Quintech Life Sciences - Cell D by hcj


Regeneration System
Company Background                     …(1)

 QuinXell Technologies Pte Ltd was founded in 2011

 QuinXell is the latest addition to Quintech Life Sciences
  (QLS) family of companies established to tap into the
  emerging Life Science industry

 QuinXell will focus in the area of Regenerative Medicine
  through its innovative cell culture-based technologies
Company Background                   …(2)

 Research on QuinXell’s TisXell Regeneration System
  was initiated as a joint project between the National
  University of Singapore (NUS) and Singapore Polytechnic
  (SP), with the National University Hospital (NUH) providing
  samples for applications

 Scientific papers supporting the benefits of biaxial
  bioreactor on functional tissue growth (tissue engineered
  constructs or TECs) on 3D scaffolds have been published in
  international journals for more than 10 years
Background Information                      …(1)

 Regenerative Medicine has been hailed as a revolutionary
  medical advancement, breathing new life into patient care

 Transplantation through in vitro cultures of organs and tissues
  or Tissue Engineering (TE) is a standardized and
  reproducible method to create functional tissues in the

 These tissues are utilized to replace, repair or
  regenerate organs loss due to disease, trauma, failure or
  cogenital defects
Background Information                       …(2)

 Traditionally, spinner flasks, rotating wall vessels (RWV),
  perfusion and uniaxial bioreactors are employed for TE

 QuinXell’s unique TisXell Regeneration System offers
  an optimal condition for high growth and high proliferation of
  cell cultures compared to conventional methods.

 TisXell controlled environment provides optimal nutrients
  and gases to growing cells and triggers cellular mechano-
  transduction signalling pathways to stimulate tissue
  remodelling onto a 3D scaffold.
Application Fields
For research institutes, hospitals, biotechnology, pharma in
• Regenerative medicine

• Tissue engineering

• Translational medicine

• Tissue and organ transplant
Cell Types
• Primary Cells

• Stem Cells

• Bone Cells

• Muscles Cells

• And many more…
         Conventional Methods
Types of Bioreactors         Advantages                          Disadvantages
Spinner flasks               Improved fluid flow (as compared Turbulence generated can be
                             to static vessels)               detrimental for seeded cells and
                                                              newly laid down ECM

Perfusion bioreactors        Enhances mesenchymal stem cell      Non-homgenous cellular
                             proliferation and osteogenic        distribution
                             differentiation in scaffold         Cells at frontal zones are washed
                             constructs                          away by the oncoming perfusion
                                                                 flow with higher flow rates
Rotating wall vessel (RWV)   Low sheer forces and 3D high        Non-homogenous cellular
bioreactors                  mass transfer (similar to perfusion distribution and ECM deposition
                             bioreactors)                        In the free floating culture,
                                                                 collision between scaffolds and
                                                                 bioreactor walls may induce
                                                                 cellular damage and disrupt
                                                                 cellular attachment and matrix
                                                                 deposition on the scaffolds
       TisXell Novel Approach
Types of Bioreactors           Advantages
Biaxial revolving bioreactor   Integrated perfusion system allows for exchange
e.g. TisXell                   between the vessel and reservoir with maximal
                               mass transfer under low sheer force

                               Biaxial revolution of the culture vessel led to more
                               homogenous cellular and ECM deposition – at the
                               surface and the deeper core of the scaffolds

                               Cellular scaffolds were secured by pins to avoid
                               scaffold and vessel wall collisions
TisXell Regeneration System
TisXell – Unique Selling Points                        …(1)

Ø Patented biaxial revolution in two independent orthogonal
  axes (spin and tumble simultaneously)

Ø Flexible operational modes available – biaxial, uniaxial,
  swing modes
TisXell – Unique Selling Points                        …(2)

Ø Efficient fluid transport within the 3D scaffolds, allowing
  optimal nutrients and waste exchange to and from the cells,
  penetrating the deepest core of the scaffolds

Ø Spherical design of vessel reduces drag and promotes
  uniform fluid mixing
TisXell – Key Benefits                  …(1)

Ø Accelerates cell growth, differentiation and cell
  proliferation, mimicking native extracellular matrix (ECM)

Ø Supports homogenous cell culture at the surface and core of
  the 3D scaffolds

Ø Maintains functionality and viability of tissue constructs
TisXell – Key Benefits                  …(2)

Ø Reduces formation of necrotic neotissue that interferes with
  subsequent implantation process

Ø Promotes integration of implants with surrounding tissue and
  support the structural integrity in regeneration of tissues
  and/or organs
Key Benefits for Bone
Applications        …(1)

In Vitro
Ø Homogenous cellular distribution

Ø Rapid stem cell expansion – up to 2-fold (or more)
  improvement in mass transfer in thicker grafts

Ø High viability

Ø Robust osteogenic differentiation and mineralization
Key Benefits for Bone
Applications        …(2)

In Vivo
Ø Increased bone formation after transplantation

Ø Promotes new vascularization
TisXell System Configuration I
TisXell Regeneration System, Basic
o Two spherical glass vessels of 500ml and 1000ml, 1 each
o Revolving stand to hold one vessel, 1
o Integrated peristaltic pump, 1
o Medium reservoir, 1
o Remote touch screen panel, 1
o Tubings and connectors starter kit, 1
o Scaffolds starter kit, 1
TisXell System Configuration II
TisXell Regeneration System, Complete
o Two spherical glass vessels of 500ml and 1000ml, 1 each
o Revolving stand to hold one vessel, 1
o Integrated peristaltic pump, 1
o Medium reservoir, 1
o Remote touch screen panel, 1
o Tubings and connectors starter kit, 1
o Scaffolds starter kit, 1
o Set of probes, 1
o Applikon console and monitor, 1

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