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BMED 7301 Advanced Seminar: Cellular and Biomolecular Engineering TBD, U. A. Whitaker, Room 1214 Instructors: Thomas H. Barker, Ph.D. Philip J. Santangelo, Ph.D. email@example.com firstname.lastname@example.org Office: UAW 2108 Office: UAW 2107 Textbooks: None. Reading material will be assigned or recommended from current research papers with supplemental information from book chapters and review articles to provide the necessary supporting information or topical examples of the principles of the course. Prereqs: IBS 555 & 556 and BMED 6782 Purpose: This course serves as the Advanced Seminar course for the Cellular and Biomolecular Engineering Thrust within the Biomedical Engineering Ph.D. curriculum. The course focuses on cutting edge technologies and methodologies for both the manipulation and detection of molecular and cellular events. The content of the course is intended to promote basic background knowledge and critical review of “state-of-the-art” molecular scale technologies by students toward the identification and understanding of their strengths and limitations. The primary topics to be discussed focus on specific techniques. Objectives: The key learning objectives of this course are: 1. Understand the fundamental variance of biological systems 2. Gain a basic knowledge of the fundamental physics and biology of detection and manipulation methods 3. Comprehend current limitations in the integration of physical methods with living biological systems. 4. Design novel approaches to understanding and overcoming current limitations in methodology. Topics: The following list of topics to be discussed this semester. 1. Basic cell and molecular biology 2. Microscopy and optical physics 3. Sub-diffraction limited microscopy 4. Advanced methods for tracking spatio-temporal dynamics of molecules 5. Molecular probes for gene expression 6. Cellular delivery strategies 7. Genetic engineering and gene delivery 8. Proteomics 9. Biomolecular mechanics 10. Protein structure and protein engineering. 11. High-throughput cell signaling and signaling networks. 12. Methods for detecting protein activity. 13. Engineering cell phenotypes Grading: Journal presentations 30% Participation 20% Research Proposal 50% Presentations: Students will be required to present a summary of ~2 journal articles throughout the semester. These will be evaluated on clarity of verbal and visual presentation and the ability of the presenter to lead a critical discussion of how the main findings of the paper relate to the themes of the course. See oral presentation rubric for details of evaluation criteria. Participation: This portion of the grade will be determined by factors such as class attendance and ability to ask relevant and critical questions about assigned articles. Proposal: Students will construct a full proposal that addresses a current, novel and testable hypothesis based on one of the topics discussed in class. The topic CANNOT be the student’s own research or related to work performed in the student’s lab. The proposal structure will conform exactly to the NIH guidelines for R01 proposals. All proposals will be reviewed in a mock-study section review. The grade will be based on evaluation criteria in the mock reviews as well as scoring by both professors.
"Advanced Seminar - Cellular _ Biomolecular Engineering"