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Introduction to Drug Design

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					Introduction to Drug Design
       Information gathering to
             application
• So far we have been learning about the cell
  – Observation under the microscope
  – Organelles and cell cycle
  – Experimental design to determine regulation
  – Much more! (Metabolic pathways, intercell
    signaling, phosphorylation cascades)
• Now we will see how to change the function
  of abnormal cells for therapeutic purposes
             Types of Drugs
• Enzyme inhibitors
• Drug-receptor interactions
• Non specific interactions
Have you 
wondered what 
actually happens 
when you take 
medicine?

 How do 
antibiotics work?
      Basic goals of drug design
• Change some physiological condition

• Interact with some element that distinguishes
  the abnormal from the normal

• Block/harm the causal agent of condition

• Develop a chemical that specifically targets
  that agent
     Antibiotics general example
• Cure bacterial infection

• Interact with some element that distinguishes
  bacteria or infection from healthy state

• Kill/harm bacteria, their function in the body

• Develop a chemical that specifically targets
  bacteria
      Penicillin specific example
• Cure bacterial infection

• Interact with bacterial cell wall

• Harm bacteria by targeting the enzyme used
  to make a cell wall- which humans do not
  have

• Develop a chemical that specifically binds to
                   Staphylococcus
                   aureus




                   Penicillin 
                   fungus


infectionnet.org
                             Research:
                             Information
                              gathering




                         Drug design
http://www.wiley.com/college/pratt/047139
3878/student/activities/proteomics/index.ht
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posted:4/11/2014
language:English
pages:9