Appendix3

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					                                                                                 #Hits in       Group
 Pathway id               Molecule name                  Pathway name
                                                                                  group          size


            AKT-1, Bad, CAP, FOXO1a, GLUT4,
            GM, InsR, insulin, IRS-1, IRS-2, mTOR,
            p110beta, p46Shc, p52Shc, p66Shc,
            p85alpha, PDK1, PTEN, PTP1B,
CH000000750 SHIP2, SOCS-3                          insulin pathway                     21           93


            p38alpha, PGC-1, PPAR-gamma1,
            PPAR-gamma2, PPAR-gamma3, PPAR- p38alpha ---> PPAR-
CH000000672 gamma4                          gamma                                           6           6



            AKT-1, Bad, p110beta, p85alpha,         VEGF-A ---/ Caspase-9,
CH000000650 PDK1, VEGF-A, VEGFR-2                   Bad                                     7       10



            AKT-1, eNOS, p110beta, p85alpha,
CH000000652 PDK1, VEGF-A, VEGFR-2                   VEGF-A ---> NO                          7       10


            AKT-1, Bad, FOXO1a, GM, InsR,
            insulin, IRS-1, IRS-2, mTOR, p110beta, insulin ---> AKT-1
CH000000651 p85alpha, PDK1, PTEN                   pathway                             13           44



            InsR, insulin, IRS-1, IRS-2, PTP1B,     insulin ---Jak1---> IRS-1,
CH000000653 SOCS-3                                  IRS-2                                   6           8


            AKT-1, Bad, eNOS, LMW-PTP,
            p110beta, p46Shc, p52Shc, p66Shc,
CH000000723 p85alpha, PDK1, VEGF-A, VEGFR-2         VEGF-A pathway                     12           53




CH000000275 p46Shc, p52Shc, p66Shc, SHIP2           CH000000275                             4           4



            GR-Abeta(h), GR-alpha, GR-Alpha-
CH000000558 2(h), GR-beta, GR-Beta-2(h)             c-Ets-2 & GR ---> CYP27                 5           8
            p46Shc, p52Shc, p66Shc, VEGF-A,
CH000000734 VEGFR-2                                VEGF-A ---> Ras            5    8


            AKT-1, IRS-1, IRS-2, p110beta,
            p46Shc, p52Shc, p66Shc, p85alpha,
CH000000926 PDK1, SOCS-1, SOCS-3                   PRL pathway                11   55



            AKT-1, AKT-2, p46Shc, p52Shc,
CH000000624 p66Shc, SHIP2                          EGF ---/ AKT               6    16




CH000000050 InsR, IRS-1, p110beta, p85alpha, PDK1 insulin ---> alphaENaC      5    11



            activated protein C, thrombin,
CH000000164 thrombomodulin                         CH000000164                3    3




CH000000735 LMW-PTP, VEGF-A, VEGFR-2               LMW-PTP ---/ VEGFR-1       3    3




CH000000969 AKT-1, PDK1, PTEN                      PTEN ---/ AKT-1            3    3




CH000000040 InsR, IRS-1, p110beta, p85alpha        insulin ---> PtdIns(3)P    4    8



            PPAR-gamma1, PPAR-gamma2, PPAR- RA, 15d-PGJ2 ---> RXR-
CH000000676 gamma3, PPAR-gamma4             beta, PPAR-gamma                  4    8




CH000001028 AKT-1, IGF-1A, IGF-1B                  IGF-1 ---> Akt-1 ---> AR   3    4
            PGC-1, PPAR-gamma1, PPAR-
            gamma2, PPAR-gamma3, PPAR-            15d-PGJ2 ---> PPAR-
CH000000677 gamma4                                gamma                         5   15




CH000000560 AKT-1, AKT-2, p110beta, p85alpha      PI3K ---/ tuberin             4   9



            ACCbeta, adiponectin, AdipoR1,
CH000004167 AMPKalpha-2                           Adiponectin --->AMPK          4   9




CH000000549 AKT-1, AKT-2, p110beta, p85alpha      PI3K ----/ Rheb               4   10




CH000000930 IRS-1, IRS-2, p110beta, p85alpha      PRL ---IRS---> PI3K           4   10



            glucokinase, glucose-6-phosphatase,
CH000003622 hexokinase-1, hexokinase-2            glycogen degradation          4   10



            glucokinase, glucose-6-phosphatase,
CH000003654 hexokinase-1, hexokinase-2            glycogen degradation          4   10




CH000000654 CAP, GLUT4, InsR, insulin, SHIP2      insulin ---> glucose uptake   5   17




CH000001009 AKT-1, AKT-2, PTEN                    ARIP ---> AKT                 3   5



                                                  PDGF A, PDGF B --->
CH000000633 AKT-1, AKT-2, p110beta, p85alpha      AKT                           4   12
CH000000732 p46Shc, p52Shc, p66Shc, SHIP2      EGF ---> SHIP1         4   12




CH000000774 AKT-1, p110beta, p85alpha, PDK1    RANKL ---> AKT         4   12




CH000000024 NRF-1, p38alpha, PGC-1             MKK6 ---> NRF-1        3   6




CH000000035 InsR, IRS-1, p110beta              insulin ---> p110      3   6




CH000000149 AT1 receptor, p110beta, p85alpha   CH000000149            3   6



            HNF-1alpha-A, HNF-1alpha-B, HNF-
CH000000529 1alpha-C                           MKK3 ---> HNF-1alpha   3   6




CH000001015 AKT-1, AKT-2, p85alpha             AR ---> AKT            3   6




CH000000348 InsR, IRS-1                        CH000000348            2   2




CH000000349 InsR, IRS-1                        CH000000349            2   2




CH000000353 InsR, PTP1B                        CH000000353            2   2
CH000000354 InsR, PTP1B                           CH000000354                2   2


            p38alpha, PGC-1, PPAR-gamma1,
            PPAR-gamma2, PPAR-gamma3, PPAR-
CH000000712 gamma4, PPARalpha (NR1C1)       PPAR pathway                     7   39



                                                  IFNalpha, IFNbeta --->
CH000000596 IRS-1, IRS-2, p110beta, p85alpha      PI3K                       4   13



                                                  insulin ---IRS---> PRK2,
CH000000657 InsR, insulin, IRS-1, IRS-2           SHP-2, MAPK cascade        4   13



            PPAR-gamma1, PPAR-gamma2, PPAR-
CH000000675 gamma3, PPAR-gamma4             MKK4 ---/ PPAR-gamma             4   13



            p110beta, p46Shc, p52Shc, p66Shc,
CH000000741 p85alpha, SOCS-3                      Epo pathway                6   31




CH000000360 IRS-1, p110beta, p85alpha             CH000000360                3   7



            AKT-1, AKT-2, IGF-1A, IGF-1B,
CH000001016 p85alpha, PDK1, PKCalpha              AR pathway                 7   42



            PPAR-gamma1, PPAR-gamma2, PPAR-
CH000000713 gamma3, PPAR-gamma4             15d-PGJ2 ---/ NF-ATc             4   14




CH000000038 InsR, IRS-1, p46Shc, p52Shc, p66Shc   insulin ---> ERK           5   23
CH000000047 CAP, GLUT4, InsR                        insulin ---> GLUT4       3   8




CH000000641 AKT-1, p110beta, p85alpha               PDGF A ---> AKT-1        3   8




CH000000642 AKT-1, p110beta, p85alpha               PDGF B ---> AKT-1        3   8




CH000000933 p46Shc, p52Shc, p66Shc                  GH ---> Grb-2            3   8




CH000000934 p46Shc, p52Shc, p66Shc                  GH pathway               3   8



            InsR, insulin, p46Shc, p52Shc, p66Shc, insulin ---Shc---> MAPK
CH000000656 SHIP2                                  cascade                   6   34




CH000000051 InsR, SOCS-3                            insulin ---> SOCS-3      2   3




CH000000362 IRS-1, p85alpha                         CH000000362              2   3




CH000000393 AKT-1, AKT-2                            CH000000393              2   3




CH000000394 AKT-1, AKT-2                            CH000000394              2   3
CH000000401 CAP, InsR               CH000000401              2   3




CH000000402 CAP, InsR               CH000000402              2   3




CH000000661 VEGF-A, VEGFR-2         VEGF-A ---> STAT1alpha   2   3



                                    AKT, MAPKAPK2 ---/
CH000000576 AKT-1, p38alpha, PDK1   tuberin                  3   9



                                    PDK1 ---> 4E-BP1,
CH000000658 AKT-1, mTOR, PDK1       p70S6K1                  3   9
Over(+)/u
  nder(-)
            p-value
represent
   ation




+           1.05E-09




+           1.28E-08




+           6.32E-08




+           6.32E-08




+           7.27E-08




+           3.29E-07




+           5.56E-06




+           5.67E-06




+           1.34E-05
+   1.34E-05




+   4.93E-05




+   6.79E-05




+   9.82E-05




+   0.000118




+   0.000118




+   0.000118




+    0.00034




+    0.00034




+   0.000454
+   0.000544




+   0.000588




+   0.000588




+   0.000944




+   0.000944




+   0.000944




+   0.000944




+   0.001035




+   0.001095




+   0.002059
+   0.002059




+   0.002059




+   0.002111




+   0.002111




+   0.002111




+   0.002111




+   0.002111




+   0.002426




+   0.002426




+   0.002426
+   0.002426




+   0.002458




+   0.002862




+   0.002862




+   0.002862




+     0.0034




+   0.003561




+   0.003815




+   0.003856




+   0.004438
+   0.005494




+   0.005494




+   0.005494




+   0.005494




+   0.005494




+   0.005504




+   0.007041




+   0.007041




+   0.007041




+   0.007041
+   0.007041




+   0.007041




+   0.007041




+   0.007947




+   0.007947

				
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posted:4/22/2013
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