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Chapter 31 Herpes Virus

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Chapter 31 Herpes Virus Powered By Docstoc
					Herpes Virus

Herpes Virus
• herpesviridae • 8 types

Human herpes type 1
2 3 4 5 6 7 8

Name Herpes simplex-1 (HSV-1)
Herpes simplex-2 (HSV-2) Varicella Zoster virus (VZV) Epstein-Barr Virus (EBV) Cytomegalovirus (CMV) Human herpes virus-6 (HHV-6) Human herpes virus-7 (HHV-7) Human herpes virus-8 (HHV-8)

common properties
• shape and structure
– spherical, 120-200nm – core – capsid – tegument – envelope

common properties
• replication
– immediate-early proteins – early proteins – late proteins

common properties
• types of infection
– apparent infection – latent infection – integration infection – congenital infection

Herpes simplex virus

Biological Propeties
• shape and structure

Biological Propeties
• Typing
– HSV-1 – HSV-2

Biological Propeties
• Cultivation

Pathogenesis
• Source: human • transmission
– HSV-1: contact – HSV-2: sex contact; vertical transmission

Pathogenesis
• types of infection
– Primary infection – Latent infection and reactivation

Primary infection
• HSV-1
– – – – – 6m-2y herpes gingivostomatitis Herpes keratitis Eczema herpeticum HSV Encephalitis

• HSV-2
– Adults: Genital herpes – Neonates: HSV infection of neonates

Latent infection and reactivation
HSV → primary infection → a little amount of virus remained → HSV-1: 三叉神经节, 颈上神经节 HSV-2:骶神经节 → latent infection → reactivated by several stimulators → arrive at the mucosa that was initially infected

Varicella-Zoster Virus

Varicella-Zoster Virus
• source: human • Transmission
– respiratory aerosols – direct contact with skin lesions

Disease
VZV → viremia → chicken pox → 脊髓后根神经节; 脑神经的感觉神经节 → reactivation → shingles

Epstein-Barr Virus

Epstein-Barr Virus
• Burkitt‘s lymphoma • nasal pharyngeal carcinoma • infectious mononucleosis

Epstein-Barr Virus
• source: human • transmission
– saliva – sex contact

Epstein-Barr Virus
• types of infection
– multiplication infection: epithelial cells – latent infection: B lymphocytes – transformation

Epstein-Barr Virus
• Diseases
– Infectious mononucleosis – Burkitt's lymphoma – Nasopharyngeal cancer

Human Cytomegalovirus (HCMV)

HCMV
• source: human • Transmission
– maternal-infant transmission – close contact – sexually transmitted – blood transfusions and transplants

Disease
• Congenital infection
– placenta – Cytomegalic inclusion disease

• Perinatal infection • adolescent and adult infection
– Granular fever

• Disease in immunosuppressed patients • transformation and carcinogenesis

Human herpes virus 6

Human herpes virus 6
• latent infection in T cells • Children: exanthem subitum • Adults: mononucleosis

Virus HSV

Treatment ACV (acyclovir)

Vaccination No Live attenuated vaccine virus being developed being developed

VZV
EBV HCMV

ACV
No GCV (Ganciclovir


				
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posted:11/9/2009
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