Compound in Broccoli Slows Down the Aging Process, Boosts the Immune System and Brings New Hope to the Fight against Cancer

					     Diindolylmethane (DIM) Information Resource Center


Compound in Broccoli Slows Down the Aging Process, Boosts the Immune System and Brings
New Hope to the Fight against Cancer

Resveratrol from grapes has received a lot of coverage in the press as an anti-aging molecule for
potentiating molecular processes that slow down the aging process and promoting life extension. A
compound in broccoli, however, called Diindolylmethane (DIM), formed during the digestion of this
vegetable, has recently been found to potentiate similar molecular pathways that slow down the aging
process and promote life extension.

The paper was recently published in the March edition of Aging Cell and has taken some time to be
digested by the scientific community. As the media and science writers covering recent
developments in the field of nutrition slowly begin to notice and digest the findings of this paper
published by German scientists at the Duisburg-Essen University in Germany, we thought this would
be an outstanding opportunity to provide a brief overview of this important compound from Broccoli
so that science writers within the media community and members of the general public get a better
appreciation for recent developments regarding this very important naturally occurring molecule
found in broccoli.

When science writers in the media write about the health benefits of broccoli, they often focus solely
on Sulforaphane, which at Johns Hopkins has been found to promote cellular detoxification.
Sulforaphane has long had an important cousin, called Diindolylmethane, which has not received as
much attention in the press, but from a point of view of therapeutic potential, it arguably has
significantly higher potential.

An overview of how Diindolylmethane is formed during the digestive process and its molecular
biology as well as scientific references dating back to 1975 are available at the Diindolylmethane
(DIM) Information Resource Center at UC Berkeley (

Diindolylmethane from broccoli has numerous very favorable biologic activities which are the basis
for why the National Cancer Institute has launched numerous clinical trials to study its potential as a
therapeutic for multiple forms of cancer.

Among these biologic activities, the most important are:

    1) Anti-inflammatory properties through the down regulation of NFK-B, a well-known
       inflammatory drug target with therapeutic properties for both cancer and cardiovascular
    2) Immune Activation through the induction of Interferon-Gamma Receptors and Interferon-
       Gamma itself which are well understood in the scientific community for their antiviral,
       antibacterial and anticancer properties.
     Diindolylmethane (DIM) Information Resource Center


   3) Synergy with Interferon-Gamma in the induction of the MHC-I complex which helps to flag
      cancer and infectious disease antigens to the immune system for destruction.
   4) The promotion of apoptosis through inhibition of PI3K /Akt. Apoptosis is programmed cell
      death. Normal cells have this process as a part of their life cycle but cancer cells lose this
      ability in the process of becoming cancerous. Hence it is an important mechanism by which
      cancer cells can be promoted to destroy themselves—behaving like normal cells again.
   5) Promotion of P38 and P21 which promote cytostasis of cancerous cells.

When all of the above are taken into account some of the epidemiological studies regarding Brassica
vegetable consumption and a lower risk of cancer come to light.

In 2001, a study published in the Journal of the American Medical Association discussed how
women who consume just one serving of Brassica vegetables per week exhibit a 40% reduction in
the risk of breast cancer development relative to those who consume very little of this vegetable
group in their diet. In 2007, scientists at the National Cancer Institute published their finding that
men who consume just one serving of Cruciferous (Brassica) vegetables per week reduce their risk of
developing aggressive prostate cancer by up to 52%. Interestingly enough, in this study, no other
vegetable group appeared to provide a statistically significant risk reduction for prostate cancer.

In a seminal paper published in 2006, Diindolylmethane was shown to synergize with Taxol (best-
selling cancer drug worldwide that also originated from plants). In this paper the authors demonstrate
how DIM significantly enhances the efficacy of this important and widely used cancer drug.

In another important paper that came out in the January of 2013, Scientists at the Karamos Cancer
Institute published that Diindolylmethane (DIM) enhances the effectiveness of Herceptin--leading
therapeutic for breast cancer currently marketed by biotech giant Genentech.

And now from this recent study in Germany, we can add to Diindolylmethane’s multitude of
favorable biological properties, the slowing down of the aging process and life extension.

Indeed Brassica vegetables (broccoli, cauliflower, cabbage, brussels sprouts) are among the most
important from a preventive nutrition point of view in the human diet given the number of extremely
favorable and health-promoting activities of Diindolylmethane (DIM).

Based on a breakthrough discovery regarding Diindolylmethane’s immune activating properties, a
dietary supplement called ActivaMune has been launched with technology exclusively licensed from
UC Berkeley that has DIM in it along with other important nutrients. The product is a fund-raiser for
nature-based cancer research and it provides the phytonutrient equivalent of consuming five pounds
of fresh organic broccoli per day. More information about ActivaMune can be found at
     Diindolylmethane (DIM) Information Resource Center


From all of us at the Diindolylmethane (DIM) Information Resource Center to you, we wish you and
your family health, longevity and good nutrition for years to come.


Diindolylmethane (DIM) Information Resource Center News Team


Aging Cell. 2013 Mar 23. Chemical genetic screen in fission yeast reveals roles for vacuolar
acidification, mitochondrial fission, and cellular GMP levels in lifespan extension. Stephan J, Franke
J, Ehrenhofer-Murray AE. Zentrum für Medizinische Biotechnologie, Universität Duisburg-Essen,
Essen, Germany.

Brassica Vegetables and Breast Cancer Risk. Terry P, Wolk A, Persson I, Magnusson C, JAMA 2001
285 (23): 2975-2976

Prospective Study of Fruit and Vegetable Intake and Risk of Prostate Cancer. Journal of the National
Cancer Institute. 2007 Jul 24; Krish VA, Peters U, Mayne ST, Subar AF, Chatterjee N, Johnson CC,
Hayes RB

3,3'-diindolylmethane Enhances the Effectiveness of Herceptin against HER-2/Neu-Expressing
Breast Cancer Cells. PLoS One. 2013;8(1):e54657. Epub 2013 Jan 22. Ahmad A, Ali S, Ahmed A,
Ali AS, Raz A, Sakr WA, Rahman KW. Department of Pathology, Karmanos Cancer Institute,
Wayne State University School of Medicine, Detroit, Michigan, United States of America.

3,3′-Diindolylmethane and Paclitaxel Act Synergistically to Promote Apoptosis in HER2/Neu
Human Breast Cancer Cells. Journal of Surgical Research, 2006 May 15;132(2):208-13. K.
McGuire, N. Ngoubilly, M. Neavyn, S. Lanza-Jacoby Department of Surgery, Jefferson Medical
College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107

Scientific Information about Diindolylmethane’s Immune Activation Properties can be found at the
Diindolylmethane (DIM) Immune Activation Data Center:

In-Depth Scientific Information and References on Diindolylmethane dating back to 1975 can be
found at the UC Berkeley Diindolylmethane (DIM) Information Resource Center:
    Diindolylmethane (DIM) Information Resource Center


More information about ActivaMune, natural immune booster and a fundraiser for nature-based
cancer research, is available at:

Diindolylmethane (DIM) Information Resource Center News Team
Media Relations Contact: Ms. Liza Crisci
Phone: 510-717-2642
2887 College Ave. #351
Berkeley, CA 94705

Description: Diindolylmethane (DIM) from Broccoli slows down the aging process at the cellular level, boosts the immune system and is currently under investigation as a naturally occurring therapeutic for multiple forms of cancer. Diindolylmethane (DIM) News Update from the Diindolylmethane (DIM) Information Resource Center (