CASIMIR meeting Hotel Ponte Sisto Rome November 11, 2009 BRC Database & Bioresource Sustainability Models The Report of RIKEN BRC Atsushi Yoshiki, Ph.D. Head, Experimental Animal Division, Yuichi Obata, Ph.D. Director, RIKEN BRC and RIKEN Tsukuba Institute The RIKEN BioResource Center No Resource, No Research No Research, No Resource Established in 2001 Mission The RIKEN BRC, as the only specialized comprehensive biological resource center in Japan, must ensure sustainable use of biological resources and must exercise the leadership Aims ! Promoting life science and bio-industry in Japan and the world by facilitating bioresources of the highest quality ! Making strategic plans and implementing them for building up bioresources that are the essential infrastructure for sustainable development of humankind The RIKEN BioResource Center Operates with Three Principles “Trust ” in our bioresources and also in the Center by the scientific community “Sustainability” of the resources, the activities and the Center itself “Leadership” in the resources, technologies and in policy making for national and global interests Foundation for Discoveries Establishment of and RIKEN BRC Brand Access to the Future Earn the appreciation and respect from the scientific community Policy of RIKEN BRC on Collection, Preservation, BRC and Distribution of Bioresources 1. Bioresources essential for research!"From living organisms, cells, genes to information 2. Focus on bioresources originally developed in Japan 3. Bioresources with a critical mass of users 4. Merits in a large scale and concentrated production 5. Collaboration with NBRP as the core facilities for 5 resources 6. Working closely with institutions in Japan and overseas 7. Based on RIKEN potential The Major Activities at the RIKEN BRC 1. Bioresource Infrastructure (1) Collection, Preservation & Distribution of Bioresources (2) Quality Improvement and Quality Control (3) Training and Education (4) International Cooperation Experimental Experimental Cell Genetic Micro Information Animal Plant Lines Materials organism 2. Key Technology Development Development of technologies for production, preservation, distribution and quality control of bioresources 3. Bioresource Frontier Programs Molecular imaging, Biological signals, Japan mouse clinic, Human disease models, Novel bioresources, Phenotype Database New Horizons of Life Sciences in 21st Century Facilitated by Intellectual Infrastructure The 1st Term: 2002~2006 The 2nd Term: 2007~2011 National Strategy on Bioresources #The MEXT will promote the project to develop, collect, preserve and provide with bio-resources together with their genetic information. #The MEXT will establish distinguished bio-resources centers. Project Aim Fundamental Genome information technologies upgrading program Universities and Research upgrading program Institutes (adding higher value by (development of Provision of genome analysis, etc.) preservation technology, bioresources and etc.) Life sciences research information Immune Brain Arabidopsis Development, Depositing of Cancer Mice Cell lines Regeneration bioresources and Core facility upgrading program feedback of (upgrading of systems for collection, Food Environment research results preservation, and provision) 27 bioresources DNA, cDNA Rat Microorganisms Original research progresses in Japan Information center upgrading program (providing of information Acquisition of an international on whereabouts and genomes, etc.) initiative NBRP and RIKEN BRC as Stations for Dissemination of Research Materials (Bioresources) Developed in Japan Japan Domestic and Industries MTA International Institutes Scientific Community Universities Universities Institutes NBRP Japanese and RIKEN’s Academic Research RIKEN bioresources Centers BRC Bio industries CDB R&D ASI BSI MTA PSC International CGM Collaboration RCAI Current financial Structure at RIKEN BRC IPR Deposit Distribute Developers Users (Universities, Institutions, MTA* MTA** Industries) NBRP RIKEN BRC Public fund Subsidies from MEXT Users Fee Public fund via RIKEN Amount of users fee should not affect the activity of collection and preservation of bioresources. Revenue for the operation at RIKEN BRC Revenue Source Purpose of use Proportion(%) Operating Government Consumables, Expenses (1) (MEXT) through direct staff costs, RIKEN energy and etc for the 78.3 infrastructure Distribution Fee Users* Partial reimbursement of the preparation and handling costs. 3.0 Not profit. External Fund MEXT, JST, JSPS Research and and others Development 8.3 Operating Government RIKEN Permanent post Expenses (2) (MEXT) through staff salary 10.4 RIKEN *We ask 30% more distribution fee from a for-profit FY2008 organization. Problems of our current financial structure (1) 1. We need diversification of revenue. The sustainable operation is not secured when it depends on a single financial source. The change of the government might change our budget. 2. There is no other major funding agencies except for the Government in Japan. 3. In Japan we are not able to expect a substantial donation from a philanthropist or a commercial entity, because there is no tax exemption system for donating to the research. Problems of our current financial structure (2) 1. The extent of cost recovery must be carefully determined within the extent so that the researchers in the community can afford to actively use the infrastructure system. 2. RIKEN BRC is not the owner of the mice, and can not ask license fee. 3. Application to the international funding agencies, since our customers are from all over the world? Collaboration with the community 1. BRC must closely collaborate with the community and get strong support from it for the necessity of the biological resource center. 2. The community must continue appealing to the government the importance and necessity of the infrastructure. 3. The number and quality of users’ publications are good indicator for evaluating BRC. The BRC must be cited properly as a source of the materials in the Journals to demonstrate its importance. 4. The Journal must encourage stipulation of a source of materials as well as sharing materials and data. 5. The reviewer of the paper must recognize the importance of stipulation of a source of materials. Other important issues 1. The funding organizations (ex. MEXT, JST, JSPS etc.) must establish guidelines for deposition and sharing of data and materials. Up to now, the deposit is a voluntary action of the depositor scientist. (We are working for it!!) 2. When a research project contains a plan to produce new materials, the necessary cost for deposition and archiving must be included in the plan and transferred to the infrastructure. 3. We have no funding system for a large scale strategic generation of new mouse resources in Japan, such as KOMP by Trans-NIH research.
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