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   Whooping Cough Study May Offer Clue on Surge                                                                         Well




   By SABRINA TAVERNISE
   Published: November 25, 2013
                                                                                                                        Aspirin Benefits Some at Risk for Colon Cancer
   Baboons vaccinated against whooping cough could still carry the                                FACEBOOK              April 23, 2014, 4:32 PM

   illness in their throats and spread it, research published in a science                        TWITTER               High Altitudes May Aid Weight Control
   journal on Monday has found. The surprising new finding has not                                GOOGLE+
                                                                                                                        April 23, 2014, 5:30 AM

   been replicated in people, but scientists say it may provide an                                                      The Limits of ‘No Pain, No Gain’
                                                                                                  SAVE
   important clue to a puzzling spike in the incidence of whooping                                                      April 23, 2014, 12:01 AM

   cough across the country, which reached a 50-year high last year.                              EMAIL
                                                                                                                        The Lure of Forbidden Food
                                                                                                  SHARE                 April 21, 2014
                       Enlarge This Image      The whooping cough vaccines now in
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                                               use were introduced in the 1990s                                         April 21, 2014
                                               after an older version, which offered        REPRINTS

                                               longer-lasting protection, was found
                                               to have side effects. But over the
                                               years, scientists have determined that
                                               the new vaccines began to lose
                                               effectiveness after about five years, a
                                               significant problem that many researchers believe has
                                               contributed to the significant rise in whooping cough
                                               cases.

                                   The new study, published on Monday in Proceedings of
      Matthew Ryan Williams for The New York
                                       Times
                                   the National Academy of Sciences, offers another
   An older vaccine with longer-lasting
                                   explanation. Using baboons, the researchers found that
   protection was found to have side
   effects.
                                   recently vaccinated animals continued to carry the
                                   infection in their throats. Even though those baboons did
                                                                                                                        Health & Fitness Tools
   not get sick from it, they spread the infection to others that were not vaccinated.
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   “When you’re newly vaccinated you are an asymptomatic carrier, which is good for you,
   but not for the population,” said Tod J. Merkel, the lead author of the study, who is a
   researcher in the Office of Vaccines Research and Review in the Food and Drug
   Administration.

   Scientists said the finding was surprising, and could be a signpost for investigators as                                         MOST EMAILED                 RECOMMENDED FOR YOU

   they try to improve the vaccines for people.
                                                                                                                                         1.   THE UPSHOT
                                                                                                                                              The American Middle Class Is No Longer
   “If Dr. Merkel is correct, then we need to develop better acellular vaccines,” said Dr.                                                    the World’s Richest
   Stanley Plotkin, an emeritus professor of pediatrics at the University of Pennsylvania.
                                                                                                                                         2. Court Backs Michigan on Affirmative
   The new vaccines are known as acellular, as they contain purified proteins, instead of                                                   Action



http://www.nytimes.com/2013/11/26/health/study-finds-vaccinated-baboons-can-still-carry-whooping-cough.html?emc=eta1&_r=3&[4/23/2014 7:29:46 PM]
Whooping Cough Study May Offer Clue on Surge - NYTimes.com




   complete bacteria that have been killed. “A great deal of thought and discussion is being
   devoted to that at the moment,” he said.                                                                                               3.   RAW DATA
                                                                                                                                               An Apple a Day, and Other Myths
   The current vaccines, usually administered in infancy, preschool and adolescence,
   protect well in early childhood. But by adolescence, the protective effects wane quickly.                                              4.   FRANK BRUNI

   Doctors often recommend boosters. Death from whooping cough can occur in infants,                                                           Autism and the Agitator

   but is unusual in adults.
                                                                                                                                          5. Under Russia, Life in Crimea Grows
   The current whooping cough vaccines were developed after a surge in concerns from                                                         Chaotic
   parents that their children were getting fevers and having seizures after receiving the old
   vaccine. Those worries added fuel to general skepticism about vaccines that had led some                                               6.   MAUREEN DOWD
                                                                                                                                               A Saint, He Ain’t
   parents to choose not to have their children vaccinated.

   But scientists say the problem of surging whooping cough cases has more to do with                                                     7.   MILITARY ANALYSIS
                                                                                                                                               Russia Displays a New Military Prowess in
   flaws in the current vaccines than with parents’ resistance. The new finding suggests yet                                                   Ukraine’s East
   another weakness of the vaccine — that even people recently vaccinated may be
                                                                                                                                          8. In Policy Shift, F.C.C. Will Allow a Web
   continuing to spread the infection without getting sick.
                                                                                                                                             Fast Lane

   “The baboon model has provided an illuminating insight into the epidemic as we are
   coping with it today,” said Dr. William Schaffner, a professor of preventive medicine at                                               9. Upsetting the Gentility That the South
                                                                                                                                             Lays Claim To
   Vanderbilt University, who was not involved in the study.

                                                                                                                                        10. Boy Who Hid in Plane’s Wheel Well Beat
   A version of this article appears in print on November 26, 2013, on page A15 of the New York edition with the headline:                  Long Odds in Surviving 5 ½-Hour Flight
   Whooping Cough Study May Offer Clue on Surge.

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          Vaccination and Immunization                                   Merkel, Tod J


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http://www.nytimes.com/2013/11/26/health/study-finds-vaccinated-baboons-can-still-carry-whooping-cough.html?emc=eta1&_r=3&[4/23/2014 7:29:46 PM]
Whooping Cough Study May Offer Clue on Surge - NYTimes.com

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http://www.nytimes.com/2013/11/26/health/study-finds-vaccinated-baboons-can-still-carry-whooping-cough.html?emc=eta1&_r=3&[4/23/2014 7:29:46 PM]

				
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