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					                                                                               #Hits in   Group
 Pathway id             Molecule name                 Pathway name
                                                                                group      size

            AKT-1, Bad, CAP, FOXO1a, GLUT4,
            GM, InsR, insulin, IRS-1, IRS-2,
            mTOR, p110beta, p46Shc, p52Shc,
            p66Shc, p85alpha, PDK1, PTEN,
CH000000750 PTP1B, SHIP2, SOCS-3                  insulin pathway                    21       93


            p38alpha, PGC-1, PPAR-gamma1,
            PPAR-gamma2, PPAR-gamma3,             p38alpha ---> PPAR-
CH000000672 PPAR-gamma4                           gamma                               6           6




            AKT-1, Bad, p110beta, p85alpha,       VEGF-A ---/ Caspase-9,
CH000000650 PDK1, VEGF-A, VEGFR-2                 Bad                                 7       10




            AKT-1, eNOS, p110beta, p85alpha,
CH000000652 PDK1, VEGF-A, VEGFR-2                 VEGF-A ---> NO                      7       10


            AKT-1, Bad, FOXO1a, GM, InsR,
            insulin, IRS-1, IRS-2, mTOR,          insulin ---> AKT-1
CH000000651 p110beta, p85alpha, PDK1, PTEN        pathway                            13       44




            InsR, insulin, IRS-1, IRS-2, PTP1B,   insulin ---Jak1---> IRS-1,
CH000000653 SOCS-3                                IRS-2                               6           8


            AKT-1, Bad, eNOS, LMW-PTP,
            p110beta, p46Shc, p52Shc, p66Shc,
CH000000723 p85alpha, PDK1, VEGF-A, VEGFR-2       VEGF-A pathway                     12       53




CH000000275 p46Shc, p52Shc, p66Shc, SHIP2         CH000000275                         4           4




            GR-Abeta(h), GR-alpha, GR-Alpha-
CH000000558 2(h), GR-beta, GR-Beta-2(h)           c-Ets-2 & GR ---> CYP27             5           8




            p46Shc, p52Shc, p66Shc, VEGF-A,
CH000000734 VEGFR-2                               VEGF-A ---> Ras                     5           8
            AKT-1, IRS-1, IRS-2, p110beta,
            p46Shc, p52Shc, p66Shc, p85alpha,
CH000000926 PDK1, SOCS-1, SOCS-3                PRL pathway                11   55




            AKT-1, AKT-2, p46Shc, p52Shc,
CH000000624 p66Shc, SHIP2                       EGF ---/ AKT                6   16




            InsR, IRS-1, p110beta, p85alpha,
CH000000050 PDK1                                insulin ---> alphaENaC      5   11




            activated protein C, thrombin,
CH000000164 thrombomodulin                      CH000000164                 3    3




CH000000735 LMW-PTP, VEGF-A, VEGFR-2            LMW-PTP ---/ VEGFR-1        3    3




CH000000969 AKT-1, PDK1, PTEN                   PTEN ---/ AKT-1             3    3




CH000000040 InsR, IRS-1, p110beta, p85alpha     insulin ---> PtdIns(3)P     4    8




            PPAR-gamma1, PPAR-gamma2,           RA, 15d-PGJ2 ---> RXR-
CH000000676 PPAR-gamma3, PPAR-gamma4            beta, PPAR-gamma            4    8




CH000001028 AKT-1, IGF-1A, IGF-1B               IGF-1 ---> Akt-1 ---> AR    3    4


            PGC-1, PPAR-gamma1, PPAR-
            gamma2, PPAR-gamma3, PPAR-          15d-PGJ2 ---> PPAR-
CH000000677 gamma4                              gamma                       5   15




CH000000560 AKT-1, AKT-2, p110beta, p85alpha    PI3K ---/ tuberin           4    9
            ACCbeta, adiponectin, AdipoR1,
CH000004167 AMPKalpha-2                           Adiponectin --->AMPK   4    9




CH000000549 AKT-1, AKT-2, p110beta, p85alpha      PI3K ----/ Rheb        4   10




CH000000930 IRS-1, IRS-2, p110beta, p85alpha      PRL ---IRS---> PI3K    4   10




            glucokinase, glucose-6-phosphatase,
CH000003622 hexokinase-1, hexokinase-2            glycogen degradation   4   10




            glucokinase, glucose-6-phosphatase,
CH000003654 hexokinase-1, hexokinase-2            glycogen degradation   4   10




                                                  insulin ---> glucose
CH000000654 CAP, GLUT4, InsR, insulin, SHIP2      uptake                 5   17




CH000001009 AKT-1, AKT-2, PTEN                    ARIP ---> AKT          3    5




                                                  PDGF A, PDGF B --->
CH000000633 AKT-1, AKT-2, p110beta, p85alpha      AKT                    4   12




CH000000732 p46Shc, p52Shc, p66Shc, SHIP2         EGF ---> SHIP1         4   12




CH000000774 AKT-1, p110beta, p85alpha, PDK1       RANKL ---> AKT         4   12




CH000000024 NRF-1, p38alpha, PGC-1                MKK6 ---> NRF-1        3    6
CH000000035 InsR, IRS-1, p110beta              insulin ---> p110          3    6




CH000000149 AT1 receptor, p110beta, p85alpha   CH000000149                3    6




            HNF-1alpha-A, HNF-1alpha-B, HNF-
CH000000529 1alpha-C                           MKK3 ---> HNF-1alpha       3    6




CH000001015 AKT-1, AKT-2, p85alpha             AR ---> AKT                3    6




CH000000348 InsR, IRS-1                        CH000000348                2    2




CH000000349 InsR, IRS-1                        CH000000349                2    2




CH000000353 InsR, PTP1B                        CH000000353                2    2




CH000000354 InsR, PTP1B                        CH000000354                2    2


            p38alpha, PGC-1, PPAR-gamma1,
            PPAR-gamma2, PPAR-gamma3,
CH000000712 PPAR-gamma4, PPARalpha (NR1C1) PPAR pathway                   7   39




                                               IFNalpha, IFNbeta --->
CH000000596 IRS-1, IRS-2, p110beta, p85alpha   PI3K                       4   13




                                               insulin ---IRS---> PRK2,
CH000000657 InsR, insulin, IRS-1, IRS-2        SHP-2, MAPK cascade        4   13
            PPAR-gamma1, PPAR-gamma2,
CH000000675 PPAR-gamma3, PPAR-gamma4             MKK4 ---/ PPAR-gamma   4   13




            p110beta, p46Shc, p52Shc, p66Shc,
CH000000741 p85alpha, SOCS-3                     Epo pathway            6   31




CH000000360 IRS-1, p110beta, p85alpha            CH000000360            3    7




            AKT-1, AKT-2, IGF-1A, IGF-1B,
CH000001016 p85alpha, PDK1, PKCalpha             AR pathway             7   42




            PPAR-gamma1, PPAR-gamma2,
CH000000713 PPAR-gamma3, PPAR-gamma4             15d-PGJ2 ---/ NF-ATc   4   14




CH000000038 InsR, IRS-1, p46Shc, p52Shc, p66Shc insulin ---> ERK        5   23




CH000000047 CAP, GLUT4, InsR                     insulin ---> GLUT4     3    8




CH000000641 AKT-1, p110beta, p85alpha            PDGF A ---> AKT-1      3    8




CH000000642 AKT-1, p110beta, p85alpha            PDGF B ---> AKT-1      3    8




CH000000933 p46Shc, p52Shc, p66Shc               GH ---> Grb-2          3    8




CH000000934 p46Shc, p52Shc, p66Shc               GH pathway             3    8
            InsR, insulin, p46Shc, p52Shc,   insulin ---Shc---> MAPK
CH000000656 p66Shc, SHIP2                    cascade                   6   34




CH000000051 InsR, SOCS-3                     insulin ---> SOCS-3       2    3




CH000000362 IRS-1, p85alpha                  CH000000362               2    3




CH000000393 AKT-1, AKT-2                     CH000000393               2    3




CH000000394 AKT-1, AKT-2                     CH000000394               2    3




CH000000401 CAP, InsR                        CH000000401               2    3




CH000000402 CAP, InsR                        CH000000402               2    3




CH000000661 VEGF-A, VEGFR-2                  VEGF-A ---> STAT1alpha    2    3




                                             AKT, MAPKAPK2 ---/
CH000000576 AKT-1, p38alpha, PDK1            tuberin                   3    9




                                             PDK1 ---> 4E-BP1,
CH000000658 AKT-1, mTOR, PDK1                p70S6K1                   3    9
 Over(+)/
 under(-)
          p-value
represen
  tation




+         1.05E-09




+         1.28E-08




+         6.32E-08




+         6.32E-08




+         7.27E-08




+         3.29E-07




+         5.56E-06




+         5.67E-06




+         1.34E-05




+         1.34E-05
+   4.93E-05




+   6.79E-05




+   9.82E-05




+   0.000118




+   0.000118




+   0.000118




+    0.00034




+    0.00034




+   0.000454




+   0.000544




+   0.000588
+   0.000588




+   0.000944




+   0.000944




+   0.000944




+   0.000944




+   0.001035




+   0.001095




+   0.002059




+   0.002059




+   0.002059




+   0.002111
+   0.002111




+   0.002111




+   0.002111




+   0.002111




+   0.002426




+   0.002426




+   0.002426




+   0.002426




+   0.002458




+   0.002862




+   0.002862
+   0.002862




+     0.0034




+   0.003561




+   0.003815




+   0.003856




+   0.004438




+   0.005494




+   0.005494




+   0.005494




+   0.005494




+   0.005494
+   0.005504




+   0.007041




+   0.007041




+   0.007041




+   0.007041




+   0.007041




+   0.007041




+   0.007041




+   0.007947




+   0.007947

				
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