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									                                             SPINE MARKET: INSIGHTS & OVERVIEW
       The $5.6 billion spinal market is the fastest growing major segment of orthopedics and as a result has
       been receiving increased attention from both financial and strategic investors.
       BBH’s Medical Technology M&A team offers the following presentation to provide investors, CEOs and
       CFOs an understanding of recent trends in the spinal market, including insights on:
       •   Current/future treatments                      •   Market sizes/opportunity              •   Valuation Metrics
       •   Overview of non-fusion technology              •   M&A Trends

       Additionally, we have included detailed profiles of the most intriguing/innovative private players.

Presentation:
  I.       Orthopedic Sector Drivers and Trends                   IV.        Selected Private Company Profiles
           •    Orthopedic Market Overview                                   •   Annulex Technologies
           •    Drivers for Growth                                           •   Applied Spine Technologies
           •    Orthopedic Public Market Overview                            •   Archus Orthopedics
           •    Recent M&A Trends                                            •   AxioMed Spine
           •    Selected Orthopedic M&A Transactions                         •   Blackstone Medical
                                                                             •   Cervitech
 II.       Spinal Market Industry Dynamics                                   •   Cortek
           •    Overview of the Spine                                        •   Disc-O-Tech
           •    Spinal Market Overview                                       •   Disc Dynamics
           •    New Market Trends Driving Growth                             •   Endius
                – Orthobiologics                                             •   Facet Solutions
                – Minimally Invasive Surgery                                 •   Globus Medical
                – Motion Preservation                                        •   Impliant
           •    Spinal Fusion                                                •   Innovative Spinal Technologies
                – Instrumented Spinal Market                                 •   Intrinsic Therapeutics
                – Machined Bone Market                                       •   LDR Medical
                                                                             •   Pearsalls
           •    Motion Preservation                                          •   Raymedica
                – Artificial Disc Market
                                                                             •   Replication Medical
                – Artificial Disc Competitive Landscape
                – Artificial Disc Timeline
                                                                             •   Scient’x
                – Nucleus Replacement                                        •   Spineology
                – Dynamic Stabilization                                      •   Spine Wave
                – Facet Joint Arthroplasty                                   •   SpineVision
                                                                             •   St. Francis Medical Technologies
           •    Spinal Market Competitive Landscape                          •   Theken
                                                                             •   TranS1
III.       Medical Technology Valuation Metrics                              •   US Spine
           •    Valuation Drivers                                            •   Vertebron
                                                                             •   X-spine Systems

               To recceive a full electronic copy of the presentation, please email lisa.mcgovern@bbh.com

                                          BROWN BROTHERS HARRIMAN
                        140 Broadway, New York, New York 10005 Tel: (212) 483-1818 Fax: (212) 493-8430
                      40 Water Street, Boston, Massachusetts 02109 Tel: (617) 772-1818 Fax: (617) 772-1148

                    John P. Molner                    John D. Chaparro                    Ivan A. Pirzada
                      (212) 493-8415                      (212) 493-8411                    (617) 772-1127
                  john.molner@bbh.com                john.chaparro@bbh.com              ivan.pirzada@bbh.com

								
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