Diuretic Notecards

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					ADH Actions

Increases absorption of H20 by making the pores permeable to water in collecting duct.

DCT Drugs

Thiazides: chlorothiazide, hydrochlorothiazide Thiazide like: chlorthalidone, metalazone,xipamide Medium efficacy/inhibitors of Na+ Cl- symport

Furosemide, bumetanide, ethacrynic acid, torsemide

Loop Diuretics

AKA- High ceiling drug, high efficacty Act on the loop of henle

Collecting Ducts Drugs


PCT Drug

Low efficacy/weak diuretics Carbonic anhydrase inhibitors K+ sparing diuretics Osmotic diuretics Xanthenes: theophyline

Acetazolamide, dorzolamide, brinzolamide Inhibit membrane-bound & cytoplasmic carbonic anhydrase => Complete aboloition of NaHCO3 reabsorption in PCT & Collecting Duct => metabolic acidosis b/c ↑HCO3- excretion Other actions: ↓ rate of formation of aqueous humor & consequently reduces IOT. ↓rate of formation of CSF Uses: Glaucoma(acute congestive), familial periodic paralysis, metabolic acidosis, epilepsy, cerebral edema Side Effects: Acidosis, hypokalemia, calculus formation b/c ppt of CaPO3 salts in alkaline urine, drowsiness, parestheisa(b/c of metabolic acidosis) Contraindications: hepatic cirrhosis, hyperchloremeic acidosis or severe COPD => more prone to acidosis

Carbonic Anhydrase Inhibitors

Function: High-Ceiling loop diuretic that acts on thick ascending Loop of Henle. Prevents Na+-K+-2Clcotransport => Ca++ & Mg++ excretion. Uses: Edema, Acute pulmonary edema, cerebral edema, forced diuresis, hypertension. 1st choice for hypertension caused renal failure/insufficiency Side Effects: Drug Intrx: Ditigalis glycosides; Thiazide diuretics, propanolol Fxn: Act on the early part of the DCT. Bind to NaCl transporter Uses: Edema associated with CHF, hepatic cirrhoisis, nephritic syndrome, chronic renal failure, acute glomerulonephritis SE: CI: Related: Increases Ca++ levels.



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