Novel Mouse Model for research an by hilen



Novel Mouse Model for research and study of
therapeutic treatments in Psoriasis

Researchers at the University of Dundee have developed a
novel in vivo experimental system which induces the
expression of human psoriatic genes without the need for
human skin grafts. The mouse model demonstrates many
clinical and histological effects of human Psoriasis within a
period of 21 days. This reliable model provides a rapidly
developed, complimentary tool for studying the
                                                                                                                 •    Suitable for screening
development and therapeutic treatment of Psoriasis.                                                                   potential therapeutic
                                                                                                                 •    Simplification technology
Background                                         psoriatic skin but is not expressed in
                                                   mouse skin. In the model, the PPARδ                           •    Demonstrates major
Psoriasis is one of the most frequent skin                                                                            hallmarks Psoriasis
                                                   gene is activated by the administration of
diseases, affecting 1-3% of the Caucasian
                                                   a synthetic ligand. Researchers developed                     •    Exclusive License
population world wide. This complex
                                                   the model to demonstrate many                                      opportunities
disease is characterised by alterations
                                                   clinical and histological effects of                          •    Patent application filed
in a variety of cells, including epidermal
                                                   Psoriasis, including dependance on
keratinocyte hyperproliferation and
                                                   Th17 lymphocytes within 21 days. The
differentiation, altered expression in
                                                   skin phenotype has 100% penetrance, is
major histocompatibility complex (MHC)
                                                   responsive to Th17 - targeted therapy,
class II, endothelial cell hyperproliferation
                                                   and fully reversible, furthermore,
resulting in angiogenesis and dilation.
                                                   transcriptional dysregulation in this
                                                   model largely overlaps with that seen
Research into the pathogenesis of                  with Psoriasis. The model does not
Psoriasis has been hampered due to the             require human skin grafting or
lack of robust animal models. Current              implantations, therefore, the ability to
models include transgenic animals which            screen is improved and the process of
demonstrate an increase in cytokines and           operating a model is simplified. This
epithelial proliferation but the models            presents advantages over existing models
only mimic the phenotype of psoriasis              and a robust complimentary tool for
rather than display the underlying                 research in inflammatory skin conditions.
pathogenesis. Different models include
grafting human skin onto mice, although                                                                          For more information contact:
                                                   A patent application was filed in August
this is limited by availability of graft           of 2008.                                                      Stuart Maxwell
material and poor animal survival rates.                                                                         Technology Licensing Associate
                                                                                                                 Tel: +44(0) 1382 385326
                                                                                                                 Fax: +44(0) 1382 385423
UoD Study                                                                                                        Email:

Researchers at the University of
Dundee have developed the first                                                                                   Research and Innovation Services
                                                                                                                   Research and Innovation Services
transgenic mouse model which induces                                                                             University of Dundee
                                                                                                                   University of Dundee
the expression of the PPARδ gene, which                                                                          11 Perth Road, Dundee, DD1 4HN
                                                                                                                   11 Perth Road, Dundee, DD1 4HN
is known to be expressed in human                                                                                Scotland, UK
                                                                                                                   Scotland, UK
                                                                                                                 Tel: +44 (0)1382 384426
                                                                                                                   Tel: +44 (0)1382 344426
                                                                                                                 Fax: +44 (0)1382 386765
                                                                                                                   Fax: +44 (0)1382 202178

                                       The University of Dundee is a Scottish Registered Charity, No. SC015096                                   D478

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