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					Commonwealth of Kentucky Lung Cancer Research Fund

Investigator-Initiated Granting Program
Cycle 9 Application Guidelines

University of Louisville

Deadline for receipt: June 15, 2009

Commonwealth of Kentucky Lung Cancer Research Program
Research Program Overview
The Commonwealth of Kentucky has long been recognized as having a disproportionately high incidence of lung cancer. Mortality from lung cancer exceeds the deaths from breast, colorectal, prostate and pancreatic cancers combined. The relationship of cigarette smoking to lung cancer has been well established, and Kentuckians have one of the highest incidences of smoking and lung cancer death rates in the nation. As such, Kentucky should be a national leader in the study and successful treatment of this leading killer. In an effort to raise awareness and improve survival of Kentuckians with lung cancer, the Kentucky General Assembly of 2000 established the Lung Cancer Research Fund (the Fund). This 20-year initiative will serve as an impetus for the combined efforts of the University of Louisville and the University of Kentucky to become nationally recognized as leaders in lung cancer epidemiology, prevention, diagnosis and treatment. A Governance Board, appointed by the Governor, administers the Fund. The Board is made up of representatives from the Council on Postsecondary Education, faculty members from the School of Medicine at the University of Louisville and the University of Kentucky, as well as representatives from the state-at-large. The Board allocates these research funds to the Universities in such a way as to increase the understanding, facilitate treatment and reduce the morbidity and mortality from lung cancer. Priority for funding will be given to basic, translational, and clinical studies of topics in the areas of science listed below: Chemotherapy, Experimental Therapeutics, and Gene Therapy Detection, Diagnosis, Prognosis Etiology, Epidemiology, Cancer Control & Prevention Tumor Cell and Molecular Biology, and Genetics Immunology, Immunotherapy and Pathology Invasion, Progression, Metastasis Radiation Biology Behavioral Oncology, Symptom and Palliative Care Complementary Therapy Funding for the project will be focused within the following themes:  Funding new researchers who demonstrate promise and who have a supportive environment for their work;  Funding established and productive researchers who propose to apply their expertise to basic lung cancer research, or to higher level animal models;  Funding to enable researchers with novel ideas to test their ideas and develop pilot data for seeking larger awards from the National Institutes of Health (NIH) and/or other funding sources; and  Funding collaborative research between investigators from the University of Kentucky and the University of Louisville.

Commonwealth of Kentucky Lung Cancer Research Program – Investigator-initiated Granting Program Cycle 9 Guidelines

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Commonwealth of Kentucky Lung Cancer Research Fund
CYCLE 9 Investigator-Initiated Research Grant Application
Deadline: June 15, 2009 Anticipated start date: October 1, 2009

Letter of Intent
Please send a Letter of Intent in the form of an email to Diane Konzen at dkkonz01@gwise.louisville.edu by Wednesday, March 18, 2009. Please include a brief description of the work you propose to submit, names of anticipated co-PI‟s or Co-investigators, and, from the list below, the area of study which most closely represents your work.
Chemotherapy, Experimental Therapeutics, and Gene Therapy [CETGT] Detection, Diagnosis, Prognosis [DDP] Etiology, Epidemiology, Cancer Control & Prevention [EECCP] Tumor Cell and Molecular Biology, and Genetics [TCMBG] Immunology, Immunotherapy and Pathology [IIP] Invasion, Progression, Metastasis [IPM] Radiation Biology [RB] Behavioral Oncology, Symptom and Palliative Care [BOSPC] Complementary Therapy [CT]

The Letter of Intent is not binding on the applicant but will be used to plan the proposal review process.

Application Format & Submission Guidelines
Please follow the guidelines provided herein and be sure to use the UofL Application Form for Cycle 8. Applications that do not adhere to these guidelines will be returned to the applicant without review.

FORMAT
Margins Type Size Face page Budget Budget Justification Relationship to KLCR priorities Research Abstract Lay Abstract Specific Aims Rationale Experimental Design and Methods Timetable Facilities/Resources Top – 1” Bottom – 0.5” and Sides – 0.75” 11- or 12-point font

Format Pages (Cover – Section 5)
provided provided provided; directions on page choose most appropriate priority(ies)

Abstracts (Section 6)
≤ 20 lines (one-half page) ≤ 20 lines (one-half page) One-half to 1 page 1 to 3 pages as appropriate, keeping in mind the 10-page limit Up to one-half page One-half to 1 page
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Narrative (Section 7) – not to exceed 10 Pages

Commonwealth of Kentucky Lung Cancer Research Program – Investigator-initiated Granting Program Cycle 9 Guidelines

Concluding Sections (not included in 10-page limit)
Biosketches References Appendices NIH format, 4 page full reference as needed

REVISED APPLICATION (an application submitted for review in a previous cycle): Include a statement, placed in front of the narrative, that lists the points raised in the previous reviews and your response to each of them. This statement should not exceed 2 pages in length and does not count as part of the 10-page limit of the narrative section.

Please note that only one application per P.I. may be submitted.

Submission
Contents of submission packet: • The complete original application signed by the PI(s) and the Contract Officer. • Along with the original hard copy, please submit – via email to dkkonz01@louisville.edu – an electronic file of the entire application.
“Binding” Instructions:  Use a binder clip or similar fastener for the original application. Please do not staple the original.

Section-by-Section Instructions
Section 1 – Basic Information Check the appropriate boxes to indicate whether this is a New or Revised application, and whether the work requires animals or human subjects. Research Title: provide a short, descriptive, title. A. Principal Investigator(s): enter the full name of the principal investigator(s) along with degree(s), primary department, phone number, and email address. B. Co-Investigator(s): enter the full name(s) and degree(s), primary department and institution for each. C. Fiscal Officer: completed for you. D. Contract Officer: name and contact information of your contract officer. E. Department Business Office Contact: name and contact information of your departmental business officer. F. Total Funds Requested: provide the total of funds requested for the entire project period. Please note that funding requests may not exceed $75,000 per year. Number of Years Requested: the project period may not exceed two (2) years. G. Signature of official signing for the Institution: No stamped or „per‟ signatures will be accepted. Section 2 – Budget and Justification Year 1 Budget A. Personnel: for each person/position requested, provide name, title, percent of effort on this project, and base salary, salary and fringe benefits requested. Although funding to support faculty salary is not allowed, indicate the percent of effort the PI will devote to the research activity described in this application; and on page 3 provide a justification for each person listed. PLEASE NOTE: Tuition costs for graduate students are not allowed. [a graduate student stipend is an allowable cost, however the KLCRP does not support tuition costs.] B. Equipment: Be aware that equipment purchase is not encouraged. Enter the cost of equipment requested in year 1.
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C. D. E. F. -

Supplies: enter the supply purchase request for year 1. Animals: enter the cost of any proposed animal charges in year 1 Travel: enter the cost of any travel requested in year 1. Other: enter costs of proposed purchases for items not included in other categories. Total Direct Costs Requested for Year 1: enter the total of A-F.

Summary of Total Budget Request A. Personnel: expenses for each year of budget request, plus a total of all years. B. Equipment: expenses for each year of budget request, plus a total of all years. C. Supplies: expenses for each year of budget request, plus a total of all years. D. Animals: expenses for each year of budget request, plus a total of all years. E. Travel: expenses for each year of budget request, plus a total of all years. F. Other: expenses for each year of budget request, plus a total of all years. G. Total Direct Costs: total of 2a thru 2f. H. Indirect Costs: maximum allowable indirect cost rate is 10% of the amount in G: Direct Costs (not 10% of the total dollar amount). I. Total Funds Requested: total of G: Direct Costs + H: Indirect Costs, not to exceed $75,000 per year. Budget Justification Follow the instructions on page 3 of the application. Section 3 - Research Support Items ‘A’ through ‘C’: directions are on the application form. Please list federal and non-federal support. Section 4 - Other Provide responses to questions and attach relevant documentation. Items ‘A’ and ‘B’ – Please note that appropriate internal university committee(s) approvals must be obtained and a copy of the approval letter must be given to Ms. Konzen in the Brown Cancer Center prior to funding of the application. Item ‘C’ – self-explanatory Item ‘D’ Research Design – Please indicate the area that most closely reflects the work presented here. Section 5 - Relationship of study to KLCR Governance Board Priorities Indicate the one (1) priority research area that is the primary focus of your proposed study. Section 6 –Abstracts Research Abstract (1/2 page)

The target audience for this abstract is primarily comprised of scientific reviewers with expertise in lung cancer research selected to critique the application. Describe aims and anticipated results. Please define terms and abbreviations when used the first time. (1/2 page)
Layperson Abstract (1/2 page)

The target audience for this abstract is the general public, many of whom are political leaders in their communities and of the state. (1/2 page) This abstract will be placed on the Kentucky Lung Cancer Research Program web site (www.kentuckylungcancer.org).
Section 7 - Narrative If this is a revised application, insert your response to the reviewers‟ comments of the original application before the narrative section. Please reiterate the points raised followed by your response. If possible, please limit your response to less than 2 pages. Your response is not included in the 10-page limit. The limit for the narrative is 10 single-spaced pages excluding references. Address each of the areas outlined below: a) Aims: State the specific aims/objectives of the research. Avoid vague generalities. What hypothesis will be tested? What products will be developed? Is this novel or innovative work? (1/2-1 page)
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b) Rationale: Describe relevant theory as well as prior and current research related to your proposal. How does your research fit into the larger picture and how is it timely? (1-3 pages) c) Methods: Describe your experimental design and laboratory methods. As appropriate to your research, this may be done in terms of each specific aim described in the “Aims” section or in the context of the overall project. In the latter case ensure that the methods associated with each specific “Aim” are clearly described. Explain procedures and provide descriptions of subjects to be studied. Be sure to indicate sample sizes, methods of statistical analysis and, in research with human subjects, procedures for subject selection. Also, if relevant, address issues raised regarding assessment of recovery of function. (as appropriate, keeping in mind the 10 page limit) d) Timetable: Tie the tasks described in “Methods”/Specific Aims to an estimated timetable. (1/2 page) e) Facilities / Resources: Describe the equipment and facilities available to you that will be used in this research. If funds are requested to purchase additional equipment, place the needed equipment in the context of equipment presently available to you. If appropriate, describe other research being done in your institution and colleagues who may provide support for your work. (1/2-1 page) Include appendices as needed to support the proposed study. Appendices do not count as part of the narrative section Appendix Biosketches: submit an NIH-style 4-page Biosketch for the Principal Investigator(s) and for all key personnel, including postdoctoral fellows. [‘Key personnel’ is defined as anyone who participates in the study design.] Publications: include URLs for up to three (3) publications representative of your work. If no URL is available, please submit a pdf of the article or the hard copy.

Please do not use the appendix as a way to subvert the page limit. Include only those items requested/relevant.

Checklist Complete the checklist and place it on top of the original application. Submission Send electronic version to: dkkonz01@louisville.edu Deliver complete original hard copy to: Diane K. Konzen, Research Coordinator Kentucky Lung Cancer Research Program 2nd floor Administrative Offices James Graham Brown Cancer Center 529 South Jackson Street Louisville, KY 40202 Phone: 502/852-5912 Fax: 502/562-4368

no later than 5:00 pm on Monday, June 15, 2009.

Questions?
If you have questions regarding the application, guidelines or submission requirements, please email Diane Konzen (dkkonz01@louisville.edu) or Mary McCarthy (m0mcca05@louisville.edu).

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