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					InDepth information sheet downloaded from - http://www.bioportfolio.com on Friday, November 27, 2009

Psoriasis
View the current Psoriasis InDepth page on BioPortfolio.com ( PDF ) (http://www.bioportfolio.com/indepth/Psoriasis.html) - Regularly Updated. Psoriasis is a disease which affects the skin and joints. It commonly causes red scaly patches to appear on the skin. The scaly patches caused by psoriasis, called psoriatic plaques, are areas of inflammation and excessive skin production. Skin rapidly accumulates at these sites and takes a silvery-white appearance. Plaques frequently occur on the skin of the elbows and knees, but can affect any area including the scalp and genitals. Psoriasis is hypothesized to be immune-mediated and is not contagious.The disorder is a chronic recurring condition which varies in severity from minor localised patches to complete body coverage. Fingernails and toenails are frequently affected - and can be seen as an isolated finding. Psoriasis can also cause inflammation of the joints, which is known as psoriatic arthritis. Ten to fifteen percent of people with psoriasis have psoriatic arthritis.The cause of psoriasis is not known, but it is believed to have a genetic component. Several factors are thought to aggravate psoriasis. These include stress, excessive alcohol consumption, and smoking. Individuals with psoriasis may suffer from depression and loss of self-esteem. As such, quality of life is an important factor in evaluating the severity of the disease. There are many treatments available but because of its chronic recurrent nature psoriasis is a challenge to treat. ( From the Wikpedia article Psoriasis .)

Recent Publications on Psoriasis:

• Further association analysis of chr 6q22-24 suggests a role of IL-20RA polymorphisms in psoriasis. Functional (non-organic) disorders of the iliopsoas muscle (IPM), i.e. the...21st November, 2009 Department of Dermatology and Venerology, University of Tartu, Estonia;- J Dermatol Sci. 2009 Nov 16. (DOI Direct Link) • Pain associated with aminolevulinic acid-photodynamic therapy of skin disease. BACKGROUND: Pain during topical aminolevulinic acid (ALA)-mediated...21st November, 2009 Cleveland Clinic Lerner College of Medicine of Case Western Reserve- J Am Acad Dermatol. 2009 Dec;61(6):1033-1043. (DOI Direct Link) • Methotrexate versus traditional Chinese medicine in psoriasis: a randomized, placebo-controlled trial to determine efficacy, safety and quality of life. Background. Psoriasis is a common and chronic immune-mediated skin...21st November, 2009 Division of Dermatology, Department of Medicine, University of Hong Kong,- Clin Exp Dermatol. 2009 Nov 19. (DOI Direct Link) • Membranoproliferative Glomerulonephritis Associated with Psoriasis Vulgaris. Psoriasis is a hereditary, chronic inflammatory disorder of the skin....21st November, 2009 - Ren Fail. 2009 Jan;31(9):858-861. (DOI Direct Link) • Estimation of cost-of-illness in patients with psoriasis in Switzerland. BACKGROUND: Evaluation of the current clinical treatment of psoriasis in...20th November, 2009 Department of Dermatology, University of Zurich, Zurich, Switzerland.- Swiss Med Wkly. 2009 Nov 19. (

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DOI Direct Link) Psoriasis during interferon beta treatment for multiple sclerosis. Previous reports have suggested an increased risk of psoriasis in MS...20th November, 2009 Multiple Sclerosis Center, Neurological Institute C Besta, Via Celoria,- Neurol Sci. 2009 Nov 19. (DOI Direct Link) Molecular Analysis of Tumor-Promoting CD8(+) T Cells in Two-Stage Cutaneous Chemical Carcinogenesis. T-pro are tumor-infiltrating TCRalphabeta(+)CD8(+) cells of reduced...20th November, 2009 Department of Dermatology and Skin Diseases Research Center, Yale- J Invest Dermatol. 2009 Nov 19. (DOI Direct Link) Possible Roles of IL-27 in the Pathogenesis of Psoriasis. The immunological significance of IL-27 has been reported and discussed in...20th November, 2009 Faculty of Medicine, Department of Dermatology, University of Tokyo,- J Invest Dermatol. 2009 Nov 19. (DOI Direct Link) Epidemiology and comorbidity of psoriasis in children. Summary Background: Psoriasis is a common disease affecting all age...20th November, 2009 CVderm - German Center for Health Services Research in Dermatology,- Br J Dermatol. 2009 Nov 18. (DOI Direct Link) Psoriasis and alcohol: is cutaneous ethanol one of the missing links? Abstract Many exogenous factors including excessive alcohol consumption...20th November, 2009 Department of Dermatology and Allergology, University of Szeged, Szeged,- Br J Dermatol. 2009 Nov 18. (DOI Direct Link) An epidemiological survey of low back pain and axial spondyloarthritis in a Chinese Han population. Objective: To investigate the prevalence of low back pain (LBP) and axial...20th November, 2009 Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen- Scand J Rheumatol. 2009;38(6):455-459. Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. Th subsets are defined according to their production of lineage-indicating...19th November, 2009 - J Clin Invest. 2009 Nov 16. pii: 40202. doi: 10.1172/JCI40202. (DOI Direct Link) Cost Comparison of Psoriasis Treatments. BACKGROUND:Knowledge of the cost of various psoriasis therapeutic options...19th November, 2009 - J Cutan Med Surg. 2009 Dec 1;13(6):303-307. A Canadian Self-Administered Online Survey to Evaluate the Impact of Moderate-to-Severe Psoriasis among Patients. BACKGROUND:Few population studies of individuals living with psoriasis...19th November, 2009 - J Cutan Med Surg. 2009 Dec 1;13(6):294-302. The Burden of Psoriasis and Barriers to Satisfactory Care: Results from a Canadian Patient Survey. BACKGROUND:The physical, mental, social, and financial burdens experienced...19th November, 2009 - J Cutan Med Surg. 2009 Dec 1;13(6):283-293.

BioNews Results for Psoriasis • Memory Foam Is Comforting to Arthritis Patients About: Nov 20 2009 2:35PM Matching: psoriasis • Possible Roles of IL-27 in the Pathogenesis of Psoriasis Journal of Investigative Dermatology: Nov 19 2009 10:05AM Matching: psoriasis • International Psoriasis Council Hosts Second Educational Symposium To Increase Global Knowledge Of Psoriasis Medical News Today: Nov 18 2009 8:43AM Matching: psoriasis

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• Impact of Adalimumab on Symptoms of Psoriatic Arthritis in Patients with Moderate to Severe Psoriasis: A Pooled Analysis of Randomized Clinical Trials Dermatology: Nov 18 2009 11:33PM Matching: psoriasis • Improvements in patient-reported outcomes in moderate-to-severe psoriasis patients receiving continuous or paused etanercept treatment over 54 weeks: the CRYSTEL study MDLinx: Nov 18 2009 10:56AM Matching: psoriasis • International Psoriasis Council Hosts Second Educational Symposium to Increase Global Knowledge of Psoriasis Individual.com: Nov 17 2009 9:54AM Matching: psoriasis • PsoriasisDX To Present Seminar On Groundbreaking Genetic Screening For Psoriatic Arthritis Genetic Engineering News: Nov 16 2009 5:56PM Matching: psoriasis • PsoriasisDX To Present Seminar On Groundbreaking Genetic Screening For Psoriatic Arthritis Centre Daily Times: Nov 16 2009 5:16PM Matching: psoriasis • PsoriasisDX To Present Seminar On Groundbreaking Genetic Screening For Psoriatic Arthritis Street Insider: Nov 16 2009 4:49PM Matching: psoriasis • PsoriasisDX To Present Seminar On Groundbreaking Genetic Screening For Psoriatic Arthritis PR inside: Nov 16 2009 4:41PM Matching: psoriasis • PsoriasisDX To Present Seminar On Groundbreaking Genetic Screening For Psoriatic Arthritis Earthtimes.org: Nov 16 2009 4:37PM Matching: psoriasis • PsoriasisDX To Present Seminar On Groundbreaking Genetic Screening For Psoriatic Arthritis Business Wire: Nov 16 2009 4:36PM Matching: psoriasis • PsoriasisDX To Present Seminar On Groundbreaking Genetic Screening For Psoriatic Arthritis Business Wire via Yahoo!: Nov 16 2009 4:36PM Matching: psoriasis • PsoriasisDX To Present Seminar On Groundbreaking Genetic Screening For Psoriatic Arthritis Yahoo! Canada: Nov 16 2009 4:34PM Matching: psoriasis • PsoriasisDX To Present Seminar On Groundbreaking Genetic Screening For Psoriatic Arthritis Business Wire UK: Nov 16 2009 4:31PM Matching: psoriasis

Psoriasis Patents:

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7612180- Humanized L243 antibodies 7615380- Methods for modulating an immune response by modulating KRC activity 7615535- Inhibiting GS-FDH to modulate no bioactivity 7615546- Topical delivery system for phytosterols 7615550- Substituted piperazines,(1,4) diazepines, and 2,5-diazabicyclo (2.2.1)iieptanes as histamine H1 and/or H3 antagonists or histamine H3 reverse antagonists 7615552- Fused heterocyclic compounds 7615553- Inhibitors of histone deacetylase 7615555- Piperidine derivatives as modulators of chemokine receptor CCR5 7615556- Piperazinyl derivatives as modulators of chemokine receptor activity 7615562- 2-aminopyrimidine derivatives and their medical use 7615565- VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines 7615359- Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use

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7615349- Melanoma gene signature 7615238- Plaster for the treatment of dysfunctions and disorders of nails, comprising sertaconazole 7612181- Dual variable domain immunoglobulin and uses thereof 7612182- Anti-IL-6 antibodies, compositions, methods and uses 7612200- Inhibitors of protein kinases 7612201- Pyrazole compounds 7612208- Crystalline form of the salt of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinoli- necarboxamide or the solvate of the salt and a process for preparing the same 7612226- Amino acid derivatives 7612238- Amino-propanol derivatives 7615214- Anti-human VEGF receptor Flt-1 monoclonal antibody 7615215- Anti-human VEGF receptor Flt-1 monoclonal antibody 7615223- Selected immunoconjugates for binding to aminophospholipids 7615576- Prevention of neutrophil recruitment 7615634- 4-aminopyrimidine-5-one derivatives 7618980- Pyrrolo(oxo)quinolines as 5HT ligands 7618981- Imidazopyridinyl-benzamide anti-cancer agents 7618982- Heteroarylpyrrolopyridinones active as kinase inhibitors 7618983- Bicyclic triazole .alpha.4 integrin inhibitors 7618993- Compounds 7619001- Utilization of dialkylfumarates 7619062- PRO214 polypeptides 7619066- IL-1ra variants 7619070- Humanized antibodies to interferon alpha receptor-1 (IFNAR-1) 7619096- 3-Aminopyrrolidines as inhibitors of monoamine uptake 7618975- 4-arylamino-quinazolines and analogs as activators of caspases and inducers of apoptosis and the use thereof 7618971- Mitotic kinesin inhibitors 7618970- 3-aminocyclopentanecarboxamides as modulators of chemokine receptors 7615643- Benzimidazole thiophene compounds 7615648- Aminomethyl-azacycle derivatives as inhibitors of monoamine uptake 7615657- Method of producing an oil extract from seeds of plants via a binary azeotropic solvent mixture 7618626- Combination treatment for non-hematologic malignancies 7618629- Manipulation of cytokine levels using CD83 gene products 7618632- Method of treating or ameliorating an immune cell associated pathology using GITR ligand antibodies 7618639- Synergistic phytoceutical compositions 7618947- Modulation of HIF-1 beta expression 7618961- Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 7618964- Benzamide derivatives, their manufacture and use as pharmaceutical agents 7619100- Physiologically active substances

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