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Session 1 Exam_2_


									Session 1 1. Which category of hypersensitivity best describes of the newborn a. Ectopic immune complex b. Cytotoxic (Type II)*

2. Complement fixation refers to a. Ingestion of c3b coated bacteria b. The heating (missed) c. Binding of complement components by antigen antibody complexes*

3. If an individual was genetically unable to make J chains, which immunoglobulins would be affected? (M and A) a. IgG b. (missed) c. IgG and IgM d. IgM and IgA*

4. Which of the following is NOT true regarding the alternating complement pathway? a. It can be triggered by infectious agents in absence of antibody b. Does not require c1, c2, or c4 c. Cannot be initiated unless c3b fragments are already present* d. Has same terminal sequence as classic pathways

5. C3 is cleaved to c3a and c3b by c3 convertase, c3b is involved in all but a. Altering vascular permeability*

b. Promoting phagocytosis c. Forming alternate pathway c3 convertase d. Forming c5 convertase

6. During maturation of B lymphocyte the first immunoglobulin heavy chain synthesized is a. γ chain (gamma) b. μ chain * (mu) c. ε chain (epsilon) d. α chain (alpha)

7. Which one group of following cells is not phagocytic in nature? a. Neutrophil polymorpholeukocyte b. B Lymphocytes*

8. Immunoglobulin isotype is determined by a. Antigen specificity b. L chain variable region c. Number of binding sites d. H chain constant region*

9. Anaphylaxis can be triggered by cross linkiing of IgE receptors on a. Monocytes b. Mast cells * c. B cells d. Neutrophils

10. Radioallergosorbent (RAST) measures a. Antigen concentration b. IgM antibody c. IgE antibody* d. IgG antibody i. (RIA – do test by labeling, for id of antigen or antibody, serological very sensitive, expensive so mostly go for ELIZA)

11. The main advantage for passive immunization over active is that a. It can be administered orally b. Provides antibody rapidly* c. Antibody persists for longer period of time d. It contains IgM

12. Which type of hypersensitivity cannot be transferred with serum antibody a. Type I b. Type II c. Type III d. Type IV *

13. A 3 year old boy has had several bouts with pneumonia. The streptococcal agent was isolated and identified. He perhaps had some sort of immunodeficiency. Had normal levels of immunoglobulin, but complement system was not working normally. The complement system is made of all (missed). Which of the following is the primary opsonization fragment in complement system? a. Factor b

b. C5 c. C3b* d. C5a

14. Which of the following is true for class II MHC molecules a. Consist of an alpha chain of three domains and beta 2 microglobulin b. Are found in all nucleated cells of body c. Involved in antigen presentation to CDA cytotoxic lymphocytes d. Consist of BP BQ BR molecules*

15. Patient in emergency room was stung by a bee about 15 min ago. A few minutes after being stung, became short of breath and saw hives appear in several places on her skin. Which of the following is most likely immunological mechanism for this a. IgE coated mast cells release histamine and leukotrienes* b. Membrane attack complexes of complement damage cells in lung and skin c. Cytotoxic helper cells release interleukin2 d. Immune cells consisting of IgG and hapten release in lung and skin

16. Each of the following concerning hapten is correct EXCEPT a. Can combine with antibody b. Cannot induce an antibody by itself, rather it may be bound by carrier protein to induce something c. In both penicillin induce anaphylaxis d. Haptens must be processed by cd8 cells to become immunogenic*

17. Direct Coombs test was performed on baby in 7th month (30 weeks), mother has had trouble with two early pregnancies and has no RHOgm. The physician is concerned about a possible

erythroblastosis case. What ingredients would be involved to prove positive direct Coombs test? a. Rh positive RBs plus mother serum and Coombs reagent b. Mothers serum Rh positive c. Rh positive from baby and Coombs reagent* d. Mothers serum RHOgm and Coombs reagent

18. Complement components are involved in which types of hypersensitivies? a. I & III b. II & III * c. II & IV d. III & IV

19. Antibody titer refers to a. Highest dilution of antibody still able to give positive result in test system* b. Concentration of specific antibody c. Availability of specific antibody d. Specific amount of specific antibody

20. The site of affinity of antibody for antigen is a. Disulfide bond b. Fc region c. Fab region* d.

21. The circulation of a two month old breast fed baby will contain maternal (WARNING: teacher was not sure of answer) [answer should be IgA] a. IgA b. IgM c. IgE d. IgG*

22. Which of the following is correct about secondary immune response? a. Class switching from IgM to IgG will occur and IgG antibody titer will rise* b. IgM titer will rise above IgG level for a period of 6 months c. IgG titer will continue to fall and IgM titer will rise due to class switching d. IgG, IgA titers will continue to rise during secondary immune response e.

23. The defense mechanism which is lodged against most extracellular bacterial pathogens that infect through respiratory and intestinal tracts is a. Immunity involving only macros b. Cell mediated c. Immunity only involving polymorphonucleocytes d. Immune surveillance by immature lymphocytes e. Antibody mediated immunity *

24. Which of the following cell types expresses receptors for IgE on surface that mounts a response to parasites such as worms a. T cells b. B cells c. Promonocytes

d. Nk cells e. Mast cells*

25. A primary immune response in adult human requires approximately how much time to produce detectable (something) levels in blood a. 12 hrs b. 1 week* c. 2 week d. 3 week e. 4 weeks

26. Biologic fluids (missed a lot) semiquantitatve to detect microbial agents in a. Radioimmunoelectroph b. Blu nitro c. Coombs test d. Hemeagglutination inhibition tests e. Counter immunoelectrophoresis* (more sensitive)

27. Regarding function of chemokines in host defense , which is most accurate? a. Chemokines bind to T cell receptor outside of the antigen binding site and activate many T cells b. Chemokines induce switching in b cells which increase amount of ige produce c. Chemokines penetrate membranes of target cell d. Chemokines attract neutrophils to site of bacterial infection thereby playing a role in inflammatory response*

28. Which genetic mechanism increases number of different antibody molecules during immune response without creating diversity of antigen receptors specificities a. Class switching* b. Somatic hypermutation c. Gene duplication d. Multiple J, G gene segments e. Imprecise V, D, J joining

29. Immediately after primary immunization which of the following phenomenons would be expected to occur? a. Production of IgM antibody* b. Production of a set of restricted B lymphocytes c. Production of low affinity IgG antibody d. Degradation of antigen by (missed)

30. Antibody binding site is formed by a. Variable regions of L chains b. Hyper-variable regions of H & L chains* c. Variable regions of H chains d. Hyper-variable of H chains e. Hyper-variable regions of L chains

31. Which of the following statements about collaboration of T & B lymphocytes is NOT correct a. T lymphocytes may stimulate antibody production by B cells b. T lymphocytes may depress antibody production by B cells c. T lymphocytes that participate in carrier recognition must recognize same antigen epitope as B lymphocyte*

d. Collaboration is not required for all antibody response e. Antigen processing by macros may be required to optimize T lymphocytes effects

32. When a precipitation reaction can be converted to an agglutination reaction by coating, it is called? a. Reverse passive b. Coagglutination c. Immune adherence d. Passive agglutination*

33. Agglutination reaction is more sensitive than precipitation reaction for detection of a. Antigens b. Antibodies* c. Antigen antibody complex d. Complement e. Heterophil antigen (sp)

34. The role of macrophage during antibody response is to a. Make antibody b. Lyse virus infected target cells c. Activate d. Process antigen and present it*

35. Each of the following concerning immunologic tolerance is correct EXCEPT a. Tolerance is not antigen specific* b. Paralysis of immune cells results in failure to

c. Tolerance is in t cells than in b cells d. Tolerance is induced more in neonates than in adults e. Tolerance is induced more by light molecules than heavy

36. Systemic Lupus Erythematosis (SLE) is associated with deficiency of a. C1 & C4* b. C2 & C3 c. C5 & C6 d. C2 & C4

37. Following are autoimmune diseases EXCEPT a. DiGeorge syndrome* b. Rheumatoid arthritis c. Hashimoto’s disease d. Myasthenia gravis

38. 1st component of complement that bind to fc of antibody molecule a. C1r b. C1q* c. C1s d. C2

39. Due to deficiency of secretory IgA infections occur predominantly in a. Respiratory tract b. GIT

c. Other tract options d. All of the above *

40. Drug induced immune hemolytic anemia is due to a. Type I b. Type II * c. Type III d. Type IV

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