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Dataset S1 _XLSX_

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Dataset S1 _XLSX_ Powered By Docstoc
					Genes up-regulated in MT
DAVID GO categories in descending order of significance for each HDM cluster shown in figure 3A.
Only categories with a p-value smaller than 0.05 are shown.
                              Cluster 1
                            GO                             Genes
Protein degradation                                      ADAM19,ADAMTS7,ARIH1,ATG4A,BTRC,CPD,CUL4A,CYLD
Insulin signaling pathway                                CRKL,EIF4E2,EIF4EBP1,GYS1,HK2,INPPL1,MAPK8,MKNK1
Microtubules                                             ARHGEF2,ATG4A,BICD2,DST,DYNC1I2,DYNC1LI1,DYNC1LI
Alternative splicing                                     1110012J17RIK,2310044G17RIK,2610110G12RIK,281047
Regulation of cell morphogenesis                         CDC42EP2,CDC42EP3,EPHB2,FYN,ITGA7,NTN1,RHOQ,RN
Negative regulation of neurogenesis                      CDC42,CFL2,EPHB2,EPHB3,FYN,NTN1,PLXNA1,RHOD,RNF
Negative regulation of cellular component organization ARHGEF2,EPHB2,MTAP1B,NTN1,PACSIN3,RHOQ,RNF6,R
Phosphate metabolism                                     ATP6V0A2,ATP6V1C1,ATP6V1D,ATP6V1E1,CAMK2D,CSK
Regulation of lymphocytes                                CD80,CDKN1A,CSK,DNAJA3,ERBB2,IL20RB,ITCH,PLDN,ST
Regulation of leukocytes                                 CD80,CDKN1A,CSK,DNAJA3,ERBB2,IL20RB,ITCH,PLDN,ST
Arrhythmogenic right ventricular cardiomyopathy (ARVC) ATP2A2,CACNA2D1,CACNG1,DAG1,DES,ITGA7,SGCB,TCF
Pathways in cancer                                       ARNT,BCL2L1,CDC42,CDKN1A,CRKL,E2F2,ERBB2,FGF11,F
Creatine metabolic process                               GAMT,GATM,STAT5B
Hypertrophic cardiomyopathy (HCM)                        ATP2A2,CACNA2D1,CACNG1,DAG1,DES,ITGA7,PRKAB2,S
ErbB signaling pathway                                   CAMK2D,CDKN1A,CRKL,EIF4EBP1,ERBB2,MAPK8,RPS6KB
Intra-Golgi vesicle-mediated transport                   COG3,GABARAPL2,PACS1
Endosome                                                 ATP6V0A2,CD164,D6WSU116E,OCIAD1,PTP4A2,RAB11FI
Regulation of translation                                CPEB2,EIF4E2,EIF4EBP1,GM672,GTPBP4,MKNK1,MTIF2,S
Inorganic cation transmembrane transport                 ATP2A2,ATP6V0A2,ATP6V1C1,ATP6V1D,ATP6V1E1,COX7
Mitochondria                                             BCL2L1,DNAJA3,DUSP18,PEO1,RNF7,RRM2B,SH3GLB1
Regulation of T cells                                    CD80,CSK,DNAJA3,ERBB2,IL20RB,ITCH,STAT5B
Intracellullar transport                                 ATG4A,BIN1,CDC42,COG3,DST,DUSP18,ELMOD2,EXOC6,
mTOR signaling pathway                                   CAB39,EIF4E2,EIF4EBP1,PDPK1,RPS6KB2,ULK1
Chronic myeloid leukemia                                 BCL2L1,CDKN1A,CRKL,E2F2,IKBKG,MDM2,STAT5B
Adherens junctions                                       CDC42,CSNK2A1,ERBB2,FARP2,FYN,SORBS1,TCF7
Cytoskeletal protein binding                             ADD3,ARHGEF2,ATG4A,BAIAP2L1,CFL2,DST,FARP2,FLNC
Response to hormone stimulus                             EIF4EBP1,GATM,INPPL1,RHOQ,SORBS1,STAT5B,ZFP106
Regulation of cell cycle                                 BTRC,CDC42,CDKN1A,CEP76,E2F2,GTPBP4,INTS3,MDM2,
Protein localization                                     AFTPH,ATG4A,CDC42,COG3,COG6,DUSP18,EXOC6,GABA
Positive regulation of cell morphogenesis                EPHB2,NTN1,RNF6,RTN4,ULK1
Prostate cancer                                          CDKN1A,E2F2,ERBB2,IKBKG,MDM2,PDPK1,TCF7
Dilated cardiomyopathy                                   ATP2A2,CACNA2D1,CACNG1,DAG1,DES,ITGA7,SGCB
Pancreatic cancer                                        BCL2L1,CDC42,E2F2,ERBB2,IKBKG,MAPK8
Fc gamma R-mediated phagocytosis                         CDC42,CFL2,CRKL,DNM1L,MYO10,PPAP2A,RPS6KB2
MAPK signaling pathway                                   CACNA2D1,CACNG1,CDC42,CRKL,DUSP8,FGF11,FLNC,IKB
for each HDM cluster shown in figure 3A.

                                          Cluster 2
                                         GO                                     Genes
                                                       Alternative splicing   1110028C15RIK,1110051M20RIK,1810020D17RIK,20
           Negative regulation of nitrogen compound metabolic process         BCL6,EID1,GM608,HEXIM1,HIPK2,PALM,PDCD4,PKIA
                                              Regulation of transcription     1300003B13RIK,A630033E08RIK,ABLIM1,APBB1,B23
                          Negative regulation of RNA metabolic process        1300003B13RIK,A630033E08RIK,ABLIM1,APBB1,B23
                                       Glycerophospholipid metabolism         CDS2,CHPT1,DGKD,GPD1L,PLA2G6
                                                              Cytoskeleton    ABLIM1,AI314180,ANXA11,ARHGAP24,CDC42SE2,EN
                                                             Neurogenesis     DCLK1,ENAH,MEF2A,MEF2D,RUFY3,SEMA6A,SLC7A5
                                                       Protein localization   BCL6,CHM,EXOC3,LRP4,MTTP,PALM,PEX14,PPP3R1,
                                                           Morphogenesis      ABLIM1,APBB1,BCL6,DCLK1,ENAH,ITGB1,KIF3A,PAR
                                        Negative regulation of cell cycle     APBB1,HEXIM1,RB1,RHOB
                                                Glycerolipid metabolism       CAT,CHPT1,DGKD,MTTP,PIGP,PIK3CB
                                                    Intracellular transport   APBB1,CHM,ENAH,KIF1B,PKIA,RAB10,RHOB,STAM,S
                                                                  Apoptosis   APBB1,EGLN3,HIP1,HIPK2,MEF2A,MEF2D,PDCD4,PE
                                                          Tumor supressor     HIPK2,PDCD4,RB1,RHOB,ZDHHC17
                                                       Pathways in cancer     EGLN3,ITGB1,JUP,LAMA2,PIK3CB,RB1,SMAD3,TGFB3
                             Embryonic cranial skeleton morphogenesis         SMAD3,TBX15,TGFB3
                                                         Pancreatic cancer    PIK3CB,RB1,SMAD3,TGFB3
                                                            Differentiation   ARHGAP24,DCLK1,EID1,ENAH,HIP1,MEF2A,MEF2D,R
                                   Phosphatidylinositol signaling system      CDS2,DGKD,INPP5A,PIK3CB
                                               Chronic myeloid leukemia       PIK3CB,RB1,SMAD3,TGFB3
                                                       Adherens junctions     INSR,PARD3,SMAD3,TJP1
                                                             Tight junction   AMOTL1,EXOC3,MPP5,PARD3,TJP1
                              Negative regulation of cell differentiation     ACAD11,BCL6,FST,ITGB1,SMAD3,TTC3
                                                      Protein degradation     ASB15,CAND2,DCUN1D2,FBXL2,HECW2,RNF216,SPS
                                           Intracellular signaling cascade    ABR,ADCY9,AKAP13,ARFGEF2,ASB15,BCL6,DCLK1,D
                                         Regulation of TGFbeta signaling      HIPK2,SMAD3,TGFB3
                                                     Small cell lung cancer   ITGB1,LAMA2,PIK3CB,RB1
                              Positive regulation of cell communication       CAT,HIPK2,LAMA2,NCAM1,TGFB3,ZRANB1
                                          Regulation of cell proliferation    ASPH,BCL6,DHCR7,FGFRL1,HIPK2,IL6ST,ITGB1,KISS1
                                                 Dilated cardiomyopathy       ADCY9,ITGB1,LAMA2,TGFB3
                               Embryonic skeletal system development          SMAD3,TAPT1,TBX15,TGFB3
            Cluster 3                                  Cluster 4
           GO                   Genes               GO               Genes
      Muscle development                     Muscle development ACTN2,ARX,CACNA2D2,CACNG5,CBFA2T3,CHR
                               ACTA1,AGT,CACNA1S,CAV3,CLIC5,CYP26B1,DLL1,EPAS1,GAA,GJA5,KY,LIMCH1,MACF
       Calcium ion binding                            Ion transport ABCC9,ATP6V1C2,CACNA2D2,CACNG5,CAMK
                               ATP2A1,CACNA1S,DLL1,DRP2,EFHD1,FREM2,GALNTL1,GAS6,ITGB1BP2,MACF1,MMP
           Cardiomyopathy                   Voltage-gated channel CACNA2D2,CACNG5,GABRD,KCNC1,KCNK1,SC
                               CACNA1S,ITGA9,MYH7,MYL2,MYL3,PRKAG3,SGCG
              Cytoskeleton                           Tight junction ACTN2,MYH14,MYH4,MYH6,MYH8
                               ABLIM2,ABLIM3,ACTA1,ANK1,CLIC5,DRP2,JAKMIP1,KY,LIMCH1,LMO7,LRRC26,MACF
          Ear development                            Neurogenesis ARX,CHRDL1,OPHN1,SIM1,SLIT3
                               CLIC5,DLL1,SOBP,TCAP,TMIE
    Neuromuscular process                         Cardiomyopathy ACTN2,ADCY1,CACNA2D2,CACNG5,MYH6
                               ABLIM2,ABLIM3,CACNA1S,CLIC5,EFNA2,GAA,HCN3,KCNB1,KCNH8,PAK6,PARK2,PLX
Monosaccharide metabolism                         Viral myocarditis MYH14,MYH4,MYH6,MYH8
                               FUCA2,GAA,OTOG,PGM5,PPARA,PRKAG3,RENBP
    Sarcoplasmic reticulum     ANK1,ART1,ATP2A1 Growth factor EGF,GDF6,IGF2,KLK1B4
         Glucose transport                   Submandibular gland EGFBP2,KLK1B26,KLK1B4
                               PRKAG3,SLC2A4,SORT1
              Tight junction   LLGL2,MYH1,MYH2,MYH3,MYH7,MYL2
              Cluster 5                                              Cluster 6
             GO                    Genes                           GO
          Alternative splicing   2310003F16RIK,A730037C10RIK,AK1,CACNB1,CAPN3,CCDC88C,CNP,CORO6,CYB5R1,
                                                                                           Muscle
         Steroid biosynthesis    CYB5R1,H2-KE6,HSD3B7,IDI1                          Cytoskeleton
             Cardiomyopathy      CACNB1,ITGB6,TNNC1,TPM2 Calcium signaling and homeostasis
  Transcription co-activatiors   ABRA,ANKRD1,CALCOCO1,H2-KE6,PCBD1 Metal ion homeostasis
             Red/ox reactions    ALOX5,CYB561D1,CYB5R1,GPX3,H2-KE6,HSD3B7,PHYHD1,PYROXD1,SUOX
                                                   Serine-type endopeptidase inhibitor activity
Protein homooligomerization      CCDC88C,GPX3,PCBD1                                      Secreted
                      Muscle     JSRP1,MYL6B,TNNC1,TPM2            Regulation of lipid catabolism
                   Exocytosis    RAB3A,SYTL2,UNC13D      Positive regulation of MAPKKK cascade
                                                                                 Stress response
                                                                         Chemical homeostasis
                                                                    Alternative promoter usage
                                                     Positive regulation of cell communication
                                                                            Calmodulin-binding
                                                                                    Signal anchor
                                                                       Notch signaling pathway
                                                             Positive regulation of JNK cascade
                                                             Response to temperature stimulus
                                                                Regulation of cell proliferation
                                           Ryanodine-sensitive calcium-release channel activity
                                                          Regulation of inflammatory response
                            Cluster 7
  Genes                   GO                   Genes
                          Retinol metabolism CYP3A11,CYP3A16,CYP3A41A,CYP3A44,CYP4A10,UGT2B34
ACTN3,ADM,ADRB2,ATP1A2,CAMK2A,CASQ1,CASQ2,CSRP3,DOK7,ERBB3,HRC,MRVI1,MYLPF,MYOD1,MYOM1,MYOM
                            Drug metabolism CYP3A11,CYP3A16,CYP3A41A,CYP3A44,UGT2B34
ACTN3,BFSP2,CDC42BPG,DAAM2,DYNC1I1,FEZ1,LIMA1,LMOD3,LSP1,MYLK,NRAP,PDLIM3,PSTPIP1,SVIL,SYNPO2L,TM
                    Linoleic acid metabolism CYP3A11,CYP3A16,CYP3A41A,CYP3A44
ACTN3,ADRB2,ASGR2,ATP1A2,BEST1,CALR4,CAMK2A,CAPN12,CASQ1,CASQ2,CDH1,CSRP3,DNASE1L3,DTNA,ERBB3,F
                                  Microsome CYP3A11,CYP3A16,CYP3A41A,CYP4A10
ACSL1,ACSL6,ADSSL1,AMHR2,ATP1A2,CDC42BPG,CLYBL,CSRP3,ENO2,HRC,IL1B,MYLK,NUDT16,PINK1,PRKAA2,PYGM,
          Regulation of cytokine biosynthesis CARD11,RNF128,TLR6
SERPINB1A,SERPINB1B,SERPINB1C,SERPINB6C,SERPINB7,SERPINB9D,SERPING1,SPINK4
                                      Muscle DMD,MEF2C,MYO18B,TCF23
ADAMTSL4,ADM,APOA2,C1QTNF3,CHRD,CP,CTRB1,DCN,FBLN5,FGF21,FGFBP1,FGL1,FNDC7,GDF5,HYAL1,IGFBP5,IL1
IL1B,MLYCD,PNPLA2
ADRB2,DUSP22,EDA2R,FGF21,IL1B
HSF2BP,HSPA2,HSPB2,HSPB3,HSPB7
ABCA2,APOA2,ASGR2,ATP1A2,CHRNG,CSRP3,HRC,IL1B,PYGM,RYR1,RYR3,TGM2,XIRP1
DUSP13,LIMA1,MYLK,TRP63
ADRB2,DUSP22,EDA2R,FGF21,FGFBP1,IL1B,PINK1,TGM2
CAMK2A,DAPK2,MYLK,MYLK2,RRAD,TTN
ACSL1,ACSL6,AI464131,ASGR2,ATP1B1,CHST5,DYSF,FUT7,GALNT6,HSD11B1,PNPLA2,SIT1,SYT8
DTX4,HEYL,PSEN2,TRP63
DUSP22,EDA2R,IL1B
ADRB2,HSPB2,HSPB3,HSPB7
ADM,ADRB2,CD28,DUSP22,FGF21,FGFBP1,H19,IL12A,IL15,INPP5D,SPRY1,TGM2,TRP63,XIRP1
RYR1,RYR3
ADRB2,CD28,SERPING1,TGM2
Permanently repressed genes
DAVID GO categories in descending order of significance for each HDM cluster shown in figure 3B.
Only categories with a p-value smaller than 0.05 are shown.
    Cluster 1                              Cluster 2
  GO     Genes                          GO                            Genes
Vision CRYBA1,MIP,OPN1SW,RRH                Cell fate commitment BARX1,CDX1,CDX2,DBX1,EVX1,FGF1,FGF3,FOXN
                                              Transcription factors BARX1,CDX1,CDX2,DBX1,DBX2,DMRTA1,EBF2,EL
                                                        Homeobox BARX1,CDX1,CDX2,DBX1,DBX2,EVX1,GBX2,GSX2
                                 Endocrine system development ELF5,GHRHR,GLI2,HNF1A,INSM1,LAMA1,MNX1,
                                         Alkali metal ion binding ACCN4,AI317395,KCNA1,KCNA2,KCNA3,KCND1,K
                                                Symporter activity AI317395,SLC12A3,SLC13A2,SLC15A1,SLC2A12,SL
                                                     Development ABI3BP,ADAMTS8,ADCYAP1R1,AKP3,APBA1,BAR
                                   Nervous system development ADCYAP1R1,AHSG,CACNA1F,CCKAR,CHRNA3,CLI
                                                 Cell-cell signaling APBA1,BARX1,CHRNA3,FGF1,FGF3,GHRHR,GJC2,
                                                 Sodium transport ACCN4,AI317395,SCN11A,SCN8A,SCNN1B,SCNN1
                                    Pituitary gland development GHRHR,GLI2,PITX1,POU3F2,SLC6A3,SOX2,TBX19
                                                          Behaviour APBA1,CCL1,CCL24,CCR7,CHRNA3,CMTM5,CXCL
                                        Spinal cord development DBX1,EVX1,GLI2,GSX2,HOXB8,MNX1,NKX2-2,NK
                                  Regulation of cell proliferation BMP15,BMP8B,BTLA,FGF1,FGF16,FGF20,FGF23,F
                                                   Immune system ADCY4,AHSG,BARX1,BMP15,BMP8B,BTLA,BTN2A
                            Maturity onset diabetes of the young GCK,HNF1A,MNX1,NKX2-2,PAX4,PDX1
                                           Pancreas development HNF1A,INSM1,MNX1,NKX2-2,NKX3-2,NKX6-2,PD
                                                                ECM ADAMTS8,C1QC,C1QL1,C1QL3,C1QTNF2,C1QTNF
                                                              Vision CACNA1F,GJD2,GNAT1,GRK1,GUCA1A,GUCY2E,N
                                                           Zymogen ADAMTS8,ASTL,CFB,CFD,CPA5,F10,F5,GGT1,GGT
                                                         GPI anchor 2210415F13RIK,AKP3,CAR4,CNTN2,EFNA3,GFRA
                                        Mesoderm development EOMES,HAND1,HNF1A,MESP1,OVOL1,TCF15,W
                   Hemopoietic or lymphoid organ development BARX1,EOMES,FGF3,HBA-X,HOXB7,IL20,IL25,NK
                                 Wnt receptor signaling pathway WNT2,WNT3,WNT3A,WNT7A,WNT8A
                                    Hedgehog signaling pathway BMP8B,GLI2,WNT2,WNT3,WNT3A,WNT7A,WNT
                                                       Cell junction ANKS1B,ARHGAP26,CAMK2N1,CHRNA2,CHRNA3
                                Formation of primary germ layer EOMES,HAND1,HNF1A,MESP1,WNT3,WNT3A
                                          Ectoderm development EDARADD,ELF5,KLK14,KRT25,KRT27,KRT6A,OVO
                                               Hormone secretion GHRHR,GLP1R,GPR120,HNF1A,RAPGEF4,RIMS2
                                               Pathways in cancer FGF1,FGF16,FGF20,FGF23,FGF3,GLI2,LAMA1,LAM
                                            FGF signaling pathway FGF1,FGF16,FGF20,FGF23,FGF3
                                                             Hearing COCH,FGF20,GBX2,GFI1,GJB6,MYO15,NKX3-2,SO
                                         Epidermis development EDARADD,KLK14,KRT25,KRT27,KRT6A,OVOL1,PO
                                   Regulation of hormone levels CHST8,DIO1,GHRHR,GLP1R,GPR120,HNF1A,LCN5
                                              Basal cell carcinoma GLI2,WNT2,WNT3,WNT3A,WNT7A,WNT8A
                                             Sensory transduction ADCY4,CACNA1F,CRB2,GNAT1,GRM4,GUCA1A,G
                                 Adenohypophysis development GHRHR,SLC6A3,SOX2
                                             Spleen development BARX1,NKX3-2,TCF21,TLX1
                                                           Intestine AKP3,CDX2,TFF3
                                  Mammary gland development ELF5,GHRHR,GLI2,SLC6A3,TNFRSF11A,WNT2,WN
                                                  Insulin secretion GLP1R,HNF1A,RAPGEF4,RIMS2
                                                   Proto oncogene FGF3,FLI1,NOTCH4,SFPI1,TAL1,VAV1,WNT3
                                       Calcium signaling pathway ADCY4,CACNA1F,CCKAR,HTR5B,NOS1,NOS2,OXT
                                           Placenta development CDX2,EOMES,HAND1,HNF1A,PRDM1,RSPO3,WN
HDM cluster shown in figure 3B.

                          Cluster 3                                     Cluster 4
                         GO                     Genes                GO                    Genes
                                 Homeobox                           Immune response AICDA,ARG1,BMP5,C9,CAMP,CCL12,C
                                               BARHL2,BSX,CDX4,CRX,DLX6,EMX2,GSC,HESX1,HOXB13,HOXB2,HOXD1,HOXD10
                        Neuronal signaling                                          Liver APOB,CAR5A,FABP1,LIPC,ORM2,TTR
                                               ACCN5,ADCY5,AGTR1A,AMPH,ATP2B2,CACNA2D3,CACNA2D4,CACNG2,CARTPT,
                              Development                                         Vision ABCA4,ACCN3,CABP4,CHRNA9,CRTA
                                               3110039M20RIK,ATOH1,ATP2B2,BARHL2,BMP3,CCK,CDX4,CERKL,CHRDL2,CML2
                                   Behavior                 Hematopoietic cell lineage CD33,CD38,CSF2,CSF3,GP9,IL1A,IL3,IL
                                               ADCY5,ADH1,AFF2,AGTR1A,ALB,AMPH,ATP2B2,BSX,CARTPT,CCK,CCL3,CCL4,CCL
                            Immune system                           Neuronal signaling F2RL1,F2RL2,FPR2,GNRHR,GPR35,GR
                                               A1BG,ADAMTS13,AMICA1,BMP3,BTNL9,C1QA,C1S,C4BP,C8A,C8B,CCL3,CCL4,CCL
                 Neuronal differentiation                                Cell adhesion CD33,CDH17,CDH3,CDH5,CLCA5,CLD
                                               3110039M20RIK,ATOH1,ATP2B2,BARHL2,BRSK2,CCK,CCR4,CORIN,CRB1,CRX,EM
             Autoimmune thyroid disease                           Sexual reproduction ACSBG2,ADCY10,APOB,CATSPER1,FIG
                                               CD40LG,H2-AA,H2-DMB2,H2-EA,H2-M10.6,H2-OB,H2-T3,IFNA12,IFNA4,IL4,IL5,TP
                                     Asthma                          Spermatogenesis ACSBG2,ADCY10,APOB,CATSPER1,GA
                                               CD40LG,EPX,H2-AA,H2-DMB2,H2-EA,H2-OB,IL4,IL5,PRG2
              Sensory organ development                                    Coagulation C9,ENTPD1,F2RL1,F2RL2,GP9,PF4
                                               3110039M20RIK,ATOH1,ATP2B2,CRB1,CRYBB2,DLX6,FOXG1,GSC,HESX1,IKZF1,IT
            Regulation of body fluid levels               Keratinocyte differentiation FOXN1,IVL,SPRR1B,SPRR2F,SPRR3
                                               ADAMTS13,CD40LG,CYP11B2,FGA,FGB,FGG,KCNMA1,KLKB1,KNG1,PAPSS2,PTGE
                          Ear development                                   Hemostasis C9,ENTPD1,F2RL1,F2RL2,GP9,PF4
                                               3110039M20RIK,ATOH1,ATP2B2,DLX6,FOXG1,GSC,HESX1,ITGA8,KCNMA1,NOX3
                  Forebrain development                                    Fertilization APOB,CATSPER1,OOEP,SMCP,STRA8
                                               DKK1,EMX2,FEZF2,FOXG1,GSC,HESX1,IKZF1,LHX3,LMX1A,NKX2-1,OTP,OTX2,POU
                                      Vision                       Gamete generation ACSBG2,ADCY10,APOB,CATSPER1,FIG
                                               ARR3,CACNA2D4,CNGA3,CRB1,CRYBB2,GLRA1,GRM6,OPN1MW,RCVRN,RGR,TH
                Neuron fate commitment                   Epidermal cell differentiation FOXN1,IVL,SPRR1B,SPRR2F,SPRR3
                                               ATOH1,FOXA1,HOXD10,NKX2-1,OLIG1,OTX2,PTF1A,TLX3
                         Blood coagulation     ADAMTS13,CD40LG,FGA,FGB,FGG,KLKB1,KNG1,PAPSS2,TFPI2
                               Homeostasis     ADAMTS13,CD40LG,FGA,FGB,FGG,KLKB1,KNG1,PAPSS2,TFPI2
                                Cell motion    3110039M20RIK,AKAP3,ATOH1,BARHL2,CCK,CCR4,CERKL,CSF3R,EMX2,FEZF2,FO
                                    Meiosis    CCNB3,DMC1,FBXO43,MEI1,SMC1B,STAG3,SYCP1
                          Disease mutation     ATP2B2,DCT,EDAR,GLRA1,KRT2,OTC,PAH,PAPSS2,PAX1
                          Circadian rhythm     ALB,CARTPT,CRX,KCNMA1,MTNR1A,PROKR2
                  Hindbrain development        ATP2B2,HOXB2,LMX1A,MYO16,NEUROD1,PHOX2B,PTF1A,TBR1
                           Chondrogenesis      BMP3,CHRDL2,LECT1,WNT5A
                      Gland development        ATP2B2,BSX,EDA,EDAR,FOXA1,HOXB13,HOXD3,IKZF1,LHX3,NKX2-1,NR0B1,OTP,
           Endocrine system development        HOXD3,LHX3,NEUROD1,NKX2-1,NR0B1,OTP,PAX1,WNT5A
                     Cell fate commitment      ATOH1,BARHL2,FOXA1,HOXD10,NEUROD1,NKX2-1,NTF3,OLIG1,OTX2,PTF1A,SIX
                Renin-angiotensin system       ACE2,AGTR1A,CPA3,MAS1
                    Regulation of appetite     CARTPT,NPY,SLC22A3
               Hematopoietic cell lineage      CD22,CSF3R,FCER2A,H2-AA,H2-EA,IL4,IL5,IL5RA,TPO
          Mechanoreceptor differentiation      ATOH1,ATP2B2,KCNMA1,NTF3,POU4F3
           Cluster 5
          GO                 Genes
                Olfaction   9830107B12RIK,A530064D06RIK,AGTR2,BAI3,C130060K24RIK,CASR,CCR1L1,CCR2,CD209A
               Antibiotic   DEFB1,DEFB10,DEFB12,DEFB14,DEFB15,DEFB35,DEFB38,DEFB39,DEFB40,DEFB5,DEFB50,D
           Cell adhesion    AMTN,ASTN1,CDH19,CDH26,CDH7,CDH8,CDH9,CHL1,CLSTN2,CNTN3,CNTN5,CNTN6,CNT
      Hormone activity      GALP,GPHB5,HAMP,NTS,OSTN,PRL2B1,PRL3A1,PRL3C1,PRL4A1,PRL7B1,PRL7C1,PRL7D1,P
Homophilic cell adhesion    CDH19,CDH26,CDH7,CDH8,CDH9,CHL1,CLSTN2,DSC3,DSG1A,DSG1C,DSG4,PCDH11X,PCDH
     Cell-cell adhesion     ASTN1,CDH19,CDH26,CDH7,CDH8,CDH9,CHL1,CLDN16,CLDN17,CLDN8,CLEC7A,CLSTN2,C
                   Heme     4833423E24RIK,CYP2A12,CYP2A22,CYP2A5,CYP2B23,CYP2B9,CYP2C38,CYP2C39,CYP2C55
  GABA receptor activity    GABRA2,GABRA4,GABRA6,GABRB1,GABRB3,GABRG1,GABRR2,MOG,OLFR93
    Retinol metabolism      ALDH1A7,CYP2A12,CYP2A22,CYP2A5,CYP2B9,CYP2C38,CYP2C39,CYP2C55,CYP2C66,CYP3A
               Pregnancy    A2M,PSG17,PSG22,PSG23,PSG27,PSG29

				
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posted:11/23/2013
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