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Dataset S1 _XLSX_

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Dataset S1 _XLSX_ Powered By Docstoc
					Genes up-regulated in MT
DAVID GO categories in descending order of significance for each HDM cluster shown in figure 3A.
Only categories with a p-value smaller than 0.05 are shown.
                                 Cluster 1
                              GO                                Genes
Protein degradation                                           ADAM19,ADAMTS7,ARIH1,ATG4A,BTRC,CPD,CUL4A,CYLD,DP
Insulin signaling pathway                                     CRKL,EIF4E2,EIF4EBP1,GYS1,HK2,INPPL1,MAPK8,MKNK1,PDP
Microtubules                                                  ARHGEF2,ATG4A,BICD2,DST,DYNC1I2,DYNC1LI1,DYNC1LI2,DY
Alternative splicing                                          1110012J17RIK,2310044G17RIK,2610110G12RIK,2810474O1
Regulation of cell morphogenesis                              CDC42EP2,CDC42EP3,EPHB2,FYN,ITGA7,NTN1,RHOQ,RNF6,R
Negative regulation of neurogenesis                           CDC42,CFL2,EPHB2,EPHB3,FYN,NTN1,PLXNA1,RHOD,RNF6,RT
Negative regulation of cellular component organization        ARHGEF2,EPHB2,MTAP1B,NTN1,PACSIN3,RHOQ,RNF6,RTN4,
Phosphate metabolism                                          ATP6V0A2,ATP6V1C1,ATP6V1D,ATP6V1E1,CAMK2D,CSK,CSN
Regulation of lymphocytes                                     CD80,CDKN1A,CSK,DNAJA3,ERBB2,IL20RB,ITCH,PLDN,STAT5B
Regulation of leukocytes                                      CD80,CDKN1A,CSK,DNAJA3,ERBB2,IL20RB,ITCH,PLDN,STAT5B
Arrhythmogenic right ventricular cardiomyopathy (ARVC)        ATP2A2,CACNA2D1,CACNG1,DAG1,DES,ITGA7,SGCB,TCF7
Pathways in cancer                                            ARNT,BCL2L1,CDC42,CDKN1A,CRKL,E2F2,ERBB2,FGF11,FZD9,
Creatine metabolic process                                    GAMT,GATM,STAT5B
Hypertrophic cardiomyopathy (HCM)                             ATP2A2,CACNA2D1,CACNG1,DAG1,DES,ITGA7,PRKAB2,SGCB
ErbB signaling pathway                                        CAMK2D,CDKN1A,CRKL,EIF4EBP1,ERBB2,MAPK8,RPS6KB2,ST
Intra-Golgi vesicle-mediated transport                        COG3,GABARAPL2,PACS1
Endosome                                                      ATP6V0A2,CD164,D6WSU116E,OCIAD1,PTP4A2,RAB11FIP5,R
Regulation of translation                                     CPEB2,EIF4E2,EIF4EBP1,GM672,GTPBP4,MKNK1,MTIF2,SRP1
Inorganic cation transmembrane transport                      ATP2A2,ATP6V0A2,ATP6V1C1,ATP6V1D,ATP6V1E1,COX7A1,C
Mitochondria                                                  BCL2L1,DNAJA3,DUSP18,PEO1,RNF7,RRM2B,SH3GLB1
Regulation of T cells                                         CD80,CSK,DNAJA3,ERBB2,IL20RB,ITCH,STAT5B
Intracellullar transport                                      ATG4A,BIN1,CDC42,COG3,DST,DUSP18,ELMOD2,EXOC6,FKBP
mTOR signaling pathway                                        CAB39,EIF4E2,EIF4EBP1,PDPK1,RPS6KB2,ULK1
Chronic myeloid leukemia                                      BCL2L1,CDKN1A,CRKL,E2F2,IKBKG,MDM2,STAT5B
Adherens junctions                                            CDC42,CSNK2A1,ERBB2,FARP2,FYN,SORBS1,TCF7
Cytoskeletal protein binding                                  ADD3,ARHGEF2,ATG4A,BAIAP2L1,CFL2,DST,FARP2,FLNC,FYN,
Response to hormone stimulus                                  EIF4EBP1,GATM,INPPL1,RHOQ,SORBS1,STAT5B,ZFP106
Regulation of cell cycle                                      BTRC,CDC42,CDKN1A,CEP76,E2F2,GTPBP4,INTS3,MDM2,SCR
Protein localization                                          AFTPH,ATG4A,CDC42,COG3,COG6,DUSP18,EXOC6,GABARAPL
Positive regulation of cell morphogenesis                     EPHB2,NTN1,RNF6,RTN4,ULK1
Prostate cancer                                               CDKN1A,E2F2,ERBB2,IKBKG,MDM2,PDPK1,TCF7
Dilated cardiomyopathy                                        ATP2A2,CACNA2D1,CACNG1,DAG1,DES,ITGA7,SGCB
Pancreatic cancer                                             BCL2L1,CDC42,E2F2,ERBB2,IKBKG,MAPK8
Fc gamma R-mediated phagocytosis                              CDC42,CFL2,CRKL,DNM1L,MYO10,PPAP2A,RPS6KB2
MAPK signaling pathway                                        CACNA2D1,CACNG1,CDC42,CRKL,DUSP8,FGF11,FLNC,IKBKG,M
ach HDM cluster shown in figure 3A.

                                              Cluster 2
                                            GO                                       Genes
                                                            Alternative splicing   1110028C15RIK,1110051M20RIK,1810020D17RIK,2010
                 Negative regulation of nitrogen compound metabolic process        BCL6,EID1,GM608,HEXIM1,HIPK2,PALM,PDCD4,PKIA,RB
                                                   Regulation of transcription     1300003B13RIK,A630033E08RIK,ABLIM1,APBB1,B23031
                                Negative regulation of RNA metabolic process       1300003B13RIK,A630033E08RIK,ABLIM1,APBB1,B23031
                                             Glycerophospholipid metabolism        CDS2,CHPT1,DGKD,GPD1L,PLA2G6
                                                                   Cytoskeleton    ABLIM1,AI314180,ANXA11,ARHGAP24,CDC42SE2,ENAH
                                                                  Neurogenesis     DCLK1,ENAH,MEF2A,MEF2D,RUFY3,SEMA6A,SLC7A5
                                                            Protein localization   BCL6,CHM,EXOC3,LRP4,MTTP,PALM,PEX14,PPP3R1,RAB
                                                                Morphogenesis      ABLIM1,APBB1,BCL6,DCLK1,ENAH,ITGB1,KIF3A,PARD3,P
                                              Negative regulation of cell cycle    APBB1,HEXIM1,RB1,RHOB
                                                      Glycerolipid metabolism      CAT,CHPT1,DGKD,MTTP,PIGP,PIK3CB
                                                        Intracellular transport    APBB1,CHM,ENAH,KIF1B,PKIA,RAB10,RHOB,STAM,STAM
                                                                      Apoptosis    APBB1,EGLN3,HIP1,HIPK2,MEF2A,MEF2D,PDCD4,PEG3,
                                                               Tumor supressor     HIPK2,PDCD4,RB1,RHOB,ZDHHC17
                                                            Pathways in cancer     EGLN3,ITGB1,JUP,LAMA2,PIK3CB,RB1,SMAD3,TGFB3
                                   Embryonic cranial skeleton morphogenesis        SMAD3,TBX15,TGFB3
                                                              Pancreatic cancer    PIK3CB,RB1,SMAD3,TGFB3
                                                                 Differentiation   ARHGAP24,DCLK1,EID1,ENAH,HIP1,MEF2A,MEF2D,RHO
                                         Phosphatidylinositol signaling system     CDS2,DGKD,INPP5A,PIK3CB
                                                    Chronic myeloid leukemia       PIK3CB,RB1,SMAD3,TGFB3
                                                            Adherens junctions     INSR,PARD3,SMAD3,TJP1
                                                                  Tight junction   AMOTL1,EXOC3,MPP5,PARD3,TJP1
                                    Negative regulation of cell differentiation    ACAD11,BCL6,FST,ITGB1,SMAD3,TTC3
                                                           Protein degradation     ASB15,CAND2,DCUN1D2,FBXL2,HECW2,RNF216,SPSB1,U
                                                Intracellular signaling cascade    ABR,ADCY9,AKAP13,ARFGEF2,ASB15,BCL6,DCLK1,DGKD
                                               Regulation of TGFbeta signaling     HIPK2,SMAD3,TGFB3
                                                         Small cell lung cancer    ITGB1,LAMA2,PIK3CB,RB1
                                    Positive regulation of cell communication      CAT,HIPK2,LAMA2,NCAM1,TGFB3,ZRANB1
                                                Regulation of cell proliferation   ASPH,BCL6,DHCR7,FGFRL1,HIPK2,IL6ST,ITGB1,KISS1R,RB
                                                      Dilated cardiomyopathy       ADCY9,ITGB1,LAMA2,TGFB3
                                     Embryonic skeletal system development         SMAD3,TAPT1,TBX15,TGFB3
           Cluster 3                                  Cluster 4
         GO                     Genes               GO               Genes
      Muscle development                       Muscle development ACTN2,ARX,CACNA2D2,CACNG5,CBFA2T3,CHRDL
                              ACTA1,AGT,CACNA1S,CAV3,CLIC5,CYP26B1,DLL1,EPAS1,GAA,GJA5,KY,LIMCH1,MACF1,MB,
       Calcium ion binding                            Ion transport ABCC9,ATP6V1C2,CACNA2D2,CACNG5,CAMK2B,F
                              ATP2A1,CACNA1S,DLL1,DRP2,EFHD1,FREM2,GALNTL1,GAS6,ITGB1BP2,MACF1,MMP15,MY
          Cardiomyopathy                     Voltage-gated channel CACNA2D2,CACNG5,GABRD,KCNC1,KCNK1,SCN10
                              CACNA1S,ITGA9,MYH7,MYL2,MYL3,PRKAG3,SGCG
              Cytoskeleton                           Tight junction ACTN2,MYH14,MYH4,MYH6,MYH8
                              ABLIM2,ABLIM3,ACTA1,ANK1,CLIC5,DRP2,JAKMIP1,KY,LIMCH1,LMO7,LRRC26,MACF1,MAP
          Ear development                            Neurogenesis ARX,CHRDL1,OPHN1,SIM1,SLIT3
                              CLIC5,DLL1,SOBP,TCAP,TMIE
    Neuromuscular process                         Cardiomyopathy ACTN2,ADCY1,CACNA2D2,CACNG5,MYH6
                              ABLIM2,ABLIM3,CACNA1S,CLIC5,EFNA2,GAA,HCN3,KCNB1,KCNH8,PAK6,PARK2,PLXNB3,RG
Monosaccharide metabolism                         Viral myocarditis MYH14,MYH4,MYH6,MYH8
                              FUCA2,GAA,OTOG,PGM5,PPARA,PRKAG3,RENBP
    Sarcoplasmic reticulum    ANK1,ART1,ATP2A1       Growth factor EGF,GDF6,IGF2,KLK1B4
         Glucose transport                     Submandibular gland EGFBP2,KLK1B26,KLK1B4
                              PRKAG3,SLC2A4,SORT1
             Tight junction   LLGL2,MYH1,MYH2,MYH3,MYH7,MYL2
              Cluster 5                                                  Cluster 6
           GO                      Genes                              GO
          Alternative splicing                                                                  Muscle
                                 2310003F16RIK,A730037C10RIK,AK1,CACNB1,CAPN3,CCDC88C,CNP,CORO6,CYB5R1,DBND
         Steroid biosynthesis    CYB5R1,H2-KE6,HSD3B7,IDI1                                Cytoskeleton
             Cardiomyopathy      CACNB1,ITGB6,TNNC1,TPM2          Calcium signaling and homeostasis
  Transcription co-activatiors   ABRA,ANKRD1,CALCOCO1,H2-KE6,PCBD1             Metal ion homeostasis
            Red/ox reactions                             Serine-type endopeptidase inhibitor activity
                                 ALOX5,CYB561D1,CYB5R1,GPX3,H2-KE6,HSD3B7,PHYHD1,PYROXD1,SUOX
Protein homooligomerization      CCDC88C,GPX3,PCBD1                                           Secreted
                       Muscle    JSRP1,MYL6B,TNNC1,TPM2                 Regulation of lipid catabolism
                   Exocytosis    RAB3A,SYTL2,UNC13D           Positive regulation of MAPKKK cascade
                                                                                       Stress response
                                                                                Chemical homeostasis
                                                                          Alternative promoter usage
                                                           Positive regulation of cell communication
                                                                                   Calmodulin-binding
                                                                                         Signal anchor
                                                                             Notch signaling pathway
                                                                   Positive regulation of JNK cascade
                                                                  Response to temperature stimulus
                                                                       Regulation of cell proliferation
                                                 Ryanodine-sensitive calcium-release channel activity
                                                                Regulation of inflammatory response
                               Cluster 7
  Genes                     GO                      Genes
                              Retinol metabolism CYP3A11,CYP3A16,CYP3A41A,CYP3A44,CYP4A10,UGT2B34
ACTN3,ADM,ADRB2,ATP1A2,CAMK2A,CASQ1,CASQ2,CSRP3,DOK7,ERBB3,HRC,MRVI1,MYLPF,MYOD1,MYOM1,MYOM2,NRAP
                                Drug metabolism CYP3A11,CYP3A16,CYP3A41A,CYP3A44,UGT2B34
ACTN3,BFSP2,CDC42BPG,DAAM2,DYNC1I1,FEZ1,LIMA1,LMOD3,LSP1,MYLK,NRAP,PDLIM3,PSTPIP1,SVIL,SYNPO2L,TMOD1,TNN
                        Linoleic acid metabolism CYP3A11,CYP3A16,CYP3A41A,CYP3A44
ACTN3,ADRB2,ASGR2,ATP1A2,BEST1,CALR4,CAMK2A,CAPN12,CASQ1,CASQ2,CDH1,CSRP3,DNASE1L3,DTNA,ERBB3,F2,FBLN5,
                                       Microsome CYP3A11,CYP3A16,CYP3A41A,CYP4A10
ACSL1,ACSL6,ADSSL1,AMHR2,ATP1A2,CDC42BPG,CLYBL,CSRP3,ENO2,HRC,IL1B,MYLK,NUDT16,PINK1,PRKAA2,PYGM,RYR1,RY
              Regulation of cytokine biosynthesis CARD11,RNF128,TLR6
SERPINB1A,SERPINB1B,SERPINB1C,SERPINB6C,SERPINB7,SERPINB9D,SERPING1,SPINK4
                                          Muscle DMD,MEF2C,MYO18B,TCF23
ADAMTSL4,ADM,APOA2,C1QTNF3,CHRD,CP,CTRB1,DCN,FBLN5,FGF21,FGFBP1,FGL1,FNDC7,GDF5,HYAL1,IGFBP5,IL12A,IL15,IL
IL1B,MLYCD,PNPLA2
ADRB2,DUSP22,EDA2R,FGF21,IL1B
HSF2BP,HSPA2,HSPB2,HSPB3,HSPB7
ABCA2,APOA2,ASGR2,ATP1A2,CHRNG,CSRP3,HRC,IL1B,PYGM,RYR1,RYR3,TGM2,XIRP1
DUSP13,LIMA1,MYLK,TRP63
ADRB2,DUSP22,EDA2R,FGF21,FGFBP1,IL1B,PINK1,TGM2
CAMK2A,DAPK2,MYLK,MYLK2,RRAD,TTN
ACSL1,ACSL6,AI464131,ASGR2,ATP1B1,CHST5,DYSF,FUT7,GALNT6,HSD11B1,PNPLA2,SIT1,SYT8
DTX4,HEYL,PSEN2,TRP63
DUSP22,EDA2R,IL1B
ADRB2,HSPB2,HSPB3,HSPB7
ADM,ADRB2,CD28,DUSP22,FGF21,FGFBP1,H19,IL12A,IL15,INPP5D,SPRY1,TGM2,TRP63,XIRP1
RYR1,RYR3
ADRB2,CD28,SERPING1,TGM2
Permanently repressed genes
DAVID GO categories in descending order of significance for each HDM cluster shown in figure 3B.
Only categories with a p-value smaller than 0.05 are shown.
     Cluster 1                                 Cluster 2
  GO       Genes                            GO                               Genes
Vision CRYBA1,MIP,OPN1SW,RRH                      Cell fate commitment BARX1,CDX1,CDX2,DBX1,EVX1,FGF1,FGF3,FOXN4,GB
                                                   Transcription factors BARX1,CDX1,CDX2,DBX1,DBX2,DMRTA1,EBF2,ELF5,E
                                                              Homeobox BARX1,CDX1,CDX2,DBX1,DBX2,EVX1,GBX2,GSX2,HN
                                       Endocrine system development ELF5,GHRHR,GLI2,HNF1A,INSM1,LAMA1,MNX1,NKX
                                               Alkali metal ion binding ACCN4,AI317395,KCNA1,KCNA2,KCNA3,KCND1,KCN
                                                     Symporter activity AI317395,SLC12A3,SLC13A2,SLC15A1,SLC2A12,SLC2
                                                           Development ABI3BP,ADAMTS8,ADCYAP1R1,AKP3,APBA1,BARX1,B
                                         Nervous system development ADCYAP1R1,AHSG,CACNA1F,CCKAR,CHRNA3,CLIC6,C
                                                       Cell-cell signaling APBA1,BARX1,CHRNA3,FGF1,FGF3,GHRHR,GJC2,GJD
                                                       Sodium transport ACCN4,AI317395,SCN11A,SCN8A,SCNN1B,SCNN1G,S
                                          Pituitary gland development GHRHR,GLI2,PITX1,POU3F2,SLC6A3,SOX2,TBX19
                                                               Behaviour APBA1,CCL1,CCL24,CCR7,CHRNA3,CMTM5,CXCL11,G
                                              Spinal cord development DBX1,EVX1,GLI2,GSX2,HOXB8,MNX1,NKX2-2,NKX6-2
                                        Regulation of cell proliferation BMP15,BMP8B,BTLA,FGF1,FGF16,FGF20,FGF23,FGF3
                                                         Immune system ADCY4,AHSG,BARX1,BMP15,BMP8B,BTLA,BTN2A2,B
                                 Maturity onset diabetes of the young GCK,HNF1A,MNX1,NKX2-2,PAX4,PDX1
                                                 Pancreas development HNF1A,INSM1,MNX1,NKX2-2,NKX3-2,NKX6-2,PDX1
                                                                     ECM ADAMTS8,C1QC,C1QL1,C1QL3,C1QTNF2,C1QTNF9,C
                                                                    Vision CACNA1F,GJD2,GNAT1,GRK1,GUCA1A,GUCY2E,NR2E
                                                                Zymogen ADAMTS8,ASTL,CFB,CFD,CPA5,F10,F5,GGT1,GGT5,K
                                                              GPI anchor 2210415F13RIK,AKP3,CAR4,CNTN2,EFNA3,GFRA2,LY
                                              Mesoderm development EOMES,HAND1,HNF1A,MESP1,OVOL1,TCF15,WNT3,
                         Hemopoietic or lymphoid organ development BARX1,EOMES,FGF3,HBA-X,HOXB7,IL20,IL25,NKX3-2
                                       Wnt receptor signaling pathway WNT2,WNT3,WNT3A,WNT7A,WNT8A
                                          Hedgehog signaling pathway BMP8B,GLI2,WNT2,WNT3,WNT3A,WNT7A,WNT8A
                                                            Cell junction ANKS1B,ARHGAP26,CAMK2N1,CHRNA2,CHRNA3,CLD
                                      Formation of primary germ layer EOMES,HAND1,HNF1A,MESP1,WNT3,WNT3A
                                                Ectoderm development EDARADD,ELF5,KLK14,KRT25,KRT27,KRT6A,OVOL1,P
                                                    Hormone secretion GHRHR,GLP1R,GPR120,HNF1A,RAPGEF4,RIMS2
                                                    Pathways in cancer FGF1,FGF16,FGF20,FGF23,FGF3,GLI2,LAMA1,LAMA4
                                                 FGF signaling pathway FGF1,FGF16,FGF20,FGF23,FGF3
                                                                  Hearing COCH,FGF20,GBX2,GFI1,GJB6,MYO15,NKX3-2,SOX2,
                                               Epidermis development EDARADD,KLK14,KRT25,KRT27,KRT6A,OVOL1,POU2F
                                         Regulation of hormone levels CHST8,DIO1,GHRHR,GLP1R,GPR120,HNF1A,LCN5,RA
                                                   Basal cell carcinoma GLI2,WNT2,WNT3,WNT3A,WNT7A,WNT8A
                                                  Sensory transduction ADCY4,CACNA1F,CRB2,GNAT1,GRM4,GUCA1A,GUCY
                                       Adenohypophysis development GHRHR,SLC6A3,SOX2
                                                   Spleen development BARX1,NKX3-2,TCF21,TLX1
                                                                 Intestine AKP3,CDX2,TFF3
                                         Mammary gland development ELF5,GHRHR,GLI2,SLC6A3,TNFRSF11A,WNT2,WNT3A
                                                        Insulin secretion GLP1R,HNF1A,RAPGEF4,RIMS2
           Proto oncogene FGF3,FLI1,NOTCH4,SFPI1,TAL1,VAV1,WNT3
Calcium signaling pathway ADCY4,CACNA1F,CCKAR,HTR5B,NOS1,NOS2,OXTR,P2
    Placenta development CDX2,EOMES,HAND1,HNF1A,PRDM1,RSPO3,WNT2
cluster shown in figure 3B.

                              Cluster 3                                       Cluster 4
                           GO                         Genes                 GO                    Genes
                                     Homeobox                               Immune response AICDA,ARG1,BMP5,C9,CAMP,CCL12,CCR
                                                    BARHL2,BSX,CDX4,CRX,DLX6,EMX2,GSC,HESX1,HOXB13,HOXB2,HOXD1,HOXD10,HOXD
                            Neuronal signaling                                             Liver APOB,CAR5A,FABP1,LIPC,ORM2,TTR,UO
                                                    ACCN5,ADCY5,AGTR1A,AMPH,ATP2B2,CACNA2D3,CACNA2D4,CACNG2,CARTPT,CCK,CH
                                   Development                                            Vision ABCA4,ACCN3,CABP4,CHRNA9,CRTAM,F
                                                    3110039M20RIK,ATOH1,ATP2B2,BARHL2,BMP3,CCK,CDX4,CERKL,CHRDL2,CML2,CML5
                                       Behavior                     Hematopoietic cell lineage CD33,CD38,CSF2,CSF3,GP9,IL1A,IL3,IL7R
                                                    ADCY5,ADH1,AFF2,AGTR1A,ALB,AMPH,ATP2B2,BSX,CARTPT,CCK,CCL3,CCL4,CCL6,CCR4
                                Immune system                               Neuronal signaling F2RL1,F2RL2,FPR2,GNRHR,GPR35,GRIN2
                                                    A1BG,ADAMTS13,AMICA1,BMP3,BTNL9,C1QA,C1S,C4BP,C8A,C8B,CCL3,CCL4,CCL6,CCR
                      Neuronal differentiation                                   Cell adhesion CD33,CDH17,CDH3,CDH5,CLCA5,CLDN1
                                                    3110039M20RIK,ATOH1,ATP2B2,BARHL2,BRSK2,CCK,CCR4,CORIN,CRB1,CRX,EMX2,FEZ
                  Autoimmune thyroid disease                              Sexual reproduction ACSBG2,ADCY10,APOB,CATSPER1,FIGLA
                                                    CD40LG,H2-AA,H2-DMB2,H2-EA,H2-M10.6,H2-OB,H2-T3,IFNA12,IFNA4,IL4,IL5,TPO,TSH
                                         Asthma                              Spermatogenesis ACSBG2,ADCY10,APOB,CATSPER1,GAL3
                                                    CD40LG,EPX,H2-AA,H2-DMB2,H2-EA,H2-OB,IL4,IL5,PRG2
                   Sensory organ development                                       Coagulation C9,ENTPD1,F2RL1,F2RL2,GP9,PF4
                                                    3110039M20RIK,ATOH1,ATP2B2,CRB1,CRYBB2,DLX6,FOXG1,GSC,HESX1,IKZF1,ITGA8,K
                 Regulation of body fluid levels                   Keratinocyte differentiation FOXN1,IVL,SPRR1B,SPRR2F,SPRR3
                                                    ADAMTS13,CD40LG,CYP11B2,FGA,FGB,FGG,KCNMA1,KLKB1,KNG1,PAPSS2,PTGER3,TFP
                               Ear development                                      Hemostasis C9,ENTPD1,F2RL1,F2RL2,GP9,PF4
                                                    3110039M20RIK,ATOH1,ATP2B2,DLX6,FOXG1,GSC,HESX1,ITGA8,KCNMA1,NOX3,NR4A
                       Forebrain development                                       Fertilization APOB,CATSPER1,OOEP,SMCP,STRA8,ZP3
                                                    DKK1,EMX2,FEZF2,FOXG1,GSC,HESX1,IKZF1,LHX3,LMX1A,NKX2-1,OTP,OTX2,POU3F3,S
                                           Vision                          Gamete generation ACSBG2,ADCY10,APOB,CATSPER1,FIGLA
                                                    ARR3,CACNA2D4,CNGA3,CRB1,CRYBB2,GLRA1,GRM6,OPN1MW,RCVRN,RGR,TH,VSX1
                     Neuron fate commitment                      Epidermal cell differentiation FOXN1,IVL,SPRR1B,SPRR2F,SPRR3
                                                    ATOH1,FOXA1,HOXD10,NKX2-1,OLIG1,OTX2,PTF1A,TLX3
                             Blood coagulation      ADAMTS13,CD40LG,FGA,FGB,FGG,KLKB1,KNG1,PAPSS2,TFPI2
                                    Homeostasis     ADAMTS13,CD40LG,FGA,FGB,FGG,KLKB1,KNG1,PAPSS2,TFPI2
                                     Cell motion    3110039M20RIK,AKAP3,ATOH1,BARHL2,CCK,CCR4,CERKL,CSF3R,EMX2,FEZF2,FOXG1,L
                                         Meiosis    CCNB3,DMC1,FBXO43,MEI1,SMC1B,STAG3,SYCP1
                              Disease mutation      ATP2B2,DCT,EDAR,GLRA1,KRT2,OTC,PAH,PAPSS2,PAX1
                             Circadian rhythm       ALB,CARTPT,CRX,KCNMA1,MTNR1A,PROKR2
                       Hindbrain development        ATP2B2,HOXB2,LMX1A,MYO16,NEUROD1,PHOX2B,PTF1A,TBR1
                                Chondrogenesis      BMP3,CHRDL2,LECT1,WNT5A
                           Gland development        ATP2B2,BSX,EDA,EDAR,FOXA1,HOXB13,HOXD3,IKZF1,LHX3,NKX2-1,NR0B1,OTP,PAX1,P
                Endocrine system development        HOXD3,LHX3,NEUROD1,NKX2-1,NR0B1,OTP,PAX1,WNT5A
                         Cell fate commitment       ATOH1,BARHL2,FOXA1,HOXD10,NEUROD1,NKX2-1,NTF3,OLIG1,OTX2,PTF1A,SIX3,TLX3
                     Renin-angiotensin system       ACE2,AGTR1A,CPA3,MAS1
                         Regulation of appetite     CARTPT,NPY,SLC22A3
                    Hematopoietic cell lineage      CD22,CSF3R,FCER2A,H2-AA,H2-EA,IL4,IL5,IL5RA,TPO
               Mechanoreceptor differentiation      ATOH1,ATP2B2,KCNMA1,NTF3,POU4F3
           Cluster 5
        GO                    Genes
                Olfaction   9830107B12RIK,A530064D06RIK,AGTR2,BAI3,C130060K24RIK,CASR,CCR1L1,CCR2,CD209A,CD20
               Antibiotic   DEFB1,DEFB10,DEFB12,DEFB14,DEFB15,DEFB35,DEFB38,DEFB39,DEFB40,DEFB5,DEFB50,DEFB6
           Cell adhesion    AMTN,ASTN1,CDH19,CDH26,CDH7,CDH8,CDH9,CHL1,CLSTN2,CNTN3,CNTN5,CNTN6,CNTNAP2,C
      Hormone activity      GALP,GPHB5,HAMP,NTS,OSTN,PRL2B1,PRL3A1,PRL3C1,PRL4A1,PRL7B1,PRL7C1,PRL7D1,PRL8A1
Homophilic cell adhesion    CDH19,CDH26,CDH7,CDH8,CDH9,CHL1,CLSTN2,DSC3,DSG1A,DSG1C,DSG4,PCDH11X,PCDHB1,PC
      Cell-cell adhesion    ASTN1,CDH19,CDH26,CDH7,CDH8,CDH9,CHL1,CLDN16,CLDN17,CLDN8,CLEC7A,CLSTN2,CTNNA2
                   Heme     4833423E24RIK,CYP2A12,CYP2A22,CYP2A5,CYP2B23,CYP2B9,CYP2C38,CYP2C39,CYP2C55,CYP2
  GABA receptor activity    GABRA2,GABRA4,GABRA6,GABRB1,GABRB3,GABRG1,GABRR2,MOG,OLFR93
    Retinol metabolism      ALDH1A7,CYP2A12,CYP2A22,CYP2A5,CYP2B9,CYP2C38,CYP2C39,CYP2C55,CYP2C66,CYP3A25,CY
              Pregnancy     A2M,PSG17,PSG22,PSG23,PSG27,PSG29

				
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