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Aim: What inherited disease will you research? 802 Agenda for Friday, February 2nd Do Now: Science News – Read the article about blue eyes on the blog and post and 2- 3 sentence response – Take out HW, I will call you up to grade it. HW Review- 3-10/ Questions from Sickle Cell Video Mini Lesson: – Inherited Disorders/ Video on Tay-Sachs Practice with Pedigrees/ Unit 3 Review Class Research: Go to firstname.lastname@example.org and choose one of the inherited diseases to research, work with a partner to create a PowerPoint presentation on the disease of your choice. Homework: Read the Sleep Gene Article and write a summary Video Questions- Sickle Cell How can a mutation be harmful in one environment and helpful in another? Why should a mutation persist if it kills people? Why are there more people with sickle cell disease in one part of the world than in other parts? Video Questions- Tay Sachs How can a mutation in a single DNA base affect the production of normal proteins? How are mutations passed on to offspring? What does it mean to be a carrier of a disease? What is the pattern of inheritance for diseases carried by recessive genes? What is Tay Sachs? Project Description Make a Power Point presentation on one of the genetic disorders listed on the blog Be sure to include the following information: What is the disease? What causes it? What are the symptoms? Can it be treated? Include pictures, diagrams, and resources Aim: What types of disorders and diseases can be inherited? 802 Agenda for Wednesday, January 30th Do Now: Quick Review – In your own words, explain why the gender of a baby is determined by the father. – Take out HW, I will come around to grade it HW Review- 3-8 and 3-9 or paragraph Mini Lesson: – Inherited Disorders/ Video on Sickle Cell Anemia Class Research: Go to email@example.com and choose one of the inherited diseases to research, post your research notes. Include your source. Homework: Reading (3-10) Homework Review 3.8 3.9 1. the 23rd pair 1. traits that are inherited along with the gender (on 23rd pair) 2. women are xx and can only donate an x 2. because she has inherited another normal allele that masks 3.The father the disorder Checking Concepts 3. because they can only inherit 1. 23rd pair one allele, if it is for a disease they 2. x chromosomes will automatically show signs of the 3. sperm disorder 4. female 4. because he would actually have hemophilia, not just carry it 5. male 5. to show how traits are passed through a family Checking Concepts 1. sex-linked 2. X 3. recessive 4. carrier 5. will Inherited Disorders Most inherited disorders or diseases are the result of a mutation A mutation is a change in the genetic material Mutations can occur be the result of a change to just one letter in the DNA code or whole missing piece of a chromosome Some inherited disorders are recessive while a few are dominant If the inherited disorder is a recessive, a person can be a carrier for a disease without having any of the symptoms of the disease Types Of Mutation: Chromosomal versus base pair Base pair occur in the actual nitrogen bases of the DNA Chromosomal include a missing or extra chromosome, or when a piece of a chromosome is missing or added. Chromosomal are often so severe that they result in miscarriage of the affected fetus When a the allele for a disorder is dominant it makes a huge difference. Sickle Cell Anemia is recessive (s) while Huntington’s Disease is coded for by a Dominant allele. S s H h S SS Ss h Hh hh s Ss ss hh h Hh Pedigree Charts Video Questions How can a mutation be harmful in one environment and helpful in another? Why should a mutation persist if it kills people? Why are there more people with sickle cell disease in one part of the world than in other parts? Aim: How do your chromosomes determine your gender? 802 Agenda for Tuesday, January 29th Do Now: – Generate 3 questions per table that you have about genetics. Write on the post-it provided and post to question wall. – Take out HW HW Review- 3-7 Video Lesson: – Gender Determination, Blood Types In Class Practice Problems: Incomplete Dominance/ CoDominance/ Blood Type Homework: Reading (3-8, 3-9) 3-7 1. the phenotypes blend together because neither allele is completely dominant 2. In incomplete dominance the alleles are blended, but in codominance both alleles appear side by side 3. none of the genes are dominant, example of codominance 4.BW x BW= BB, BW, WW 1. Pink flowers: RW 2. RR x WW= 100% pink, RW 3. WW- white feathers 4. BW will give you black and white feathers 5. BW x BW= 25% BB, 50% BW, 25% WW Blood Type A O B AB B O A OO Aim: What is the difference between Incomplete Dominance and Co-Dominance? 802 Agenda for Monday, January 28th Do Now: Practice 8th Grade Science Test Problems – Clear off your desk, as if you were about to take a quiz and complete the handout (No talking!) HW Review- Practice Punnett Square Problems Mini-Lesson: Incomplete and Co-Dominance Blog-Baby Swaps, Crime Scenes & DNA tests go to japplebaum.edublogs.org and read and post Homework: KWL, Reading (3-7) Rabbit 1- is heterozygous Black Rabbit 2- is Brown B b b Bb bb b Bb bb Results of a Pea Plant homozygous for purple (PP) and a homozygous white plant (pp): F1 generation: 100% heterozygous purple (Pp) P P p Pp Pp p Pp Pp Results of a a cross between any two F1 generation plants (Pp X Pp) F2 generation: 50% heterozygous purple (Pp), 25% homozygous purple (PP), 25% homozygous white (pp), (75% Purple,25% white) P p P PP Pp p Pp pp Test Cross 1: Unknown Guinea Pig has a homozygous black coat (BB) Test Cross 2: Unknown Guinea Pig has a heterozygous black coat (Bb) BOTH ARE CROSSED WITH A HOMOZYGOUS BROWN (BB) B B B b b Bb Bb b Bb bb b Bb Bb bb b Bb Incomplete Dominance In incomplete dominance both of the alleles are expressed, so when an organism is heterozygous the result is a blended phenotype. Ex: Red + White = Pink CoDominance In co-dominance both alleles are expressed fully. The phenotype is NOT a blend. Ex: If you mate a Brown roan cattle with white cattle, you will get a speckled brown and white cow Pea Plant 1 is Tt, Plant 2 is tt T t t Tt tt t Tt tt Hypothesis There are 2 great models: If, then, because – If (describe the independent variable here) then the (dependent variable) will because (provide a reason). – If the mother alien has homozygous squiggly and the father has straight antennas then all of the baby aliens will have heterozygous squiggly antennas because the Punnett Square shows that each will get one recessive and one dominant gene. IV impacts DV because – (The independent variable) will affect (the dependent variable) by (describe how) because (explain why). Hypothesis In order to write a good hypothesis, you must be able to identify the independent and dependent variables Independent variable- the factor changed Dependent variable- the factor being observed or measured There are 2 great models: If, then, because – If (describe the independent variable here) then the (dependent variable) will because (provide a reason). IV impacts DV because – (The independent variable) will affect (the dependent variable) by (describe how) because (explain why).
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