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					NEOPLASIA

Terminology:
 Neoplasia:

New growth.  Tumor: Swelling d/t inflammation.  Now, Tumor - synonymous with
neoplasm.  Oncology.

Definition:
A neoplasm is an abnormal mass of tissue, the growth of which  exceeds &  is uncoordinated with that of the normal tissues &  persists in the same excessive manner after cessation of the stimuli which evoked the change.

NEOPLASIA

BENIGN

MALIGNANT

Neoplasia
Uncontrolled & Irreversible*  Benign
– Localized, non-invasive.
 Malignant

(Cancer)

– Spreading, Invasive.

Controlled,Reversible

Uncontrolled,Irreversible,Autonomous

NORMAL

ADAPTATION

BENIGN

MALIGNANT

Non-Neoplastic POLYCLONAL

Neoplastic MONOCLONAL

Nomenclature
Neoplasia
Can arise from

Epithelial cells

Mesenchymal cells

Benign

Malignant

Benign

Malignant SARCOMA

CARCINOMA

Nomenclature-benign tumors
Benign epithelial tumors


Benign mesenchymal tumors Usually named after  Suffix “Oma” to the microscopic architecture cell of Origin
Fibrous Tissue Glandular pattern Adenoma Chondrocytes
Osteocytes

Fibroma
Chondroma Osteoma Angioma

Papillary pattern

Papilloma

Blood vessels Smooth muscle

Leiomyoma

Wartlike

Villus

Polypoid
Papillomatous

Malignant tumors
Malignant epithelial tumors-CARCINOMA
Named after the cell of origin or the pattern Squamous epithelium Renal cells Gastric mucosa Squamous cell Carcinoma Renal cell Carcinoma Gastric Adenocarcinoma

Malignant Mesenchymal tumors-SARCOMA
Named after the cell of origin

Fibrous tissue
Osteocytes

Fibrosarcoma
Osteosarcoma

Few tumors have misnomers
– Malignant tumor arising from melanocytesMelanoma – Malignant tumor arising from hepatocytes Hepatoma


				
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posted:9/29/2008
language:English
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