Docstoc

Task Force on Desensitization

Document Sample
Task Force on Desensitization Powered By Docstoc
					Task Force on Desensitization
• Preliminary Questionnaire
– In which clinical situations have desensitization been performed – To which drugs? – Which protocol (reference/s)? – Total number of patients in each drug group – Total number of desensitizations (for each drug group) – Outcomes / how they have been measured? – Simultaneous in vitro analysis have bee done?

Task Force on Desensitization
Gul Karakaya Dpt Chest Diseases – Adult Allergy Unit – Turkey ASA/ 22 patients/ modified protocol (?) Outcomes: Clinical scales, FEV1, QoLQ

Gulfem Celik Dpt Allergy Ankara Medical School - Turkey
Kvedariene Violeta (Lithuania) Joanna Makowska (Poland) Antonino Romano Unità di Allergologia, Complesso Integrato Columbus - Italy Andreas Bircher Allergologische Poliklinik - Switzerland Pascal Demoly Hôpital Arnaud de Villeneuve - France

Atb (quinolones – protocol ?) Going to start on ASA
No (planning) No (planning) No (only in Polliclinico Gemely – Betalactams in CF – protocol ?) ASA/Beta-lactams (personnal protocol) and riphampicin (Int Arch Allergy Immunol 2006; 140:20-26) ASA - >50 pts (1/10/20/50 mg every 30 min) CTZ - >100 pts (Demoly et al) Others (insulin, TB drugs, anti-HIV drugs) – some as CTZ

Task Force on Desensitization
Drug Allergy Unit – Allergy and Clinical Immunology Division, Hospital São João and Oporto Faculty of Medicine, Portugal

ASA 100mg (prophylaxis for CD)
ASA 500 mg (AERD – nasal polyposis) Cotrimoxazole (HIV+ patients)

10 pts (modified protocol based in Stevenson et al)
5 pts (modified protocol based in Stevenson et al) >50 pts (modified protocol based in Demoly et al. J Allergy Clin Immunol. 1998 Dec;102:1033-6) 6 pts (based on Middleton’s Allergy: Principles and Practice 4th edition) 3 pts (based in Allergy. 2003 Jul;58(7):690) 1 pt (based on oral penicillin desensitization protocol) 3 pts (based in Lee et al Gynecol Oncol. 2005 Nov;99(2):393-9)

Penicillin (pregnant women, atb resistance) Allopurinol (gout) Levofloxacin (pts with bronchiectasis) Carboplatin (optochiasmatic gliomas)

Task Force on Desensitization
Drug Allergy Unit – Allergy and Clinical Immunology Division, Hospital São João and Oporto Faculty of Medicine, Portugal
Insulin 2 pts ( based on Drug Allergy and Protocols for Management of Drug Allergies – 2nd Edition. Roy Patterson et al) 3 pts (based on (Int Arch Allergy Immunol 2006; 140:20-26) 2 pts. Josefina Rodrigues
et al, (The Internet

Riphampicin (HIV+ and TB infection) Isoniazid (systemic TB)

Journal of Pharmacology. 2004. Volum 3 Number1)

L-asparaginase – E coli (Leukemia) Anastrozole (Breast cancer) Anti-thymocyte globulin (thymoglobulin) leukemia Methylphenidate (ADHS)

4 pts (based on J Allergy Clin Immunol 1998;101:571-572) 2 pts - Personnal protocol (EAACI 2007) 1 pt (based on J Allergy Clin Immunol 1998;101:571-572) - Failure 1 pt (based on J Child Adolesc Psychopharmacol. 2005;15:703-5) EAACI 2007 4 pts (based on Ann Allergy Asthma Immunol. 1999;83:23-4

Sulfasalazin (IBD)

Task Force on Desensitization
• Proposal
• • • • • • • • • • •

– Register desensitization protocols in program
Main disease Concomitant diseases Drug Initial dose Route of administration Interval Cumulative dose Continuous Intermittent Outcomes Protocol reference(s)

EXCEL


				
DOCUMENT INFO
Shared By:
Categories:
Tags:
Stats:
views:7
posted:11/15/2009
language:English
pages:5