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					                          WHY ARE SCARS PERMANENT (or are they?)

April 29 — Every scar tells a story — about the time you fell from your bike or the day you burnt your
hand. Every scar also tells about the body’s amazing ability to heal itself. But it’s not perfect. Why? If
skin cells are continually dying and being replaced, shouldn’t there be no scars?

THE SCIENCE BEHIND the question is complex. And the answer to whether a wound will leave a scar
is dependent on a combination of biological processes that include the characteristics of the original
wound and how it healed, and the way the skin cells regenerate.

Unfortunately, many times when our skin is wounded, the cut isn’t clean, the healing conditions are not
ideal and we end up with a scar. “Evolution has selected for scarring,” says Dr. John Newman, a
cosmetic surgeon and researcher at the Laser Center of Virginia in Virginia Beach. “Scarring is the
result of a system that has learned to respond extremely quickly to a wound.”

When the skin is split open, the body immediately starts to pull the edges of the wound together. It does
this by growing epithelial tissue over the open wound at the rate of approximately 1 millimeter every 24
hours. Fibroblasts (special collagen-producing cells found in the dermis, the second layer of skin) then
rush into the wounded tissue and start laying down collagen to strengthen the skin.

Normally, fibroblasts produce an organized lattice of collagen that is very strong, but when in
emergency-response mode, they respond by laying down collagen in a very unorganized, haphazard
way. “It is kind of like nailing down a crisscross of two-by-fours over a hole in a deck,” says Newman.
“It seals the hole, but it doesn’t look very nice.”

He explains that “a scar is actually a bunch of unorganized collagen in the dermal layer of the skin.”
Over time, the tissue will try to reorganize, and the scar may appear to soften, but the skin may never
completely return to its original state — particularly if the cut extends beyond the epidermis, the skin’s
outer layer.

Skin cells regenerate from the bottom up, with a turnover time of roughly one month. “You can think of
the epidermis (the top layer of skin that you see) as a staircase,” says Newman, “where the bottom stair
is the base of the epidermis and the top stair is exposed to the air.” New epidermal cells are formed by
cell division at the bottom of the staircase. To make room for these new cells, the older epidermal cells
are pushed upward toward the top of the staircase. The oldest cells die and fall off.

The genetic material, or DNA, within any cell does not generally change, so the cells that are dividing
on the bottom stairs are transmitting the same genetic characteristics from one generation of cells to the
next. Unfortunately, if these characteristics are of scar tissue, that is what will be regenerated. And
regardless of how much epithelial regeneration occurs above it, the scar can still show.

While surgical repair helps, most deep wounds will leave a scar. Cosmetic surgery is making
tremendous advances, using everything from lasers to fibroblast cell cultures. But the best medicine is to
take steps to prevent scarring, says Dr. David McDaniel, director of the Laser Center of Virginia and an
assistant professor of clinical dermatology at Eastern Virginia Medical School. The most common
mistakes people make that lead to scarring, he says, are: letting wounds dry out (an antibacterial
ointment or even petroleum jelly should be applied), picking off scabs and waiting too long before
getting medical attention for a wound that is large or healing poorly.

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