INSTITUTE OF BIOTECHNOLOGY Special Topics _Ⅰ_ _Ⅱ_ _Ⅲ_ _Ⅳ_:4 by vivi07


Special Topics (Ⅰ) (Ⅱ) (Ⅲ) (Ⅳ):4 credits, 1 credit for each semester of the first and second year graduate program. The goal of the course is to encourage students to get involved in Biotechnology and the research of the faculty, to survey information in topics of interest, to collect references, and to strengthen their ability in oral defense. Instructors: Dr.’s Huey-Lang Yang , Lynn L. H. Huang, Mei-Fen Jeng, Tzong-Yueh Chen, Ching-Chun Chang , Jiann-Ruey, Hong. Seminar (Ⅰ) (Ⅱ) (Ⅲ) (Ⅳ) 4 credits, 1 credit for each semester of the first and : second year graduate program. The seminar course will broaden the academic knowledge in biotechnology and help students to understand the current situation of the bioindustry status in the world. Outstanding speakers will be invited from areas of teaching and/or research institute as well as in the biotechnology industry. Instructors: Dr.’s Huey-Lang Yang , Lynn L. H. Huang, Mei-Fen Jeng, Tzong-Yueh Chen, Ching-Chun Chang, Jiann-Ruey, Hong. Biotechnology(Ⅰ) (Ⅱ): 3 credits each semester. This course will help students to understand more completely the area of Biotechnology. One of the main points is to increase the students' interest and thinking ability in Biotechnology. Instructors: Dr.’s Huey-Lang Yang, Chien Tai, Lynn L. H. Huang, Mei-Fen Jeng, Tzong-Yueh Chen, Ching-Chun Chang, Jiann-Ruey, Hong, Hong-Hwa Chen, Yu-Chung Chao, Su-May Yu. Advanced Molecular Biology: 3 credits Introduction of biological phenomena at the molecular level, and with emphasis on eukaryotic molecular biology. Principles of the main techniques of genetic engineering, experimental approaches and examples are also included. Instructors: Dr.’s. Mei-Fen Jeng, Tzong-Yueh Chen, Ching-Chun Chang, Jiann-Ruey, Hong Special Topics in Biochemistry: 3 credits


Study of the special structures and functions in cells including the biochemical mechanism of cell signal transduction, chromosomal genetics, proteins folding, tissue development and in vitro fertilization. Instructor: Oi-Tong Mak. Advanced Techniques in Microbiology: Culture methods of bacteria, fungi and virus are introduced, focusing on the study of spontaneous mutagenesis and its prevention. The biochemical techniques for condensation, purification of viral proteins and nuclei acids are introduced, such as ultracentrifugation, chromatography, electrophoresis, antibody and immunology analysis etc. Instructor: Enzymology: 3 credits Study of the important factors- enzymes – in metabolism and their basic structures, purification methods, enzyme kinetics, reaction mechanism, the control of enzymes in cells, and applications in clinical and industrial settings. Instructor: Oi-Tong Mak. Structure Biology: 3 credits Four topics are included: the contents, structure, stability, and physical interactions of macromolecules. II. The structure-function relationship, and the interaction between macromolecules and biologically active molecules. III. The tools for structural determination of macromolecules. IV. How to understand the function of a macromolecule from its structure, and structure-based drug design. Instructors: Mei-Fen Jeng. Cellular Biotechnology: 3 credits This course focuses on advanced related culture techniques, research methodology, recent mass production techniques, and their applications. Instructor: Lynn L. H. Huang. Protein Technology: 3 credits This course focuses on recent developments in protein biotechnology. Topics on


recombinant protein production, isolation, purification identification, and applications are covered. Instructor: Lynn L. H. Huang. Research Methods in Biomaterials: 3 credits The purpose is to train graduate students with capabilities of identifying important problems, literature search, experimental design, data analysis, model and hypothesis establishment, as well as writing a good paper. Instructor: Lynu L.H. Huang. Biophysical Techniques: 3 credits Introduction of the physical properties and identification techniques of proteins, nucleic acids, and other bioactive macromolecules. Instructor: Mei-Fen Jeng. Protein Chemistry: 3 credits Recombinant proteins are the major products of biopharmaceutical industry. There key techniques are required for production of recombinant proteins: 1. Recombinant DNA Technique 2. Mammalian Cell Culture / Microbial Fermentation 3. Protein Purification / Quantitative and Qualitative Analysis This course will focus on Protein Purification / Quantitative & Qualitative analysis. In addition, some examples of production and purification recombinant protein products will be discussed. Instructor: Shyh-Yu Shaw. Experimental Methods: 3 credits The principle and application of research methods in life science. Instructor: Mei-Fen Jeng. Genetic Engineering of Animals: 3 credits The principle of gene construction, the production of genetically modified animals, the application of biotechniques in vaccine production, genetic mapping of domestic stocks, and the legislation of animal genetic engineering will be discussed. Instructor: Chien Tai.


Molecular Cell Biology: 3 credits The structure and function of each component of a cell, and molecular mechanism of cells will be covered. Instructor: Hong-Hwa Chen. Crop Breeding and Biotechnology: 2 credits (1) General introduction to crop breeding (2) Crop reproduction and breeding methods (3) Breeding of rice (4) Sugarcane breeding (5) Orchid breeding (6) Anthurium breeding (7) Lily breeding (8) Plant tissue culture technique (9) Somaclonal variation and breeding (10) In vitro ferization and embryo rescue (11) Protoplast technique (12) Somatic hybridization (13) Molecular breeding-transgenic technology (14) Molecular breeding-insect residtance (15) Molecular breeding-virus resistance (16) Molecular breeding-herbicide resistance (17) Molecular breeding-modification of flower. Instructor: Vaccine Protocols: 3 credits (1) Basic immunology (2) Role of antibodies in the defense against infection. (3) Role of cellular immunity in the defense against infection (4) Induction of immunity (5) Inactivated vaccine (6) Live attenuated vaccine (7) Subunit vaccine (8) Recombinant subunit vaccine (9) Recombinant live vaccine. (10) Synthetic peptide vaccine (11) DNA vaccine (12) Administration of vaccine (13) Biological modifier (14) Survey of current vaccines Instructor: Shih-Hui Chen. Selected Topics in Cell Biology: 2 credits Study of the molecular mechanism of the phenomena in a cell, with readings and oral report to better understand the research approach. Instructor: Hong-Hwa Chen. Selected Topics in Molecular Biology: 3 credits The molecular structure of chromosomes, genes, repeated sequences, microsatellites, and the structure and function of the nucleic acids of microsatellites. Instructor: Chi-Chin Chen. Virology: 3 credits Discusses the purification, classification, structure, biochemistry, genetics, and life cycles of viruses of animals, plants and bacteria. The pathogenesis of viruses is


also discussed. Instructor: Shih-Hui Chen. Industrial Microbial Processes: 3 credits Microbiology, biochemistry, biotechniques, formation and their application in industry are discussed. Instructor: Teri-Lain Chen. Biomedical Engineering: 3 credits The study of biomedical engineering from a chemical engineering perspective. Instructors: Chien-Hsiung Chang, Rey-Ter Lin. Molecular Genetics: 3 credits The basic knowledge of gene cloning - the composition translation, and transcription of a chromosome - is discussed. Oncogenic and growth factors are also discussed. Instructor: W. L. Wu. Principles of Biocompatibility: 3 credits The course is for graduate students interested in applied science research. Topics include immunological reactions to foreign materials toxicological aspects, hematocompatibility, in vitro/ in vivo/ clinical evaluations of biocompatibility, biocompatibility of various materials, and related topics. Instructor: Lynn L. H. Huang. Selected Topics in Biophysical Chemistry: 3 credits The course covers a broad range in biophysical area - including basic, techniques and approaches used to study the physical properties of biological macromolecules and complexes and demonstration of techniques and principles used in concert to gain an understanding of the behavior and properties of biological macromolecules and their complexes. Instructor: Mei-Fen Jeng. Proteomic Techniques and Experiments: 1 credits This course is major focusing on the technology of functional genomics which is used to study the expression level for specific proteins in organism. The related experiments include two-dimensional electrophoresis, gel imaging analysis, and


spot picking etc., and the student can operate all experiments by self. Instructor: Tzong-Yueh Chen Advanced Biomedical Technology: 3 credits This course hope to guide students to get more information and knowledge about medical biotechnology. In this semester, the technology we learn including cell activity test in matrix, fixation and imbedding, kinds of strain and photo condition, and building experimental operation in detail. Instructor: Lynn L. H. Huang. Plant Biochemistry: 3 credits The purpose of this course is to introduce the process of primary and secondary metabolism in plants, and sescribe how to metabolic engineering the metabolic pathways to improve the welfare of human beings Instructor: Ching-Chun Chang Special topics for Plant Molecular Molecular Biology: 3 credits The purpose of this course id to introduce the most up-to-date knowledge in the molecular levels of plant genome structure, gene expression, plant development, plant-pathogen interaction and plant against environmental stresses. Instructor: Ching-Chun Chang Advanced Topics on Biological Model Systems: 3 credits The purpose of this course is to introduce the biological model systems and discuss their advantages and disadvantages of these systems. It will including: (1) Escherichia coli (2) Saccharomyces cerevisiae (3) cultured insect cell and baculovirus (4) cultured mammalian cell (5) Nematodes (Caenorhabditis elegans) (6) Drosophila (7) Zebrafish (8) mouse (9) plant Genomics: 3 credits The arts and techniques of genome research, including the molecular markers, genome mapping, linkage analysis, large-scale sequencing, and the application of the knowledge of genome research. Instructor: Hong-Hwa Chen Vaccinology: 3 credits


The main topics are: review of immune responses, basic concepts of immunization, principles of vaccination, adjuvant, carriers, various methods of vaccine preparation, future improvements of vaccine, vaccination against viral infection and tumor. Instructor: Shih-Hui Chen Molecular Virology: 3 credits Establish the basic knowledge on currently virology and how to applied on the life science In the content will includes 1. Introduction, 2. Particles, 3. Genomes, 4. Replication, 5. Expression, 6. Infection, 7. Pathogenesis and 8. Novel Infectious Agents for systematic to introduce the virus from the viral gene level to host interaction. Instructor: Jiann-Ruey, Hong. Special Topics in Virology: 3 crdeits The main topics include current interests in virology, such as viral genetics, gene therapy, viral vaccine, emerging viral diseases, and slow viral diseases. Instructor: Shih-Hui Chen Bacteriology: 3 credits The main topics are detailed ultrastructure, function, and classification of bacteria; morphology, cultivation, biochemical characteristics, pathogenesis, diagnosis, epidemiology, prevention, and treatment of various bacterial infections. Instructor: Shih-Hui Chen. Functional Genomics: 2 credits The functional genomics including position cloning (map based cloning) and the comparative genomics are focused. Instructor: Hong-Hwa Chen Immunobiotechnology: 3 credits Establish the background of molecular immunology and its how to applied on experimental design and disease control. In this course will introduce the immunology how important on the current life science and how to change the major focus in this field and some biotechniques may be useful on immunological study and disease control. In the section I will introduce what is Immunology and its properties. Recognition of antigen will include in Section II and Section III will


introduce the lymphocytes how to maturation, activation and regulation in in vivo system. Effector mechanism of immune responses that include in Section IV that describes the cytokines, innate immunity, cell-mediated and humoral immunity and so on. Finally, immunity how to apply on defense and disease control in Section V that are very important and still developed area. Instructor: Jiann-Ruey, Hong Advanced Topic in Biotechnological Research: 3 credits To encourage students to get involved in Biotechnology and the research of the faculty, to strengthen their ability of experimental design and solving problems. Contents: 1. Development of artificial tissue for regenerative medicine 2.Develop plant chloroplast as a bioreactor and generate an abiotic stress resistant plant, 3. Marine molecular biology and biotechnology, 4. Drug discovery in post genomic era, 5. Introduction of molecular genetic laboratory, 6.Birnavirus controls host apoptosis and functional genomic studies on grouper with nodavirus infection, 7. Plant molecular farming, 8.Vaccine research for aquatic animals, 9.Baculovirus as a tool for nonlytic protein, 10. Production and functional genomics studies, 11. Bambmm mosaic virus and its associated satellite, 12.PNA :from biology to biotechnology, 13.The study of prostaglandin metabolism, 14. Expression of Arabidopsis CBF1 regulated by an ABA/stress inducible promoter in transgenic tomato confers stress tolerance without affecting yield, 15.Thansgenic poultry, Bioinformatics, 16.Introduction of structural biology laboratory,17. Innate immunity induced by bacterial DNA and its application in vaccine. Instructor: Dr.’s Huey-Lang Yang , Lynn L. H. Huang, Mei-Fen Jeng, Tzong-Yueh Chen, Ching-Chun Chang , Jiann-Ruey, Hong, et al.. Laboratory and Advanced Topics for Tissue Engineering: 3 credits Experiments Instructor: Lynn L. H. Huang Tissue Engineering: 3 credits Instructor: Lynn L. H. Huang Vaccine Technology: 3 credits To introduce vaccine technology, both principles and applications. Lecture and


experiment. Dr.’s Tzong-Yueh Chen, Mei-Fen Jeng Vaccine Development : 3 credits To introduce the process of vaccine development, quality control and the methods of vaccine delivery. Dr.’s Huey-Lang Yang, Tzong-Yueh Chen, Mei-Fen Jeng Recombinant DNA Techniques: 3 credits Instructor: Wen-Luan Wu Animal Bredding and Biotechnology : 3 credits Instructor: Chien Tai Animal Biotechnology: 3 credits Instructor: Chien Tai Animal Reproduction Technology: 3 credits Instructor: Chien Tai Enzyme Technology: 3 credits Instructor: Oi-Tong Mak. Advanced Topics on Protein Technology: 3 credits Instructor: Dr. Tzong-Yueh Chen Advanced Topics on Biotechnology Patent Instructor: Dr’s Huey-Lang Yang, Tzong-Yueh Chen Scientific Writing of Biotechnology: 3 credits Instructor: Lynn L. H. Huang Plant Cell Culture: 3 credits


Protein Structure, Folding and Design: 3 credits To introduce protein structure, protein folds and the techniques used to study and analyze protein structure and protein folding pathway. Also, how to use these information and knowledge to design and engineer the predetermined functions into the peptide and protein is included. Instructor: Mei-Fen Jeng Genomics and Bioinformatics: 3 credits Instructor: Hong-Hwa Chen Applied Molecular Biology: 3 credits Instructor: Ming-Chung Chang Management of Technology in Biotechnology: 3 credits Instructor: Huey-Lang Yang Investment in Biotech Industry: 3 credits Instructor: Huey-Lang Yang Special Topics in Genetic Engineering of Animals: 3 credits Instructor: Chien Tai Features: The research interest of the faculty of this institute covers most of the important areas in biotechnology. All faculties have high input into both research and teaching and are very active in the link between NCKU and industry. In training of graduate students, not only specific knowledge, but also their ability, to express themselves, logical thinking and experimental techniques are also emphasized. Student activities: Students are free to and encouraged to attend extracurricular activities and sports. Student academic activities: Graduate students are encouraged to attend both national and international


academic activities to present their research. All students will also have opportunity to give oral presentations in public.


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