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USP 797 Compliant Expiration Date Chart - Vanderbilt University

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					I.V. Expirations and Dilutions
Drug Dilution of dispensed product 500mg/50ml 700mg/100ml provide filtered set 6mg/ml any dose/100ml 5 g/ 250 ml 500mg/500ml 1mg/10ml 1mg/ml Constitute with Concentration sterile water unless of solution specified 5 ml to 500 mg 100 mg/ml 50 mg/ml
Expiration when refrigerated unless noted is:

vial 7 days 7 days

syringe 24 hrs 2 days 2 days

piggyback Premix 24 hrs 2 days

Acetazolamide Acyclovir Injection Albumin Allopurinol Amikacin Injection Aminocaproic Acid Aminophylline Amphotericin B Ablecet

24 hrRT 14 days 14 days 7 days 7 days 7 days

N/A 14 days 2 days 24 hrs 24 hours 24 hours

24 hrsRT 14 days 3 days 24 hrs 24 hrs 10 days 4hr in d5w 3days in ns

10ml to 50mg 2.5ml to 250mg 5ml to 500mg 9.5ml to 1g 18.8ml to 2g 94ml to 10g 14 ml to 1.5g 13 ml to 3g

5 mg/ml

Ampicilin

1g/50ml

100 mg/ml

4 hrs

12 Hrs

Amp/Sulbactam Aquasol A Ascorbic Acid Azathioprine Azithromycin Aztreonam Baclofen Intrathecal Betamethasone Caffeine citrate Caspofungin

1.5g/50ml 50,000 IU/ml dose in 100 ml NS 100 mg/50ml 100mg/ml

1.5gm=100 mg/ml 1 hr 3 gm=200mg/ml 24 hrs 500 mg/ml 10 mg/ml 100mg/ml 1gm=100 mg/ml 2 gm=200mg/ml 200mcg/ml 3 mg/ml 28 days 14 days 1 hr 7 days 8 days 7 days 7 days

3 days 24 hrs 48 hours 8 days 7 days 24 hours 24 hours 24 hours N/A 8 days 7 days 7 days 14 days

Cefazolin Cefepime Cefotaxime

Vial RT dose Refrigerator 10ml to 100mg 4.8 ml to 500 mg 9.6ml to 1g 1 g/50ml 9.2ml to 2 g use pres free NS filter w 0.22 mn 9ml to 1ml of 2000 mcg/ml NA NA 10 mg/ml 50mg: 10.5ml NS to 0.2mg/ml 70 mg 70mg: 10.5ml NS to 0.28mg/ml 50 mg 9.5ml to 1g 1 g/50ml 19ml to 2g 96 ml to 10g 2g/50ml 17.5 ml to 2 g 9.7ml to 1g 1 or 2 g/50ml 8.9ml to 2 g 97 ml to 10 gm 1 g/50ml 2 gm/100 ml 1 g/50ml 1 g/50ml 2 g/50ml 10ml to 1g ml to 2 gm 9.4ml to 1g 19ml to 2g 56 ml to 6g 9.6ml to 1g 19.2ml to 2 g 95ml to 10g 20

24 hours 48 hours

100 mg/ml 100 mg/ml
1GM=100 mg/ml 2GM=200 mg/ml 10GM=100 mg/ml

10 days 7 Days 7 days

14 days 7 Days 5 days

14 days 7 Days 7days

30 days

10 days

Cefoxitin Ceftazidime

100mg/ml 100 mg/ml

7 days 7days

2 days 3 days

9 days 7 days 7 days

Ceftriaxone

100 mg/ml

10 days

10 days

10 days

21 days

Ceftriaxone IM Cefuroxime Chloramphenicol Chlorthiazide Cimetidine Ciprofloxacin 1.5 g/50 ml 2 mg/50ml 300mg/50ml 200mg 100ml 400mg 200ml

1.8 ml lidocaine 1% 450 mg/ml to 1000 mg 14ml to 1.5g (Abraxis) 10ml to 1g 20ml to 500mg 100mg/ml 100 mg/ml 25 mg/ml

2 days 7 days 2 days 2 days 14 days

2 days 7 days 2 days 2 days 14 days 7 days 2 days 24 hrs 2 days See premixed 14 days 14 days 28 days

I.V. Expirations and Dilutions
Drug Dilution of dispensed product 6,9,12mg/ml 150 mg/50 ml 50mg/20-100ml in D5 glass in NS glass Daptomicin max 5mg/ml 10 mL of NS 50 mg/ml 48 hr Constitute with Concentration sterile water unless of solution specified 3 ml to 150 mg 50mg/ml
Expiration when refrigerated unless noted is:

vial 14 days 2 days

syringe 2 days n/a

piggyback Premix 2 days 24 hours 4 hrs 24 hrs

Clindamycin Colistin Cong Estrogen Cyclosporine Sandimmune

11 hrs 12 hrs RT 12 hrs RT 48 hr Ref. 48 hr Ref. 2 days 24 hrs 48 hrs 30 days 30 days

Dexamethasone Dobutamine Dopamine Doxycycline Epinephrine Ertapenem Erythromycin Esmolol Ethacrynic Acid Famotidine Single Dose Vial Fluconazole

20mg/50ml 1mg/ml^ 100mg/100ml 1mg/250ml^ 500mg/100ml 50mg/50ml 0.2mg/ml 100mg/50ml 200mg/100ml 400mg/200ml 12mg/ml Peripheral, 24 mg/ml Central line 1,8,20mg PE/ml 10mg/ml 10ml to 500mg 20ml to 1000 mg 10ml to 50mg 10mg/ml^ 5 mg/ml 10 mg/ml 10ml to 100mg 20ml to 200mg 10 mg/ml 4mcg/ml^

30 days MDV 7 2 days days SDV

12 hours

2 days

3 days 48 hrs

14 days 24 hrs discard vial after used NA

24 hrs 24 hrs 14 days

24 hrs 24 hrs 24 hrs 14 days 30 days

2 mg/ml

2 days 14 days undiluted 2 days diluted 14 days

2 days 14 days undiluted 2 days diluted 12 hrs 24 hrs

30 days

Foscarnet

14 days

Fosphenytoin Furosemide

7 days

2 days

Ganciclovir

10 ml to 500 mg 1g/168 ml, USE REMAINING Pediatric doses DRUG IN VIAL TO 5mg/ml 500mg in 100 START NEXT ml. of D5W DOSE Any dose in 100ml 2mg/ml pres free saline 100mg/100ml 500mg/100ml 1000mg/250ml 1mg/ml in NS 1mg/250ml^ 200mg/60ml 250mg/50ml 500mg/100ml 200mg/250ml^ Dose in 100 ml NS 2 mg/ml 1 or 2g/50ml NS

12 hrs

5 days (syringe doses are 5 days diluted in D5W) 14 days 14 days 24 hrs

Gentamicin Gent intrathecal filtered 5 mn Heparin Hydrocortisone Imipenem Insulin Isoproterenol Itraconazole Levofloxin Labetalol Levetiracetam Linezolid Meropenem

14 days

10ml to 500mg

50mg/ml 4mcg/ml

14 days 3 days 24 hrs 28 days NA

7 days 24 hours 24 hrs 24 hours 24 hours 14 days 14days

48 hrs 24 hrs
2 Days in NS

24hrs/d5w 24 hrs 24 hrs 2 days 14 days 28 days 24 hrs 24 hrs

100 mg/ml 5ml to 500mg 10ml to 1g 17.5ml to 2g

7 days 2 days 12 hr

2 days 30 days 4hr rm 30 days temp, 24hr fridge

I.V. Expirations and Dilutions
Drug Dilution of dispensed product 50ml to 2 g >10 mg in 50ml 500mg/100ml dose in 100 ml 5 ml NS to 50mg NS 50mg/50ml 6mg/ml 1. 2g/ 50ml 9.4ml to 1g 94 ml to 10g 100 mg/ml Constitute with Concentration sterile water unless of solution specified 12.5ml to 500mg 25ml to 1g
Expiration when refrigerated unless noted is:

vial 2 days 7 days

syringe 24 hrs 14 days 2 days

piggyback Premix 24 hrs 7 days 2 days 24 hours 30 days 48 hrs 4 hours 7 days 48 hours 14 days 21 days 30 days

Methylprednisone Metoclopramide Metronidazole Micafungin Midazolam Milrinone Mycophenolate Nafcillin Nicardipine Nitroglycerin in glass Nitroprusside Norepinephrine Octreotide Ondansetron Oprelvekin Oxacillin

10 mg/ml

24 hous

4 hrs 7 days

N/A 7 days

max:400mcg/m l 50 mg/250ml^ 2 ml in 50 mg 4mg/250ml^ 50mcg/ml 2mg/ml 1 ml to 5 mg 2g/100ml 10ml to 1g 40ml to 4g 92 ml to 10g

30 days 200mcg/ml^ 16mcg/ml^ 14 days 14 days 24 hours 4 days

48 hrs 24 hrs 24 hrs 24 hrs 7 days 7 days in NS 4 days in D5W

100mg/ml

7 days

Pen G

8ml to 5mu 31.5 ml to 20munits 2.5 MU/100ml 500,000 un/ml (Pfizerpen 33 ml/20munits)

7 days

3 days

3 days

14 days

Phenytoin send 0.22 mfilter Phenylephrine Phytonadione Piperacillin Pip/Tazobactam Potassium chloride Potassium Phosphate Procainamide

4 hrs
30 mg in 250 ml^

Quinapristin/Dalf

120 mcg/ml^ 10mg/ml 4g/50ml 17.4ml to 4g 200 mg/ml 2.25g/50 ml 8.8 ml to 2.25gm 3.375g/50 ml 225 mg/ml 13.2 to 3.375 gm 4.5g/50ml 10 meq/50ml any dose in 250ml 1g in 250ml 5 ml to 500 mg USE REMAINING 500mg in D5W DRUG IN VIAL TO 100 mg/ml 250 START NEXT DOSE 600 mg/500ml 10 ml to 600 mg 50mg/2ml dose in 100 ml NS 50meq/1000ml any dose mg/ml dose in 100 ml NS 3.1 g/50 ml 3.1g/ in 100 8ml to 3.1g 76 ml to 31 g 60mg/ml

7 days 2 days

30 days 24 hrs 10 days 7 days

48hrs 48 hours 7 days 7 days 48 hrs 48 hrs 48 hours 14 days 30 days

48 hours

Rifampin Ranitidine Selenium Sodium Bicarb Tacrolimus Thiamine Ticar/Clavulanate

24 hrs roomtemp 7 days 10 days

24 hrs NS 4 hours D5W 10 days 24 hours

40mcg/ml

7 days 24 hours

9 days 24 hours 24 hours 3 days 7 days

1 mg/ml 50mg/ml 310 mg/ml

24 hrs 7 days 3 days

24 hours 24 hours 3 days

I.V. Expirations and Dilutions
Drug Dilution of dispensed product 50mg/50ml any dose/100ml 5ml/50ml 5ml/100ml 5ml/125ml Constitute with Concentration sterile water unless of solution specified 5.3 ml 10mg/ml 40 mg/ml
Expiration when refrigerated unless noted is:

vial 1 hr 14 days 7 days 7 days 7days 14 days

syringe 6 hr RT 24 hr ref 14 days 3 days 3 days 3 days 14 days 14 days 24 hours 72 hrs

piggyback Premix 6 hr RT 24 hr ref 14 days 2 hrs 4 hrs 6 hrs 14 days 30 days

Tigecycline Tobramycin TMP/SMX

Vancomycin Vancomycin Vanc Intrathecal Vanc Inhalation Valproic sodium

5ml to 500mg 500mg/100ml 10ml to 1g 100 mg/ml 95ml to 10g 1g/200ml 10ml PF NS to filter w 0.22 mn 500mg Lilly brand, filter dose 4.16ml to 500mg lilly brand 100mg/50ml

2 days

24 hrs

(wr)wrapper removed room temperature protect from light Critical Care Drip ^ standard drip concentration Call For Changes due to USP 797 If sterility testing is done

Final Volume

Use a

< .75 ml. 1 ml .76 - 1.9 ml. 3 ml. 2 - 4.6 ml. 6 ml. 4.7 - 9.6 ml. 12 ml. 9.6 - 15.9 ml. 20 ml. 16 - 27.9 ml. 35 ml. 28 - 45.9 ml. 60 ml. viaflex bag > 46 ml. Pediatric doses may go up to 60 ml in a 60 ml syringe Add 0.1ml overfill on all pediatric doses up to 5 ml

USP Beyond Use Dating (BUD)
Use the following chart to derive the maximum BUD for item not listed above as long as you do not exceed published stability data .
Type of Product Low Risk :
simple dilutions, less that 3 sterile components

Room Temperature Expiration

Refrigerated Expiration

Frozen Expiration

48 Hours 30 Hours 24 Hours

14 days 9 days 72 hours

45 days 45 days 45 days

Medium Risk:
more complex dilutions, more than 3 sterile components

High Risk: made
from non sterile components or exposed to less than ISO5 air.

06/17/07rbo

I.V. Expirations and Dilutions
Drug Dilution of dispensed product Constitute with Concentration sterile water unless of solution specified
Expiration when refrigerated unless noted is:

vial

syringe

piggyback Premix


				
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