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									Third Announcement Second International Conference on Cancer Risk Assessment (ICCRA 2)
Mathematical, Statistical and Computational Methods
May 25-27, 2007 Santorini, Greece

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1. GENERAL
The first International Conference on Cancer Risk Assessment (ICCRA) took place successfully in Athens (Greece), August 22-24, 2003, at the Technological Educational Institute of Athens. There were 52 participants, 35 papers from 16 countries. Therefore, the International Organizing Committee, decided, at the BIOSTAT2006 meeting in Cyprus (May 29-31, 2006), to proceed to the second ICCRA meeting. The meeting will take place At the island of Santorini, (Cyclades), Greece – www.greekislands.com/cuclades/santorini. The venue will take place at the hotel SANTORINI IMAGE – www.santorini-image.gr. For traveling instructions, booking etc please contact Mr Elias Frangoulis Director of the travel office KYVERNITIS at ilias@kyvernitis.gr SEE ALSO BELOW. The aim of this conference is to provide a forum for the discussion and exchange of ideas, new concepts and recent methods in cancer risk assessment. Stimulation of research on the interface between molecular biological research and mathematical modeling of the carcinogenic process and an improved transfer of risk assessment methodology to the risk management process are further achievements to be expected form this meeting.
Web site http://www.iccra.gr/02/iccra2.pdf

2. List of Topics
Carcinogenesis Modeling Biomarkers Probability Models for Cancer Research Nutrition, Aging and Cancer Studies Low-dose Response Analysis Biology of Aging Models Statistical Inference and Case Studies for Cancer Research Oncological Clinical Trial Environmental Toxicity and Carcinogenesis New Biological Data and Effects Appropriate Software for Cancer Research Microarray Data and Transcriptomics Analysis of Proteomic Data Pharmacokinetics and Pharmacogenetics Epidemiological Cancer Studies Prognostic and Predictive Studies . Please consider that you might submit either an Abstract OR a full Paper according to the instructions and the dates below: ABSTRACT : should be no more than two pages in WORD (14 for title, 12 for author name and address, 10 for the text and references) PAPER : should be no more than 14 pages. Please ask for the GuideLines file from the Local Organizer (xkitsos@teiath.gr

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3. Important Dates
Submission of Full Paper Notification and Review of the Paper Submission of the Final paper Submission of Abstracts to the Conference : : : : February 28, 2007 March 28, 2007 April 28, 2007 April 28, 2007

Fees, until 12 March 2007
The Regular Conference Fee is : 170 Euro For Students and Accompanying persons the Fee is : 100 Euro There is an extra charge of 50 Euros for all the delayed fees, beyond March 12, 2007.

4. The International Organizing Committee (IOC)
Mikhail Nikulin (France) Mei-Ling Ting Lee (USA) Lutz Edler ( Germany), Christos Kitsos ( Greece) Catherine Huber (France) Valeri Fedorov (USA) Nikolaos Limnios (France) Ilia Vonta (Cyprus) Annette Kopp-Schneider (Germany), Amaral Mendes (Portugal) Constantinos Sekeris (Greece) Giovanni Zapponi (Italy) Vladimir Bencko (Czech Republic)

5. Local Organizing Committee (LOC)
Christos Kitsos (TEI of Athens, Chairman) Alex Rigas (Uni. of Thace, Xanthi) Michael Glambedakis (TEI Athens) Chrys Caroni (NTU , Athens) Dionisis Cavouras (TEI Athens) Makis Voutsinas (Democritos Research Canter ) Erricos Ventouras (TEI Athens) Paula C. Trandafir (U. Salamanca) Miltos Chalikias (TEI Pereas) Bas. Basiliadis (Uni. Thrace, Xanthi) John Kandarakis (TEI Athens)

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6. Provisional Program
PROPOSED SESSIONS Session by Prof N. Limnios (University of Technology Compiegne) "Hitting time distributions and tests in multistate models" with speakers: - Sneh Gulati (Florida International University, France) - Vlad Barbu (University of Rouen, France) - Samis Trevezas (University of Technology of Compiegne, France) - Nikolaos Limnios (IARC, Grance) Sessions by Prof Mei-Ling Ting Lee. Session on “Lifetime Data Analysis” Friday, May 25, 2007 With speakers 1: Catherine Huber 2: Chrys Caroni 3: Zhezhen Jim 4: Ilia Vonta Session on “Microarrays and Proteomics” Saturday, May 26, 2007 With speakers 1: Philippe BROËT University Paris-XI - France broet@vjf.inserm.fr 2: Mark Segal, University of California, San Francisco, CA, USA mark@biostat.ucsf.edu 3: Mei-Ling Ting Lee, Ohio State University, Columbus, OH, USA meiling@sph.osu.edu Session on “Cancer Studies and Clinical Trials” Saturday, May 26, 2007, With speakers 1: Mark Chang, Millennium Pharmaceuticals, Inc., Boston, MA, USA email: mchang@mpi.com 2: Steve Lagakos, Harvard University, Boston, MA, USA lagakos@hsph.harvard.edu 3: Laurel Beckett, University of California, Davis, CA, USA labeckett@ucdavis.edu

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Session on “Bioinformatics” Sunday, May 27, 2007 With speakers 1: Kim-Anh Do, Ph.D., Professor The University of Texas, Houston, Texas, USA http://odin.mdacc.tmc.edu/~kim 2: Bradley Broom The University of Texas, Houston, Texas, USA

Session by Prof Valera Design of clinical trials in oncology With speakers : - Prof. C. P. Kitsos : Optimal Bioassays for Cancer Studies Session by Prof V. Fedorov Response driven designs in oncology trials Session by Prof. C. P. Kitsos Quantitative Methods and Models in Cancer With speakers Dr Alessandra La Spina : Prognostic and Predictive Studies Dr Milt. Chalikias : A quantitative approach to Brest Cancer

Session by Prof. Catherine Huber Degradation models and survival data analysis in carcinogenesis With speakers :

- Dr A. I. Michalski : Heterogeneity adjusted risk estimation in the range of low-dose radiation

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6a. List of confirmed speakers
Kim-Anh Do, The University of Texas M.D, Anderson Cancer Center Bradley Broom, The University of Texas M.D, Anderson Cancer Center Lutz Edler, German Cancer Research Center Philippe BROËT, University Paris-XI – France Mark Chang, Millennium Pharmaceuticals, Inc. Nikolaos Limnios, Prof of University Technology of Compiegne Steve Lagakos, Biostatistics Department, Harvard University Alex Rigas, Demokritos University of Thrace Zhezhen Jim, Biostatistics Department, Columbia University Mark Segal, Biostatistics Department, University of California, San Francisco Laurel Beckett, Biostatistics Department, University of California, Davis Vladimir Bencko, Institute of Hygiene & Epidemiology, Charles University in Prague Marek Kimmel, Department of Statistics, Rice University Karl-Ernst Biebler, Institut für Biometrie und Medizinische Informatik Greifswald

7. Paper Submission & Events Please send your Abstract, Paper, or participation by e-mail to the
Local Organizer Christos P. Kitsos e-mail: xkitsos@teiath.gr Department of Mathematics Technological Educational Institute (TEI) of Athens
• Social Events included in fees 1. Welcome reception on Friday, May 25th 2. Dinner on Saturday, May 26th • Other social events are announced below, not included in fees

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8. TRAVELLING & ACCOMMODATION For traveling instructions, booking etc please contact Mr Elias Frangoulis Director of the travel office KYVERNITIS at ilias@kyvernitis.gr
ICCRA2 MEETING IN SANTORINI 25 – 27 MAY, 2007

NEW Rates for the rooms read as follows:

Single room

€ 105,00 per night incl. breakfast

Double room € 129,00 per night incl. breakfast Air Tickets Athens – Santorini, from € 126,00 per person, economy class, included taxes, per way Heraklion (Crete) – Athens, from € 125,00 per person, economy class, included taxes, per way Ferry Tickets per person, per way Piraeus – Santorini or VV with High Speed ferry, from € 65,00 economy class, Santorini – Heraklion or VV with flying Cat 4, from 58,00 economy class, Heraklion – Piraeus with usual ship, economy class (no cabin), from € 65,00, Hotel Accommodation in Athens We can offer hotel accommodation in Athens for Pre & Post stay, in A’ Class (4*) hotel, from € 95,00 the Single room & from € 115,00 the Double room incl. American buffet breakfast, per night. Important Note: The above given rates for Air / Ferry tickets are the actual for the year 2006. If there will be any difference for the next year due to fuel, we will advise you accordingly. The normal check-out time is 12:00 hours. If your guests need the rooms after this time, an extra charge of 50% will be added for the Day Use and up - to 17:00 hours. After 17:00 hours the hotel is going to charge one night more.

For your registration and your travel arrangements, please contact the Official Organizer of the Congress:
Attn: Mr. Elias Frangoulis, 4, Apollonos Str., 105 57 Athens - Greece Tel: +30 210 33 12 512 Fax: +30 210 32 20 166

KYVERNITIS TRAVEL & SHIPPING SA

e-mail: ilias@kyvernitis.gr

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9. MORE INFORMATION
Flights:
23 / 24 / 25 MAY,2007 ATHENS – SANTORINI with Olympic Airlines (OA) & Aegean Airlines (A3) OA550 ATH 05:55 SANTORINI 06:45 A3350 ATH 05:55 SANTORINI 06:45 A3354 ATH 11:15 SANTORINI 12:00 OA552 ATH 12:25 SANTORINI 13:15 A3356 ATH 12:45 SANTORINI 13:30 OA558 ATH 18:20 SANTORINI 19:10 A3358 ATH 19:00 SANTORINI 19:45 OA560 ATH 21:15 SANTORINI 22:05

PS: Above schedules are valid as per Central Reservation System “CRS” up today

10. PAYMENT

ICCRA2

2d International Conference on Ca Risk Assessment
SANTORINI , May 25-27, 2007 GREECE
CREDIT CARD CHARGE AUTHORIZATION FORM

Family Name : …………………….. First Name Affiliation Address : ……………………. : ……………………. : ………………….. ………………….. ………………….. e-mail : ………………….

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I hereby authorize the “KYVERNITIS TRAVEL & SHIPPING S. A” to charge my credit card. Credit Card Type/Name …………………… Credit Card Number …………………..

3 last digits from the back side XXX Expires on …../…..

TOTAL AMOUNT Euro………. For : 1) 2) 3) 4) …..days accommodation X ……. Fees for participant Accompanying Person fees = ………… = ………… = …………

Trips by boat or air 4.1 Pereas – Santorini = ………… 4.2 Santorini – Pereas = ………… 4.3 Santorini – Irakleion(Crete) = ………… 4.4 Irakleion- Pereas = …………

5) Extra (possible days) accommodation in Athens ……….

Signature

Date

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11. Alternative way of payment:
For the participants who wish to pay via “Bank Transfer” :

PIREOS BANK ACCOUNT NUMBER: 5012 005355 – 105 BENEFICIARY: KYVERNITIS TRAVEL & SHIPPING SA IBAN: GR 3001720120005012005355105 Swift Code: PIRBGRAA PIREOS BANK AMALIAS BRANCH 2012 24, Amalias Ave 105 57, Athens , GREECE

List of services :
1) …..days accommodation X ……. = …………

2)

Fees for participant

=

…………

3)

Accompanying Person fees

=

…………

4)

Trips by boat or air 4.1 Pereas – Santorini =

…………

4.2

Santorini – Pereas =

…………

4.3

Santorini – Heraklion (Crete) = …………

4.4

Heraklion - Pereas

=

…………

5) Extra (possible days) accommodation in Athens ……….

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12. Optional Tours in Santorini For accompanying persons and not only
Minimum participation 10 persons

1st Caldera morning
(Boat Tour)

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Boat Morning Tour Route: Volcano-Hot Springs –Thirassia

The program is as follows: We will depart from the old port of “Fira” Capital by boat in order to visit the Volcano Island “Nea Kemeni”. We will ascend by foot from the terra path in order to approach the caldera and enjoy the marvelous view. Departure from there and sail to the famous Island of “Palaia Kameni “where are the “Hot Springs”. We will stay for about thirty minutes. We will sail to approach the “Thirassia” Island and stay. Optional visit to the Village “Manolas “by donkeys and have lunch to the local taverns . Return back. Departure Time Return time Price per person Included : 10:30 hrs : 18:00 hrs approximate : € 28,00 per person : Tour leader fee, bus transfer to / from port

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2d Caldera and Oia Sunset
(Boat Tour)

- Noon Boat Tour - Route : Hot Springs, Volcano, Thirassia, Oia Sunset. This includes the approach by boat to the volcano island “Palaia Kameni” in which there are the “Hot Springs “. Optional swimming into the warm and blue-green waters for about thirty minutes! Afterwards we will depart so as to visit the Volcano Island “Nea kameni” stay for a few moments and climb onto from the terra path in order to approach the caldera and marvel the spectacular view from above. Then depart for the “Thirassia” Island and stay. Optional visit to the Village “Manolas “by donkeys and have lunch to the local taverns or swim to the beach near the harbor. Return back to Santorini island to the harbor” Armeni” and visit the “Oia” village where is our last destination. We will walk between the picturesque, narrow streets so that to “meet” with the magnificent sunset! Stay about fifteen minutes at “Oia” after the sunset and back to the meeting point to depart. Departure time Return Price per person Included : 10:30 hrs : After Sunset : € 33,00 per person : Tour leader fee, bus transfer to / from port

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