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					TABLE S4 Gene Symbol ACP5 ACTB AKT1 ALS2CR2 ARHGAP26 C9orf98 CAMK2B CDC2L1 CRK CSNK2A2 DMPK DUSP6 ENPP5 EPHB2 FES FLJ25006 IGF1R IKBKE ITGB1 LIMS1 LOC390975 MAP3K11 NRP1 PHPT1 PIK3R5 PRKCE PTPN6 RSU1 SGK3 TLN1 VEGFB VIM CONTROL Entrez Gene ID Migration bin Adhesion 54 D- cells become stretched during migration +++ 60 unique, extremely small protrusions, limited movement +++ 207 E- not significantly distinguishable from control -very small protrusions +++ 55437 E- not significantly distinguishable from control +++ 23092 D- cells become stretched during migration +++ 158067 E- not significantly distinguishable from control +++ 816 B- dynamic adhesions, vertical migration ++ 984 E- not significantly distinguishable from control +++ 1398 E- not significantly distinguishable from control +++ 1459 A- weak adhesion, erratic migration, unpolarised ++ 1760 B- dynamic adhesions, vertical migration ++ 1848 E- not significantly distinguishable from control +++ 59084 C- dynamic adhesion, larger cells ++ 2048 E- not significantly distinguishable from control +++ 2242 unique, large cells, death at end +++ 124923 E- not significantly distinguishable from control - larger cells +++ 3480 E- not significantly distinguishable from control -very small protrusions +++ 9641 D- cells become stretched during migration +++ 3688 E- not significantly distinguishable from control -very small protrusions +++ 3987 E- not significantly distinguishable from control +++ 390975 C- dynamic adhesion, larger cells ++ 4296 E- not significantly distinguishable from control - larger cells ++ 8829 E- not significantly distinguishable from control - larger cells +++ 29085 E- not significantly distinguishable from control -very small protrusions +++ 23533 E- not significantly distinguishable from control ++ 5581 D- cells become stretched during migration +++ 5777 A- weak adhesion, erratic migration, unpolarised ++ 6251 C- dynamic adhesion, larger cells ++ 23678 E- not significantly distinguishable from control ++ 7094 E- not significantly distinguishable from control +++ 7423 B- dynamic adhesions, vertical migration +++ 7431 E- not significantly distinguishable from control - larger cells +++ +++ Migration Directed, collective Directed, collective None Directed, collective Directed, collective, leader cells Directed, collective, leader cells Vertical Directed, collective, leader cells None Random None None Directed, random at edge None None Directed, collective, leader cells Directed. collective Directed, collective, leader cells None Directed, collective Directed, collective Directed, collective Directed, collective None Directed, collective Directed, collective, leader cells Random Directed Directed, collective, leader cells Directed, collective, leader cells Directed, vertical Directed Directed, collective Shape Epithelial, spinning nucleolus Epithelial Epithelial Epithelial Epithelial, spinning nucleolus Epithelial Epithelial, elongated, some death at end Epithelial, spinning nucleolus Larger epithelial Epithelial then elongated, some death at end Epithelial, some elongated edge cells, spinning nucleolus Epithelial Larger epithelial Larger epithelial Epithelial, lot of death at end Epithelial, larger at wound edge Epithelial Epithelial Epithelial, death at end Elongated, some death at end Larger epithelial, some death at end Larger epithelial Epithelial Compact epithelial Compact epithelial, some elongated, death at end Compact epithelial Epithelial and elongated Larger epithelial Epithelial Epithelial Larger epithelial Larger epithelial Epithelial DistanceMonolayer ++ +++ + ++ + ++ +++ ++ +++ + + + +++ + +++ +++ + +++ + +++ ++ + +++ + + + ++ + ++ +++ +++ + +++ + +++ + +++ + + + + +++ ++ +++ +++ + ++ ++ +++ + + + ++ + + +++ +++ Protrusion morphology Proliferation Medium, broad, edge only 11 Extremely small, edge only 7 Very small, edge only 45 Small, some narrow, edge only 10 Small to medium, edge only 26 Small, edge only 12 Small, some narrow, edge only 46 Small, edge only 15 Small, edge only 35 Very small, edge only 47 Small, some narrow, edge only 15 Small, some narrow, edge only 18 Small, some narrow 35 Medium, edge only 5 Very small, edge only 1 Small to medium, broad, edge only 20 Very small, edge only 14 Medium, broad, edge only 50 Very small, edge only 38 Small, edge only >50 Small to medium, edge only 30 Small, edge only 16 Small, edge only 36 Very small, edge only 32 Small to medium, some narrow, edge only45 Medium, broad, edge only 22 Large, many cells 6 Medium, edge only 18 Medium, broad, edge only 50 Small to medium, edge only 28 Medium, edge only 20 Medium, many cells 33 Small to medium, broad, edge only >50


				
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