of Vol. 30 No. 1
Tabriz University of Medical Sciences Spring 2008
The role of mean platelet volume in determination of the prognosis of
Idiopathic Thrombocytopenic Purpura
SAKHA K, MD¹: Associate Professor of Pediatrics (Corresponding author)
REZAMAND A, MD²: Assistant Professor of Pediatrics Hematology Oncology
Department of pediatrics, Tabriz University of Medical Sciences
Backgrounds and Objectives: The mean platelet volume is an indicator for platelet
disorders, which shows the rate of platelet destruction in peripheral blood, and platelet
production in bone marrow. In this study we evaluated the role of (Mean Platelet Volume,
MPV) in prediction of prognosis in (Idiopathic Thrombocytopenic Purpura, ITP).
Materials and Methods: Fifty patients with ITP that were admitted toTabriz Pediatric
Medical Center from Oct 2003 to 2005 were studied. Chronic ITP and other purpuras were
The blood parameters including platelet count, WBC, Hb, and MPV were measured by CBC H1
and bone marrow aspiration was done by hematologist before treatment.
The patients were divided based on MPV to three groups of low (MPV<7 fl), normal
(MPV=7-11 fl) and high (MPV>11 fl) platelet volume. The patients followed in one, two weeks
and one month after treatment.
Results: In this study 42 % of patients had low, 40 % normal and 18 % high MPV before
First week (P=0.004), second week (P=0.001) and one month (P=0.001) after treatment all
patients in low and normal groups of MPV had good prognosis. But in the patients with high
MPV, even though in first week (P=0.04) and second week (P=0.002) had favorable prognosis
but after one month of treatment there was no statistically meaningful correlation between high
MPV and favorable prognosis (P=0.161).
The Patients with viral infections exposure or vaccination before disease had low or normal
MPV and had good prognosis (P=0.001).
Conclusion: Low or normal MPV before treatment in ITP patients and those who had
history of viral infection or vaccination in last month before disease had favorable prognosis.
But in patients with high MPV prognosis of diseases can not be evaluated.
Key Words: Thrombocytopenia, Prognosis, Idiopathic Thrombocytopenic Purpura, Mean
Platelet Volume, Platelet