Database Bioresource Sustainability Models The Report of RIKEN BRC by itlpw9937


									                     CASIMIR meeting
                   Hotel Ponte Sisto Rome
                    November 11, 2009
 Database & Bioresource Sustainability Models
          The Report of RIKEN BRC
                   Atsushi Yoshiki, Ph.D.
             Head, Experimental Animal Division,
                    Yuichi Obata, Ph.D.
      Director, RIKEN BRC and RIKEN Tsukuba Institute
        The RIKEN BioResource Center
               No Resource, No Research
               No Research, No Resource
                                                      Established in 2001
The RIKEN BRC, as the only specialized comprehensive biological
resource center in Japan, must ensure sustainable use of biological
resources and must exercise the leadership
! Promoting life science and bio-industry in Japan and the world by
  facilitating bioresources of the highest quality
! Making strategic plans and implementing them for building up
  bioresources that are the essential infrastructure for sustainable
  development of humankind
        The RIKEN BioResource Center
        Operates with Three Principles
“Trust ”
in our bioresources and also in the Center by the scientific
of the resources, the activities and the Center itself
in the resources, technologies and in policy making for
national and global interests

                                    Foundation for Discoveries
        Establishment of                      and
        RIKEN BRC Brand               Access to the Future
Earn the appreciation and respect from the scientific community
       Policy of RIKEN BRC on Collection, Preservation,
       and Distribution of Bioresources

 1. Bioresources essential for research!"From living organisms,
      cells, genes to information

 2. Focus on bioresources originally developed in Japan

 3. Bioresources with a critical mass of users

 4. Merits in a large scale and concentrated production

 5. Collaboration with NBRP as the core facilities for 5 resources

 6. Working closely with institutions in Japan and overseas

 7. Based on RIKEN potential
          The Major Activities at the RIKEN BRC
    1. Bioresource Infrastructure
       (1) Collection, Preservation & Distribution of Bioresources
       (2) Quality Improvement and Quality Control
       (3) Training and Education
       (4) International Cooperation

Experimental   Experimental   Cell        Genetic       Micro
   Animal         Plant       Lines      Materials    organism

    2. Key Technology Development
        Development of technologies for production, preservation,
    distribution and quality control of bioresources
    3. Bioresource Frontier Programs
        Molecular imaging, Biological signals, Japan mouse clinic,
        Human disease models, Novel bioresources, Phenotype Database
New Horizons of Life Sciences
in 21st Century Facilitated by
Intellectual Infrastructure

  The 1st Term: 2002~2006
  The 2nd Term: 2007~2011
National Strategy on Bioresources

#The MEXT will promote the project to
 develop, collect, preserve and
 provide with bio-resources together
 with their genetic information.
#The MEXT will establish
 distinguished bio-resources centers.
                                              Project Aim
Genome information                technologies
                                upgrading program                              Universities and Research
upgrading program                                                                      Institutes
 (adding higher value by            (development of           Provision of
  genome analysis, etc.)        preservation technology,   bioresources and
                                          etc.)                                 Life sciences research

                                                                               Immune          Brain

                      Arabidopsis                                                          Development,
                                                              Depositing of    Cancer
      Mice                                  Cell lines                                     Regeneration
                                                           bioresources and
        Core facility upgrading program                        feedback of
           (upgrading of systems for collection,                                Food       Environment
                                                            research results
               preservation, and provision)
                   27 bioresources

  DNA, cDNA                                        Rat
                                                                Original research progresses in
          Information center upgrading
           program (providing of information                     Acquisition of an international
             on whereabouts and genomes, etc.)                              initiative
            NBRP and RIKEN BRC as Stations for
            Dissemination of Research Materials
             (Bioresources) Developed in Japan

                                                  Domestic and
Industries                      MTA               International
Institutes                                          Scientific
Universities                                       Universities
                 NBRP    Japanese and RIKEN’s
                                                Academic Research
  RIKEN                  bioresources
  Centers        BRC
                                                  Bio industries
  CDB                                                  R&D
                  ASI   BSI      MTA
     PSC                                          International
     CGM                                          Collaboration
Current financial Structure at RIKEN BRC

                 Deposit               Distribute
 Institutions,   MTA*                  MTA**
  Industries)                NBRP
                           RIKEN BRC

Public fund      Subsidies from MEXT   Users Fee    Public fund
                      via RIKEN

 Amount of users fee should not affect the activity
  of collection and preservation of bioresources.
Revenue for the operation at RIKEN BRC
     Revenue             Source            Purpose of use       Proportion(%)

Operating           Government         Consumables,
Expenses (1)        (MEXT) through     direct staff costs,
                    RIKEN              energy and etc for the
Distribution Fee    Users*             Partial reimbursement
                                       of the preparation and
                                       handling costs.              3.0
                                       Not profit.
External Fund       MEXT, JST, JSPS    Research and
                    and others         Development                  8.3
Operating           Government         RIKEN Permanent post
Expenses (2)        (MEXT) through     staff salary                10.4

*We ask 30% more distribution fee from a for-profit                FY2008
Problems of our current financial structure (1)

1. We need diversification of revenue. The sustainable
   operation is not secured when it depends on a single
   financial source. The change of the government might
   change our budget.
2. There is no other major funding agencies except for the
   Government in Japan.
3. In Japan we are not able to expect a substantial donation
   from a philanthropist or a commercial entity, because there
   is no tax exemption system for donating to the research.
   Problems of our current financial structure (2)

1. The extent of cost recovery must be carefully determined within

   the extent so that the researchers in the community can afford to

   actively use the infrastructure system.

2. RIKEN BRC is not the owner of the mice, and can not ask

   license fee.

3. Application to the international funding agencies, since our

   customers are from all over the world?
       Collaboration with the community
1. BRC must closely collaborate with the community and get strong
   support from it for the necessity of the biological resource center.
2. The community must continue appealing to the government the
   importance and necessity of the infrastructure.
3. The number and quality of users’ publications are good indicator for
   evaluating BRC. The BRC must be cited properly as a source of
   the materials in the Journals to demonstrate its importance.
4. The Journal must encourage stipulation of a source of materials as
   well as sharing materials and data.
5. The reviewer of the paper must recognize the importance of
   stipulation of a source of materials.
               Other important issues
1. The funding organizations (ex. MEXT, JST, JSPS etc.) must
   establish guidelines for deposition and sharing of data and
   materials. Up to now, the deposit is a voluntary action of the
   depositor scientist. (We are working for it!!)
2. When a research project contains a plan to produce new
   materials, the necessary cost for deposition and archiving must
   be included in the plan and transferred to the infrastructure.
3. We have no funding system for a large scale strategic
   generation of new mouse resources in Japan, such as KOMP by
   Trans-NIH research.

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