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Advanced Seminar - Cellular _ Biomolecular Engineering


									                                           BMED 7301
                      Advanced Seminar: Cellular and Biomolecular Engineering

                                   TBD, U. A. Whitaker, Room 1214

Instructors: Thomas H. Barker, Ph.D.                        Philip J. Santangelo, Ph.D.
             Office: UAW 2108                               Office: UAW 2107

Textbooks:    None.
              Reading material will be assigned or recommended from current research papers with
              supplemental information from book chapters and review articles to provide the necessary
              supporting information or topical examples of the principles of the course.

Prereqs:      IBS 555 & 556 and BMED 6782

Purpose:      This course serves as the Advanced Seminar course for the Cellular and Biomolecular
              Engineering Thrust within the Biomedical Engineering Ph.D. curriculum. The course
              focuses on cutting edge technologies and methodologies for both the manipulation and
              detection of molecular and cellular events. The content of the course is intended to
              promote basic background knowledge and critical review of “state-of-the-art” molecular
              scale technologies by students toward the identification and understanding of their
              strengths and limitations. The primary topics to be discussed focus on specific

Objectives:   The key learning objectives of this course are:
                 1. Understand the fundamental variance of biological systems
                 2. Gain a basic knowledge of the fundamental physics and biology of detection and
                    manipulation methods
                 3. Comprehend current limitations in the integration of physical methods with living
                    biological systems.
                 4. Design novel approaches to understanding and overcoming current limitations in

Topics:       The following list of topics to be discussed this semester.
                 1. Basic cell and molecular biology
                 2. Microscopy and optical physics
                 3. Sub-diffraction limited microscopy
                 4. Advanced methods for tracking spatio-temporal dynamics of molecules
                 5. Molecular probes for gene expression
                 6. Cellular delivery strategies
                 7. Genetic engineering and gene delivery
                 8. Proteomics
                 9. Biomolecular mechanics
                 10. Protein structure and protein engineering.
                 11. High-throughput cell signaling and signaling networks.
                    12. Methods for detecting protein activity.
                    13. Engineering cell phenotypes

Grading:         Journal presentations                30%
                 Participation                        20%
                 Research Proposal                    50%

Presentations:      Students will be required to present a summary of ~2 journal articles throughout the
                    semester. These will be evaluated on clarity of verbal and visual presentation and the
                    ability of the presenter to lead a critical discussion of how the main findings of the
                    paper relate to the themes of the course. See oral presentation rubric for details of
                    evaluation criteria.

Participation:      This portion of the grade will be determined by factors such as class attendance and
                    ability to ask relevant and critical questions about assigned articles.

Proposal:           Students will construct a full proposal that addresses a current, novel and testable
                    hypothesis based on one of the topics discussed in class. The topic CANNOT be the
                    student’s own research or related to work performed in the student’s lab. The
                    proposal structure will conform exactly to the NIH guidelines for R01 proposals. All
                    proposals will be reviewed in a mock-study section review. The grade will be based
                    on evaluation criteria in the mock reviews as well as scoring by both professors.

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