DIC by akashyap

VIEWS: 36 PAGES: 7

									Disseminated Intravascular coagulation

 



 

Widespread thrombi in circulation Circulatory insufficiency – particularly brain, lungs, heart and kidneys Rapid consumption of platelets and coagulation factors Also known as Consumption Coagulopathy Thrombotic disorder



Bleeding disorder

Etiology




Not a primary disease Complication of other conditions
Infections
Gram negative infections Meningococcemia

Obstretric diseases
Retained dead fetus Amniotic fluid embolism

Carcinoma
Ca of Pancreas, colon

Massive tissue injury
Trauma Burns Extensive surgery

Mechanisms
2 major mechanisms  - release of tissue factor into the circulation  - widespread endothelial injury

Consequences
2 fold - widespread thrombi- ischemia of affected organs - haemorrhagic diathesis

Clinical Course
- Onset can be rapid and fulminant - insidious Laboratory tests -Prothrombin time -prolonged -Activated partial thromboplastin time-prolonged - FIBRIN DEGRADATION PRODUCTS

Thankyou &
Good luck for exams!


								
To top