陈永 冯斌 时迎斌
陈娜 徐平 周强
There are more than
70,000 new cases of
Syphilis, chronic and
slowly progressive, is
the third most common
Gram negative bacteria
long, thin, helical and motile
Axial filaments - (a form of flagella) -
are the locomotory organelles
• found between the peptidoglycan layer and
outer membrane and running parallel to them
The antibodies result
from tissue injury,
developing to self
T. pallidum is generally transmitted by
Transmission in utero or during birth can also
It can also be transmitted through
Symptoms like secondary
stage of syphilis
After initial infection
hard chancre present.
Mainly seen in outer
Last for 4 to 8 weeks.
The organisms has penetrate and
systemically spread during this
The patient has flu-like symptoms
with secondary lesion particularly
affecting the skin(2-10 weeks
Mainly in trunk and limbs.
of primary and secondary syphilis
In these two stages large
numbers of T. Pallidum
Strong infection , weak
The final stage is tertiary syphilis ( after
several years later).
As the disease progresses immunity
controls the bacterial replication and
few organisms are seen.
Main manifestation are chronic
granuloma and tissue necrosis.
The organisms are often present in
sufficient numbers in exudates
detected by dark field microscopy.
The actively motile organisms
appears brightly lit against the dark
试验) is often used.
1. Serological methods are usually
used to detect syphilis.
2. Screening methods are based on
detecting serum antibodies to cardiolipin
in patients (including VDRL test).
3.VDRL and RPR are also widely
No vaccine exists, but
(usually penicillin G)
is usually highly
That is all .