Paediatric Index

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					,
Handbook on Pediatric Medicine

•••

A

SQUARE

PHARMACEUTICALS L TO. BANGLADESH

I

•

... A Handbook on Pediatric Medicine

______

Preface

_ _ _ ___ _ _

We are glad to present the first edition

of "Pedindex ­

a Handbook on Pediatric Medicine" to your hand.
The compilation is based on the indication and the dosage schedule of different drugs of different therapeutic classes from

SQUARE house. We hope. this new compilation will be helpful in
your daily practice while treating pediatric patients. Publication of Pedindex is a part of SQUARE's continual effort to share updated clinical information of the medicines for pediatrics only. We really believe that your suggestions or comments would help us to bring further improvement on this initiation.

Best Regards Product Management Department

Body Surface Area
In physiology and medicine, the Body Surface Area (BSA) is the measured or calculated su rface of a human body. For many clinical purposes BSA is a better indicator of metabolic mass than body weight because it is less affected by abnormal adipose mass. Estimation of BSA is simpler than many measures of volume.
Uses r:l Renal function is usually fractioned over the BSA to gain an

appreciation of the true required Glomerular Filtration Rate (GFR);
r:l The cardiac index is a measure of cardiac output divided by the BSA,

giving a better approximation of the required cardiac output;
r:l Chemotherapy is often dosed according to the patient's BSA. r:l Glucocorticoid dosing is also expressed in terms of BSA for calcu lating

maintenance doses or to compare high dose use with maintenance requirement
Calculation : Equations

Various calculations have been published to arrive at the BSA without direct measurement, starting in 1916 with the Dubois & Dubois formula. A commonly used formula is the Mosteller formula, published in 1 987: Metric (area in square metres from weight in kilograms and height in centimetres):
X=

weight x height 3600

Half-English units (area in square metres from weight in pounds, height in inches): weight x height 3125

Another is the Haycock formula On children):
x
=

0.024265 x weight (kg),mo x height (cm)"'"

Du Bois & Du Bois :
x
=

(71 .84 x weight (kg)'''' x height (cm),n,)/ 1 0000

Dr,
Body Surface Area (m)
=

0.007184 x

(patient height in em)"" x (patient weight in kg)�

Boyd's Fonnuia:
S
=

0.00003207 x height (cm)" x (weight (kg) x 1 000)·'".."

..'· ....hO

Normal BSA Values

General BSA is taken to be 1.7 m'. Men Women Child (9 years) Child (1 O�ars) Child (12-13 years) 1 .9 m' 1 .6 m' 1.07 m' 1 . 1 4 m' 1 .33 m'

(Reference : Chapman RM Gonadal toxicity and teratogenicity. In: Perry MC, ed. The chemotherapy source book Baltimore: Williams & Wilkjns, 1992:711)

8MI
Body Mass Index is a number calculated from an individual's weight and heigh� that is used to determine whether a person is within, or outside of a normal weight range.

:
Dose Calculation Calculilllons on Body Weight

e

In ex

Example : A child weighing 76 Ibs. is ordered to receive 1 50 mg of "x"
•

6h. The pediatric drug handbook states the recommended dose is 8-20 mg/kg/day in four divided doses. The "x" is supplied in 100 mg scored tablets. What is the safe total daily dose? 76 Ibs. + 2.2 kg/ l b. Minimum Dose: 8 mg/kg/day x 34.5 kg Maximum Dose: 20 mg/kg/day x 34.5 kg
Calculations based on Body Surface Area
=

34.5 kg 276 mg/day 690 mg/day

=

=

(BSA)

The formula for calculating child's dosage is:-

-1C':.7:-CM'"'2o-- x

Child's BSA

ad u It dosage

Example: If a child weighs 35 pounds and is 30 inches tall, If the "y"

is ordered at 1 00 mg/m 2, what is the child's correct dosage?

The BSA of that baby is:I

X=

weight x height 3125

BSA Sqrt {(35 x 30) / 3125} 0.58 m2 Therefore the child's dose should be: 100 mg x 0.58 (BSA of the Baby) 58 mg.
= = =

"�
..

Pedi ndex

BMI
Girls
NAME

,

Birth to 36 months Length-for-Age and Weight-for-Age percentiles

______ __ __ __ __ __ __ __ __

RECORD#
33

___ _

L E N G T H

-38L

E N G
T H

-34-32-30- w
E

-28- I
� 12-

G

-26-

H T

1- 24 0-22-

-18-

AGE (MONTHS)
24 W 27

____ ______

"' ,.kg

-16 Ib

30

33

36

E
I

G
H T

I

Birth

3

�" BMI
Girls
-

Pedindex

o 20 years: Girls 12 13

NAME

_________ _ _

Stature -for-age and Weight-for -age percentiles

RECORD'

_ _ _ _ _

14 15 16 17 16 19 20

S T A T U R E

S T A T U R E

W E I G H T

W E I G H T

3

4

5

6

7

8

: B
Boys
Birth 0 36 months: Length-for -age and Weight-for -age percentiles
18 21 NAME

Pedindex

____ __ __ ____ ___ _

___

RECORD' 24 27 30 33

_______

_

L E N G T H

G T

L E N

-36-

-34 -32-30- W E -28- I G 2H -26T 1--2 4-

H

-18-

(MONTHS)
12 W E I
G T

__ ________ _

15

18

24

27

30

33

36

kg

­
Ib

'---- """""

;;;;;,;;;
'

Gestaliooa l

H

3

6

9

�, BMI
Boys
2 to 20 years: Boys Stature -for-age and Weight-for -age percentiles
NAME

,

Pedi ndex

_ __

RECORD'

___ _ _

,

,

,
or

W�ghl j i b}

S T A T U R E

S T A T U R E

W E I G H
T

W E I G H T

2

3

6

7

8

9

10 11

12 13

14 15 1

CON ENTS I

AntiflaWlent

Flacol® (Simethicone)
Antispasmodic

..... ", .........

1 1 1
2

Espa® (Drotaverine)
18K1ltive
•

·..... .... ....,'.

Osmolax® (lactulose)
Gastroprokinetic

•••••••••••••••••

Motigut® (Domperidone)
Antiulcerants

• ••••••••••••••••

Neotack® (Ranitidine)
Antibiotics Antibacterial Combinations

""........ .....

2

Cotrim® (Sulphamethoxazole + T rimethoprim)
Broad Spectrum Penicillins

.................

3 3
4

Moxacil® (Amoxicillin) Moxaclav"' (Amoxicillin + Clavulanic Acid)
Cephalosporins

"

..... .. ,' .... ..

•••••••••••••••••

Cef-3® (Cefixime) Cefdir® (Cefdinir) Cefotil" [Cefuroxime) Ceftron® (Ceftriaxone) Lebac® (Cephradine) Loracef® (Cefaclor) Maxcef® (Cefotaxime)
Doxycycline

•••••••••••••••••

•••••••••••••••••

•••••••••••••••••

•••••••••••••••••

.................

••••• ••••••••••••

"

,........ ..""

5 5 6 7 7 8 8 8 9

Doxacil® (Doxycycline)
Fluroquino/one

.................

Ciprocin® (Ciprofloxacin)

•••••••••••••••••

Macrolides

Eromycin� (Erythromycin) Zimax� (Azithromycin)
Medium and Narrow spectrum Penicillin

•••••• • • • • • • • • • • •

9 10

•••••••••••••••••

Penvik� (phenoxymethyl Penicillin) Phylopen� (Flucloxacillin)
Other {3-/actum antibiotic except Penicillin

• ••••••• •••••• •••

..."... "

', .. ...

10 11 11 12
12

Specbac� (Meropenem)
Tetracyclines

• ••••••••••••••••

Tetrax® (Tet racycline)
Quina/one

.................

Nalid® (Nalidixic Acid)

•••••••••••••••••

Epitra® (Clonazepam)
Antihistamine

•••••••••••••••••

13

Adryl® (Diphenhydramine) Alarid® (Ketotifen) Alatrol® (Cetirizine) Antista® (Chlorpheniramine) Lorat in® (Loratadi ne) Sedno® (Desloratadine)

•••••••••••••••• •

14 14

•••••••••••••••••

•••••••••••••••••

•••••••••••••••••

15 15
16 16

•••••••••••••••••

·.... .. ...... ....

Almex® (Albendazole) Ermox® (Mebendazole) Malacide� (Sulphadoxine + Pyrimethamine)

.................

17 17 17

•••••••••••••••••

•••••••••••••••••

Amodis® (Metronidazole) Secnid® (Secnidazole) Zox® (Nitazoxanide)

•••••••••••••••••

18 18 19

........... " ....

•• •• • • •• •••••••••

Colicon" (Dicycloverine)
Calcium

•••••••••••••••••

19

Cal bo' Jr (Calcium Carbonate)
CNS Anti-emetics and Anti-vertigo

.................

20

Cinaron® (Cinnarizine)
Anti-migraine

•••••••••••••••••

21 21 21

Migranil® (Pizotifen)
Tranquillizers

•••••••••••••••••

Sedil® (Diazepam)
and Ear

•••••••••••••••••

Alacot® (Olopatadine) Ciprocin® (Ciprofloxacin) Genacyn® (Gentamicin) Iventi® (Moxifloxacin) Mexia" (Lomefloxacin) Nacromin® (Sodium Cromoglycate) SQ-Mycetin· (Chloramphenicol)
Hematinics

•••••••••••••••••

22
22 22 23 24 24 24

·............'...

•••••••••••••••••

· ............ ....

• ••••••••••••••••

• ••••••••••••••••

•••••••••• • ••• • ••

Polyron® (Elemental Iron)
Non-narcotic

.. , . , ............

25

Ace· (Paracetamol)

•••••••••••••••••

25

Neurolep® (Piracetam)

••• •••••••••••• ••

27

CONTENTS
Clofenac® (Diclofenac Sodium) Sonap® (Naproxen Sodium)
tract
•••••••••••••••••

27 28

•••••••••••••••••

Asthma Preventers Beclomin® (Beclomethasone) Nacromin® (Sodium Cromoglycate) Salmate® (Salmeterol) Ticamet® (Salmeterol + Fluticasone) Bronchodilator drugs Iprex® Opratropium) Levostar'" (Levosalbutamol) Sultolin® (Sulbutamol) Cough & Cold Remedies Ambrox'" (Ambroxol) Brofex'" (Dextromethorphan) Mucospel® (Bromhexine) Tusca'" (Guaiphenesin + Pseudoephedrine + Triprolidine) Nasal Decongestant Antazol� (Xylometazoline) Nocon® (Oxymetazoline)
Multivitamin & Multiminerals

••••••• ••••••••• •

•• • •••• ••••••••• •

· .......

.

. ,......

•••••••••••••••••

28 29 29 30 31 32 32 34 34 35 36 36 36

•••••••••••••••••

•••••••••••••••••

, ....

.. .
...

......

••••• •• ••••••••••

"."

..

.

.........

·.......... , ....

.

•••••••••••••••••

••••• •••• ••••••••

•••••••••••••••••

B-50® (Vitamin B Complex) ...... Bicozin" (Multivitamin & Multiminerals) Ceevit" (Ascorbic Acid + Sodium Ascorbate) ................. Panvit" (Multivitamin & Multiminerals) .. . Zesup® (Elemental Zinc) .
...... , . . . . . .. ....,.. .. ..... ... , .. .. . . .. . . .," .. , ... .. ... .

37 38 38 39 39

CONTENIS

Antfungals i Candex® (Nystatin) Flugal� (Fluconazole)

• ••••••••••••••••

••••••••••••• • • • •

40 40

Anti-infectives Neb.anol'" (Neomycin Sulphate + Bacitracin Zinc) Antiscabies Scabex" (Permethrin) Anti-itching and Moisturizer Equra® [Urea) Non-steroidal Anti-eczema Remus'" (facrolimus) Plain Antifungal Afun®(Clotrimazole) Fungidal'" [Miconazole) Plain Steroid Ticas® (Fluticasone) Topicort'" (Hydrocortisone)

.................

41 41 42 42 42 42 43 43

• •• ••••••••••••••

.................

•••••• •••••• •••••

•••••••••••••••••

...... ,.. ........

.................

•••••••••••••••••

Alimentary Preparation
Antiflatulent Product Name : Flacol�

(Simethicone)
Composition Indication Dose

: Each ml of Pediatric drop contains 67 mg simethicone USP. : Infantile colic, relieves excess gas in Gil in children & Infants. : Infants under 2 years : 20 mg (0.3 ml Flacol Drops), 4 times daily. Children 2 - 12 years : 40 mg (0.6 ml Flacol Drops), 4 times daily.

Antispasmodic Product Name : Espa®

(Drotaverine)
Composition Indication Dose
:

. Each tablet contains Drotaverine HCI I N N 40 mg.
Spastic conditions of the gastrointestinal tract, biliary tract and urogenital tract. : Adults: 1 to 2 tablets, 3 times daily Children (over 6 years): 1/2 to 1 tablet, 1-2 times daily. Children (1-6 years): 1/4 to 1/2 tablet, 1-2 times daily.

Laxative Product Name : Osmolaxs

(Lactulose)
Composition Indication Dose

. Each 5 ml concentrated oral Solution contains Lactulose USP 3.40 gm. . Constipation, Hepatic encephalopathy (portal systemic encephalopathy) : hepatic coma.
.

Babies under 1 year : 2.5 ml twice daily Children under 5 years : 5 ml twice daily Children 5 to 1 0 years : 10 ml twice daily.

Gastroprokinetic Product Name : Motigut®

(Domperidone)
Composition

Indication Dose

: Motigut® Pediatric Drops : Each ml contains Domperidone BP 5 mg. Motigut® Suspension : Each 5 ml suspension contains Domperidone BP 5 mg . . Infants Regurgitation, Vomiting. . The usual recommended dose is 0.2 - 0.4 mg/kg body weight every 4 8 hours interval.
-

Antiulcerants Product Name . Neotack®

(Ranitidine)
Composition Indication Dose
.

Neotack® Syrup : Each 5 ml syrup contains Ranitidine 75 mg as Ranitidine hydrochloride USP. The recommended oral dose for the treatment of peptic ulcer in children is 2 mg/kg to 4 mg/kg twice daily to a maximum of 300 mg ranitidine per day.

: Peptic ulcer (Duodenal ulcer, Gastric ulcer).

Antibiotics
Antibacterial Combinations

Product Name Composition

:

Cotrim®

(Sulphamethoxazole + Trimethoprim) . After reconstitution, each 5 ml suspension contains Sulphamethoxazole 200 mg and Trimethoprim 40 mg. . For the treatment of respiratory tract infections, genitor-urinary tract infections, skin infections.
: 2 teaspoonful twice daily 6-12 years 6 months - 5 years : 1 teaspoonful twice daily 6 weeks 6 months : 0.5 teaspoonful twice daily.
-

Indication Dose

Broad Spectrum Penicillin (with �-lactamase Inhibitor)

Product Name : Moxacil® CAmoxiciliin) Composition : Moxacil® Suspension : Each 5 m l of reconstituted suspension contains Amoxicillin Trihydrate BP equivalent to Amoxicillin BP 125 mg. Moxacil® Forte Suspension : Each 5 ml of reconstituted suspension contains Amoxicillin Trihydrate BP equivalent to Amoxicillin BP 250 mg. Moxacil® Paediatric Drops : When reconstituted each 1 .25 m l contains Amoxicillin Trihydrate BP equivalent to Amoxicillin BP 125 mg. Moxacil® 500 Injection : Each vial contains Amoxiciliin Sodium BP equivalent to Amoxicillin BP 500 mg.

Indication

Dose

Moxacil® is indicated in the treatment of Infections of the ear, nose, and throat due to Streptococcus species (and hemolytic strains only), S. pneumoniae, Staphylococcus species, or H. influenzae. : < 2 years : 62.5 mg 3 times daily increasing to 125 mg 3 times daily for more severe infection. 2-1 0 years : 1 25 mg 3 times daily increasing to 250 mg 3 times daily for more severe infections.

Product Name . Moxaclav· (Amoxicillin + Clavulanic Acid) Composition : Moxaclav· : Each 5 ml reconstituted suspension contains Amoxicillin BP 1 25 mg as trihydrate and Clavulanic acid USP 3 1 .25 mg as potassium salt. Moxaclav· Forte : Each 5 ml reconstituted suspension contains Amoxicillin 400 mg & Clavulanic acid 5Z5 mg/5 ml. Indication . For the treatment of respiratory tract infections including acute & chronic bronchitis, pneumonia, otitis media, sinusitis, tonsillitis, pharyngitis, skin infection. : MoxaclaVO : 1-6 years: 1 teaspoonful (156 mg) every 8 hours. Below 1 year: 25 mg/kg/day in divided doses (8 hrly). Moxaclav· Forte : Usual recommended daily dose: 25/3.6 mg/kg/day. 2 - 6 years (13 - 21 kg) : 2.5 ml suspension b.i.d.
7 - 12 years (22 - 40 kg): 5 ml suspension b.i.d.

Dose

,

I

Children under 2 years should be dosed according to body weight.
Weight in kg 2 3 4 5
6

7

8

9

10

"

12 13 14 15

25/3.6 mg/kgl 0.3 0.5 0.6 0.8 0.9 1.1 l.3 l.4 l.6 1.7 l.9 2.0 2.2 2.3 day (mllb .i .d.) 45/6.4 mg/kgl 0. 6 0.8 " l.4 1.7 2.0 2.3 2.5 2.8 3.1 3.4 3.7 3.9 4.2 day (ml/b.i .d.)

Cephalosporins Product Name : Cef-3"

(Cefixime)
Composition

: Each 5 ml reconstituted suspension contains Cefixime trihydrate USP equivalent to Cefixime anhydrous 1 00 mg. : Cef-3" is indicated for the treatment of urinary tract infections, upper and lower respiratory tract infections, acute otitis media, gonococcal urethritis and enteric fever.
B mg/kg daily as a single dose or in two divided

Indication

Dose

doses for 7-14 days or for children of age 6 months - 1 year : 3.75 ml or 75 mg : 5 ml or 100 mg 1 - 4 years : 1 0 ml or 200 mg 5 - 1 0 years " - 12 years : 15 ml or 300 mg Above 12 years : Adult dose may be administered.
Product Name Composition Indication
:

Celdi!'" (Cefdinir)

: After reconstitution, each 5 ml Suspension contains 125 mg Cefdinir INN. Acute Community Acquired Pneumonia, Exacerbation of Chronic Bronchitis, Acute Maxillary Sinusitis, PharyngitisfTonsillitis & Uncomplicated Skin and Skin Structure Infections

Dose
,

. 1 25 mg/5 mi. Pediatric Patients (Age 6 months - 1 2 years)

Types of infections

Dosage

Duration

Acute Bacterial I nfection Otitis Media Acute Maxillary Sinusitis Pharyngitis!Tonsillitis Uncomplicated Skin and Skin Structure Infections Product Name Composition
:

7mg/kg q 1 2h or 1 4mg/kg q24h 7mg/kg q 1 2h or 14mg/kg q24h 7mg/kg q 1 2h or 14mg/kg q24h 7mg/kg q 1 2h

5 to 1 0 days 1 0 days 1 0 days 1 0 days 5 to 1 0 days 1 0 da s 1 0 days

Cefotil®

(Cefuroxime) . Cefotil® 750 mg IMIIV injection: Each vial contains Cefuroxime 750 mg, as Cefuroxime sodium BP. Cefotil® 70 ml Powder for Suspension: Each 5 ml suspension contains Cefuroxime 1 25 mg as Cefuroxime axetil BP. Indication . Upper respiratory tract infections, Lower respiratory tract infections, Skin and soft tissue infections, Genito-urinary tract infections, Gonorrhoea . : The usual dose is 125 mg b. d., or 1 0 mg/kg b. d. to a maximum of 250 mg daily. For otitis media, in children less than 2 years of age the usual dosage is 1 25 mg b. d., or 1 0 mg/kg b. d. to a maximum of 250 mg daily and in children over 2 years of age, 250 mg b. d., or 1 5 mg/kg b. d. to a maximum of 500 mg daily. There is no expe:ience in children under three months of age. The usual course of therapy is seven days. Cefuroxime should be taken after food for optimum absorption.

•

Dose

Infants and children (> 3 months) : 50 to 1 00 mg/kg/day in equally divided doses every 6 to 8 hours. Use 1 00 mg/kg/day not to exceed the maximum adult dose) for more severe or serious infections. Product Name Composition
Ceftron®

(Ceftriaxone) : Each 1 gm vial contains dry su bstance equivalent to 250 mg, 500 mg & 1 gm Ceftriaxone (as sterile Ceftriaxone Sodium U S P) accom panied by a solvent ampoule of 3.5 ml Lidocaine 1 % Injection USP for 1 M injection or 5 or 1 0 ml Water for Injection BP for IV injection. : Renal and Urinary Tract Infections, Lower Respiratory Tract Infections, Particularly Pneum onia, Skin and soft tissue, bone and joint infections, Bacterial Meningitis & ENT infections.
.

Indication

Dose

Typhoid Fever: 4 to 1 7 years : 75 mg/kg o.d. 1M, 7 days Septc i days Infectious o.d. 1M, 3 days.

Product Name . Lebac® (Cephradine) . After reconstitution, each 1 .25 ml Pediatric drop Composition contains Cephradine BP 1 25 mg. . Infectious diseases. Indication Dose . 25 to 50 mg/kg/day given in 2 to 4 equally divided doses.

Product Name Composition Indication Dose Product Name Composition

:

LoraceF

,

(Cefaclor) Each 5 ml reconstituted suspension contains Cefaclor 1 25 mg as Cefaclor Monohydrate USP. Infectious diseases. 1 month to 1 year: 0.625 mi.
:

MaxceF

(Cefotaxime) : Each vial injection contains Cefotaxime USP 250 mg, 500 mg & 1 gm as Cefotaxime Sodium. Each ampoule contains a solvent of 5 or 1 0 ml water for injection. Infectious diseases. Children: 1 00 - 1 50 mg/kg/day in 2 to 4 divided doses Neonates: 50 mg/kg/day in 2 to 4 divided doses.

Indication Dose

Doxycycline

Product Name Composition Indication

:

Doxacil"

(Doxycycline) . Each capsule contains Doxycycline Hydrochloride BP equivalent to Doxycycline BP 1 00 mg. . RTI, Genitourinary tract infection, C h lamydial infection, Streptococcal & Staphylococcal infection, Tropical sprue. : Children over 8 yrs: 4.4 mg/kg on first day followed by 2.2 mg/Kg/day.

Dose

Fluroquinolone

Product Name Composition

.

Ciprocin®

(Ciprofloxac in) . Afte r Reconstitution, each 5 ml suspension contains Ciprofloxacin USP 250 mg as Hydroc hloride. Complicated Urinal)' Tract Infection or Pyelonephritis. Ciprocin® may be given orally without regard to meals. Patients receiving Ciprocin' should be well hydrated and should be instructed to drink plenty of fluids liberally. Because of the risk of cl)'stalluria, it is recommended that the usual dosage of the drug should not be exceeded. The usual oral dose is 1 0 mglkg (maximum 750 mg per dose; not to be exceeded even in patients weighing> 51 kg) twice daily for 1 0-21 days. The intravenous dose is 6- 1 0 mglkg (maximum 400 mg per dose; not to be exceeded even in patients weighing> 5 1 kg) 8 hourly for 1 0-21 days.
Macrolides

Indication Dose

Product Name Composition

Eromycin®

(Erythromycin) Each 5 ml of paediatric drops contains Erythromyc in ethylsuccinate USP equivalent to 200 mg Erythromycin USP. Alternative to a penic illin in penicillin-sensitive penicillin-resistant staphylococcal patients, infect ions, alternative to a tetracyc line in Mycoplasma pneumonia, Pertusis diphtheria, especially in treatment of the carrier state. Rheumatic fever prophylaxis, Chronic bronchitis, Otitis media.

Indication

Dose

. The usual regimen is 30 - 50 mg/kg/day. In severe cases the dose may be doubled.
Zimax'

Product Name Composition

(Azithromycin) After reconstitution, each 5 ml suspension contains Azithromycin USP 200 mg as Azithromycin Dihydrate. LRTI including Bronchitis & Pneumonia. URTI including Sinusitis & Pharyngitis / Tonsillitis. Otitis media. Skin & Soft tissue infections.
Dose

Indication

Children over 6 months of age: 1 0 mg/kg body weight once daily for 3 days. Children with body weight 1 5-25 kg (3-7 years): 200 mg once daily for 3 days. Children with body weight 26-35 kg (8- 1 1 years): 300 mg once daily for 3 days; Children with body weight 36-45 kg (12-14 years): 400 mg once daily for 3 days. Children with body weight over 45 kg: Normal adult dosage is recommended.

Medium and Narrow Spectrum Penicillin Product Name Composition Penvik®

"

(Phenoxymethyl Penic illin) Each 5 ml reconstituted suspension contains Phenoxymethyl penicillin BP 1 25 mg as Potassium salt. . For the treatment of mild to moderate infections by gram-positive organisms including upper respiratory tract infections, recurrence of rheumatic fever.

Indication

Dose

. Children: 1 25-250 mg every 6 hours. Infants: 62.5-125 mg every 6 hours.

Product Name . Phylopen® (Fl ucloxaci Ilin) Composition Each 5 ml reconstituted suspension contains Flucloxacillin BP 1 25 mg as Flucloxac illin Sodium BP. . For the treatment of skin and soft tissue infections including boils, abscesses, carbuncles, celiulites, infected burns, wounds, impetigo. 2-10 years: 1 25 mg (5 ml) every 6 hours. Under 2 years: 62.5 mg (2.5 ml) every 6 hours.

Indic ation

Dose

Other /3-lactum Antibiotic except
Product Name : Specbac® (Meropenem) Composition Specbac® 500 mg IV injection : Each vial contains dry substance equivalent to Meropenem USP 500 mg accompanied by a solvent ampoule of 1 0 ml Water for Injection BP. Specbac· 1 gm IV injection : Each vial contains dry substance equivalent to Meropenem USP 1 gm accompanied by two solvent ampoules of 10 ml Water for Injection BP. Indication : Pneumonias and Nosocomial Pneumonias Urinary Tract Infections Intra-abdominal Infections Skin and Skin Structure Infections Meningitis Septicaemia Other polymicrobial infections Infants under 3 months:

Dose

Effic acy and tolerability in infants under 3 months old have not been established; therefore, Specbac is not recommended for use below this age. Children over 3 months: Over 3 months to 1 2 years 1 0 to 20 mg/kg every 8 hours Children over 50 kg weight, adult dosage should be used 4 years to 1 8 years with cystic fibrosis - 25 to 40 mg/kg every 8 hours In meningitis - 40 mg/kg every 8 hours There is no experience in children with altered hepatic or renal function.
-

Tetracyclines

Product Name Composition Indication

Tetrax�

[Tetracycline) . Each capsule contains Tetracycline Hydroch loride BP 500 mg. . Ricketsial infection, Chlamydial infection, Relapzing Fever, Bronchitis & Anaerobic Infections with susceptible organisms. Dose : Children over 8 years: 25-50 mg/kg/day or, 0.6-1.2 g/square metre

Quinolone

Product Name . Nalid® (Nalidixic Acid) Composition Indication Dose : After reconstitution, each 5 ml suspension contains Nalidixic acid BP 300 mg. . Urinary tract infection. Infants and children 3 months of age and over:-

Initial : Oral 1 3.75 mg/kg every six hours for 1 -2 weeks. Maintenance : Oral 8.25 mg/kg every six hours or as prescribed by the physician.
Anti-Epileptic

Product Name . Epitra® (Clonazepam) Composition Epitra® 0.5 mg tablet: Each tablet contains Clonazepam 0.5 mg. Epitra® 2 mg tablet: Each tablet contains Clonazepam 2 mg. Indication . Clonazepam is a 'Calmer' and is often prescribed to treat (but not to cure) general symptoms of Anxiety as well as panic disorder, with or without agoraphobia; Epilepsy and other seizure disorders. Alone or as an adjunct in the management of myoclonic and akinetic seizures and petit mal variant (Lennox-Gastaut syndrome). May also be of some value in patients with absence spells (petit mal) who have failed to respond to succinim ides. . Must be determined individually according to clinical response and tolerance and depends primarily on the patient's age. In order to minimize drowsiness, the initial dose for infants and children (up to 10 years of age or 30 kg) should be between 1 0 and 30 mcg/kg/day and should not exceed 50 mcg/kg/day given in 2 or 3 divided doses. Dosage should be increased by no more than 250 to 500 mcg every third day until a maintenance dose of 1 00 to 200 mcg/kg has been reached, unless seizures are controlled or adverse effects preclude further increase.

Dose

Whenever possible, the daily dose should be divided into 3 equal doses. If doses are not equally divided, the larger dose should be given before retiring.
Antihistamine

Product Name Composition Indication

.

Adryl"

(Diphenhydramine) . Each 5 ml syrup contains Diphenhydramine Hydrochloride BP 1 0 mg Seasonal, perennial & vasomotor rhinitis; urticaria, angioneurotic edema, anaphylaxis; pruritus; preanesthetic medication, emesis, motion sickness; cough & cold. Sometimes it may use as a night time sleep aid and for the short-term management of Insomnia.
• •

Dose

6to 12years: 1 0 mg (5 ml of synup) 3 to 4 times a day.
I to 6years: 5 mg (2.5 ml of synup) 3 to 4 times a day.

The maximum daily dose should not exceed 300 mg. Product Name . Alarid" (Ketotifen) Composition Indication Each 5 ml syrup contains Ketotifen Fumarate BP 1 .38 mg equivalent to 1 mg Ketotifen.

. It is indicated for the symptomatic treatment of allergic conditions including rhinitis and conjunctivitis, prophylactic treatment of bronchial asthma.

Dose

6 months to 3 years: 0.05 mg (0.25 ml of syrup) per kg of body weight twice daily with food, On the morning and evening). Children above 3 years: 1 mg twice daily with food. Patients known to be easily sedated should begin treatment with 0.5 to 1 mg at night for the first few days or as directed by the physician.

Product Name Composition

Alatrol®

(Ceti rizi ne) . Alatrol® Paediatric Drops : Each m l Pediatric Drop contains Cetirizine Dihydrochloride BP 2.5 mg. Alatrol® Syrup : Each 5 ml syrup contains Ceti rizine Dihydrochloride BP 5 mg. Indication : Symptomatic relief of allergic conditions including rhinitis (seasonal & perennial), chronic idiopathic urticaria and pruritus for children 6 months of age & older. Alatrol® Paediatric Drops : 6 months to 77 months: 1 ml (2.5 mg) once daily. 72 months to 23 months: 1 ml (2.5 mg) once daily. The dose can be increased to a maximum dose of 2 ml (5 mg) per day, given as 1 ml (2.5 mg) every 12 hours. Alatrol® Syrup : 6 months to < 2 years: '/2 teaspoonful once daily. The dose in children 1 2 to 23 months of age can be inc reased to a maximum dose as '/2 teaspoonful every 1 2 hours. 2 to 6 years: Alatrol® Syrup : 1 teaspoonful once daily or '/2 teaspoonful twice daily Children over 6 years and older: Alatrol® Syrup : 2 teaspoonfuls once daily or 1 teaspoonful twice daily. Product Name Composition
Antista®

Dose

(Ch lorphen ira mine) : Each 5 ml syrup contains Chlorpheniramine Maleate BP 2 mg

Indication

Symptomatic relief of allergic conditions including urticaria and angioedema, rhinitis, and conjunctivitis, pruritic skin disorders, symptomatic treatment of cough and the common cold. 7 to 2 years : 1 mg twice daily. 2 to 5 years : 1 mg every 4 to 6 hours (maximum 6 mg daily). 6 to 72 years : 2 mg every 4 to 6 hours (maximum 1 2 mg daily).
•

Dose

Product Name Composition Indication

Loratin®

(Loratadine) Each 5 ml Suspension contains Loratadine USP 5 mg.
•

It is indic ated for the treatment of al lergic rhinitis (seasonal & perennial), skin allergies including chronic idiopathic urticaria (CIU). 2 to 5 years : 1 teaspoonful once daily. Children over 6 years and older : 2 teaspoonfuls once daily.

Dose

Product Name CompOSition Indic ation

Sedno®

(Desloratadine) Each 5 ml syrup contains Desloratadine INN 2.5 mg. Allergic rhinitis : It is indicated for the relief of the nasal and non-nasal symptoms of allergic rhinitis (Both seasonal and perennial) . Chronic Idiopathic Urticaria : It is also indicated for the symptomatic relief of pruitus, reduction in the number of hives and size of hives, in patients with chronic idiopathic urticaria. Dose
•

2 to 5 years : 2.5 ml (teaspoonful) once dai ly. 6 to 77 years :

5 ml (1 teaspoonful) once daily. Children over 72 years : 1 0 ml (2 teaspoonfuls) once daily.
Antiparasite Preparations

Product Name : Almex® (Albendazole) Composition . Almex' 400 tablet : Each chewable Tablet contains Albendazole USP 400 mg. Almex® Suspension : Each 5 ml Suspension contains Albendazole USP 200 mg. Indication Dose · Mixed helminthic infections. : 200 mg as a single dose. : 1 - 2 years 2 years & above : 400 mg as a single dose.

Product Name : Ermox® (Mebendazole) Composition : Ermox® 1 00 Tablet : Each tablet contains Mebendazole USP 100 mg. Ermox® Suspension : Each 5 ml suspension contains Mebendazole USP 1 00 mg.
.

Indication Dose

· Mixed helminthic infection. · 2 years and above : Ermox® 1 00 Tablet : One tablet twice daily for 3 days. Ermox® Suspension : One teaspoonful twice daily for 3 days.

Product Name : Malacide® (Sulphadoxine + Pyrimethamine) Composition . Each tablet contains Sulphadoxine BP 500 mg and Pyrimethamine BP 25 mg.

Ind ication

: Malara i malariae. Prophylactic Management. Chloroquine Resistance.

Dose

Curative and prophylactic treatment : 1/2 tablet as a single dose for children under 4 years 1 tablet as a single dose for children 4 8 years 2 tablets as a single dose for 8 1 4 years.
-

Antiprotozoal
Product Name Composition Amodis"

(Metronidazole)
.

Amodis® 400 Tablet : Each tablet contains Metronidazole BP 400 mg. Amodis® Suspension : Each 5 ml suspension contains Benzoyl Metronidazole equivalent to Metronidazole BP 200 mg.

Indication Dose

Intestinal amoebiasis, Anerobic infections. Amodis� 400 Tablet : 7 years and above: One tablet ti.d. for 5 to 1 0 days. Amodis" Suspension : 1 3 years : 200 mg t.i.d. for 5 to 1 0 days.
-

3
7

-

7 years

:

200 mg q.i.d. for 5 to 1 0 days.

-

10 years: 400 mg t.i.d. for 5 to 1 0 days.

Product Name . Secnid" (Secnidazole)
Composition

. Secnid' DS tablet : Secnid" DS aromatic film coated tablet contains Secnidazole INN 1 gm.

Secnid® 500 mg Suspension : Dry granules for oral suspension equivalent to Secnidazole I N N 500 mg in a single dose bottle. Indication : Secnidazole is ind icated for the treatment of intesti nal Amoebiasis, Hepatic Amoebiaisis, Giardiasis. Acute Intestinal Amoebiasis and Giardiasis : 30 mg Ikg body weight as a single dose. Asymptomatic Amoebiasis : 30 mg/kg once daily for 3 days, taken preferably just before meal. Hepatic Amoebiasis (5 days treatment) : 30 mg/kg body weight as a single or divided doses before meals for 5 days. In suppurative hepatic amoebiasis, Secnidazole therapy should be complemented by abscess drainage. Product Name : Zox® (Nitazoxanide) Composition Indication Dose . After reconstitution, Each 5 ml Suspension contains Nitazoxanide INN 1 00 mg. . Protozoal diarrhea, Intestinal amoebiasis, Giardiasis, Helminthic infection. . 1 4
-

Dose

4 years

:

1 00 mg twice daily for 3 days.

-

1 1 years : 200 mg twice daily for 3 days. : 500 mg twice daily for 3 days.

> 12 years

Antispasmodic Drugs

Product Name . Colicon® [Dicycloverine) Composition : Colicon® Tablet : Each tablet contains Dicycloverine hydrochloride BP 1 0 mg. Colicon® Syrup : Each 5 ml syrup contains Dicycloverine hydrochloride BP 1 0 mg.

Colicon® Injection : Each 2 ml ampoule contains dicycloverine Hydroc hloride BP 20 mg. Indication Irritable bowel syndrome (Diarrhoea Predominant) Infantile colic G IT spasm Diverticulitis Abdominal colic Diarrhea, Dysentery. . 6 months 2 years : 5-10 mg 3 times/day.
-

Dose

2 years

-

12 years : 1 0 mg 3 times/day.

Calcium

Product Name Composition

Calbo® Jr, (Calc ium Carbonate) Each chewable Tablet contains Calcium Carbonate BP 625 mg equivalent to 250 mg elemental Calcium. Raised calcium requirement for children and adolescents at times of rapid growth, inadequate intake of calcium in the diet due to maln utrition, preve ntion and treatment of osteoporosis, disorders of osteogenesis and tooth formation (in addition to specific treatment), latent tetany and during pregnancy and lactation. Children Adolescents : 1 tablet daily : 1 - 2 tablets daily.

Indication

Dose

eNS
Anti-Emetics and Anti-Vertigo

Product Name : Cinaron� (Cinnarizine) Composition . Each tablet contains Cinnarizine BP 1 5 mg. Indication Dose
Anti-Migraine

. Prophylaxis of motion sickness : 5 to 12 years: 15 mg two hours before the start of journey, 7.5 mg every 8 hourly during the journey.

Product Name : Migranil" (pizotifen) Composition Indication : Each film-coated tablet contains Pizotifen BP 0.5 mg & 1.5 mg. : It is indicated for the prophylactic treatment of vascular headaches of the migraine type such as classic migraine, common migraine & cluster headache . Up to 1 .5 mg daily, usually as a divided dose. Use of 1.5 mg at a time is not recommended but up to 1 mg has been given as a single daily dose at night.
Tranquillizers

Dose

Product Name Composition

Sedil'

(Diazepam) . Sedil" Tablet : Each tablet contains Diazepam BP 5 mg. Sedil" Injection : Each ml injection contains Diazepam BP 5 mg. Indication Dose : Not indicated for children less than 6 month. Used as muscle relaxant, status epilepticus. : 0.2 to 0.3 mg/kg body weight IV / 1M or 1 mg per year of age.
"

Eye and Ear Preparations

Product Name Composition

Alaco�

(Olopatadine) . Alacot'" 0.1% Eye Drops : Each ml contains Olopatadine 1 mg as Olopatadine Hydrochloride INN. : Alacot® 0.1 % Eye Drops is indicated for the treatment of the signs and symptoms of allergic conjunctivitis. : One drop in each affected eye two times per day at an interval of 6 to 8 hours.
Ciprocin'"

Indication

Dose Product Name Composition

(Ciprofloxacin) Each ml of Ciprocin'" 0.30(0 Eye/Ear Drops contains Ciprofloxacin hydrochloride USP 3.5 mg equivalent to 3 mg base. . Ocular Infections: conju nctivitis, keratitis, keratoconj unctivitis, corneal ulcers, blepharitis, blepharoconjunctivitis, acute meibomianitis and dacryocystitis due to strains of microorganisms susceptible to antibiotics. Otic infections: Otitis externa, acute otitis media, chronic suppurative otitis media. . Ocular infections the usual dose is 1 -2 drops in the affected eyers) 4 times a day. In severe infections, the dosage for the first two days may be 1 -2 drops every 2 hours during working hours. Product Name : Genacyn'" (Gentamicin) . Each Composition ml of Genacyn® 0.3% Eye/Ear Drops contains Gentamicin BP 3 mg as sulphate.

Indication

Dose

Indication

. Ocular Infections: conjunctivitis, keratitis, keratoconj unctivitis, corneal ulc ers, blepha ritis, blepharoconjunct ivitis, acute meibomianitis and dacryocystitis due to strains of microorganisms susceptible to antibiotics. Otic Infections : For the prophylaxis against infection in trauma of the ear.

Dose

. Ocular Infections: 1 or 2 drops should be instilled in the affected eye up to six times a day, or more frequently if required. Severe infections may require 1 or 2 drops every fifteen to twenty mi nutes initially, reducing the frequency of instillation gradually as the infection is controlled. Otic Infections : The area should be cleaned and 23 drops instilled in the affected ear 3-4 times a day and at night, or more frequently if required.

Product Name Composition Indication

Iventi"

(Moxifloxacin) Eac h ml 0.5% eye drop contains Moxifloxacin 5 mg as Moxifloxac in Hydrochloride INN. Bacterial conjunctivitis caused by susceptible strains of the following organisms :Aerobic Gram-positive mic roorganisms Corynebac terium species, Micrococcus luteus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolytic us, Staphylococcus hominis, Staphylococcus warneri, Streptococcus pneumoniae, Streptococcus viridans group. microorganisms: Gram-negative Aerobic Acinetobacter Iwoffii, Haemophilus influenzae, Haemophilus parainfluenzae. Other microorganisms : Chlamydia trachomatis. One drop in the affected eye 3 times a day for 7 days.

Dose

Product Name Composition Indication

Mexlo®

(Lomefloxacin) . Each ml of Mexlo· 0.3% Eye Drops contains Lomefloxacin INN 3 mg (as hydrochloride 3.31 mg). . Ocular Infecton i (eg, conjunctivitis, keratitis, keratoconjunctivitis, corneal ulc ers, blepharitis, blepharoconjunctivitis, acute meibomianitis and dac ryocystitis) due to strains of microorganisms suscepti ble to antibiotics. Dose A loading dose of one drop every 5 minutes for 20 min utes (5 doses) followed by a maintenance dosing schedule of one drop two times a day for 79 days.
Nacromino

Product Name Composition Indic ation

(Sodium Cromoglycate) Each ml Nacromino 2% eye drops contains sodium c romoglycate BP 20 mg. For the prophylaxis and symptomatic treatment of acute allergic conjunctivitis, chronic allergic conjunctivitis and vernal kerato conjunctivitis. Children over 4 years: 2 drops in each eye 4 times daily at regular intervals.
SQ-Mycetin"

Dose Product Name Composition Indication

(Chloramphenicol) . Each ml SQ-Mycetin® 0.5% Eyel Ear drops contains 5 mg Chloramphenicol BP. Ocular Infections : conju nctivitis, keratitis, keratoc onjunctivitis, corneal ulcers, blepharitis, blepharoconjunctivitis, acute meibomianitis and dacryocystitis due to strains of microorganisms susceptible to antibiotics.

Otic Infections : Otitis externa caused susceptible bacteria. Dose

by

: Ocular Infections: Instill 2 drops in affected eye(s) every hour, or instill four times per day depending on the severity of the infection. Otitis externa : Instill 2-3 drops into the the affected ear canal(s) every 6-8 hours.
Hematinics

Product Name Composition

.

Polyron"

(Elemental Iron) Each 5 ml syrup contains Iron (III) Hydroxide Polymaltose Complex equivalent to 50 mg Elemental Iron. Treatment of Iron deficiency Anaemia. Premature babies (Less than 1500 gm) : 3 mg Iron/kg body weight daily. Infants (5-1 0 kg): 2.5 ml to 5 ml once daily immediately after meals. Children ( 2-6 years) : 5 ml once or twice per day immediately after meals. Children (6- 12 years) : 5 ml to 1 0 ml once or twice per day immediately after meals.
Non-Narcotic

Indication Dose

Product Name Composition

Ace®

(Paracetamol) Ace" Syrup : Each 5 ml syrup contains Paracetamol BP 120 mg. Ace® Suspension : Each 5 ml suspension contains Paracetamol BP 120 mg.

Indication

Ace� Paediatric Drops (1 5 ml & 30 mil : Each ml drop contains Paracetamol BP 80 mg. Ace'" Suppository (60 mg, 125 mg & 250 mg) : Each suppository contains 60 mg, 125 mg & 250 mg Paracetamol BP. Fever, common cold and influenza, headache, toothache, earache, bodyache, inflammatory pain, and post-vaccination pain and fever of children. T ablet (500 mg) : Children (6- 12 years) : 1/2 to 1 tablet 3 to 4 times daily. Syrup and Suspension (120 mg/ml): Children Under 3 months: 1 0 mg/kg body weight (reduce to 5 mg/kg if jaundiced) 3 to 4 times daily. 3 months to below 1 year : 1/2 to 1 teaspoonful 3 to 4 times daily. 1 -5 years : 1 -2 teaspoonful 3 to 4 times daily. 6- 1 2 years : 2-4 teaspoonful 3 to 4 times daily. Paediatric Drop (80 mg/mO : Children months : 0.5 ml (40 mg) 4 to 1 1 months : l .0 m l (80 mg) 1 to 2 years : l .5 ml (120 mg) Upto 3

Dose

Suppository (60 mg, 725 mg & 250 mg) : Suppository should be administered rectaly. Children 3 months-1 year : 60-120 mg, 1 -4 times daily. Children 1 -5 years : 1 25-250 mg, 1 -4 times daily. Children 6-12 years : 250-500 mg, 1 -4 times daily.

Product Name : Neurolep"

(Piracetam)
Composition Indication
.

Each Tablet contains 800 mg Piracetam. i) Cerebral vascular accid ents and cerebral insufficiencies : Ischemic or even hemorrhagic acute accidents, chronic manifestations of the above accidents or of cerebral atherosclerosis. ii) Mental retardation in children : Ease of resuming individual contact, sociability and learning, improved intellectual performance and school results. iii) Behaviour and psychotic problems in old age : Memory deficits, particularly with regard to fixation and evocation asthenia adoption disorders, disturbed psychoomotor reactions.

.

Dose

: The total daily dose can range from 30- 1 60 mg/kg/day depending on the indication.This is administered twice daily, but may also be given in 3 or 4 separate doses.
NSAlDs

Product Name Composition

Clofenac"

(Diclofenac) Each enteric coated tablet contains Diclofenac Sodium BP 25 mg. Each suppository contains Diclofenac Sodium BP 12.5 mg.
Indication

: Juvenile Arthritis (for children of 1 - 1 2 years old)

Dose Product Name Composition

• •

1-3 mg/kg daily in divided doses (by mouth & by rectum)
Sonap®

•

(Naproxen)
•

Each enteric coated tablet contains Naproxen Sodium USP 273.87 mg equivalent to Naproxen USP 250 mg.
.

Indication Dose

• •

Juvenile Arthritis (for children over 5 years). 1 0 mg/kg daily in 2-divided doses.
Tract

• •

Asthma Preventers

Product Name : Beclomin® (Beclomethasone) Composition Indication . Metered-dose aerosol delivers Beclomethasone Dipropionate BP 1 00 �g per puff. Beclomin Inhaler is indicated for a wide range of patients with bronchial asthma including patients whose asthma is poorly controlled by bronchodilators alone; those who are inadequately controlled by sodium cromoglycate in addition to bronchodilators; those with severe asthma who are dependent on systemic corticosteroids, or adrenocorticotrophic hormone (ACTH) or its synthetic equivalent. Composition Beclomethasone dipropionate 1 00 mcg/puff Presentation 200 puffs

Dosage form Beclomin 1 00 Inhaler Dose

: Children : 200-800 mcg/day.

Product Name Composition Indication

Nacromin'"

(Sodium Cromoglycate) Each Nacromin'" Cozycap contains Sodium Cromoglycate BP 20 mg . . Nacromin cozycaps is indicated for the prophylactic therapy of bronchial asthma, including the prevention of exercise-induced asthma. Nacromin cozycaps are not indicated for the relief of acute bronchospasm. Nacromin cozycaps should only be used for inhalation through the cozyhaler Dose Children above 2 years : Initiating dose : 1 cozycap 4 times daily, using the cozyhaler Maintenance dose : 2 or 3 cozycaps per day, using the cozyhaler. Product Name Composition .
Salmate'"

(Salmeterol) Each puff delivers Salmeterol Xinafoate I N N equivalent to 25 �g Salmeterol l N N. Each Salmate'" inhaler canister contains 5 mg of Salmeterol INN as Xinafoate. : Salmate is indicated in the longterm treatment of asthma Oncluding patients with nocturnal asthma and exercise induced asthma) and chronic obstructive pulmonary disease (CO PO). Patients with asthma should normally also be receiving anti­ inflammatory therapy. Salmate is not indicated for the relief of acute bronchospasm. Composition Salmeterol 25 mcg/puff Presentation 200 puffs

Indication

Dosage form Salmate Inhaler

Dose Product Name Composition

Children 4 years & above : Asthma: 2 puffs twice daily.
Ticamet®

(Salmeterol + Fluticasone) . Each single actuation of Ticamet provides 25 micrograms of sal meterol (as salmeterol xinafoate) and 50, 1 25 or 250 micrograms of fluticasone propionate (delivered from the valve). Ticamet is indicated in the regular treatment of asthma where use of a combination product Oong­ acting beta-2-agonist and inhaled corticosteroid) is appropriate : Patients who are not adequately controlled with inhaled corticosteroids and 'as needed' inhaled short acting beta-2-agonist or Patients who are already adequately controlled on both inhaled corticosteroid and long-acting beta2-agonist Dose Adolescents 72 years and older : Two inhalations of 25 micrograms salmeterol and 50 m icrograms fluticasone propionate twice daily. or, Two inhalations of 25 micrograms salmeterol and 1 25 micrograms fluticasone propionate twice daily. or, Two inhalations of 25 micrograms salmeterol and 250 micrograms fluticasone propionate twice daily. Children of 4 years and older: Two inhalations of 25 micrograms salmeterol and 50 micrograms fluticasone propionate twice daily.

Ind ication

Bronchodilators

Product Name Composition

Iprex®

Opratropium) Iprex® Inhaler : Each puff delivers 20 IIg of Ipratropium Bromide BP. Each canister of Iprex· inhaler contains 4 mg of Ipratropium Bromide BP. Iprex® Respirator Solution : Iprex· Respirator Solution is an aqueous colorless solution of Ipratropium bromide. Each ml of the solution contains 250 mcg of Ipratropium Bromide BP. Indication Iprex® Inhaler : For the treatment of chronic reversible airways obstruction, particularly in chronic bronchitis. There is evidence that the concurrent administration of Iprex and sympathomi metic drugs produces a greater relief of bronchospasm than either agent given alone. Iprex Inhaler has been shown to produce effective bronchodilation in patients receiving beta­ adrenergic blocking agents. Dosage form Iprex Inhaler Composition Ipratropium Bromide 20 mcg/puff Presentation 200 puffs

Iprex· Respirator Solution : Maintenance treatment of bronchospasm associated with chronic obsructive pulmonary disease including chronic bronchitis and emphysema. Dose . Iprex· Inhaler Children of 6- 72 years : 1 -2 puffs thrice daily Children Under 6 years : 1 puff thrice daily. Iprex· Respirator Solution Children over 3 years : 0 . 4-2 m l of the prepared solution should be administered 3 times daily.

Product Name Composition

.

Levostar"

(levosalbutamolj . Levostar" 1 Tablet : Each tablet contains Levosalbutamol Sulphate equivalent to Levosalbutamol lN N 1 mg. Levostar" 2 Tablet : Each tablet contains Levosalbutamol Sulphate to equivalent Levosalbutamol lNN 2 mg. Levosta� Syrup: Each 5 ml syrup contains Levosalbutamol Sulphate equivalent to Levosalbutamol lNN 1 mg . Indication : Treatment or prevention of bronchospasm in adults, adolescents, and children of 6 years and older with reversible obstructive airway disease. Levosta� 1 & 2 mg Tablets : Adolescents above 12years : 1-2 mg three times daily. Children of 6 1 1 years : 1 mg three times daily.
-

Dose

Levosta� Syrup : Children of 6 I I years : 5 ml three times daily.
-

Product Name Composition

Sultolin®

(Sulbutamoi] Sultolin® Tablet : Each Tablet contains 4 mg Salbutamol as Salbutamol Sulphate BP. Sultolin® Syrup : Each 5 ml Syrup contains 2 mg Salbutamol as Salbutamol Sulphate BP. Sultolin® Inhaler : Metered-dose aerosol delivers Salbutamol BP 1 00 �g per puff. Sultolin® Respirator Solution : It is an aqueous colourless solution of Salbutamol Sulphate BP adjusted with acid pH 3.5. Each millilitre of the solution contains 5 mg of Salbutamol BP.

Indication

: For the relief of bronchospasm in patients with reversible obstructive airway diseases like Bronchial asthma, Chronic bronchitis, Emphysema etc. Sultolin® Respirator Solution is indicated for the treatment of severe acute asthma (status asthmaticus) and also forms of bronchospasm.

Dose

: Sultolin® Tablet : 2 - 4 mg 3

-

4 times daily.

Sultolin® Syrup : 1 - 2 mg 3 - 4 times daily (Children of 2 - 6 years) Sultolin® Respirator Solution : By Intermittent Administration Children under 12 years of age : 0.5 ml of the solution diluted to 2.0 - 4.0 ml with normal saline. Some children may however require higher doses of upto 1 .0 ml of the solution. Intermittent treatment may be repeated four times a day. By Continuous Administration : Sultolin Respirator Solution is diluted with normal saline for injection, 1 -2 ml solution made upto 1 00 ml with dil uent. The diluted solution is administered as an aerosol by a suitably driven nebuliser. The usual rate of administration is 1 -2 mg/hour. Delivery of the aerosol may be by face mask or via an endotracheal tube. Intermittent positive pressure may be used but is rarely necessary. When there is risk of anoxia through hypoventilation, oxygen should be added to the inspired air. Dilution : Sultolin Respirator Solution may be diluted with Sodium Chloride Injection MP (normal saline). Solutions in nebulisers should be replaced daily.

& Cold Remedies
Product Name : Ambrox® (Ambroxol) Composition Ambrox' Pediatric Drops : Each ml contains 6 mg Ambroxol hydrochloride BP. Ambrox· Syrup : Each 5 ml contains 1 5 mg Ambroxol hydrochloride BP. Indication Productive Cough : Acute and chronic inflammatory disorders of respiratory tract disorders associated with viscid mucus. Inflammatory disorder of rhino-pharyngeal tract (e.g. rhinitis, laryngitis, pharyngitis). Asthmatic bronchitis, bronchial asthma with hard expectoration. Dose . Ambrox· Pediatric Drops : o 6 months : 0.5 ml, 2 times a day
-

6 7

-

72 months : 1 ml, 2 times a day 2 years : 1 .25 ml, 2 times a day

-

Ambrox· Syrup : 2 - 4 years : 2.5 ml (1/2 teaspoonful) 2-3 times a day. 5 - 70 years : 5 ml 0 teaspoonful) 2-3 times a day. 70 years and above : 1 0 ml (2 teaspoonfuls) 3 times a day. . Product Name : Brofex· (Dextromethorphan) Composition Indication . Each 5 ml sugar free syrup contains Dextromethorphan Hydrobromide BP 1 0 mg. : Chronic dry cough / unproductive cough Acute dry cough which is interfering with normal function or sleep

..

Dose

.

2-6 years old: 2.5-5 mg every 4 hours or 7.5 mg every 6-8 hours to a maximum of 30 mg daily. 6-72 years old : 5-1 5 mg every 4-8 hours to a maximum of 60 mg daily. 72 years old and above: 1 0-20 mg every 4 hours or 30 mg every 6-8 hours to a usual maximum of 120 mg daily.

Product Name : Mucospel$ [Bromhexine) Composition . Mucospel$ Syrup : Each 5 ml syrup contains Bromhexine Hyrdochloride BP 4 mg. Mucospelo Tablet : Each tablet contains Bromhexine Hyrdochloride BP 8 mg. Indication : Indicated in the treatment of respiratory disorders associated with viscid or excessive mucus or productive cough which includes: Tracheobronchitis Bronchitic with emphysema Bronchiectasis Bronchitis with bronchospasm Chronic inflammatory pulmonary conditions Pneumoconiosis : Mucospelo Syrup : Children over 70 years: 2 to 4 teaspoonfuls (8 1 6 mg) 3 times a day. Initially 4 teaspoonfuls 3 times a day, then as required.
-

Dose

Children 5 daily

-

70 years: 1 teaspoonful (4 mg) 3 times

Children 2 - 5 years: '/2 teaspoonful (2 mg) 3 times daily Children below 2 years: 1 /4 teaspoonful (1 mg), 3 times daily.

MucospelO Tablet : Children over 10 years : 1 -2 tablets (8 1 6 mg), 3 times daily.
-

Children 5 10 years : '/2 tablet (4 mg) 3 times daily.
-

Product Name : l usca·

(Guaiphenesin + Pseudoephedrine + Triprolidine)
Composition

Indication Dose

: Each 5 m l syrup contains Guaiphenesin BP 1 00 mg, Pseudoephedrine hydrochloride BP 30 mg, Triprolidine hydrochloride BP 1 .25 mg. . Productive cough and upper respiratory tract disorders associated with productive cough 2 6
-

6 years : 2.5 ml C'h teaspoonful) 3 times daily. 12 years : 5 ml (1 teaspoonful) 3 times daily

-

12 years & above : 1 0 ml (2 teaspoonfu l) 3 times daily.
Nasal Decongestant Product Name : Antazol®

(Xylometazoline)
Composition Indication

: Each ml Antazol® 0.050/0 Nasal Drops contains Xylometazoline hydrochloride BP 0.5 mg & 1 mg. For the symptomatic relief of nasal congestion, perennial allergic rhinitis Oncluding hay fever), sinusitis. 1 or 2 drops in each nostril once or twice daily. Not to be used in infants under 3 months. (Oxymetazoline)

Dose

Product Name : Nocon· Composition

: Each ml Nocon® 0.050/0 Nasal Drops contains Oxymetazoline HCI USP 0.5 mg. Each ml Nocon® 0.0250/0 Pediatric Nasal Drops contains Oxymetazoline HCI USP 0.25 mg.

f
Indication : Relief of nasal congestion associated with: Acute and chronic rhinitis. Common cold. Sinusitis. : 6 years & above : 2 to 3 drops of Nocon® 0.05% in each nostril twice daily, in the morning and evening.
•

Dose

2 - 5 years : 2 to 3 drops of Nocon® 0.025% in each nostril twice daily in the morning and evening. Dosage for children younger than 2 years of age has not been established. Dxymetazoline HCI should generally be used for no longer than 3 - 5 days.
Multivitamin & Multiminerals
•

Product Name : 8-50$ Forte (Vitamin B-ComplexJ Composition
• •

Syrup Each 5 ml contains : Thiamine Hydrochloride Riboflavin Pyridoxine hydrochloride Nicotinamide

BP BP BP BP

5 2 2 20

mg mg mg mg

Indication

: B-Complex deficienciesDifferent physiological stressful conditions including conditions caused depletion or reduced absorption by glossitis, stomatitis, cheilosis, beriberi, polyneuritis. Maintenance of normal growth & health during early days of children. To supplement suspected depletion of B vitamins in pregnancy & lactation.

Dose Product Name Composition

For all age group of children : 2-3 teaspoonfuls daily or as di rected by the physician.
Bieozin"

(Multivitamin & Multiminerals) Each 5 ml of syrup contains Vitamin Bl (fhiamine Hydrochloride) Vitamin B, (Ribonavin-5-Phosphate Sodium) Vitamin B6 (Pyridoxine Hydrochloride) Nicotinamide Zinc (as Zinc Sulphate Monohydrate USPJ BP BP BP 5 mg
2 2

mg mg mg

BP 20 mg
10

Indication

For the treatment and prevention of B-vitamins and Zinc deficiencies & for the healthy growth and development of children. Infants & children <1 year : 5 ml (1 teaspoonful) 1 to 2 times daily or as recommended by the physicians. 1 - 16years : 1 0 ml (2 teaspoonfuls) 1 to 3 times daily or as recommended by the physicians.

Dose

Product Name Composition

•

Ceevit"

(Ascorbic Acid + Sodium Ascorbate)
• •

Each chewable Tablet contains Ascorbic acid BP and Sodium ascorbate BP equivalent to 250 mg of Ascorbic acid BP. Vitamin C deficiencies 2 years & older : 1 -2 tablets daily or as directed by physician

,

,

Indication Dosage

•

Product Name : Panvit® (Multivitamin & Multiminerals) Composition : Each 0.6 ml pediatric drops contains :
Vitamin A Vitamin D3 ,"tamin B, (Thiamine hydrochloride) ,"tamin B, (Riboftavin 5- Phosphate Sodium) ,"tamin B, (Pyridoxine hydrochloride) Nicotinamide Calcium D-Pantothenate Ascorbic acid (Sodium ascorbate) in palatable flavoured base BP BP BP BP BP BP BP BP
3000 600 0.96 0.60 0.60 6.0 3.0 30

IU IU mg mg mg mg mg mg

Indication Dose Product Name Composition Indication

: For prevention and treatment of threatened, mild, latent subclinical multivitamin deficiency. : 1 0-20 drops daily in divided doses or as advised by the physicians.
:

Zesup®

(Elemental Zinc) . Each 5 ml Synup contains Zinc Sulphate Monohydrate USP equivalent to 10 mg elemental Zinc. : Recurrent RespiratOlY Tract Infections Diarrhoea, Loss of appetite, Severe growth retardation, Deformed bone formation, Impaired Acrodermatits immunological response, enteropathica, Parakeratatic skin lesions, Defective and delayed wound healing, Anaemia, Night blindness, Mental disturbances. : Children under /0 kg : 1 teaspoonful 2 times daily. Children within /0 to 30 kg : 2 teaspoonfuls 1-3 times daily. Children over 30 kg body weight : 4 teaspoonfuls 1-3 times daily.

Dose

Antifungals

Product Name Composition Indication

.

Candex®

(Nystatin) Each ml Suspension contains Nystatin 1 lac units. . The prevention and treatment of candidal infections of the oral cavity, oesophagus and intestinal tract In intestinal and oral candidiasis (thrush) in infants and children, 1 ml should be dropped into the mouth four times a day. For prophylaxis in the new born, the suggested dose is 1 ml once daily. Product Name Composition Indication
Flugal®

Dose

(Fluconazole) Each 5 ml suspension contains Fluconazole I N N 50 mg. Superficial candida I infections, systemic candidiasis and cryptococcal infections Oncluding meningitis). . Children over 1 year : Superficial Candidal Infections : 1 -2 mg/kg daily; systemic candidiasis and cryptococcal infections Oncluding meningitis): 3-6 mg/kg daily On serious life threatening infections up to 12 mg/kg daily has been given to children aged 5-13 years-maximum 400 mg daily).

Dose

T opical Preparation
Anti-Infectives Product Name . Nebanol�

(Neomycin Sulphate + Bacitracin Zinc)
Composition

: Nebanol® Ointment : Each gram contains Neomycin Sulphate BP 5 mg and Bacitracin Zinc BP 500 I.U. Nebanolo Powder : Each gram contains Neomycin Sulphate BP 5 mg and Bacitracin Zinc BP 250 I.U.

Indication Dose

Nebanolo is indicated in the treatment of topical bacterial infections.
·

Oi ntment : A thin film to be applied 2 to 4 times daily Powder : To be applied 4 times daily.

Anti s cabies Product Name Composition Indication Dose
• •

Scabex'

(permethrin) Each 1 00 gm of Scabex· Cream contains 5 gm of Permethrin INN. Scabies. Scabex 1 5 gm
Children (over 12 years) Children aged 6-12 years Children aged 1- 5 years Children aged 2 months to
I

Scabex 30 gm
I

2 full tube

full tube

1 full tube up to '/2 of a tube year up to '/4 of a tube

up to '/2 of a tube up to '/4 of a tube up to '/8 of a tube

Anti-Itching and Moisturizer Product Name Composition Indication Dose Equra®

(Urea) . Each gram Cream contains 1 00 mg Urea BP. : Ichthyosis and dry skin condition, Management of Eczema and Psoriasis . . Apply thinly to the affected area for 2-3 times daily.

Non-Steroidal Anti-Eczema Product Name Composition Indication Dose Remus®

(Tacrolimus) Each gram Ointment contains 0.3 mg Tacrolimus INN. Eczema. Apply a thin layer of ointment to the affected area 2 times daily.

Plain Antifungal Product Name Composition Indication Dose Afuno

(Clotrimazole) Each gram Cream contains 1 0 mg Clotrimazole BP. Fungal infection. Apply thinly to the affected area 2 to 3 times daily for 2 to 3 weeks.
Fungidal"

Product Name Composition Indication Dose

(Miconazole) Each gram Cream contains Miconazole Nitrate BP 20 mg. Fungal infection. Apple to the affected area 2 to 3 times in a day for 2 to 5 weeks.

Plain Steroid

Product Name Composition

T icas®

(Fluticasone) : Ticas® 0.05% Cream : Each 1 00 mg ot Ticas· Cream contains 0.05 mg of Fluticasone Propionate. Ticas· 0.005% Ointment : Each 1 00 mg of Ticas· Ointment contains 0.005 mg of Fluticasone Propionate. Indication Dose : Dermatitis and Eczema. . Cream- Apply a thin layer of cream to the affected area once daily. Ointment- Apply a thin layer of ointment to the affected area twice daily.
Topicort·

Product Name Composition Indication Dose

(Hydrocortisone) . Each 1 0 gm Topicort" Cream contains Hydrocortisone Acetate BP 1 00 mg. : Dermatitis and Eczema. . Apply to the affected area 2 to 3 times daily.

irst Edition: June 2007

Published by: Product Management Department

SQUARE PHARMACEUTICALS LTD.

Square Centre 48 Mohakhali Commercial Area Dhaka-1212, Bangladesh. Telephone: (880)-2-8833047-56,8859007 ( 1 0 lines) Fa" (880)-2-8828608, 8828609 E-mail: pmdmail@squaregroup.com Web: www.squarepharma.com.bd

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