                                                         organization for the patient with cancer, but I believe they need
                                                                                         to do more proactive outreach to all Americans.”
                                                                                             A recent study showed 72 percent of Americans are confused
                                                                                         about what they can do to decrease their risk of cancer. Dr.
                                                                                         Huerta wants to see ACS reaching out to all American house-
                                                                                         holds, the way he reaches millions of Hispanic households right
                                                                                         now, by working with the media to get the messages out.
                                                                                             His second reason is even bigger.
                                                                                             “I believe we have a duty to export what we know here in
                                                                                         the United States to underdeveloped nations,” he said. “Eighty
                                                                                         percent of cervical, breast and colorectal cancers are found at
                                                                                         incurable stages elsewhere in the world. That is something we
                                                                                         can help with.”



                  LombardiMagazine 4 s u m m e r     2008                                  To find out more:    http://lombardi.georgetown.edu
                                                                                                                                            11




                                                                                                                                           Research Update
Building the Cancer Preventorium
Dr. Huerta’s first radio segment in the United States aired on       dr. Huerta’s daily broadcasts
December 4 , 1989. In fact, Dr. Huerta’s first order of busi-
              th

ness upon arrival in Baltimore (where he was enrolled in an
internal medicine residency program in order to receive cer-
tification to practice in the US), had been to find a Spanish-
language radio station willing to partner with him on his
health outreach efforts.
    “The first thing any immigrant does when they arrive
some place new is to look for media broadcasting in your own
language,” he explained. “I was no different.”
    He produced a series on tobacco and the risks of smok-
ing. The five minute segments were broadcast three times a
day throughout December. By the end of the month, the show           11:30–11:45      Salud y humor con el doctor
was so popular that the station asked Dr. Huerta to produce                           (Health and Humor with the Doctor)
a daily segment. But as a resident, he had little time to spare                       broadcast live on dc’s radio america affiliate
outside of the hospital.                                             11:45–12:00      Cuidando su salud (Taking Care of Your Health)
    “I needed a plan so the show wouldn’t be a burden on me.                          broadcast in peru
I decided to choose an article from JAMA, NEJM, Lancet               1:00–3:00        Cita con el doctor
or one of the other top medical journals and put the story                            (Appointment with Your Doctor)
in common words,” he explained. This kept him up-to-date                              broadcast live in 14 states on 31 radio stations
on the medical literature, and provided an array of topical          to learn more about dr. Huerta and listen to his radio shows
issues for discussion on the show. That one-minute segment,          visit his website www.prevencion.org.
Cuidando su salud (Taking Care of Your Health), has aired
every day for the past 19 years on the Washington, DC Radio
America affiliate.
    Then in 1994, Dr. Huerta got the chance to make his second not have learned about the benefits of preventive health and may
dream come true. He was approached by Lawrence Lessing, MD, not have access to insurance or quality healthcare.
then director of the Washington Cancer Institute at Washington           Yet Dr. Huerta knew there was a market for this service.
Hospital Center, about opening a cancer prevention clinic.           Because of his radio and television shows, he had been invited
    “When I was still in Peru and seeing patients come to the to give talks at large churches and community centers on week-
emergency room with disease so advanced, I wondered if it ends. People told him that their primary care doctors were not
would be possible to have a medi-                                                                     giving them the prevention infor-
cal office one day with a sign on                                                                     mation and services they sought:
                                           “When I was still in Peru and seeing
the door that said this is a place                                                                    nutrition guidelines, pap smears,
for healthy people to come.”                  patients come to the emergency                          mammograms, and PSA tests.
    On July 27th, 1994, the Cancer                                                                       Now fourteen years later,
                                             room with disease so advanced, I
Preventorium opened at Washing-                                                                       Dr. Huerta has never run out of
ton Cancer Institute (Lombardi’s            wondered if it would be possible to                       patients. By May of this year, he
sister hospital). By August 17 —  th
                                                                                                      was booked through October. He
                                            have a medical office one day with
just three weeks later—the clinic                                                                     has seen over 22,000 patients,
was booked through December.               a sign on the door that said this is a                     80 percent of whom are female.
The clinic is designed for the                                                                        He has discovered 75 cancers,
                                             place for healthy people to come.”
large low-income Latino popula-                                                                       around half of which were breast
tion in the Washington, DC area.                                                                      cancers. Most often he finds early
It is run as a fee for service clinic, with patients paying $120 out symptoms of heart disease or diabetes.
of pocket to see Dr. Huerta when they are healthy.                       But he is not done yet. Dr. Huerta wants to expand the clinic,
    He describes this as a revolutionary concept. While doctors      bringing on additional physicians or nurse practitioners to see
recommend a yearly physical or check-up with a primary care patients. He is also constantly working to bring the message of
physician, most people tend to only visit a doctor when they are preventive health to more people and hopes this will inspire bet-
sick. This is especially true in immigrant communities, who may ter health awareness throughout the US. LM



Lombardi CancerLine:       (202) 444-4000                                                        summer 2008 4        LombardiMagazine
 12



                      Genetic Counselors Turn to Unconventional
Research Update




                      Counseling to Meet Demand


                      I
                            magine receiving genetic test results for a disease you            Genetic counseling and testing, particularly for adult onset con-
                            could develop later in life without having anyone with         ditions, is a trend that will continue to grow as additional genes
                            whom to discuss your options for managing the risk. That’s     are identified and as such testing diffuses into mainstream clini-
                            becoming a common occurrence as people turn to the             cal care. Telephone counseling has been used with increased fre-
                      Internet and other outlets for genetic testing without genetic       quency despite a lack of data about its efficacy and concern about
                      counseling. In an effort to broaden accessibility to genetic coun-   its use as a substitute for face-to-face contact with patients.
                      seling, Lombardi researchers are exploring non-conventional              “In anticipation of this increased demand, it is imperative we
                      counseling methods that challenge traditional approaches.            find alternatives to traditional genetic susceptibility counseling
                         “The delivery of genetic test results for a disease like cancer   and that we develop and evaluate these possible options now,”
                      can trigger a range of emotions and can be more distressful than     Beth explained. “A successful alternative would be one that
                      anticipated—particularly when there’s been no counseling and         effectively delivers information but allows greater accessibility,
                      the results are ‘positive,’” explained Beth N. Peshkin, MS, CGC,     such as telephone counseling.”
                      senior genetic counselor at Lombardi and educational direc-              To address these issues, Beth and her colleagues have
                      tor of the Jess and Mildred Fisher Center for Familial Cancer        launched a randomized clinical trial—the largest to date—to
                      Research. “While in-person genetic counseling is ideal, it’s not     evaluate telephone genetic counseling versus in person genetic
                      convenient for people who live in rural areas or don’t have access   counseling among women at high risk of carrying a BRCA1/2
                      to an academic center.”                                              mutation that increases the risk of breast and ovarian cancers. LM

                      to learn more about the study, or to learn about genetic counseling & testing services at lombardi call (202) 687-1750.




                                                  Shawna Willey Elected President
                                                  of Breast Surgeons’ Society

                                                         S
                                                                  hawna C. Willey, MD, FACS, a member of the Breast Cancer Program at Lombardi, has
                                                                  been elected president of the American Society of Breast Surgeons (ASBS). She assumed
                                                                  her one-year term on May 4th at the annual meeting in New York City.
                                                                     The ASBS promotes the research and development of advanced surgical techniques,
                                                         to improve standards of practice for breast surgery and serves as a forum for the exchange of
                                                         ideas. The Society was founded in 1995 and has more than 2400 members in the United States
                                                         and from 35 countries worldwide.
                                                             Dr. Willey joined Lombardi in 2002 to direct the Betty Lou Ourisman Breast Health Center,
                                                         designed to provide professional breast health care by coordinating services across specialties to
                                                         maximize efficiency and produce optimal screening, diagnosis, and surgical outcomes.
                                                     Dr. Willey is active in clinical research and collaborates with many Lombardi investigators on breast
                                                  cancer research. She recently presented a preliminary analysis of ongoing research at the ASBS annual
                                                  meeting that suggests women at high-risk for breast cancer who do not have a BRCA mutation may face
                                                  a greater chance for developing a second breast cancer than previously believed.
                                                     Dr. Willey is also interested in international health and education, and has conducted programs
                                                  throughout the world, including lectures in Poland and the Philippines, as well as consultations in Saudi
                                                  Arabia.
                                                     A native of Iowa, Willey received her MD from the University of Iowa and completed her internship
                                                  and residency in surgery at the George Washington University Medical Center. LM



                  LombardiMagazine 4 Wui m T eerr 22000078
                                     s n m                                                   To find out more:     http://lombardi.georgetown.edu
                                                                                                                                             13



Synthetic Cocoa Chemical Slows




                                                                                                                                            Research Update
Growth of Tumors

A
            synthetic chemical based on a compound found
            in cocoa beans slowed growth and accelerated
            destruction of human tumors in laboratory stud-
            ies. Lombardi researchers believe it should be
tested further for cancer chemoprevention or even treatment.
    “We have all heard that eating chocolate is good for you;
this study suggests one reason why that might be true,” said the          The researchers have long studied
study’s lead author Min Kim, PhD, a research scientist in the          the beneficial effects of flavanols, which
Department of Oncology at Lombardi.                                    are molecules in vegetables and fruits
    Published in the peer-reviewed journal Cell Cycle, the             that exhibit potent anti-oxidant and,
researchers describe how four different human tumor cell lines         potentially, anti-tumor properties. As part of
out of 16 tested were sensitive to the chemical, known as              these studies, investigators have been testing a new synthetic
GECGC. The strongest response was seen in two different colon          version of natural procyanidins, a class of flavanols, created and
cancers where growth was cut in half and most of the tumor cells       patented by the confectionery company, Mars Incorporated. The
were damaged.                                                          company provided GECGC as a gift, and this project was funded
    Normal cells were not affected by GECGC, which makes the           in part by Mars.
chemical a candidate for cancer chemoprevention, said Dr. Kim.            They found sensitivity to GECGC in both colon cancer cell
    “This chemical seems to be safe, which makes sense because         lines they tested, in cervical cancer cells and in one line of
it has a structure similar to a natural product in cocoa beans—        leukemia cells. Other cell lines were resistant, including ovarian
the same beans that are used to make chocolate,” he said.              and prostate cancer cells. LM




       elected New Grant Funding

4Maria Laura Avantaggiati, MD, received a $392,000 r21                 4post-doctoral fellow, Edgar Diaz-Cruz, PhD, received a
 from the national cancer institute (nci) to study func-                $225,000 grant from susan g. Komen for the cure to
 tional mimicry of the p53 tail by the ubiquitin-like mol-              study the interaction between estrogen signaling path-
 ecule, sumo-1.                                                         ways and p53 in breast cancer.
4Stephen Byers, PhD, received a $1.6 million r01 from                  4Amanda Graham, PhD, received a $373,000 r21 grant
 the nci to study beta-catenin-specific regulation of the               from the nci to and evaluate an internet-based smoking
 vitamin d pathway in colon cancer.                                     cessation program among latino smokers.
4doctoral students Joseph LaConti, Priya Prahalad, and                 4Kristi Graves, PhD, received a K07 award for $684,000
 Geoffry Storchan each received $97,000 fellowship                      from the nci to study behavioral science in personalized
 grants from the department of defense.                                 genetic medicine.
4the Capital Breast Care Center received an $800,000                   4Bassem Haddad, MD, received a $400,000 grant from
 grant from the avon Foundation to support ongoing                      the avon Foundation to improve the diagnostic power of
 operations as well as a $250,000 grant for expansion                   ductal lavage for early detection of breast cancer.
 from the dc government.                                               4Usha Kasid, PhD, received a $460,000 department of
4Esther Chang, PhD, and Matthew Freedman, MD, MBA,                      defense idea award to study nF-κb in prostate cancer.
 received a 3-year $1.7 million r01 grant from the nci to              4Christopher Loffredo, PhD, received a $375,000 grant
 develop and characterize a tumor-targeting, nano-immu-                 from the department of energy to develop a biological
 noliposome complex for early detection of lung cancer.                 specimen repository.
4Robert Clarke, PhD, DSc, received a $460,000                          4Habtom Ressom, PhD, received an $80,000 grant from
 department of defense idea award to study unfolded                     the prevent cancer Foundation to identify serum bio-
 protein response and endocrine responsiveness.                         markers for early detection of liver cancer.

Financial awards are listed as total funds given (direct and in-direct) for the term of the award.




Lombardi CancerLine:        (202) 444-4000                                                           summer 2008 4     LombardiMagazine
 14


                      Georgetown Undergraduate                                                     Lombardi Student
Research Update




                      Wins Poster Competition at                                                   Selected for Prestigious
                      International Meeting                                                        Bouchet Society



                      Z                                                                            A
                                 achary Dobbin, a Georgetown University under-                                    natasha Crawford, a doctoral candidate in
                                 graduate student conducting cancer research at                                   Lombardi’s Interdisciplinary Program in Tumor
                                 the Lombardi Comprehensive Cancer Center, took                                   Biology, has been named a member of the
                                 1st place in the 2008 AACR Undergraduate                                         Edward A. Bouchet Graduate Honor Society
                      Poster Competition at the American Association for Cancer                     (Bouchet Society). The Society, named for the first African
                      Research annual meeting in San Diego.                                         American doctoral recipient in the United States, aims to
                          Zach conducts research in the laboratory of Robert                        recognize outstanding scholarly achievement and promote
                      Clarke, PhD, DSc. As reported in the Summer 2007 issue                        diversity and excellence in doctoral education and the pro-
                      of Lombardi Magazine, Zach was one of only 10 undergradu-                     fessoriate.
                      ate students to be awarded the AACR-Thomas J. Bardos                              Tasha was selected a charter member of the Georgetown
                      Science Education Awards in                                                                                  University chapter of the
                      2007. The 2007 and 2008                                                                                      Bouchet Society, established
                      Bardos Science Award winners                                                                                 in 2007. She also conducts
                      competed in the undergraduate                                                                                research in the laboratory of
                      poster competition Saturday.                                                                                 Dr. Clarke, who is co-leader of
                          Zach has been studying the                                                                               Lombardi’s Breast Cancer Pro-
                      effect of chemotherapy agents                                                                                gram. Tasha’s dissertation fo-
                      on one protein found in breast                                                                               cuses on how and why cancer
                      cancer cells. His winning                                                                                    becomes resistant over time to
                      AACR poster titled, “Caveolin-                                                                               therapy, specifically looking at
                      1 regulation of Bcl-2 in pacli-                                                                              resistance to antiestrogen treat-
                      taxel-mediated apoptosis in                                                                                  ments for breast cancer.
                      breast cancer,” explores the re-                                                                                “I became very interested in
                      lationship between CAV1 and                                                                                  breast cancer research because
                      Bcl-2, proteins that appear to                                                                               my grandmother had breast can-
                      have a role in preventing the                                                                                cer. That was the main reason
                      formation of cancer. He found                                                                                I came to Lombardi. I wanted
                      that the two proteins form a                                                                                 to learn in a place that has a
                      complex in breast cancer cells                                                                               focus on cancer research,” she
                      when treated with the chemo-          Dr. Clarke mentored both Tasha and Zach in his laboratory at           said.
                      therapy paclitaxel. This data         Lombardi, which is dedicated to understanding the molecular               To achieve its goals, the
                      suggests that together, the two       biology of breast cancer.                                              Bouchet Society is developing a
                      proteins mediate the response                                                                                network of preeminent scholars
                      to treatment, halting the growth                                                                             who exemplify academic and
                      of a cancer.                                                                  personal excellence, foster environments of support, and
                          Specifically, Bcl-2 mediates apoptosis, a process of pro-                 serve as examples for students who have been traditionally
                      grammed cell death. This is a normal process in the body                      underrepresented in the academy.
                      which helps prevent the formation of cancer by eliminating                        “Tasha exemplifies professional excellence and embod-
                      abnormal cells. In order for a cancer to develop, cells must                  ies the high qualities consistent with membership in the
                      overcome the safeguards directing this process. Many can-                     Bouchet Society,” said Dr. Clarke.
                      cer therapies work by re-sensitizing cells to the apoptotic                       She plans to continue to work in her community and as
                      signals.                                                                      an advocate for increasing the presence of minorities in PhD
                          “Our results give us more information about chemothera-                   programs in the field of biomedical research. Tasha gradu-
                      peutic drug targets that can increase the efficacy-to-toxicity                ated magna cum laude from Spelman College in Atlanta,
                      ratio in breast cancer patients,” Zach said.                                  with a BS in biology. In 2007, she was selected as a Minority
                          Zach received his bachelor of science in biology in May                   in Cancer Research Scholar by the American Association for
                      from Georgetown University. He has been accepted to an                        Cancer Research. LM
                      MD/PhD program, and he plans to pursue a career in clini-
                      cal cancer research. LM



                  LombardiMagazine 4 Wui m T eerr 22000078
                                     s n m                                                      To find out more:     http://lombardi.georgetown.edu
                                                                                                                                               15



Expressive Writing may Enhance




                                                                                                                                              Research Update
Well-Being for Cancer Patients


I
      n one of the first studies published in an oncology journal        When people used a greater number of positive emotion
      about the benefits of writing therapy, Lombardi research- words in their writing, they also reported more change in how the
      ers found that patients reported changes in thoughts about writing affected their thoughts and feelings about the illness. In
      their illness and, in some cases, better physical quality of the end, these reports of change in thoughts were significantly
life after writing about their experience.                           related to reports of better physical quality of life at follow-up.
    “Previous research suggests expressive writing may enhance           “Waiting for your appointment in the clinic can be a time of
physical and psychological well-being,” said Nancy P. Morgan, anxiety and stress for cancer patients,” said Bruce D. Cheson,
MA-TLA, director of Lombardi’s Arts                                                                MD, head of hematology at Lombardi
and Humanities Program. “Here, we                                                                  and a co-author on the study. “I’m
                                                “Don’t get me wrong, cancer
found that just one writing session in a                                                           pleased to see that so many of our
busy cancer clinic where the patients are       isn’t a gift, it just showed me                    patients were interested in this kind of
frequently interrupted can have a posi-                                                            therapy. Our study supports the benefit
                                                what the gifts in my life are.”
tive impact on patients.”                                                                          of an expressive writing program and the
    The study, which appeared in the                          —Lombardi patient in writing study   ability to integrate such a program into
February issue of The Oncologist, a peer                                                           a busy clinic.”
reviewed journal, asked participants to complete a 20-minute             The study was conducted in the clinic waiting area of the
expressive writing exercise, responding to prompts such as: Lombardi Comprehensive Cancer Center between July and
How has cancer changed you and how do you feel about those November 2006. Seventy-one adult leukemia or lymphoma
changes?                                                             patients attending an appointment with a medical oncologist
    “We were interested in assessing psychological and social participated.
outcomes following the writing, including quality of life, whether       “We’re grateful to the patients who assisted our research team
the writing changed the way partici-                                                in carrying out an innovative study,” Morgan said.
pants thought and felt about their                                                   “They enabled us to better understand the benefits
cancer experience, and what sort                                                     of expressive writing.”
of impact cancer had on their
lives,” Morgan said. “Writing
about only the facts has
shown no benefit.”
    A post-writing sur-
vey indicated that 49
percent of partici-
pants who completed the writing exercise felt that writing changed
their thoughts about their illness, while 35 percent reported that
the writing changed they way they felt about their illness.                                    Prelimin-
These numbers were even higher—53 percent and 38 percent,                              ary results from this
respectively—when participants were asked again three weeks                       study coincided with one
later during a follow-up telephone survey.                                of the largest gifts in the his-
    As a writing clinician, Nancy was also interested in discover- tory of arts in healthcare and the
ing the deeper transformations brought on by the writing process. Lombardi Arts and Humanities
So the team conducted a content analysis of the compositions, Program. Trustees of the Robert M.
examining each text for themes, words, and phrases suggesting a Fisher Foundation created a $1.5
transformation due to their experience with cancer.                  million endowment fund in memory of
    Of the 63 texts, Nancy and her colleagues Kristi Graves, PhD, Cecelia F. “Cookie” Rudman, a longtime
and Elizabeth Ann Poggi found that 60 showed a transformation cancer center volunteer. The Fund expands
brought about by the cancer experience. Many of the changes the program to ensure all Lombardi
expressed in the writing were positive and related to feelings patients and caregivers have access to arts
about family, spirituality, work, and the future. As one patient programs. Thanks to the gift, each new
wrote, “Don’t get me wrong, cancer isn’t a gift, it just showed me patient now receives a writing journal dur-
what the gifts in my life are.”                                      ing patient orientation. LM




Lombardi CancerLine:        (202) 444-4000                                                         summer 2008 4         LombardiMagazine
 16



                                                                      Poetry Collection Chronicles
Community Update




                                                                      Cancer Journey


                                                                      F
                                                                                ive years ago, Lisa Flaxman was diagnosed with breast cancer. At that time, her chil-
                                                                                dren were six, four, and one. She was the CEO of musiKids, a company she had founded
                                                                                and been building for six years. Following the diagnosis, Lisa went through two years of
                                                                                surgeries, chemotherapy, and radiation.
                                                                         Early this year, Lisa published her first collection of poetry, Glances at Time. The collection
                                                                      chronicles her journey as a young mother with breast cancer. Through her poetry, Lisa connects
                                                                      with others who are battling cancer.
                                                                         “This book is for the patient, the friend, the family, the health care provider, the doctor, the
                                                                      psychologist—anyone who is or has been close to illness,” she said.
                                                                         Lisa’s experience as a breast cancer patient at Lombardi reawakened her once again to the
                                                                      arts and their importance in life. Lisa recounts the story of how she first met Nancy P. Morgan,
                                                                      MA-TLA, who runs Lombardi’s Arts & Humanities Program.
                                                                         “I had been writing a lot of poetry, but I had never shown it to anyone before. When I men-
                                                                      tioned this to Nancy, she asked to see it, and once she read it, she said, ‘Show me more,’” said
                                                                      Lisa. “Nancy dared me to take a risk and get creative.”



                      True Friend                                                                                                   “ This book is for the
                      She tells me I’m beautiful when I look at her                                                                   patient, the friend, the
                      with red eyes and a fuzz covered hat                                                                            family, the health care
                      She tells me I look great for someone going through
                                                                                                                                      provider, the doctor,
                      what I’m going through
                                                                                                                                      the psychologist—
                      She tells me that I’m amazing for continuing to work
                                                                                                                                      anyone who is or has
                      through near complete exhaustion
                      She picks up my daughter from school and casually
                                                                                                                                      been close to illness.”
                      drops off food to taste
                      She calls me up each day to see how I am feeling
                      and knows how to cheer me up                                                        For the past three years the Arts & Humanities Program has
                                                                                                       published a collection of poetry by the Lombardi community,
                      She treats me like the normal person I used to be
                                                                                                       called “Lombardi Voices.” Lisa was part of the inspiration for
                      unusual                                                                                publication, and serves as editor and publisher for each
                      my friend                                                                              new volume that comes out.
                                                                                                                 “Everyone in the audience of Lisa’s readings who has
                                                                                                             faced the challenge of cancer has been grateful for her
                                                                                                             gift of putting into words what they’ve experienced,” said
                            Author Lisa Flaxman and
                                                                                                             Nancy. “With Lisa’s poignant poetry, both writer and the
                            composer elaine Agnew                                                            reader are gently healed.”
                            prepare for a concert at                                                             Glances at Time is self-published and available for sale
                                  Lombardi last fall.                                                        at Politics & Prose in Washington, DC, as well as from the
                                                                                                             Arts & Humanities Program at Lombardi. A portion of the
                                                                                                             proceeds will be donated to the Program. LM




                                                        r i ta a b r a H a m y u r o W




                   LombardiMagazine 4 s u m m e r              2008                                      To find out more:    http://lombardi.georgetown.edu
                                                                                         spirit of Life Honoree                                     17
                                                                                           Linda rabbitt (right),
                                                                                        with friend Janet Davis

Women & Wine Dinner




                                                                                                                                                   Community Update
Raises Awareness and Funds


T
          he sold out Third Annual Women & Wine Dinner              the festivities. The evening included a grand door prize, courtesy
          presented by the National Cancer Prevention Fund          of American Airlines and a silent auction with over 40 items.
          (NCPF) was held on April 28th. Hosted by the Tysons       Everyone praised event sponsors Helen Haerle, KPMG, and
          Palm in McLean, VA, the event was a resounding suc-       McGuireWoods, as well as the hard working co-chairs (pictured
cess, raising over $85,000, for the Nina Hyde Center for Breast     below) for a very successful evening! LM
Cancer Research at Lombardi.
   Over 220 area businesswomen attended, and learned first
hand the facts about breast cancer from Claudine Isaacs, MD,
co-leader of Lombardi’s Breast Cancer Program. Dr. Isaacs also
took questions from the audience, and described the ongoing
research at the Nina Hyde Center.
   During the evening, the first-ever Lombardi Spirit of Life
Award was presented to Linda D. Rabbitt, the chairman and
CEO of rand* Construction Corporation. The Award honors a
person who exemplifies character and leadership in promoting
breast cancer research and awareness, while instilling hope
and a spirit of life in all who meet them. Ms. Rabbitt, who is a
breast cancer survivor herself, has supported the activities of a
number of breast cancer organizations—including renovating          Women & Wine Dinner Co-Chairs
the National Breast Cancer Coalition’s new offices pro bono. The    Front row (L-r): Dianne Carlson; randi schweitzer; Karin m. gifuni, Wachovia
Lombardi Spirit of Life Award was designed and donated by           Wealth management; Claudine isaacs, mD; Kirsten Lawrence Brazley, BB&T
                                                                    Wealth management. Back row: stephanie nashman, Computer sciences
Tiffany & Company.                                                  Corp.; Janet s. Davis, Brandywine realty Trust; Barbara schaefer, mcDuffie,
   Honorary co-chair of the Dinner, Greta Kreuz who is an           Beers + Cutler; Diane ray Brown, Tiffany & Co; molly Decker, Long & Foster;
anchor at the local ABC-affiliate ABC7/WJLA, participated in        Alexandra n. senyi de nagy-unyom, Yelverton Law Firm p.L.L.C.




New gifts

the Cherry Blossom Breast Cancer Fund awarded minetta               Jeffrey toretsky, md received several
liu, md, $11,000 to support her research into circulating           gifts in support of his ewing’s sarcoma
tumor cells.                                                        research. these include $173,000 from
                                                                    the Go4theGoal Foundation, a $10,000
Swing fore the Cure gave $30,000 to the nina Hyde
                                                                    grant from Dani’s Foundation, and a $50,000
center for breast cancer research to support breast
                                                                    grant from the Liddy Shriver Sarcoma Initiative and the
cancer research at lombardi. swing Fore the cure has
                                                                    Amschwand Sarcoma Foundation.
donated more than $170,000 to the nina Hyde center.
                                                                    the “Go Bo” Fund donated $50,000 to the Family
lombardi’s cancer survivorship program was awarded
                                                                    emergency relief Fund which supports patients in critical
$40,000 by Hyundai Motor America’s Hope on Wheels
                                                                    times of need.
Program for 2008. Hyundai has given $185,000 to the
program in the past four years. the program, which is               the Prevent Cancer Foundation awarded a $50,000 grant
dedicated to providing comprehensive, on-going follow-              to aziza shad, md, to develop and publish a pediatric
up care for children who had been treated for cancer, also          cancer survivor’s guide.
recently received a $5,000 grant from Clark Construction.
                                                                    the Polo Ralph Lauren Foundation supported the
the lombardi institute for Quality of life received                 ourisman center’s patient navigator program, part of
$136,000 from Prince Charitable Trusts to support pro-              the nina Hyde center for breast cancer research, with a
gramming in 2008. the prince trusts has given $276,000              $50,000 gift. polo ralph lauren has supported the patient
in support of the institute over the past two years.                navigator program since 2005 with a total of $200,000.




Lombardi CancerLine:      (202) 444-4000                                                            summer 2008 4           LombardiMagazine
 18



                      Avon Foundation Awards $800,000
Community Update




                      to Support CBCC


                      I
                             n front of thousands of breast cancer survivors, advo-
                             cates and their families at the May 4th Avon Walk for
                             Breast Cancer, the Avon Foundation presented a check
                             for $800,000 to Lombardi’s Capital Breast Care Center




                                                                                               pHoto courtesy matt mendelsoHn pHotograpHy
                      (CBCC). The Avon Foundation has provided $3 million to the
                      CBCC since its opening in October 2003.
                          The Avon Walk in Washington, DC drew over 3500 par-
                      ticipants and raised more than $8 million. Led by Jeanne
                      Mandelblatt, MD, MPH, associate director for population sci-
                      ences at Lombardi, a Lombardi/CBCC team individually raised
                      over $13,000 for the walk.
                          In addition, the CBCC, Lombardi Comprehensive Cancer
                      Center, and Georgetown University Hospital served as the medi-
                      cal sponsors for the event. Volunteer physicians, nurses, and
                                                                                                                                            Drs. Weiner, mandelblatt, and shields with actress reese Witherspoon and
                      other medical professionals provided care for the 3500 walk-                                                          CBCC executive Director Amari sokoya pearson-Fields, mpH.
                      ers during the two day event. Lombardi Deputy Director Peter
                      Shields, MD, who co-directed the medical team, said the most
                      common ailments were blisters and dehydration.                                                                        striking disparities in breast health care in the DC area.”
                          Over the past four years, the CBCC, a signature outreach pro-                                                         The CBCC provides extraordinary quality care regardless of
                      gram of the cancer center, has reached more than 4000 women,                                                          a woman’s ability to pay to underserved women in Washington,
                      providing cancer screening services in a culturally respectful                                                        DC, a city in which women die from breast cancer at a rate of
                      environment. Through increased outreach to local communities                                                          65 percent above the national average and has the highest death
                      over the past year, the Center has doubled the number of women                                                        rate in the country. The CBCC serves DC women who would oth-
                      it serves, reaching a new milestone of 200 women served each                                                          erwise not have access to vital services such as mammograms,
                      month.                                                                                                                genetic testing, patient navigation, and quality care. LM
                          Avon’s grant will support “critical safety net services to medi-
                      cally underserved women in the Washington metropolitan area.                                                           to learn more about the cbcc visit www.capitalbreastcare.org
                      The grant continues the Avon Foundation commitment to reverse




                                                                                                                                                            for patients...
                      Amputee Support Group                             “Caregiver Connections” Support Group                                                         Hemophilia and Other Complications
                      For amputees with/without cancer, their fami-     For family and friends of adult patients at                                                   (HIV+, Hepatitis C, etc.) Support Group
                      lies and friends, and healthcare professionals.   lombardi. rsvp required.                                                                      First Monday of each month, 6:30–8 pm
                      led by dr. John steinberg, dpm.                   First Tuesday of every month, 5–6 pm                                                          Contact: mary Jane berry, licsW
                      Second Tuesday of every month                     Contact: sara moore, ma, lpc                                                                  (202) 687-5560
                      5:30–7:30 pm                                      (202) 444-0109
                                                                                                                                                                      Look Good…Feel Better
                      Contact: Jessica ciacco, (202) 444-3059
                                                                        GI Cancer Resource and Support Group                                                          an education program to address
                      Bereavement Support Group                         For patients, family, and caregivers of                                                       appearance-related side effects of
                      For those who have experienced the loss           patients with gi cancers.                                                                     cancer treatment. registration required.
                      of a loved one who received care at               Fourth Wednesday of every month                                                               Second Monday of each month
                      lombardi.                                         5:30–7:00 pm                                                                                  9:30–11:30 am
                      Six week group meets periodically                 Contact: leonard ellentuck, msW, lgsW                                                         Contact: Joanne assarsson, licsW
                      throughout the year                               (202) 444-6288                                                                                (202) 444-3755
                      Contact: rev. sharon graham
                                                                        Head and Neck Cancer Support Group                                                            Lung Cancer Support Group
                      (202) 444-3746
                                                                        Third Monday of each month                                                                    First Wednesday of each month
                                                                        12:15–1:45 pm                                                                                 11:30 am–1 pm
                                                                        Contact: Joanne assarsson, licsW                                                              Contact: mary Kardauskas, licsW
                                                                        (202) 444-3755                                                                                (202) 444-1684




                   LombardiMagazine 4 s u m m e r        2008                                                                                 To find out more:       http://lombardi.georgetown.edu
                                                                                                                                          19



The Infinite Power of One




                                                                                                                                         Community Update
I
       f one NCI Comprehensive Cancer Center can spark its               Proceeds will go directly to the twelve cancer centers whose
       community to donate to cancer research, imagine the col-          research will change the face of cancer.
       lective efforts of twelve centers. That is what led fundrais-        The CRA launched this campaign between Mother’s Day
       ing teams from many of the nation’s leading cancer centers        and Father’s Day, May 11 through June 15, 2008. Supporters of
to form the Cancer Research Alliance (CRA).                              the cancer centers were asked to visit our sponsor’s website
    In April, the CRA launched its first campaign, called the            www.celebrations.com. Donors were also invited to add their
Infinite Power of One. It is proof that together, we are more pow-       photos to the mosaic of photos across America who share the
erful than cancer.                                                       passion to end cancer.
    The campaign is asking all Americans who can, to go online              Lombardi is a founding member of the CRA, which aims to
and donate $1. Imagine the impact of 300 million people each             leverage the national profile of its member cancer centers to
donating $1 toward the cure. Therein lies the Infinite Power of One.     partner nationally with leading companies. While the campaign
    Lombardi Comprehensive Cancer Center is an enthusiastic              ended June 15th, more information can be found on the CRA
partner in the Cancer Research Alliance’s nationwide rollout.            website at www.cancerresearchalliance.org. LM



and caregivers
Platelet Disorders Support Group               Young Women’s Breast Cancer
(ITP, TTP, etc.)                               Support Group
For adults and children with platelet          For women with breast cancer, age 40
disorders and their families, sponsored by     and under. registration required.
the platelet disorders support association.    First Wednesday of every month
Five times a year, second Tuesday of month,    5:30–7:00 pm
7–8:45 pm                                      Contact: Joanne assarsson, licsW, osW-c
Contact: mary ann Kibarian, pdsa               (202) 444-3755
(301) 770-6636
Women with Cancer Support Group                please contact the facilitator directly
For women with gyn cancer or breast cancer.    for details (building, room location, etc.)
each session features creative activities.     about any group in which you are
Fouth Monday of every month                    interested in attending.
12:30 –1:30 p.m. Registration required.
Contact: ann richardson, rn
(202) 444-2118




Lombardi CancerLine:        (202) 444-4000                                                        summer 2008 4       LombardiMagazine
                                                   BAR




                                           LO M

                                                          DI
                                                                                 Concert For Cancer
                                              Starring                            To Benefit Pancreatic and Prostate Cancer Programs at
                                                                                  Georgetown University’s Lombardi Comprehensive Cancer Center

                           gendary” Teenagers                                                                                                  The Warner Theatre
      Frankie Lymon’s “Le
                       LS FALL IN LOVE                                                     The Duprees
                    WHY DO FOO                                               YOU BELONG TO ME and HAVE                                         Courtesy of Vornado/Charles E. Smith
                                                                                                                YOU HEARD
                           Fred Parris
                                           and The Sati                                                                                        Washington, DC
                              IN THE STILL              ns
                                                                                              d The Skyliners
                                                                                                                                               Saturday
                                              OF THE NIGHT
                                                                             Jimmy Beaumont an E YOU
                                                                                          SINCE I DON’T HAV

                     d The Planoton
       Kenny Vance an AN ECHO
                   LOOKING FOR
                                    es
                                                                                               Terry Johnso
                                                                                                            n’s Flamingo
                                                                                                                                               Sept. 6, 2008
                                                                  rm          ers                                        s
                                                          a Perfo
                                                                                                                                               7:30 pm
                                                                                                   I ON   LY HAVE EYES
                                                 -Acapell                                                                FOR YOU
                                 Edition
                         The 3rd
                                                                                    Sammy Sax
                                                                                              and the M
                                                                                     The Top Oldie                    D’s                      Presenting Sponsor
                                                                           featuring Leslie        s Band in the
                                                                                                                 Country
               Vito Picone and The Elegants                                Still and The
                                                                                            Anderson, lea
                                                                                         Dubs and int      d singer of Cle
                                                                                                       roducing Ms         veland              Marvin McIntyre and Family
                                LITTLE STAR                                                                        . Denise Sergi


                      For More Information, visit http://lombardi.georgetown.edu or call (202) 687-3866

    E&A-376_DooWop_LombardiAd_7.25x41 1                                                                                                                                   5/28/08 3:52:20 PM




T     he Lombardi Comprehensive Cancer Center,
      part of Georgetown University Medical Center,
is a full-service cancer center that includes a strong
                                                                               For information about cancer:
                                                                               4Lombardi CancerLine: (202) 444-4000
                                                                                                                                                 LOmBARDI COmPREhENSIvE CANCER CENTER
                                                                                                                                                 Louis M. Weiner, MD
                                                                                                                                                 Director
                                                                               For correspondence about the magazine:
core of basic science and clinical research, a program
                                                                               4	lombardieditor@georgetown.edu                                   GEORGETOWN UNIvERSITy mEDICAL CENTER
of high-priority clinical trials, and a commitment
                                                                               4	Allison Whitney                                                 Howard Federoff, MD, PhD
to community service and outreach activities related
                                                                                 Lombardi Magazine Editor                                        Executive Vice President
to cancer prevention and control. Lombardi is one
                                                                                 Lombardi Comprehensive Cancer Center
of only 39 National Cancer Institute-designated                                                                                                  GEORGETOWN UNIvERSITy hOSPITAL
                                                                                 3970 Reservoir Road NW, Suite E501
comprehensive cancer centers in the nation, and                                                                                                  M. Joy Drass, MD
                                                                                 Washington, DC 20057
the only one in the Washington DC area.                                                                                                          President
    Lombardi Magazine is produced four times a year                            To view the Lombardi Magazine online or
for patients and their families, community members,                            to learn more about Lombardi:                                               A Comprehensive Cancer Center
and friends of the Lombardi Comprehensive Cancer                               4http://lombardi.georgetown.edu                                             Designated by the
                                                                                                                                                           National Cancer Institute
Center at Georgetown University.

georgetown university medical Center does not discriminate against any person on the basis of race, color, religion, sex, national origin,
age, disability, veteran status or sexual orientation. This policy covers all programs, services, policies and procedures of the university.
georgetown university medical Center is subject to the District of Columbia Human rights Laws.




                                                                                                                                                                             non-profit
                                                                                                                                                                            organization
                                                                                                                                                                           postage paid
                                                                                                                                                                           Washington DC
                                                                                                                                                                           permit no. 3901
Georgetown University
The Research Building, Suite E501
Box 571468
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Washington, DC 20057-1468

								
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