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					Syphilis

主讲人:叶茜


   制作人:
    陈永 冯斌 时迎斌
    张伟强 孙景福
    陈娜 徐平 周强
    于晓宁 叶茜
Syphilis
       There are more than
        70,000 new cases of
        syphilis(梅毒) each
        year .
       Syphilis, chronic and
        slowly progressive, is
        the third most common
        sexually transmitted
        disease.
             Spirochetes
 Gram negative bacteria
 long, thin, helical and motile
 Axial filaments - (a form of flagella) -
  are the locomotory organelles
     • found between the peptidoglycan layer and
     outer membrane and running parallel to them
T.Pallidum
Mechanism


  The antibodies result
   from tissue injury,
   with autoimmunity
   developing to self
   components.
            Transmission
 T. pallidum is generally transmitted by
  genital/genital contact.
 Transmission in utero or during birth can also
  occur.
   It can also be transmitted through
   blood transfusion.
Congenital syphilis
Blood Transfusion

         The main
          manifestation
         Fever
         Robeola
         Symptoms like secondary
          stage of syphilis
      Pathogenic process

   Primary syphilis

   Secondary syphilis

   Tertiary syphilis
Primary syphilis

            After initial infection
             hard chancre present.
            Mainly seen in outer
             genital organ.
            Last for 4 to 8 weeks.
       Secondary syphilis
   The organisms has penetrate and
    systemically spread during this
    time period.
   The patient has flu-like symptoms
    with secondary lesion particularly
    affecting the skin(2-10 weeks
    later)
   Mainly in trunk and limbs.
Secondary Syphilis
Secondary Syphilis
        Common features
of primary and secondary syphilis
     In these two stages large
      numbers of T. Pallidum
      often present.
     Strong infection , weak
      damage.
     Self-limited
        Tertiary syphilis
   The final stage is tertiary syphilis ( after
    several years later).
   As the disease progresses immunity
    controls the bacterial replication and
    few organisms are seen.
   Main manifestation are chronic
    granuloma and tissue necrosis.
Tertiary Syphilis
Tertiary Syphilis
          Diagnosis(1)
   The organisms are often present in
    sufficient numbers in exudates
    detected by dark field microscopy.
   The actively motile organisms
    appears brightly lit against the dark
    backdrop.
   The FTA-ABS(荧光密螺旋体抗体吸收
    试验) is often used.
Diagnosis(2)

1. Serological methods are usually
   used to detect syphilis.
2. Screening methods are based on
detecting serum antibodies to cardiolipin
in patients (including VDRL test).
3.VDRL and RPR are also widely
  used.
         Therapy

   No vaccine exists, but
    antibiotic therapy
    (usually penicillin G)
    is usually highly
    effective.
That is all .

Thank you!

				
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posted:4/18/2013
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