20th BIENNIAL MEETING of the ISN SATELLITE SYMPOSIUM “MOLECULAR

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					20th BIENNIAL MEETING of the ISN SATELLITE SYMPOSIUM

“MOLECULAR BASIS FOR SIGNAL TRANSDUCTION IN NEURODEGENERATION AND NEUROREGENERATION”

August 27 – 30, 2005 Warsaw, Poland
Conference Venue: Medical Research Center, Polish Academy of Sciences 02-106 Warsaw, 5 Pawinskiego St.

PROGRAMME 20th BIENNIAL MEETING of the ISN SATELLITE SYMPOSIUM “MOLECULAR BASIS FOR SIGNAL TRANSDUCTION IN NEURODEGENERATION AND NEUROREGENERATION” August 27 – 30, 2005 Warsaw, Poland

Organizer:

Joanna B. Strosznajder

August 27th
Sightseeing of Warsaw 18.00-19.00 Registration 19.00 Welcome reception

August 28th

9.00-9.15 Opening ceremony: Zbigniew Czernicki Andrzej Trzebski Joanna B. Strosznajder 9.15-9.45 Opening Lecture: Ryszard Gryglewski “Mechanism of endothelial dysfunction and its pharmacological correction” (Poland)

9.45-10.30 Plenary Lecture: Nicolas Bazan "Neuroprotective signaling in neurodegeneration and neurorepair" (USA)

10.30-10.50 Coffee break

Session 1 Molecular basis for signaling pathways in cell death and survival Chairs: N. Bazan (USA) E. Przegaliński (Poland) 10.50-11.20 Lecture : (USA) G. Y. Sun “Phospholipase A2 in neurodegenerative diseases”

Speakers: 11.20 – 11.40 1. J. B. Strosznajder, H. Jesko, J. Glowacka, A. Zabielna, A. Eckert, M. Chalimoniuk “Nitric Oxide the molecular switch for cells life and death in brain aging and neurodegeneration” (Poland) 11.40 - 12.00. 2. G. Czapski, J. B. Strosznajder “The role of NO in mechanism of inflammation-related mitochondria failure in the brain” (Poland) 12.00 - 12.20 3. J. Marsala, N. Lukacova signaling” (Slovakia) 12.20 - 12.40 4. R. R. Fiscus "Neuroprotective/anti-apoptotic effects of the nitric oxide/cGMP/protein kinase G signaling pathway: BAD, CREB and IAPs as downstream target proteins" (Hong-Kong) 12.40 - 13.00 5. A. Gorczyca "Cyclic GMP-dependent pathways in cell protection of mononuclear cells" (Poland) “The role of NO in the primary sensory

13.00-13.15

Poster session: 1. K. Domek-Łopacińska, M. Kamińska, D. Kopczuk, J. B. Strosznajder “Changes in cGMP level and nitric oxide synthase activity during maturation of the rat brain” 2. N. Lukáčová, M. Kolesárová, M. Chalimoniuk, J. Langfort, J. Maršala „Consequences of spinal cord lesion on changes in NOS pools” 3. G. Sulkowski, L. Strużyńska, B. Dąbrowska-Bouta, B. Kwiatkowska-Patzer, U.
Rafałowska “Changes in the expression of glutamate transporters and

metabotropic glutamate receptors (group I) in experimental autoimmune encephalomyelitis (EAE)”. 4. L. Strużyńska, G. Sulkowski, 1M. Chalimoniuk „Regional differences in the
expression of glutamate transporters in lead toxicity”.

5. K. Dzwonek, M. Zaremba, A. Fiedorowicz, I. Figiel-Ożóg, I. KurkowskaJastrzębska, I. Joniec, B. Oderfeld-Nowak “Differential expression of nestin in glial cells in murine and rat hippocampus during trimethyltin-induced neurodegeneration”

13.15 -14.00

Lunch

Session 2 Molecular dynamics of intracellular calcium and lipids signaling.

Chairs:

A. Szutowicz (Poland) R. Donato (Italy) Lecture: G. Goracci „Secretory phospholipases A2 in neural cells: localizations and functions” (Italy)

14.00 - 14.30

Speakers: 1. M. Alberghina „MAPKs mediate activation of PLA2 by prooxidants (oxLDL and amyloid-β) in microvascular cells” (Italy)

14.30 - 14.50

14.50 – 15.10 15.10 – 15.30 15.30 – 15.50 15.50 – 16.10

2. R. Donato „Neurotrophic and neurotoxic effects of the Ca2+ modulated protein, S100B: Mechanism of action” (Italy) 3. M. Toborek "Lipid signaling mechanisms of spinal cord trauma: in vitro and in vivo models" (USA) 4. S. Nakamura „Sphingolipid metabolism and neuronal function” (Japan) 5. A. Szutowicz, H. Bielarczyk, S. Gul „Phenotype-dependent vulnerability of cholinergic neurons to neurodegenerative signals” (Poland)

16.10 – 16.15

Poster session: 1. M. Chalimoniuk, A. Stolecka, J. B. Strosznajder “Regulation of NO-evoked cytosolic phospholipase A2 activity and its role in cell death in PC12 cells”.

19.00 Dinner

August 29th
Session 3 Molecular mechanism of brain aging and Alzheimer Disease.

Chairs:

W. Müller (Germany) J. B. Strosznajder (Poland)

9.00 – 9.30

Lecture: H-M. Huang, G. Gibson "Interactions of calcium homeostasis and oxidative processes in Alzheimer's Disease"(USA)

Speakers: 1. A. Eckert “Pivotal role of mitochondria in amyloid beta induced cell death” (German/Switzerland)

9.30 - 9.50

9.50 - 10.10 10.10 – 10.30

2. W. Müller “Calcium regulation in brain aging and Alzheimer’s disease” (Germany) 3. M. Lynch „Are age-related neurodegenerative changes triggered by an imbalance between proinflammatory and antiinflammatory influences?” (Ireland)

10.30 – 10.50 10.50 – 11.10

4. W. J. Lukiw “Inflammatory Signaling and Oxidative Stress in Experimental Models of Alzheimer's Disease” (USA) 5. E. Yavin “Amyloid A-beta (1-40) action: Friendly and stressful consequences experienced in cell culture and in vivo” (Israel)

11.10 - 11.30

Poster session: 1. M. Baksalerska-Pazera, G. Niewiadomska, G. Riedel ”Changes in cellular localization of cytoskeletal tau protein in aged cholinergic neurons.” 2. V. W. H. Chow, R. R. Fiscus, S. B. C. Chew “Changes in apoptotic DNA fragmentation in mouse brain caused by aging or genetic deletion of the neuronal-nitric-oxide-synthase (NOS-1) gene”
3. H. Jęśko, A. Adamczyk, A. Eckert, M. Chalimoniuk, J. B. Strosznajder „The mechanism of age-related alteration of endothelial Nitric Oxide Synthase in striatum and other parts of the brain”. 4. H. Wehr, M. Bednarska-Makaruk., W. Lipczyńska-Łojkowska, A. Graban, D. Hoffman-Zacharska, A Kuczyńska-Zardzewiały, J. Mrugała, M. Rodo, A. Bochyńska, A. Sułek, D. Ryglewicz “Differences in apolipoprotein E and interleukin 1 genes polymorphisms between dementia with neurodegenerative traits and vascular dementia” 5. A. Kowalska, M. Wender “Interleukin (IL)1- α and IL1- β gene polymorphisms and risk for sporadic late-onset Alzheimer’s disease” 6. M. Gacia “Presenilin 1 promoter polymorphism is not a risk factor for Alzheimer’s Disease”

11.30 -12.30

lunch

Session 4 Signal transduction in Parkinson Disease.

Chairs:

M. Lynch (Ireland) J. Vetulani (Poland) Lecture: K. Ueda “α -synuclein in neurodegeneration” (Japan)

12.30- 13.00

Speakers: 13.00 – 13.20 13.20 – 14.4 0 1. P. B. Chan „Does synuclein play a central role in dopaminergic neuronal degeneration?” (China) 2. A. Adamczyk, J. Solecka, J.B. Strosznajder “Age-related alteration of αsynuclein and its role in dopaminergic system in relation to Parkinson Disease”(Poland) 13.40 – 14.00 14.00 – 14.20 14.20 – 14.40 3. A. Ciesielska, A. Członkowski “Role of cytokines in pathogenesis of Parkinson’s disease – gender difference” (Poland) 4. M. Chalimoniuk, A. Stępień, J.B. Strosznajder “A possible role of NO/cGMP pathway in pathomechanism of Parkinson Disease” (Poland) 5. A. Storch “Intracellular signaling pathways in dopaminergic specification of mesencephalic neural stem cells” (Germany) 14.40 – 14.50

Poster session:
1. M. Cąkała, J. Drabik, A. Adamczyk, D. Kopczuk, J. B. Strosznajder „Failure of mitochondrial respiration affects dopamine metabolism and its transporter function”

2. G. A. Czapski, M. Chalimoniuk, B. Gajkowska, J. B. Strosznajder „The effect of
lipopolysaccharide on endothelial cells in the brain”

Sightseeing of Łazienki King Palace

August 30th
Session 5 Signal transduction and oxidative stress in brain ischemia reperfusion injury

Chairs:

T. Wieloch (Sweden) A. Członkowska (Poland)

9.00 – 9.30

Lecture: T. Wieloch „Gene profiling of the post ischemic brain reveals novel pathways for recovery of function following stroke” (Sweden)

Speakers: 9.30 – 9.50

1. S. Tanaka, K. Ueda "Poly(ADP-ribose) polymerase-1 activation and mitochondrial impairment in in vitro model of cerebral ischemia" (Japan) 2. R. P. Strosznajder, R. Gadamski, M. Walski “Inhibition of poly(ADPribosyl)ation protects brain against ischemia reperfusion injury” (Poland) 3. A. Y. Sun, Q. Qang, A. Simonyi, G.Y. Sun “Polyphenols protects cerebral ischemia-induced mitochondrial dysfunction and neuronal apoptosis” (USA) 4. T. Zalewska „Ischemia modulates signal transduction from extracellular matrix” (Poland) 5. E. Koźniewska, K. Borcuch, M. Walski, M. Frontczak-Baniewicz, Z. Czernicki „Cerebral haemorrhage" (Poland) microcirculation after experimental subarachnoid

9.50 - 10.10 10.10 – 10.30 10.30 – 10.50 10.50 – 11.10

11.10 – 11.15

Poster session: 1. R. P. Strosznajder, H. Jesko, J. Dziewulska „Effect of carvedilol on neuronal
survival and poly(ADP-ribose) polymerase activity in hippocampus after transient forebrain ischemia.

2. R. Mozzi, S. Buratta, M. Felicetti „Presence of serine base exchange enzyme in
triton-insoluble floating fraction from rat cerebral cortex and stimulation of the plasma membrane enzyme by hypoxia”

11.15 – 12.15

Lunch

Session 6 The novel therapeutic approaches for treatment of neurodegenerative diseases

Chairs:

R. Pelliciari (Italy) P. Grieb (Poland)

12.30 – 13.00

Lecture: J. Vetulani “Neuroprotective and neurotoxic potential of Tetrahydroisoquinolines”(Poland)

Speakers: 13.00 – 13.20 13.20 – 13.40 1. R. Pelliciari „Design of novel selective PARP inhibitors in search for new neuroprotective agents” (Italy) 2. G. Reiser „Mitochondrial calcium regulation and reactive oxygen species generation: sources for neurodegeneration after brain ischaemia and targets for neuroprotective mechanisms” (Germany) 13.40 – 14.00 14.00 – 14.20 14.20 – 14.40 14.40 – 15.00 3. P. Grieb "Pharmacological activation of heat-shock proteins and hypoxiainducible genes" (Poland) 4. I. Kurkowska-Jastrzębska, A. Członkowska, „Anti-inflammatory therapy in neurodegeneration” (Poland) 5. J. Gadek-Wesierski „Novel therapeutic approaches for treatment of degenerative diseases using CDK inhibitors” (Austria) 6. R. Butterworth “Signal transduction pathways in hyperammonemia” (USA)

15.00- 15.15

Poster session:
1. G. Barreda-Gómez, M. Teresa Giralt, R. Rodríguez-Puertas “Modulation of muscarinic cholinergic receptors in the central nervous system of galanin-treated rats”

2. E. Zielińska, D. Kuc, W. A. Turski “The effect of nicotine on the kynurenic acid production in rat brain – in vitro and in vivo study”.

Closing ceremony