Epitope Diagnostics Launches the Second Generation Immunoassay Kits Exclusively for the Quantitative Measurement of Antibody Drug Conjugate (ADC) Levels

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Epitope Diagnostics Launches the Second Generation Immunoassay Kits Exclusively for the Quantitative Measurement of Antibody Drug Conjugate  (ADC) Levels Powered By Docstoc
					Epitope Diagnostics Launches the Second Generation Immunoassay Kits
Exclusively for the Quantitative Measurement of Antibody Drug Conjugate
(ADC) Levels

Epitope Diagnostics has recently launched second-generation ADC kits exclusively for the
quantitative measurement of DM1-, MMAE-, and MMAF-ADC level. These kits measure both
humanized monoclonal antibody based ADC and mouse monoclonal antibody based ADC.
Additional benefits for testing PK samples from mice are utilized by these second generation kits.

San Diego, CA, October 12, 2013 --(PR.com)-- Epitope Diagnostics, Inc. is proud to introduce second
generation ADC kits that measure both humanized monoclonal antibody-based ADC and mouse
monoclonal antibody-based ADC. This new model of EIA kits has been developed to best fit PK studies
and broadly apply to samples from almost all species (including mouse, rat, primate, human, etc.).

Measurement of circulating specific cytotoxic ADCs are extremely important for pre-clinical and clinical
studies Based on the specific antibodies against DM1, MMAE, MMAF, Epitope Diagnostics has
developed three enzyme immunoassay (EIA) kits measuring DM1-ADC, MMAE-ADC, and
MMAF-ADC (respective antibody conjugates). These EIA kits were developed by coating
anti-DM1/MMAE/MMAF-specific antibodies to microtiter plates. The advantage of using this test
method is that there is no assay interference, even from a high concentration of mouse immunoglobulin in
test specimens. Incredibly, the analytical sensitivity (LLOD) of these second generation ADC kits is
higher (0.0012 μg/mL) than the first generation kits. The DAR of ADC conjugate has less of an
impact of the test results.

Much like the first generation ADC EIA kits, these newly developed kits feature a total incubation period
of less than 3 hours. The standard curve spans from 0.030 μg/mL to 20 μg/mL. The assay
procedure is very simple to perform with just a one-step plate wash.

"We're very excited to offer these second generation quantitative ADC test in ELISA format. These test
kits will be extremely useful in studies related to ADC metabolism or pharmacokinetics, particularly in
the mouse model, in which there is no need for any sample dilution," says Epitope Diagnostics' President,
Ping Gao. "Our effort to improve the drug development and pharmaceutical community is very
gratifying. We will continually strive to develop innovative tests for the benefit of the ADC community."

The second generation EDI™ DM1 ADC EIA Kit, EDI™ MMAE ADC EIA Kit, and the EDI™ MMAF
ADC EIA Kit are available now. Additionally, high affinity and specific antibodies to DM1, MMAE and
MMAF are also available. Epitope Diagnostics is currently interested in collaborating with
pharmaceutical companies to develop and manufacture customized ADC immunoassays and antibodies.
For more information, contact the Epitope Diagnostics, Inc. customer service department at
slenart@epitopediagnostics.com or by telephone: +1 (858) 693-7877

Product List:
1) DM1 ADC EIA Kit (KTR756)

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2) MMAE ADC EIA Kit (KTR757)
3) MMAF ADC EIA Kit (KTR758)

References:
The Next Advancements in Cancer Drug Development: Antibody-Drug Conjugates - Onco'Zine - The
International Cancer Network, June 14, 2012 [1]
Dimond (9 Mar 2010). "Antibody-Drug Conjugates Stage a Comeback"
Doronina SO et al. Nat Biotechnol. 2003;21(7):778-784
Alley SC et al. Curr Opin Chem Biol. 2010;14(4):529-537
Hamblett KJ et al. Clin Cancer Res. 2004;10(20):7063-7070
Antibody Drug Conjugates: A Marriage of Biologics and Small Molecules - Pharmaceutical Technology.
Pharmtech.findpharma.com.




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Contact Information:
Epitope Diagnostics, Inc.
Stefanie Lenart
858-693-7877
Contact via Email
www.epitopediagnostics.com


Online Version of Press Release:
You can read the online version of this press release at: http://www.pr.com/press-release/521528




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Description: Epitope Diagnostics has recently launched second-generation ADC kits exclusively for the quantitative measurement of DM1-, MMAE-, and MMAF-ADC level. These kits measure both humanized monoclonal antibody based ADC and mouse monoclonal antibody based ADC. Additional benefits for testing PK samples from mice are utilized by these second generation kits.
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