Docstoc

NEOPLASIA

Document Sample
NEOPLASIA Powered By Docstoc
					ORGAN
SYSTEM:                               LUNG                          MALE REPRODUCTIVE SYS                          FEMALE REPRODUCTIVE SYS

                                                                            Nonseminomatous
CANCER:                  LUNG Ca                   MESOTHELIOMA PROSTATE Ca Testicular Tumors      OVARIAN   VAGINAL CLEAR CELL         CERVIX               BREAST Ca
  carcinogenic asbestos (bronchogenic),            asbestos
    chemicals Chromium & Nickel vapors,
                                                                                                                    DES
               Uranium

      radiation moderate sensitivity to ionizing                                                                                                         moderate sensitivity
                 rad                                                                                                                                     to ionizing rad




   DNA&RNA                                                                                                                        HPV{16,18,31,33}
     viruses,                                                                                                                     invasive sq cell CA;
     bacteria                                                                                                                     HPV {6,11} warts
    Relevant                                                                                                                                             erb-B2 oncogene/
 Genes, gene                                                                                                                                             HER-2
 products, etc


tumor-assoc. ↑ hCG:lung CA, PTH:Sq Cell,
   hormones ACTH & ADH:Small Cell                                             hCG                                                                        hCG

 non-endocrine Acanthosis Nigricans &
      effects Thrombosis via Tumor Mucins
              (Lung); Dermatomyositis &                          DIC
              Clubbed Fingers & Myasthenia
              (Bronchus CA)
tumor markers CEA (lung); NSE (Small Cell)                                                                                                               Cathepsin D, CA-15-
                                                                 Prostatic Acid                                                                          3, Estrogen Receptor
                                                                 Phosphatase, AFP               CA-125                                                   & Progesterone
                                                                 PSA                                                                                     Receptor


 social factors smoking                                                                                                                                  ? Animal fat diet

  predisposing
    conditions
ORGAN
SYSTEM:                      LIVER                                                   ORAL

                                                                                                        ESOPHAGEAL
CANCER:              LIVER       HEMANGIOSARCOMA        MOUTH Ca           ORAL Ca          LARYNX Ca       Ca       STOMACH Ca
  carcinogenic Aflatoxin B1                                                                                          asbestos,
    chemicals (hepatoma);                                                                                            nitrosamines
                                Polyvinyl Chloride
               aromatic amines,                                                                                      (smoked foods)
               azo dyes
      radiation                                      salivary gland:                                                 GI tract:low
                                                     moderate                                                        sensitivity to
                                                     sensitivity to                                                  ionizing rad
                                                     ionizing rad


   DNA&RNA HBV, HCV                                                                                                  H. Pylori:
     viruses, (hepatoma)                                                                                             Gastic CA &
     bacteria                                                                                                        MALTomas
    Relevant
 Genes, gene
 products, etc


tumor-assoc. ↑ Insulin
   hormones

 non-endocrine                                                                                                       Acanthosis
      effects                                                                                                        Nigricans



tumor markers


                  AFP



 social factors                                      chewing betel     smoking; alcohol   smoking       smoking
                  alcohol
                                                     nuts
  predisposing                                                                                                       chronic atophic
    conditions                                                                                                       gastritis in
                                                                                                                     pernicious
                                                                                                                     anemia
ORGAN
SYSTEM:                                                                                                                                          BLOOD, LYMPHATICS

                                             COLON                                                                                      KAPOSI
CANCER:                PANCREAS Ca             Ca        BLADDER Ca         SKIN Ca             BONE            MUSCLE   THYROID       SARCOMA     LEUKEMIA              LYMPHOMA
  carcinogenic                                         B-naphthylamine                                                                           alkylating
    chemicals                                          (trans cell CA) arsenic                                                                   agents,
                                                                                                                                                 benzene
                                                                                                                                                 (Acute L)
      radiation                                                       UVB rays; low         low sensitivity              in young:               AML&CML:
                                                                      sensitivity to        to ionizing rad              high                    high sensitivity
                                                                      ionizing rad                                       sensitivity             to ionizing rad
                                                                                                                         to ionizing
                                                                                                                         rad

   DNA&RNA
                                                                                                                                                 HTLV-1 (T-         HTLV-1; EBV (Burkitt's);
     viruses,                                                                                                                          KSHV
                                                                                                                                                 cell)
     bacteria
    Relevant                                 MSH2,
 Genes, gene                                 MLH1
 products, etc                               Hered.                                                                                              t(9:22) CML        myc t(8:14) Burkitt's
                                             Non
                                             Polyp.
tumor-assoc. ↑ ACTH (Cushing's Syndrome):
   hormones pancreatic islet cell
                  neoplasms
 non-endocrine Thrombosis via Tumor Mucins                                                                                                       DIC- Acute    Renal: immune
      effects                                                                                                                                    Promyelocytic complexes (Hodgkin's)
                                                                                                                                                 Leukemia


tumor markers                                                                                                                                    Ig's
                                                                                                                                                 (myelomas)
                                             CEA,
                  CEA, CA-19-1                                                                                Desmins    Calcitonin
                                             CA-19-1


 social factors                              animal smoking           skin tumors-
                                             fat diet                 caucasians
  predisposing                                                        solar keratoses;
    conditions                                                        leukoplakia of oral
                                                                      cavity, vulva &
                                                                      penis(CA)
ORGAN
SYSTEM:                                 BRAIN & NERVOUS SYSTEM

                     glioma,
CANCER:            astrocytoma neuroblastoma neurofibromatosis    RETINOBLASTOMA
  carcinogenic
    chemicals


      radiation




   DNA&RNA
     viruses,
     bacteria
    Relevant sis proto-
 Genes, gene oncogene
 products, etc (gliomas)        N-myc         NF-1               Rb


tumor-assoc. ↑
   hormones

 non-endocrine
      effects




tumor markers Glial Filaments
                  (gliomatous
                  tumors),       NSE
                  Neurofilaments
                  (neuronal)

 social factors

  predisposing
    conditions

				
DOCUMENT INFO
Shared By:
Categories:
Tags:
Stats:
views:3
posted:3/26/2014
language:Unknown
pages:4