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									Supplemental Table 8 for "Strong contrasts between adap
evolution" by R. Haygood, C. C. Babbitt, O. Fedrigo, and
Sup.    Tab.   8aSpecificity        to   Novartis    tissues     across    coding surveys
Sup.    Tab.   8bSpecificity        to   Novartis    tissues     across    noncoding surveys
Sup.    Tab.   8cSpecificity        to   Novartis    tissues     across    coding surveys, minu
Sup.    Tab.   8dSpecificity        to   Novartis    tissues     across    coding surveys, minu
Sup.    Tab.   8eSpecificity        to   Novartis    tissues     across    coding surveys, minu
Sup.    Tab.   8f Specificity       to   Novartis    tissues     across    noncoding surveys, m
Sup.    Tab.   8gSpecificity        to   Novartis    tissues     across    noncoding surveys, m
Sup.    Tab.   8hSpecificity        to   Novartis    tissues     across    noncoding surveys, m
Sup.    Tab.   8i Specificity       to   Novartis    tissues     across    coding surveys, rand
Sup.    Tab.   8j Specificity       to   Novartis    tissues     across    noncoding surveys, r
In all parts, mean n is mean number of genes in the tissue per survey.

In parts a–h, penr is upper one-tailed p-value for one-sample z test, while in parts i and j, it is upper on
rrb = 0. Green shading indicates penr < 0.05, and red shading indicates penr > 0.95.

In parts a and b, phet is p-value for chi-squared distribution with two degrees of freedom, while in parts
homogeneity. Yellow shading indicates phet < 0.05.
s between adaptive coding and noncoding changes during huma
 . Fedrigo, and G. A. Wray
ding surveys
ncoding surveys
ding surveys, minus Bustamante et al., 2005
ding surveys, minus Nielsen et al., 2005
ding surveys, minus Kosiol et al., 2008
ncoding surveys, minus Pollard et al., 2006
ncoding surveys, minus Prabhakar et al., 2006
ncoding surveys, minus Haygood et al., 2007
ding surveys, random-effects meta-analysis
ncoding surveys, random-effects meta-analysis


parts i and j, it is upper one-tailed p-value for one-sample t-test with two degrees of freedom; null hypothesis is
0.95.

s of freedom, while in parts c–h, it is p-value for chi-squared distribution with one degree of freedom; null hypothe
nges during human




of freedom; null hypothesis is mean



egree of freedom; null hypothesis is
Supplemental Table 8a: Specificity to Novartis tissues acr
tissue                     mean n   mean r r, sstderr mean r r, s
TestisLeydigCell            7375      0.0383           0.0070
TestisInterstitial          7375      0.0378           0.0070
atrioventricularnode        7375      0.0348           0.0068
TestisSeminiferousTubule    7375      0.0302           0.0070
ciliaryganglion             7375      0.0295           0.0069
DRG                         7375      0.0313           0.0069
TrigeminalGanglion          7375      0.0305           0.0069
SuperiorCervicalGanglion    7375      0.0291           0.0068
Appendix                    7375      0.0275           0.0069
TestisGermCell              7375      0.0240           0.0069
skin                        7375      0.0222           0.0068
UterusCorpus                7375      0.0220           0.0068
salivarygland               7375      0.0194           0.0069
SkeletalMuscle              7375      0.0192           0.0069
AdrenalCortex               7375      0.0173           0.0068
Ovary                       7375      0.0171           0.0071
fetalliver                  7375      0.0135           0.0068
testis                      7375      0.0134           0.0071
TONGUE                      7375      0.0130           0.0070
Tonsil                      7375      0.0124           0.0069
Pancreas                    7375      0.0126           0.0070
Pons                        7375      0.0122           0.0069
Liver                       7375      0.0103           0.0068
PancreaticIslets            7375      0.0078           0.0071
OlfactoryBulb               7375      0.0065           0.0067
bonemarrow                  7375      0.0061           0.0068
globuspallidus              7375      0.0059           0.0067
trachea                     7375      0.0032           0.0070
fetalThyroid                7375      0.0020           0.0068
Heart                       7375      0.0016           0.0067
Pituitary                   7375      0.0006           0.0068
BM-CD71+EarlyErythroid      7375      0.0003           0.0068
lymphnode                   7375      0.0004           0.0067
MedullaOblongata            7375     -0.0020           0.0067
adrenalgland                7375     -0.0022           0.0067
TemporalLobe                7375     -0.0024           0.0067
subthalamicnucleus          7375     -0.0033           0.0068
ParietalLobe                7375     -0.0030           0.0066
cerebellum                  7375     -0.0044           0.0067
Prostate                    7375     -0.0055           0.0068
Uterus                      7375     -0.0058           0.0069
Thyroid                     7375     -0.0059           0.0068
CardiacMyocytes             7375     -0.0079           0.0070
kidney                      7375     -0.0070           0.0066
spinalcord                  7375     -0.0086           0.0068
CerebellumPeduncles         7375     -0.0084           0.0066
WHOLEBLOOD                  7375     -0.0088           0.0068
caudatenucleus              7375     -0.0100           0.0067
BM-CD105+Endothelial       7375   -0.0110   0.0067
CingulateCortex            7375   -0.0112   0.0066
fetallung                  7375   -0.0126   0.0068
PB-CD19+Bcells             7375   -0.0143   0.0068
PB-CD4+Tcells              7375   -0.0146   0.0068
ADIPOCYTE                  7375   -0.0144   0.0069
Hypothalamus               7375   -0.0141   0.0067
fetalbrain                 7375   -0.0146   0.0065
Amygdala                   7375   -0.0165   0.0066
thymus                     7375   -0.0173   0.0068
PB-CD8+Tcells              7375   -0.0171   0.0067
PB-CD56+NKCells            7375   -0.0177   0.0068
WholeBrain                 7375   -0.0184   0.0066
BM-CD33+Myeloid            7375   -0.0203   0.0068
PrefrontalCortex           7375   -0.0190   0.0066
Lung                       7375   -0.0201   0.0067
PLACENTA                   7375   -0.0219   0.0069
OccipitalLobe              7375   -0.0201   0.0064
Thalamus                   7375   -0.0217   0.0067
PB-CD14+Monocytes          7375   -0.0245   0.0067
721_B_lymphoblasts         7375   -0.0243   0.0066
BM-CD34+                   7375   -0.0265   0.0068
PB-BDCA4+Dentritic_Cells   7375   -0.0313   0.0066
bronchialepithelialcells   7375   -0.0308   0.0068
SmoothMuscle               7375   -0.0340   0.0068
vartis tissues across coding surveys
             penr      phet
          0.0000    0.1981
          0.0000    0.0616
          0.0000    0.0708
          0.0000    0.0311
          0.0000    0.0145
          0.0000    0.0256
          0.0000    0.0490
          0.0000    0.0303
          0.0000    0.0136
          0.0003    0.5269
          0.0005    0.0694
          0.0007    0.2097
          0.0024    0.6201
          0.0026    0.6772
          0.0056    0.2785
          0.0078    0.4882
          0.0233    0.8530
          0.0286    0.2345
          0.0306    0.0227
          0.0365    0.3458
          0.0358    0.5139
          0.0397    0.2223
          0.0640    0.1644
          0.1359    0.7241
          0.1662    0.4625
          0.1845    0.2416
          0.1923    0.2793
          0.3251    0.5533
          0.3848    0.0365
          0.4033    0.0242
          0.4624    0.3837
          0.4833    0.0150
          0.4778    0.6075
          0.6187    0.0203
          0.6286    0.3652
          0.6418    0.0161
          0.6889    0.6965
          0.6760    0.3264
          0.7462    0.2160
          0.7916    0.0265
          0.8003    0.1069
          0.8095    0.0006
          0.8685    0.0258
          0.8535    0.0050
          0.8991    0.0028
          0.8980    0.0139
          0.9041    0.0014
          0.9312    0.0062
0.9496   0.0036
0.9557   0.0456
0.9684   0.6114
0.9826   0.0063
0.9847   0.0024
0.9812   0.1530
0.9824   0.0032
0.9873   0.0027
0.9940   0.0000
0.9946   0.5126
0.9949   0.0041
0.9954   0.0082
0.9973   0.0002
0.9987   0.0480
0.9981   0.0000
0.9987   0.2452
0.9993   0.0413
0.9991   0.0017
0.9994   0.0000
0.9999   0.0040
0.9999   0.0044
1.0000   0.0004
1.0000   0.0021
1.0000   0.8020
1.0000   0.0844
Supplemental Table 8b: Specificity to Novartis tissues acr
tissue                     mean n   mean r r, sstderr mean r r, s
Appendix                    4771      0.0398           0.0083
ciliaryganglion             4771      0.0396           0.0083
TrigeminalGanglion          4771      0.0395           0.0085
SuperiorCervicalGanglion    4771      0.0386           0.0082
globuspallidus              4771      0.0365           0.0082
Ovary                       4771      0.0361           0.0084
atrioventricularnode        4771      0.0338           0.0084
SkeletalMuscle              4771      0.0286           0.0083
DRG                         4771      0.0297           0.0083
UterusCorpus                4771      0.0252           0.0083
skin                        4771      0.0259           0.0084
TONGUE                      4771      0.0245           0.0084
Pons                        4771      0.0239           0.0086
Heart                       4771      0.0218           0.0083
subthalamicnucleus          4771      0.0214           0.0082
TestisLeydigCell            4771      0.0203           0.0083
ParietalLobe                4771      0.0193           0.0082
salivarygland               4771      0.0188           0.0084
MedullaOblongata            4771      0.0168           0.0084
bonemarrow                  4771      0.0161           0.0084
fetalliver                  4771      0.0162           0.0083
TemporalLobe                4771      0.0158           0.0082
Liver                       4771      0.0158           0.0084
trachea                     4771      0.0138           0.0082
cerebellum                  4771      0.0133           0.0083
Pancreas                    4771      0.0129           0.0081
kidney                      4771      0.0125           0.0083
CingulateCortex             4771      0.0124           0.0084
OlfactoryBulb               4771      0.0120           0.0085
TestisInterstitial          4771      0.0114           0.0083
OccipitalLobe               4771      0.0088           0.0083
Tonsil                      4771      0.0086           0.0082
CardiacMyocytes             4771      0.0092           0.0084
AdrenalCortex               4771      0.0069           0.0085
Amygdala                    4771      0.0070           0.0084
ADIPOCYTE                   4771      0.0068           0.0085
fetalbrain                  4771      0.0067           0.0084
CerebellumPeduncles         4771      0.0061           0.0083
Hypothalamus                4771      0.0062           0.0083
Prostate                    4771      0.0052           0.0084
spinalcord                  4771      0.0051           0.0083
WholeBrain                  4771      0.0029           0.0083
adrenalgland                4771      0.0026           0.0083
caudatenucleus              4771      0.0019           0.0083
Pituitary                   4771      0.0016           0.0085
TestisSeminiferousTubule    4771      0.0001           0.0082
BM-CD71+EarlyErythroid      4771     -0.0005           0.0084
fetalThyroid                4771     -0.0006           0.0085
Uterus                     4771   -0.0020   0.0083
PrefrontalCortex           4771   -0.0030   0.0083
bronchialepithelialcells   4771   -0.0034   0.0084
PancreaticIslets           4771   -0.0042   0.0083
testis                     4771   -0.0059   0.0084
lymphnode                  4771   -0.0065   0.0083
TestisGermCell             4771   -0.0076   0.0083
Thalamus                   4771   -0.0078   0.0082
Lung                       4771   -0.0108   0.0083
thymus                     4771   -0.0113   0.0082
PLACENTA                   4771   -0.0114   0.0084
fetallung                  4771   -0.0151   0.0083
PB-CD4+Tcells              4771   -0.0158   0.0084
BM-CD105+Endothelial       4771   -0.0162   0.0085
SmoothMuscle               4771   -0.0163   0.0083
PB-CD19+Bcells             4771   -0.0168   0.0084
WHOLEBLOOD                 4771   -0.0181   0.0083
Thyroid                    4771   -0.0199   0.0087
PB-CD8+Tcells              4771   -0.0216   0.0084
PB-CD14+Monocytes          4771   -0.0253   0.0084
721_B_lymphoblasts         4771   -0.0297   0.0084
PB-CD56+NKCells            4771   -0.0356   0.0084
BM-CD34+                   4771   -0.0349   0.0085
BM-CD33+Myeloid            4771   -0.0400   0.0083
PB-BDCA4+Dentritic_Cells   4771   -0.0426   0.0084
vartis tissues across noncoding surveys
             penr      phet
          0.0000    0.0108
          0.0000    0.0002
          0.0000    0.0011
          0.0000    0.0000
          0.0000    0.0455
          0.0000    0.0023
          0.0000    0.0034
          0.0003    0.0427
          0.0002    0.0044
          0.0013    0.2279
          0.0011    0.0023
          0.0018    0.0914
          0.0027    0.1064
          0.0044    0.0647
          0.0044    0.3907
          0.0073    0.1249
          0.0090    0.7515
          0.0128    0.0116
          0.0224    0.2279
          0.0276    0.0688
          0.0256    0.4665
          0.0274    0.1078
          0.0292    0.1399
          0.0470    0.5709
          0.0536    0.6537
          0.0561    0.4432
          0.0654    0.0266
          0.0697    0.7841
          0.0789    0.7943
          0.0858    0.3043
          0.1447    0.9847
          0.1474    0.5639
          0.1376    0.4080
          0.2065    0.1796
          0.2013    0.9768
          0.2110    0.5853
          0.2137    0.9499
          0.2326    0.7486
          0.2277    0.9734
          0.2682    0.5507
          0.2711    0.6529
          0.3659    0.8628
          0.3773    0.3186
          0.4098    0.7592
          0.4244    0.1481
          0.4974    0.6920
          0.5253    0.2954
          0.5287    0.4627
0.5964   0.2335
0.6395   0.7443
0.6555   0.2810
0.6928   0.3913
0.7581   0.1244
0.7827   0.7634
0.8210   0.4635
0.8297   0.6577
0.9042   0.8005
0.9150   0.2442
0.9128   0.0312
0.9653   0.1203
0.9690   0.1160
0.9712   0.2158
0.9750   0.0961
0.9780   0.0642
0.9857   0.3452
0.9893   0.8760
0.9952   0.0508
0.9986   0.2215
0.9998   0.0413
1.0000   0.3352
1.0000   0.1302
1.0000   0.0567
1.0000   0.1332
Supplemental Table 8c: Specificity to Novartis tissues acr
tissue                     mean n   mean r r, sstderr mean r r, s
TestisLeydigCell            9531      0.0414           0.0076
atrioventricularnode        9531      0.0407           0.0074
TestisInterstitial          9531      0.0406           0.0076
ciliaryganglion             9531      0.0378           0.0075
TrigeminalGanglion          9531      0.0373           0.0074
SuperiorCervicalGanglion    9531      0.0364           0.0074
DRG                         9531      0.0366           0.0075
Appendix                    9531      0.0357           0.0075
TestisSeminiferousTubule    9531      0.0319           0.0076
skin                        9531      0.0286           0.0074
UterusCorpus                9531      0.0264           0.0074
TestisGermCell              9531      0.0265           0.0076
SkeletalMuscle              9531      0.0216           0.0075
AdrenalCortex               9531      0.0204           0.0074
salivarygland               9531      0.0204           0.0074
Ovary                       9531      0.0201           0.0076
TONGUE                      9531      0.0196           0.0075
testis                      9531      0.0157           0.0076
Pancreas                    9531      0.0153           0.0076
fetalliver                  9531      0.0148           0.0073
Pons                        9531      0.0139           0.0075
Liver                       9531      0.0119           0.0073
Tonsil                      9531      0.0080           0.0075
OlfactoryBulb               9531      0.0069           0.0072
PancreaticIslets            9531      0.0072           0.0077
globuspallidus              9531      0.0060           0.0072
trachea                     9531      0.0063           0.0075
fetalThyroid                9531      0.0059           0.0073
Heart                       9531      0.0053           0.0072
bonemarrow                  9531      0.0046           0.0074
adrenalgland                9531      0.0006           0.0072
kidney                      9531      0.0003           0.0072
lymphnode                   9531     -0.0016           0.0073
Pituitary                   9531     -0.0016           0.0074
Uterus                      9531     -0.0030           0.0074
subthalamicnucleus          9531     -0.0039           0.0073
TemporalLobe                9531     -0.0041           0.0072
MedullaOblongata            9531     -0.0041           0.0072
Thyroid                     9531     -0.0050           0.0073
Prostate                    9531     -0.0055           0.0074
ParietalLobe                9531     -0.0058           0.0071
cerebellum                  9531     -0.0069           0.0072
BM-CD71+EarlyErythroid      9531     -0.0072           0.0073
CardiacMyocytes             9531     -0.0092           0.0076
fetallung                   9531     -0.0099           0.0073
spinalcord                  9531     -0.0099           0.0073
CerebellumPeduncles         9531     -0.0100           0.0072
ADIPOCYTE                   9531     -0.0111           0.0075
caudatenucleus             9531   -0.0122   0.0073
CingulateCortex            9531   -0.0129   0.0071
Hypothalamus               9531   -0.0160   0.0072
WHOLEBLOOD                 9531   -0.0165   0.0072
Lung                       9531   -0.0190   0.0072
BM-CD105+Endothelial       9531   -0.0199   0.0073
thymus                     9531   -0.0205   0.0073
PLACENTA                   9531   -0.0211   0.0074
fetalbrain                 9531   -0.0205   0.0070
PB-CD19+Bcells             9531   -0.0231   0.0073
PrefrontalCortex           9531   -0.0224   0.0071
Amygdala                   9531   -0.0232   0.0071
PB-CD4+Tcells              9531   -0.0244   0.0073
Thalamus                   9531   -0.0245   0.0072
WholeBrain                 9531   -0.0244   0.0071
OccipitalLobe              9531   -0.0240   0.0069
PB-CD56+NKCells            9531   -0.0264   0.0074
PB-CD8+Tcells              9531   -0.0261   0.0072
BM-CD33+Myeloid            9531   -0.0268   0.0073
bronchialepithelialcells   9531   -0.0312   0.0074
SmoothMuscle               9531   -0.0319   0.0074
721_B_lymphoblasts         9531   -0.0330   0.0072
PB-CD14+Monocytes          9531   -0.0332   0.0072
BM-CD34+                   9531   -0.0378   0.0074
PB-BDCA4+Dentritic_Cells   9531   -0.0404   0.0071
vartis tissues across coding surveys, minus Bustamante et al., 2
             penr      phet
          0.0000    0.1421
          0.0000    0.5031
          0.0000    0.0313
          0.0000    0.8918
          0.0000    0.7926
          0.0000    0.9280
          0.0000    0.0543
          0.0000    0.4919
          0.0000    0.0100
          0.0001    0.5831
          0.0002    0.4300
          0.0002    0.4466
          0.0020    0.7136
          0.0028    0.2580
          0.0029    0.3618
          0.0042    0.5528
          0.0046    0.1341
          0.0199    0.1299
          0.0215    0.5060
          0.0222    0.7325
          0.0323    0.1032
          0.0511    0.0711
          0.1426    0.9799
          0.1691    0.2182
          0.1717    0.4333
          0.2027    0.1105
          0.2029    0.8453
          0.2097    0.0353
          0.2326    0.0167
          0.2658    0.1092
          0.4663    0.3374
          0.4861    0.0552
          0.5842    0.4705
          0.5865    0.2685
          0.6593    0.0626
          0.7020    0.4078
          0.7141    0.0050
          0.7186    0.0075
          0.7537    0.0001
          0.7707    0.0070
          0.7926    0.2907
          0.8306    0.1369
          0.8374    0.3285
          0.8858    0.0076
          0.9128    0.8679
          0.9136    0.0007
          0.9199    0.0042
          0.9312    0.1167
0.9538   0.0021
0.9656   0.0164
0.9869   0.0009
0.9885   0.0357
0.9958   0.1034
0.9969   0.3421
0.9974   0.9152
0.9978   0.0122
0.9983   0.0106
0.9992   0.6476
0.9992   0.0000
0.9995   0.0000
0.9996   0.8135
0.9997   0.0000
0.9997   0.0006
0.9997   0.0013
0.9998   0.9792
0.9999   0.6517
0.9999   0.5317
1.0000   0.5170
1.0000   0.0355
1.0000   0.4959
1.0000   0.5260
1.0000   0.8630
1.0000   0.5212
tamante et al., 2005
Supplemental Table 8d: Specificity to Novartis tissues acr
tissue                     mean n   mean r r, sstderr mean r r, s
TestisLeydigCell            7448     0.0303            0.0085
TrigeminalGanglion          7448     0.0286            0.0082
atrioventricularnode        7448     0.0289            0.0083
Appendix                    7448     0.0265            0.0085
ciliaryganglion             7448     0.0262            0.0084
SuperiorCervicalGanglion    7448     0.0253            0.0083
TestisInterstitial          7448     0.0258            0.0087
UterusCorpus                7448     0.0234            0.0083
skin                        7448     0.0218            0.0082
AdrenalCortex               7448     0.0208            0.0082
DRG                         7448     0.0203            0.0084
SkeletalMuscle              7448     0.0198            0.0083
TestisGermCell              7448     0.0194            0.0084
Pons                        7448     0.0186            0.0083
TestisSeminiferousTubule    7448     0.0180            0.0084
Liver                       7448     0.0178            0.0083
TONGUE                      7448     0.0168            0.0085
salivarygland               7448     0.0148            0.0083
Tonsil                      7448     0.0146            0.0084
Pancreas                    7448     0.0144            0.0085
globuspallidus              7448     0.0128            0.0081
Ovary                       7448     0.0129            0.0086
OlfactoryBulb               7448     0.0118            0.0082
fetalliver                  7448     0.0114            0.0082
TemporalLobe                7448     0.0114            0.0083
Thyroid                     7448     0.0115            0.0084
PancreaticIslets            7448     0.0117            0.0086
MedullaOblongata            7448     0.0108            0.0081
Heart                       7448     0.0110            0.0083
fetalThyroid                7448     0.0098            0.0083
spinalcord                  7448     0.0085            0.0085
Prostate                    7448     0.0070            0.0084
Pituitary                   7448     0.0068            0.0083
Amygdala                    7448     0.0066            0.0082
CerebellumPeduncles         7448     0.0052            0.0081
caudatenucleus              7448     0.0052            0.0083
CardiacMyocytes             7448     0.0053            0.0086
testis                      7448     0.0052            0.0086
cerebellum                  7448     0.0035            0.0082
ParietalLobe                7448     0.0029            0.0080
PrefrontalCortex            7448     0.0027            0.0082
trachea                     7448     0.0024            0.0086
Hypothalamus                7448     0.0022            0.0083
Uterus                      7448     0.0016            0.0085
Thalamus                    7448     0.0014            0.0083
adrenalgland                7448     0.0007            0.0082
subthalamicnucleus          7448     0.0005            0.0082
CingulateCortex             7448     0.0005            0.0081
fetalbrain                 7448   -0.0001   0.0080
WholeBrain                 7448   -0.0001   0.0080
bonemarrow                 7448   -0.0001   0.0081
BM-CD71+EarlyErythroid     7448   -0.0005   0.0083
lymphnode                  7448   -0.0019   0.0081
kidney                     7448   -0.0020   0.0081
OccipitalLobe              7448   -0.0041   0.0079
ADIPOCYTE                  7448   -0.0086   0.0085
PLACENTA                   7448   -0.0106   0.0085
BM-CD105+Endothelial       7448   -0.0110   0.0082
PB-CD4+Tcells              7448   -0.0115   0.0081
PB-CD19+Bcells             7448   -0.0125   0.0081
fetallung                  7448   -0.0132   0.0083
Lung                       7448   -0.0131   0.0082
PB-CD56+NKCells            7448   -0.0137   0.0082
WHOLEBLOOD                 7448   -0.0146   0.0082
PB-CD8+Tcells              7448   -0.0153   0.0079
thymus                     7448   -0.0164   0.0081
BM-CD33+Myeloid            7448   -0.0200   0.0082
BM-CD34+                   7448   -0.0225   0.0081
PB-CD14+Monocytes          7448   -0.0231   0.0082
721_B_lymphoblasts         7448   -0.0232   0.0080
PB-BDCA4+Dentritic_Cells   7448   -0.0238   0.0081
SmoothMuscle               7448   -0.0252   0.0084
bronchialepithelialcells   7448   -0.0276   0.0084
vartis tissues across coding surveys, minus Nielsen et al., 2005
             penr      phet
          0.0002    0.5564
          0.0003    0.0155
          0.0003    0.0530
          0.0009    0.0034
          0.0009    0.0047
          0.0011    0.0119
          0.0015    0.7775
          0.0024    0.0819
          0.0037    0.0210
          0.0055    0.1635
          0.0077    0.1863
          0.0084    0.3814
          0.0102    0.5620
          0.0126    0.3092
          0.0161    0.8408
          0.0161    0.2727
          0.0243    0.0082
          0.0373    0.9275
          0.0413    0.1664
          0.0441    0.2761
          0.0576    0.6314
          0.0667    0.4063
          0.0745    0.6124
          0.0829    0.7395
          0.0829    0.8297
          0.0851    0.1524
          0.0869    0.9580
          0.0912    0.9552
          0.0946    0.0465
          0.1200    0.0452
          0.1565    0.5722
          0.2029    0.4150
          0.2080    0.6200
          0.2108    0.2029
          0.2624    0.8322
          0.2640    0.9222
          0.2669    0.7178
          0.2713    0.7498
          0.3347    0.6372
          0.3589    0.4643
          0.3717    0.9731
          0.3882    0.2806
          0.3933    0.7921
          0.4241    0.1344
          0.4317    0.7543
          0.4638    0.2030
          0.4740    0.9753
          0.4758    0.9616
0.5037   0.1364
0.5047   0.1803
0.5054   0.3448
0.5247   0.0038
0.5918   0.3890
0.5988   0.0022
0.6980   0.5449
0.8436   0.1199
0.8945   0.3074
0.9116   0.0008
0.9235   0.0007
0.9372   0.0016
0.9437   0.3246
0.9440   0.3937
0.9521   0.0030
0.9626   0.0007
0.9737   0.0010
0.9785   0.2554
0.9924   0.0138
0.9972   0.0001
0.9977   0.0009
0.9981   0.0010
0.9984   0.0018
0.9987   0.1888
0.9995   0.9555
sen et al., 2005
Supplemental Table 8e: Specificity to Novartis tissues acr
tissue                     mean n   mean r r, sstderr mean r r, s
TestisInterstitial          5147      0.0489           0.0101
TestisSeminiferousTubule    5147      0.0454           0.0103
TestisLeydigCell            5147      0.0447           0.0104
DRG                         5147      0.0381           0.0104
atrioventricularnode        5147      0.0322           0.0101
TestisGermCell              5147      0.0261           0.0101
salivarygland               5147      0.0244           0.0102
SuperiorCervicalGanglion    5147      0.0210           0.0101
testis                      5147      0.0211           0.0103
TrigeminalGanglion          5147      0.0203           0.0102
ciliaryganglion             5147      0.0191           0.0102
bonemarrow                  5147      0.0186           0.0101
Ovary                       5147      0.0177           0.0104
Tonsil                      5147      0.0170           0.0100
BM-CD71+EarlyErythroid      5147      0.0152           0.0100
WHOLEBLOOD                  5147      0.0147           0.0101
fetalliver                  5147      0.0143           0.0099
Appendix                    5147      0.0142           0.0100
SkeletalMuscle              5147      0.0141           0.0100
UterusCorpus                5147      0.0117           0.0100
skin                        5147      0.0109           0.0101
lymphnode                   5147      0.0075           0.0100
AdrenalCortex               5147      0.0058           0.0102
BM-CD105+Endothelial        5147      0.0053           0.0098
Pancreas                    5147      0.0049           0.0104
PancreaticIslets            5147      0.0031           0.0103
PB-CD19+Bcells              5147     -0.0005           0.0101
PB-CD4+Tcells               5147     -0.0009           0.0102
Pons                        5147     -0.0010           0.0103
trachea                     5147     -0.0013           0.0099
OlfactoryBulb               5147     -0.0019           0.0098
PB-CD8+Tcells               5147     -0.0023           0.0101
Liver                       5147     -0.0029           0.0097
TONGUE                      5147     -0.0040           0.0101
Pituitary                   5147     -0.0041           0.0101
globuspallidus              5147     -0.0051           0.0101
ParietalLobe                5147     -0.0066           0.0098
PB-CD56+NKCells             5147     -0.0076           0.0101
subthalamicnucleus          5147     -0.0083           0.0102
BM-CD33+Myeloid             5147     -0.0088           0.0099
721_B_lymphoblasts          5147     -0.0094           0.0098
PB-CD14+Monocytes           5147     -0.0105           0.0098
BM-CD34+                    5147     -0.0112           0.0102
cerebellum                  5147     -0.0112           0.0098
adrenalgland                5147     -0.0117           0.0098
thymus                      5147     -0.0125           0.0102
fetalThyroid                5147     -0.0164           0.0100
fetallung                   5147     -0.0167           0.0099
MedullaOblongata           5147   -0.0170   0.0099
Heart                      5147   -0.0164   0.0094
TemporalLobe               5147   -0.0184   0.0097
Uterus                     5147   -0.0209   0.0099
Prostate                   5147   -0.0228   0.0098
CardiacMyocytes            5147   -0.0239   0.0101
fetalbrain                 5147   -0.0240   0.0095
CingulateCortex            5147   -0.0246   0.0096
CerebellumPeduncles        5147   -0.0251   0.0097
PB-BDCA4+Dentritic_Cells   5147   -0.0252   0.0096
caudatenucleus             5147   -0.0273   0.0098
ADIPOCYTE                  5147   -0.0278   0.0099
kidney                     5147   -0.0276   0.0097
spinalcord                 5147   -0.0284   0.0096
Thyroid                    5147   -0.0314   0.0098
Lung                       5147   -0.0315   0.0096
Hypothalamus               5147   -0.0332   0.0097
WholeBrain                 5147   -0.0337   0.0097
bronchialepithelialcells   5147   -0.0345   0.0097
Amygdala                   5147   -0.0355   0.0095
OccipitalLobe              5147   -0.0359   0.0094
PLACENTA                   5147   -0.0392   0.0100
PrefrontalCortex           5147   -0.0426   0.0095
Thalamus                   5147   -0.0467   0.0095
SmoothMuscle               5147   -0.0495   0.0098
vartis tissues across coding surveys, minus Kosiol et al., 2008
             penr      phet
          0.0000    0.0741
          0.0000    0.0906
          0.0000    0.1103
          0.0001    0.0105
          0.0007    0.0229
          0.0049    0.2741
          0.0082    0.4753
          0.0190    0.0160
          0.0203    0.1738
          0.0236    0.0397
          0.0301    0.0108
          0.0332    0.7812
          0.0437    0.2321
          0.0448    0.1894
          0.0630    0.0414
          0.0723    0.0747
          0.0753    0.5796
          0.0770    0.0229
          0.0794    0.5880
          0.1221    0.2819
          0.1396    0.0808
          0.2277    0.7766
          0.2844    0.6159
          0.2965    0.0136
          0.3197    0.5812
          0.3837    0.6134
          0.5186    0.0094
          0.5334    0.0031
          0.5396    0.8261
          0.5505    0.3744
          0.5764    0.6954
          0.5894    0.0071
          0.6179    0.8189
          0.6560    0.1478
          0.6583    0.2201
          0.6942    0.5237
          0.7490    0.1576
          0.7732    0.0054
          0.7935    0.5896
          0.8120    0.0608
          0.8294    0.0098
          0.8578    0.0074
          0.8632    0.0006
          0.8749    0.1422
          0.8818    0.5929
          0.8906    0.3317
          0.9503    0.6334
          0.9543    0.4157
0.9577   0.0596
0.9590   0.8327
0.9719   0.0851
0.9824   0.8909
0.9900   0.2611
0.9909   0.1164
0.9943   0.0016
0.9948   0.1146
0.9950   0.0783
0.9955   0.0007
0.9974   0.0407
0.9976   0.7145
0.9977   0.1315
0.9985   0.0716
0.9993   0.2006
0.9995   0.7529
0.9997   0.0425
0.9997   0.0003
0.9998   0.6854
0.9999   0.0000
0.9999   0.0061
1.0000   0.4395
1.0000   0.0032
1.0000   0.0056
1.0000   0.8038
iol et al., 2008
Supplemental Table 8f: Specificity to Novartis tissues acro
tissue                     mean n   mean r r, sstderr mean r r, s
globuspallidus              5703      0.0368           0.0092
Appendix                    5703      0.0308           0.0094
ciliaryganglion             5703      0.0304           0.0094
TrigeminalGanglion          5703      0.0305           0.0096
atrioventricularnode        5703      0.0272           0.0095
Ovary                       5703      0.0253           0.0095
SkeletalMuscle              5703      0.0248           0.0095
SuperiorCervicalGanglion    5703      0.0232           0.0092
subthalamicnucleus          5703      0.0190           0.0090
UterusCorpus                5703      0.0195           0.0095
Pons                        5703      0.0187           0.0096
skin                        5703      0.0182           0.0094
DRG                         5703      0.0182           0.0095
TONGUE                      5703      0.0175           0.0095
ParietalLobe                5703      0.0168           0.0092
Heart                       5703      0.0151           0.0093
TestisLeydigCell            5703      0.0144           0.0094
Liver                       5703      0.0139           0.0094
MedullaOblongata            5703      0.0136           0.0094
fetalliver                  5703      0.0133           0.0092
OlfactoryBulb               5703      0.0135           0.0097
cerebellum                  5703      0.0124           0.0093
salivarygland               5703      0.0120           0.0095
TemporalLobe                5703      0.0111           0.0092
CingulateCortex             5703      0.0109           0.0093
trachea                     5703      0.0102           0.0092
OccipitalLobe               5703      0.0093           0.0092
Pancreas                    5703      0.0088           0.0092
Tonsil                      5703      0.0083           0.0092
fetalbrain                  5703      0.0079           0.0095
Amygdala                    5703      0.0075           0.0093
bonemarrow                  5703      0.0073           0.0094
TestisInterstitial          5703      0.0070           0.0094
Hypothalamus                5703      0.0067           0.0094
CardiacMyocytes             5703      0.0045           0.0094
kidney                      5703      0.0040           0.0094
ADIPOCYTE                   5703      0.0028           0.0095
CerebellumPeduncles         5703      0.0027           0.0095
spinalcord                  5703      0.0020           0.0093
Prostate                    5703      0.0015           0.0095
WholeBrain                  5703      0.0010           0.0093
AdrenalCortex               5703      0.0009           0.0096
caudatenucleus              5703     -0.0011           0.0094
PrefrontalCortex            5703     -0.0017           0.0092
Uterus                      5703     -0.0018           0.0093
TestisSeminiferousTubule    5703     -0.0024           0.0092
adrenalgland                5703     -0.0028           0.0094
PLACENTA                    5703     -0.0050           0.0094
bronchialepithelialcells   5703   -0.0054   0.0094
fetalThyroid               5703   -0.0057   0.0096
Pituitary                  5703   -0.0066   0.0097
PancreaticIslets           5703   -0.0072   0.0094
BM-CD71+EarlyErythroid     5703   -0.0072   0.0095
Thalamus                   5703   -0.0075   0.0092
lymphnode                  5703   -0.0087   0.0093
TestisGermCell             5703   -0.0101   0.0093
Lung                       5703   -0.0134   0.0093
testis                     5703   -0.0134   0.0093
fetallung                  5703   -0.0135   0.0093
thymus                     5703   -0.0142   0.0092
PB-CD4+Tcells              5703   -0.0185   0.0094
SmoothMuscle               5703   -0.0206   0.0092
Thyroid                    5703   -0.0217   0.0097
WHOLEBLOOD                 5703   -0.0211   0.0092
BM-CD105+Endothelial       5703   -0.0225   0.0096
PB-CD19+Bcells             5703   -0.0238   0.0093
PB-CD8+Tcells              5703   -0.0245   0.0093
PB-CD14+Monocytes          5703   -0.0277   0.0094
721_B_lymphoblasts         5703   -0.0348   0.0094
BM-CD34+                   5703   -0.0377   0.0096
BM-CD33+Myeloid            5703   -0.0369   0.0093
PB-CD56+NKCells            5703   -0.0381   0.0095
PB-BDCA4+Dentritic_Cells   5703   -0.0420   0.0093
vartis tissues across noncoding surveys, minus Pollard et al., 20
              penr      phet
           0.0000    0.0130
           0.0006    0.0265
           0.0006    0.0004
           0.0008    0.0018
           0.0020    0.0025
           0.0038    0.0137
           0.0044    0.0184
           0.0061    0.0001
           0.0179    0.2216
           0.0199    0.2431
           0.0260    0.0802
           0.0268    0.0029
           0.0274    0.0371
           0.0324    0.1443
           0.0334    0.6473
           0.0525    0.0859
           0.0621    0.1315
           0.0686    0.0537
           0.0732    0.1226
           0.0742    0.3054
           0.0807    0.5539
           0.0902    0.3696
           0.1025    0.0109
           0.1140    0.0788
           0.1207    0.5509
           0.1346    0.5290
           0.1568    0.9094
           0.1692    0.4146
           0.1840    0.2854
           0.2009    0.8888
           0.2113    0.8557
           0.2192    0.2620
           0.2268    0.2448
           0.2386    0.8337
           0.3165    0.4603
           0.3353    0.0618
           0.3844    0.6468
           0.3900    0.9669
           0.4169    0.5680
           0.4389    0.5135
           0.4560    0.7428
           0.4642    0.2128
           0.5445    0.7641
           0.5711    0.4836
           0.5783    0.0882
           0.6034    0.5368
           0.6165    0.3864
           0.7006    0.0298
0.7192   0.1307
0.7246   0.6698
0.7515   0.4219
0.7760   0.2315
0.7765   0.7617
0.7935   0.3618
0.8261   0.6143
0.8614   0.2753
0.9239   0.7576
0.9244   0.3551
0.9269   0.0428
0.9374   0.1253
0.9749   0.0486
0.9871   0.0594
0.9872   0.7451
0.9887   0.2045
0.9904   0.3130
0.9949   0.1155
0.9957   0.0193
0.9983   0.1009
0.9999   0.0288
1.0000   0.0558
1.0000   0.0229
1.0000   0.1735
1.0000   0.0453
Pollard et al., 2006
Supplemental Table 8g: Specificity to Novartis tissues acr
tissue                     mean n   mean r r, sstderr mean r r, s
Appendix                    4174     0.0323            0.0110
Ovary                       4174     0.0283            0.0109
SuperiorCervicalGanglion    4174     0.0257            0.0107
TrigeminalGanglion          4174     0.0262            0.0109
DRG                         4174     0.0248            0.0110
ciliaryganglion             4174     0.0239            0.0109
UterusCorpus                4174     0.0219            0.0108
Pancreas                    4174     0.0207            0.0106
TONGUE                      4174     0.0200            0.0108
atrioventricularnode        4174     0.0195            0.0108
globuspallidus              4174     0.0198            0.0110
ParietalLobe                4174     0.0184            0.0111
CardiacMyocytes             4174     0.0173            0.0110
SkeletalMuscle              4174     0.0167            0.0108
Tonsil                      4174     0.0154            0.0107
Heart                       4174     0.0157            0.0109
Pons                        4174     0.0161            0.0114
subthalamicnucleus          4174     0.0153            0.0109
bonemarrow                  4174     0.0152            0.0110
TestisLeydigCell            4174     0.0151            0.0110
OlfactoryBulb               4174     0.0147            0.0110
trachea                     4174     0.0123            0.0104
ADIPOCYTE                   4174     0.0124            0.0109
skin                        4174     0.0121            0.0110
Prostate                    4174     0.0121            0.0111
Pituitary                   4174     0.0118            0.0109
fetalliver                  4174     0.0116            0.0111
spinalcord                  4174     0.0107            0.0107
CingulateCortex             4174     0.0096            0.0112
OccipitalLobe               4174     0.0091            0.0110
MedullaOblongata            4174     0.0090            0.0113
Uterus                      4174     0.0084            0.0108
CerebellumPeduncles         4174     0.0083            0.0109
cerebellum                  4174     0.0082            0.0110
TemporalLobe                4174     0.0080            0.0112
Amygdala                    4174     0.0078            0.0111
salivarygland               4174     0.0074            0.0109
bronchialepithelialcells    4174     0.0073            0.0108
Hypothalamus                4174     0.0073            0.0110
TestisInterstitial          4174     0.0071            0.0109
kidney                      4174     0.0068            0.0107
PancreaticIslets            4174     0.0049            0.0106
fetalbrain                  4174     0.0049            0.0110
Liver                       4174     0.0048            0.0110
AdrenalCortex               4174     0.0031            0.0108
caudatenucleus              4174     0.0022            0.0110
WholeBrain                  4174     0.0021            0.0110
BM-CD71+EarlyErythroid      4174     0.0018            0.0107
thymus                     4174    0.0010   0.0110
adrenalgland               4174    0.0009   0.0108
TestisGermCell             4174    0.0009   0.0108
PrefrontalCortex           4174    0.0006   0.0111
fetalThyroid               4174    0.0002   0.0111
PB-CD4+Tcells              4174   -0.0009   0.0111
SmoothMuscle               4174   -0.0014   0.0108
lymphnode                  4174   -0.0016   0.0109
PB-CD19+Bcells             4174   -0.0018   0.0109
TestisSeminiferousTubule   4174   -0.0021   0.0108
PLACENTA                   4174   -0.0021   0.0109
Thalamus                   4174   -0.0023   0.0107
fetallung                  4174   -0.0037   0.0107
PB-CD8+Tcells              4174   -0.0045   0.0110
BM-CD105+Endothelial       4174   -0.0051   0.0112
testis                     4174   -0.0062   0.0111
WHOLEBLOOD                 4174   -0.0080   0.0108
Lung                       4174   -0.0109   0.0109
721_B_lymphoblasts         4174   -0.0117   0.0111
PB-CD14+Monocytes          4174   -0.0135   0.0108
Thyroid                    4174   -0.0166   0.0113
BM-CD34+                   4174   -0.0201   0.0113
PB-CD56+NKCells            4174   -0.0254   0.0109
BM-CD33+Myeloid            4174   -0.0280   0.0107
PB-BDCA4+Dentritic_Cells   4174   -0.0299   0.0111
vartis tissues across noncoding surveys, minus Prabhakar et al.
             penr      phet
          0.0017    0.0047
          0.0047    0.0010
          0.0082    0.0000
          0.0084    0.0016
          0.0118    0.0013
          0.0142    0.0005
          0.0214    0.0989
          0.0249    0.5936
          0.0314    0.0372
          0.0356    0.0080
          0.0360    0.3160
          0.0483    0.4560
          0.0584    0.4812
          0.0610    0.0693
          0.0749    0.6878
          0.0753    0.0301
          0.0786    0.0646
          0.0806    0.2802
          0.0833    0.0208
          0.0846    0.0574
          0.0913    0.5747
          0.1201    0.3024
          0.1292    0.5141
          0.1359    0.0037
          0.1365    0.6111
          0.1397    0.2075
          0.1485    0.2851
          0.1601    0.6770
          0.1970    0.5598
          0.2035    0.8653
          0.2137    0.1682
          0.2163    0.4542
          0.2238    0.4879
          0.2292    0.5539
          0.2371    0.0665
          0.2403    0.8535
          0.2488    0.0126
          0.2499    0.9082
          0.2544    0.8567
          0.2557    0.1564
          0.2621    0.0106
          0.3232    0.9259
          0.3276    0.8405
          0.3291    0.2181
          0.3858    0.0778
          0.4216    0.4586
          0.4247    0.5940
          0.4326    0.1282
0.4625   0.9358
0.4668   0.1357
0.4683   0.9394
0.4767   0.5523
0.4928   0.2164
0.5341   0.7996
0.5517   0.8363
0.5570   0.7953
0.5671   0.3407
0.5763   0.4227
0.5767   0.0224
0.5863   0.6515
0.6349   0.2438
0.6587   0.7170
0.6743   0.3954
0.7128   0.0413
0.7714   0.9060
0.8415   0.5048
0.8534   0.7926
0.8930   0.8782
0.9291   0.8225
0.9628   0.7929
0.9903   0.9593
0.9955   0.1095
0.9964   0.3145
Prabhakar et al., 2006
Supplemental Table 8h: Specificity to Novartis tissues acr
tissue                     mean n   mean r r, sstderr mean r r, s
TrigeminalGanglion          4438     0.0634            0.0107
SuperiorCervicalGanglion    4438     0.0699            0.0103
Appendix                    4438     0.0572            0.0103
Ovary                       4438     0.0570            0.0105
ciliaryganglion             4438     0.0657            0.0105
atrioventricularnode        4438     0.0559            0.0106
globuspallidus              4438     0.0507            0.0103
DRG                         4438     0.0479            0.0104
skin                        4438     0.0487            0.0107
SkeletalMuscle              4438     0.0447            0.0105
salivarygland               4438     0.0385            0.0107
TONGUE                      4438     0.0384            0.0109
Pons                        4438     0.0372            0.0107
Heart                       4438     0.0363            0.0106
UterusCorpus                4438     0.0353            0.0105
TestisLeydigCell            4438     0.0325            0.0104
subthalamicnucleus          4438     0.0300            0.0103
TemporalLobe                4438     0.0283            0.0102
kidney                      4438     0.0290            0.0106
Liver                       4438     0.0287            0.0106
bonemarrow                  4438     0.0278            0.0105
MedullaOblongata            4438     0.0273            0.0104
ParietalLobe                4438     0.0231            0.0101
fetalliver                  4438     0.0237            0.0104
TestisInterstitial          4438     0.0209            0.0106
trachea                     4438     0.0203            0.0108
cerebellum                  4438     0.0189            0.0103
AdrenalCortex               4438     0.0188            0.0110
CingulateCortex             4438     0.0168            0.0106
adrenalgland                4438     0.0110            0.0105
Pancreas                    4438     0.0107            0.0103
CerebellumPeduncles         4438     0.0082            0.0104
OccipitalLobe               4438     0.0078            0.0104
OlfactoryBulb               4438     0.0076            0.0107
CardiacMyocytes             4438     0.0076            0.0108
fetalbrain                  4438     0.0068            0.0107
ADIPOCYTE                   4438     0.0065            0.0109
WholeBrain                  4438     0.0058            0.0105
BM-CD71+EarlyErythroid      4438     0.0058            0.0109
Amygdala                    4438     0.0056            0.0105
caudatenucleus              4438     0.0053            0.0104
TestisSeminiferousTubule    4438     0.0053            0.0105
fetalThyroid                4438     0.0051            0.0108
Hypothalamus                4438     0.0047            0.0105
testis                      4438     0.0041            0.0106
spinalcord                  4438     0.0036            0.0106
Prostate                    4438     0.0036            0.0107
Tonsil                      4438     0.0025            0.0104
Pituitary                  4438    0.0019   0.0108
Lung                       4438   -0.0076   0.0104
PrefrontalCortex           4438   -0.0077   0.0103
lymphnode                  4438   -0.0081   0.0104
PancreaticIslets           4438   -0.0095   0.0106
bronchialepithelialcells   4438   -0.0118   0.0111
Uterus                     4438   -0.0126   0.0107
TestisGermCell             4438   -0.0126   0.0106
Thalamus                   4438   -0.0136   0.0105
BM-CD105+Endothelial       4438   -0.0186   0.0108
thymus                     4438   -0.0184   0.0102
Thyroid                    4438   -0.0209   0.0111
PB-CD19+Bcells             4438   -0.0221   0.0108
WHOLEBLOOD                 4438   -0.0238   0.0105
SmoothMuscle               4438   -0.0251   0.0107
PB-CD4+Tcells              4438   -0.0261   0.0107
PLACENTA                   4438   -0.0282   0.0106
fetallung                  4438   -0.0285   0.0107
PB-CD14+Monocytes          4438   -0.0339   0.0109
PB-CD8+Tcells              4438   -0.0340   0.0106
721_B_lymphoblasts         4438   -0.0401   0.0108
PB-CD56+NKCells            4438   -0.0423   0.0108
BM-CD34+                   4438   -0.0447   0.0107
PB-BDCA4+Dentritic_Cells   4438   -0.0549   0.0105
BM-CD33+Myeloid            4438   -0.0564   0.0108
vartis tissues across noncoding surveys, minus Haygood et al.,
             penr      phet
          0.0000    0.6200
          0.0000    0.0764
          0.0000    0.3162
          0.0000    0.2060
          0.0000    0.5741
          0.0000    0.9156
          0.0000    0.3154
          0.0000    0.1328
          0.0000    0.6327
          0.0000    0.8529
          0.0002    0.6983
          0.0002    0.3887
          0.0003    0.6635
          0.0003    0.4371
          0.0004    0.5056
          0.0009    0.5032
          0.0018    0.8997
          0.0028    0.6503
          0.0031    0.3267
          0.0035    0.7332
          0.0042    0.1569
          0.0043    0.8889
          0.0108    0.6943
          0.0112    0.7947
          0.0237    0.6450
          0.0298    0.6192
          0.0332    0.8855
          0.0428    0.4800
          0.0557    0.9091
          0.1475    0.4373
          0.1498    0.2195
          0.2144    0.4971
          0.2281    0.9364
          0.2383    0.9542
          0.2393    0.1874
          0.2634    0.7488
          0.2736    0.3010
          0.2888    0.7845
          0.2956    0.2082
          0.2967    0.9685
          0.3064    0.6112
          0.3082    0.7620
          0.3177    0.3705
          0.3259    0.9921
          0.3479    0.1837
          0.3678    0.3702
          0.3698    0.2880
          0.4036    0.6243
0.4322   0.0507
0.7671   0.6725
0.7720   0.9730
0.7813   0.4910
0.8136   0.2655
0.8559   0.2773
0.8808   0.5145
0.8832   0.3262
0.9010   0.7743
0.9579   0.0868
0.9638   0.2272
0.9706   0.6200
0.9796   0.0268
0.9881   0.2442
0.9905   0.0843
0.9925   0.1712
0.9961   0.6203
0.9962   0.6093
0.9991   0.2318
0.9993   0.1200
0.9999   0.0449
1.0000   0.2776
1.0000   0.1817
1.0000   0.5365
1.0000   0.8033
Haygood et al., 2007
Supplemental Table 8i: Specificity to Novartis tissues acro
tissue                     mean n   mean r r, sstderr mean r r, s
fetalliver                  7375      0.0136           0.0022
SkeletalMuscle              7375      0.0195           0.0033
TestisGermCell              7375      0.0243           0.0045
TestisLeydigCell            7375      0.0389           0.0074
salivarygland               7375      0.0195           0.0039
TestisInterstitial          7375      0.0372           0.0095
atrioventricularnode        7375      0.0347           0.0092
Ovary                       7375      0.0172           0.0048
TrigeminalGanglion          7375      0.0307           0.0096
UterusCorpus                7375      0.0221           0.0069
DRG                         7375      0.0317           0.0110
TestisSeminiferousTubule    7375      0.0310           0.0109
SuperiorCervicalGanglion    7375      0.0293           0.0103
AdrenalCortex               7375      0.0170           0.0063
Pancreas                    7375      0.0126           0.0046
ciliaryganglion             7375      0.0298           0.0114
skin                        7375      0.0224           0.0088
Appendix                    7375      0.0282           0.0115
PancreaticIslets            7375      0.0077           0.0033
Tonsil                      7375      0.0119           0.0055
testis                      7375      0.0135           0.0069
Pons                        7375      0.0117           0.0070
Liver                       7375      0.0107           0.0074
OlfactoryBulb               7375      0.0065           0.0048
TONGUE                      7375      0.0134           0.0110
bonemarrow                  7375      0.0065           0.0067
globuspallidus              7375      0.0055           0.0062
trachea                     7375      0.0034           0.0043
Heart                       7375      0.0031           0.0105
fetalThyroid                7375      0.0019           0.0102
lymphnode                   7375      0.0005           0.0038
Pituitary                   7375      0.0006           0.0055
BM-CD71+EarlyErythroid      7375      0.0002           0.0113
TemporalLobe                7375     -0.0017           0.0110
MedullaOblongata            7375     -0.0022           0.0108
Thyroid                     7375     -0.0051           0.0149
adrenalgland                7375     -0.0022           0.0055
Prostate                    7375     -0.0050           0.0106
spinalcord                  7375     -0.0069           0.0131
ParietalLobe                7375     -0.0031           0.0058
kidney                      7375     -0.0067           0.0123
WHOLEBLOOD                  7375     -0.0080           0.0144
Uterus                      7375     -0.0054           0.0084
cerebellum                  7375     -0.0043           0.0067
CardiacMyocytes             7375     -0.0076           0.0110
CerebellumPeduncles         7375     -0.0083           0.0112
caudatenucleus              7375     -0.0096           0.0123
Amygdala                    7375     -0.0150           0.0185
BM-CD105+Endothelial       7375   -0.0114   0.0128
Hypothalamus               7375   -0.0134   0.0130
PrefrontalCortex           7375   -0.0177   0.0169
subthalamicnucleus         7375   -0.0035   0.0034
fetalbrain                 7375   -0.0140   0.0129
Thalamus                   7375   -0.0195   0.0174
WholeBrain                 7375   -0.0180   0.0160
PB-CD4+Tcells              7375   -0.0151   0.0132
CingulateCortex            7375   -0.0108   0.0094
PB-CD19+Bcells             7375   -0.0145   0.0122
PB-CD8+Tcells              7375   -0.0172   0.0125
OccipitalLobe              7375   -0.0197   0.0132
PB-CD56+NKCells            7375   -0.0181   0.0120
ADIPOCYTE                  7375   -0.0137   0.0077
BM-CD34+                   7375   -0.0272   0.0152
PB-CD14+Monocytes          7375   -0.0245   0.0128
721_B_lymphoblasts         7375   -0.0245   0.0125
BM-CD33+Myeloid            7375   -0.0205   0.0095
PLACENTA                   7375   -0.0215   0.0100
PB-BDCA4+Dentritic_Cells   7375   -0.0312   0.0134
Lung                       7375   -0.0197   0.0064
fetallung                  7375   -0.0126   0.0039
SmoothMuscle               7375   -0.0334   0.0087
thymus                     7375   -0.0174   0.0044
bronchialepithelialcells   7375   -0.0306   0.0026
vartis tissues across coding surveys, random-effects meta-analy
             penr
          0.0124
          0.0141
          0.0159
          0.0170
          0.0189
          0.0294
          0.0318
          0.0355
          0.0425
          0.0427
          0.0513
          0.0520
          0.0526
          0.0565
          0.0569
          0.0604
          0.0631
          0.0666
          0.0720
          0.0822
          0.0956
          0.1179
          0.1422
          0.1536
          0.1735
          0.2153
          0.2352
          0.2521
          0.3984
          0.4336
          0.4561
          0.4598
          0.4951
          0.5557
          0.5723
          0.6170
          0.6347
          0.6588
          0.6749
          0.6777
          0.6806
          0.6822
          0.7060
          0.7065
          0.7211
          0.7326
          0.7421
          0.7488
0.7670
0.7944
0.7978
0.7980
0.8043
0.8104
0.8112
0.8151
0.8162
0.8213
0.8477
0.8623
0.8651
0.8917
0.8920
0.9020
0.9057
0.9176
0.9178
0.9273
0.9538
0.9583
0.9689
0.9707
0.9965
ffects meta-analysis
Supplemental Table 8j: Specificity to Novartis tissues acro
tissue                     mean n   mean r r, sstderr mean r r, s
OccipitalLobe               4771      0.0088           0.0008
Amygdala                    4771      0.0070           0.0011
Hypothalamus                4771      0.0063           0.0011
ParietalLobe                4771      0.0190           0.0036
fetalbrain                  4771      0.0067           0.0016
OlfactoryBulb               4771      0.0121           0.0033
CingulateCortex             4771      0.0123           0.0034
subthalamicnucleus          4771      0.0213           0.0065
globuspallidus              4771      0.0356           0.0118
UterusCorpus                4771      0.0246           0.0082
cerebellum                  4771      0.0129           0.0044
trachea                     4771      0.0142           0.0049
fetalliver                  4771      0.0159           0.0060
Appendix                    4771      0.0382           0.0146
TONGUE                      4771      0.0251           0.0104
SkeletalMuscle              4771      0.0284           0.0122
Pons                        4771      0.0232           0.0106
TrigeminalGanglion          4771      0.0388           0.0180
Pancreas                    4771      0.0126           0.0060
Ovary                       4771      0.0353           0.0167
atrioventricularnode        4771      0.0338           0.0163
TestisLeydigCell            4771      0.0198           0.0098
ciliaryganglion             4771      0.0388           0.0199
Heart                       4771      0.0219           0.0112
MedullaOblongata            4771      0.0158           0.0085
DRG                         4771      0.0280           0.0158
Tonsil                      4771      0.0086           0.0051
Liver                       4771      0.0159           0.0096
CerebellumPeduncles         4771      0.0057           0.0035
skin                        4771      0.0259           0.0170
TestisInterstitial          4771      0.0112           0.0074
SuperiorCervicalGanglion    4771      0.0375           0.0250
TemporalLobe                4771      0.0149           0.0103
CardiacMyocytes             4771      0.0092           0.0066
bonemarrow                  4771      0.0156           0.0111
salivarygland               4771      0.0189           0.0145
ADIPOCYTE                   4771      0.0066           0.0051
spinalcord                  4771      0.0048           0.0044
WholeBrain                  4771      0.0028           0.0026
Prostate                    4771      0.0052           0.0053
kidney                      4771      0.0123           0.0127
AdrenalCortex               4771      0.0073           0.0089
caudatenucleus              4771      0.0017           0.0036
adrenalgland                4771      0.0024           0.0071
Pituitary                   4771      0.0006           0.0094
TestisSeminiferousTubule    4771      0.0001           0.0041
BM-CD71+EarlyErythroid      4771     -0.0006           0.0074
fetalThyroid                4771     -0.0007           0.0061
Uterus                     4771   -0.0025   0.0082
bronchialepithelialcells   4771   -0.0043   0.0078
testis                     4771   -0.0058   0.0100
PrefrontalCortex           4771   -0.0027   0.0037
PancreaticIslets           4771   -0.0049   0.0066
PLACENTA                   4771   -0.0111   0.0127
TestisGermCell             4771   -0.0079   0.0060
thymus                     4771   -0.0105   0.0079
PB-CD19+Bcells             4771   -0.0166   0.0115
PB-CD4+Tcells              4771   -0.0157   0.0101
SmoothMuscle               4771   -0.0165   0.0104
fetallung                  4771   -0.0158   0.0098
PB-CD8+Tcells              4771   -0.0215   0.0118
lymphnode                  4771   -0.0064   0.0035
Thalamus                   4771   -0.0080   0.0043
BM-CD105+Endothelial       4771   -0.0162   0.0086
721_B_lymphoblasts         4771   -0.0294   0.0123
WHOLEBLOOD                 4771   -0.0182   0.0070
PB-CD14+Monocytes          4771   -0.0259   0.0085
Lung                       4771   -0.0110   0.0032
BM-CD34+                   4771   -0.0345   0.0099
BM-CD33+Myeloid            4771   -0.0411   0.0114
PB-BDCA4+Dentritic_Cells   4771   -0.0422   0.0097
PB-CD56+NKCells            4771   -0.0359   0.0072
Thyroid                    4771   -0.0200   0.0026
vartis tissues across noncoding surveys, random-effects meta-a
             penr
          0.0046
          0.0109
          0.0154
          0.0175
          0.0251
          0.0339
          0.0346
          0.0409
          0.0472
          0.0472
          0.0503
          0.0511
          0.0592
          0.0602
          0.0692
          0.0724
          0.0802
          0.0822
          0.0838
          0.0848
          0.0870
          0.0909
          0.0954
          0.0955
          0.1016
          0.1088
          0.1166
          0.1190
          0.1231
          0.1333
          0.1340
          0.1358
          0.1422
          0.1476
          0.1480
          0.1604
          0.1610
          0.1941
          0.2017
          0.2156
          0.2170
          0.2493
          0.3435
          0.3834
          0.4792
          0.4932
          0.5301
          0.5417
0.6040
0.6798
0.6899
0.7262
0.7296
0.7626
0.8408
0.8422
0.8573
0.8692
0.8727
0.8752
0.8959
0.8961
0.8966
0.9002
0.9302
0.9395
0.9536
0.9628
0.9631
0.9656
0.9754
0.9810
0.9919
m-effects meta-analysis

								
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