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Master File of Lead Contact, Lead cc, Contributor cc and Budget Officers (FY09 - FY11) - Performance Assessments Group

Perf. Contact

Scientific Research Outcomes (SRO) SRO-1.3 By 2010, develop an experimental robotic exoskeleton that can be tested for clinical rehabilitation of upper extremity movement. SRO-1.4 By 2012, identify signatures of gene expression in peripheral tissues that are associated with alcoholinduced disorders. SRO-2.1 By 2015, evaluate islet transplantation in combination with immune modulation strategies for the treatment of type 1 diabetes in clinical trials. SRO-2.2 By 2009, evaluate the efficacy of two novel approaches to prevent weight gain and/or treat obesity in clinical trials in humans. SRO-2.4 By 2009, develop and test multidisciplinary biobehavioral interventions to prevent/attenuate disease- and treatment-related symptoms such as pain, fatigue, and psychological distress to reduce related symptom burden and to increase functional status and quality of life. SRO-2.5 By 2011, identify and evaluate 5 novel molecular-targeted interventions for cancer, and determine suitability for use in early phase clinical trials. Chanya Liv, Debbie Clay Kenneth Warren Patricia Powell Jane Lockmuller



PERFORMANCE MEASURES and TARGETS



Lead IC



Lead Contact



Lead cc



Contributors IC



Contributor Contacts



Lead Budget Officer(s)



Ken Ambrose



NICHD NIAAA



Mona Rowe Bridget WilliamsSimmons Kevin Wright Daphne Robinson Amy Magra Patrick Donohue Eleanor Hoff John Grason



NIBIB (financial contributor) None



Mary Beth Kester



Nancy Parfitt Hondros Keith Lamirande Dee Crouse



Ken Ambrose



Deborah Duran



NIAID



NIDDK, NIBIB



Richard Farishian, Amy Magra, Patrick Donohue & Eleanor Hoff (NIDDK); Mary Beth Kester (NIBIB) Mona Rowe & Chanya Liv (NICHD); Carl Roth, Melissa Antman & Stephanie Burrows (NHLBI); Margaret Ames & Jim Corrigan (NCI)



Summer Martinez Charles Zellers Michelle Shorter Kevin Green Kevin Wilson Weston Ricks Shannon West Laurie Johnson Vicki Grigston



Deborah Duran



NIDDK



Richard Farishian



NICHD, NHLBI (FY08 PT), NCI



Ken Ambrose



NINR



Doug Hussey



None



Deborah Duran



NCI



Jim Corrigan



Margaret Ames



NIAID



Kevin Wright, Daphne Robinson, Jane Lockmuller



Ken Ambrose



SRO-2.6 By 2011, develop one field deployable sensor device for use in human studies and develop one biomarker to characterize the impact of environmental exposures on biological pathways. SRO-2.7 By 2011, complete clinical testing of one candidate medical countermeasure that could be used to diagnose or treat victims of a chemical terrorist attack or accident, and complete preclinical testing for two others. SRO-2.8 By 2013, advance two emerging new strategies for treating muscular dystrophy to the point of preparedness for clinical trials. SRO-3.1 By 2013, identify at least one clinical intervention that will delay the progression, delay the onset, or prevent Alzheimer’s disease (AD). SRO-3.2 By 2010, develop one universal antibiotic effective against multiple classes of biological pathogens. SRO-3.3 By 2013, determine the efficacy of using salivary diagnostics to monitor health and diagnose at least one systemic disease.



NIEHS



Bill Jirles



Sheila Newton



NIDA, NIAAA, NIBIB



Susan Weiss & Gaya Dowling & Genevieve deAlmeida-Morris (NIDA); Kenneth Warren, Patricia Powell & Bridget Williams-Simmons (NIAAA); Mary Beth Kester (NIBIB) Kevin Wright, Daphne Robinson, Jane Lockmuller (NIAID), Anita Linde, Wilma PetermanCross & Jonelle Drugan (NIAMS), Sheila Newton, Bill Jirles & Sheila Newton (NIEHS), Juliana Blome (NIGMS) Anita Linde, Wilma Peterman-Cross & Jonelle Drugan (NIAMS), Mona Rowe & Chanya Liv (NICHD) Paul Scott & Rebecca Farkas (NINDS); Mary Beth Kester (NIBIB); Della Hann, Marina Volkov & Keisha Shropshire (NIMH) Amy Adams & Sue Hamann



Deborah Duran



NINDS



Rebecca Farkas



Paul Scott



NIAID, NIAMS, NIEHS, NIGMS



Ken Frushour Susan Free Ken Frushour Susan Free Robert Feaga Van Nguyen Summer Martinez Bret Dean George Coy



Deborah Duran



NINDS



Rebecca Farkas



Paul Scott Jeannie Borger, Kathie Reed Jane Lockmuller



NIAMS, NICHD



Ken Ambrose **



NIA



Kate Nagy Kevin Wright Daphne Robinson Sue Hamann



NINDS, NIBIB, NIMH



Deborah Duran



NIAID



NIDCR



Ken Ambrose



NIDCR



Amy Adams



None



Deborah Duran **



SRO-3.4 By 2015, develop an HIV/AIDS vaccine.



NIAID



Kevin Wright Daphne Robinson



Jane Lockmuller



NICHD, NCRR, OAR, FIC, NIEHS, NHLBI, NHGRI, NCI, NIAMS, NIGMS, NIDA, NIDCR



Mona Rowe & Chanya Liv (NICHD); Patricia Newman & Stephen Seidel (NCRR); Wendy Wertheimer & Robert Eisinger (OAR); Karen Hofman, Linda Kupfer & Rachel Sturke (FIC); Sheila Newton & Bill Jirles (NIEHS); Carl Roth, Melissa Antman & Stephanie Burrows (NHLBI); Phyllis Frosst & Sanja Basaric (NHGRI); Margaret Ames & Jim Corrigan (NCI); Anita Linde & Wilma Peterman Cross (NIAMS); Juliana Blome (NIGMS); Susan Weiss & Gaya Dowling & Genevieve deAlmeida-Morris (NIDA); Amy Adams & Sue Hamann (NIDCR)



Summer Martinez Donna Aderly



Ken Ambrose



SRO-3.5 By 2013, identify and characterize at least 2 human candidate genes that have been shown to influence risk for substance use disorders and risk for psychiatric disorders using high-risk family, twin, and special population studies. SRO-3.6 By 2012, develop and apply clinically one new imaging technique to enable tracking the mobility of stem cells within cardiovascular tissues. SRO-3.7 By 2019, develop at least two novel therapies for immune-mediated disease.



NIAAA



Bridget WilliamsSimmons Melissa Antman Stephanie Burrows Laurence (Larry) Chloupek



Kenneth Warren Patricia Powell Carl Roth



NIDA, NIMH



Susan Weiss & Gaya Dowling & Genevieve deAlmeida-Morris (NIDA); Della Hann, Marina Volkov & Keisha Shropshire (NIMH) Mary Perry & Betsy Wilder (Roadmap)



Keith Lamirande Dee Crouse Fred Wong Jimmy Do



Deborah Duran ** Evelyn Botchway



NHLBI



Roadmap



OIR



Richard Wyatt



NHLBI, NIDDK, NIAMS



Carl Roth, Melissa Antman & Stephanie Burrows (NHLBI); Amy Magra, Patrick Donohue Contributin IC Budget Officers & Eleanor Hoff (NIDDK); Wilma Peterman Cross (NIAMS) Laurence (Larry) Chloupek (OIR) Weston Ricks Shannon West



Deborah Duran



SRO-3.8 By 2016, determine the optimal tailored treatment regimen for patients with early stage breast cancer that maximizes the benefits of chemotherapy while minimizing the side-effects of unnecessary treatment. SRO-4.3 By 2009, evaluate the safety and efficacy of two new treatments for nonalcoholic steatohepatitis (NASH) in adults. SRO-4.4 By 2011, identify or study additional genes involved in communication disorders in humans and animal models.



NCI



Jim Corrigan Amy Magra Patrick Donohue Eleanor Hoff Laura Cole



Margaret Ames



None



Deborah Duran



NIDDK



Richard Farishian



None



Charles Zellers



Deborah Duran



NIDCD



Buck (Baldwin) Wong



NHGRI



Phyllis Frosst & Sanja Basaric Susan Weiss & Gaya Dowling & Genevieve deAlmeida-Morris (NIDA); Kenneth Warren, Patricia Powell & Bridget Williams-Simmons (NIAAA); Della Hann, Marina Volkov & Keisha Shropshire (NIMH); Richard Farishian, Amy Magra, Patrick Donohue & Eleanor Hoff (NIDDK); Shefa Gordon & Richard Fisher (NEI); Carl Roth, Melissa Antman & Stephanie Burrows (NHLBI)



Catherine Langston



Deborah Duran



SRO-4.5 By 2011, identify genetic and environmental factors which predispose to three complex diseases.



NHGRI



Phyllis Frosst Sanja Basaric



NIDA, NIAAA, NIMH, NIDDK, NEI, NHLBI



Eddie Rivera Ken Ow & Betsy Parker



1



Master File of Lead Contact, Lead cc, Contributor cc and Budget Officers (FY09 - FY11) - Performance Assessments Group

Perf. Contact



PERFORMANCE MEASURES and TARGETS



Lead IC



Lead Contact



Lead cc

Anita Linde Wilma Peterman Cross



Contributors IC



Contributor Contacts



Lead Budget Officer(s)

Cassie Terra Stephanie Kreider



SRO-5.2 By 2009, determine the efficacy of statins in preventing the progression of atherosclerosis in children with Scientific Research Outcomes (SRO) Ken Ambrose systemic lupus erythematosus (SLE, or lupus).

Evelyn Botchway **



NIAMS



Louise Rosenbaum



NIAID



Kevin Wright, Daphne Robinson, Jane Lockmuller



SRO-5.3 By 2009, expand the range of available methods used to create, analyze, and utilize chemical libraries, which can be used to discover new medications. Specifically, use these chemical libraries to discover 10 new and unique chemical structures that could serve as the starting point for new drugs.



NIGMS



Juliana Blome



NIBIB, FIC, RM



Mary Beth Kester (NIBIB); Rachel Sturke, Karen Hofman & Linda Kupfer (FIC); Mary Perry & Betsy Wilder (RM)



Tony Moore Nancy Vess



Ken Ambrose



SRO-5.6 By 2009, identify 1 or 2 new medication candidates to further test and develop for the treatment of tobacco addiction.



NIDA



Susan Weiss, Gaya Dowling, Genevieve deAlmeida-Morris



NCI



Margaret Ames & James Corrigan



Lawrence Raigrodski Jewell Webb



Deborah Duran



SRO-5.7 By 2010, validate and compare 3 imaging methods that could offer increased sensitivity over computed tomography (CT) as a means of assessing lung cancer response to therapy.



NCI



Jim Corrigan



Margaret Ames



NIBIB



Mary Beth Kester



Weston Ricks Shannon West



Deborah Duran Deborah Duran **



SRO-5.8 By 2012, improve device(s) to measure hot flashes and test in clinical studies of hot flash therapies.



NCCAM



Yancy Bodenstein



None



Steve Casady



SRO-5.9 By 2010, establish the role of genetic factors in three major diseases for which health disparities are noted between populations. SRO-5.10 By 2011, conduct studies of girls aged 6 through 8 years to determine the associations between the age of onset of puberty and progression through puberty with 12 environmental exposures. SRO-5.11 By 2012, develop and test at least two behavioral strategies for the management of symptoms to reduce the effects of disease, disability, or psychological distress on quality of life and outcomes.



NHGRI



Phyllis Frosst Sanja Basaric



NCI, NIDDK, NHLBI (not in FY10)



Margaret Ames & James Corrigan (NCI); Richard Farishian, Amy Magra, Patrick Donohue & Eleanor Hoff (NIDDK); Carl Roth, Melissa Antman & Stephanie Burrows (NHLBI)



Eddie Rivera Ken Ow & Betsy Parker Laurie Johnson Vicki Grigston Kevin Green Kevin Wilson



Ken Ambrose



NIEHS



Bill Jirles



Sheila Newton



NCI



Margaret Ames & James Corrigan



Ken Ambrose



NINR



John Grason Susan Weiss, Gaya Dowling, Genevieve deAlmeidaMorris Shefa Gordon Amy Magra Patrick Donohue Eleanor Hoff Melissa Antman Stephanie Burrows



Doug Hussey



NCI



Margaret Ames & James Corrigan



Ken Ambrose



SRO-5.12 By 2013, identify several potential targets and/or molecules that modulate or enhance the extinction of learned behaviors and conditioned associations supporting addiction, compulsion, or anxiety disorders.



NIDA



NIMH



Della Hann, Marina Volkov & Keisha Shropshire



Lawrence Raigrodski Jewell Webb



Ken Ambrose



SRO-6.1 By 2012, identify the genes that control the risk of development of age-related macular degeneration (AMD) and glaucoma in humans. SRO-6.2 By 2011, assess the efficacy of at least three new treatment strategies to reduce cardiovascular morbidity/mortality in patients with type 2 diabetes and/or chronic kidney disease. SRO-6.4 By 2014, identify and characterize two molecular pathways of potential clinical significance to serve as the basis for discovering new medications for preventing and treating asthma exacerbations.



NEI



Richard Fisher



None



Kurt John Marilyn Laurie Carl Roth, Stephanie Burrows & Melissa Antman Charles Zellers Michelle Shorter Fred Wong Jimmy Do



Deborah Duran ** Deborah Duran



NIDDK



Richard Farishian



NHLBI



NHLBI



Carl Roth



NIAID



Kevin Wright, Daphne Robinson, Jane Lockmuller Kenneth Warren, Patricia Powell & Bridget Williams-Simmons (NIAAA), Susan Weiss & Gaya Dowling & Genevieve deAlmeida-Morris (NIDA), Mona Rowe & Chanya Liv (NICHD), Della Hann, Marina Volkov & Keisha Shropshire (NIMH); Rachel Sturke, Linda Kupfer, Karen Hofman (FIC); Wendy Wertheimer & Christina Brackna (OAR) Margaret Ames & James Corrigan Kate Nagy, Jeannie Borger, & Kathie Reed (NIA); Lisa Begg (ORWH); Mary Beth Kester (NIBIB); Illeana Herrell (NCMHD)



Deborah Duran



SRO-6.5 By 2014, develop and evaluate two new interventions for the prevention and/or treatment of HIV disease utilizing the newly restructured HIV/AIDS clinical trials networks.



NIAID



Kevin Wright Daphne Robinson



Jane Lockmuller



NIAAA, NIDA, NICHD, NIMH, FIC, OAR



Summer Martinez Brad Schwartz



Ken Ambrose



SRO-6.6 By 2015, provide at least one new or significantly improved minimally-invasive treatment for patients using image-guided interventions. SRO-7.4 By 2009, create research resources to aid in the identification and evaluation of biomarkers as candidates for surrogate endpoints for osteoarthritis. SRO-7.5 By 2009, determine the feasibility of applying at least 2 tailored interventions designed to prevent dental caries in one or more underserved populations. SRO-7.7 By 2011, assess community-based methods for facilitating cancer research and providing patients access to optimal cancer care. SRO-8.2 By 2009, identify and characterize two molecular interactions of potential clinical significance between bone-forming cells and components of bone. Such interactions are defined as those having significant impact on the accrual of bone mass or the actual mechanical performance of bone (i.e., fracture resistance) in laboratory animals. SRO-8.4 By 2009, assess the impact of two major Institutional Development Award (IDeA) Programs on the development of competitive investigators and their capacities to compete for NIH research funding. SRO-8.5 By 2009, develop an item bank and computerized adaptive testing system available to clinical researchers to improve assessment of non-specific symptoms (e.g., pain and fatigue) and other domains of health-related quality of life in chronic disease. SRO-8.6 By FY 2011, develop stable national estimates of vision impairment by extending the vision component of the National Health and Nutrition Examination Survey (NHANES).



NIBIB



Mary Beth Kester Anita Linde Wilma Peterman Cross Amy Adams



NCI



Shirley Finney Joe Mosimann Cassie Terra Stephanie Kreider Bret Dean George Coy



Ken Ambrose



NIAMS



Jonelle Drugan



NIA, ORWH, NIBIB, NCMHD



Ken Ambrose



NIDCR



Sue Hamann



None



Deborah Duran



NCI



Jim Corrigan



Margaret Ames



NINR



Doug Hussey & John Grason



Weston Ricks Shannon West



Ken Ambrose



NIAMS



Jonelle Drugan



Anita Linde Wilma Peterman Cross Lori Mulligan, Steve Seidel Louise Rosenbaum Anita Linde Wilma Peterman Cross Richard Fisher



NIDCR



Amy Adams & Sue Hamann



Cassie Terra



Evelyn Botchway



NCRR



Patricia Newman



None



Terry Smith, Louis Frazier Fawn Friedman



Ken Ambrose



NIAMS



Louise Rosenbaum (NIAMS)



Roadmap



George Bramhall, Mary Perry & Betsy Wilder (Roadmap)



Cassie Terra, Stephanie Kreider



Ken Ambrose



NEI



Shefa Gordon



None



Kurt John Marilyn Laurie



2



Master File of Lead Contact, Lead cc, Contributor cc and Budget Officers (FY09 - FY11) - Performance Assessments Group

Perf. Contact



PERFORMANCE MEASURES and TARGETS



Lead IC



Lead Contact

Marina Volkov & Keisha Shropshire



Lead cc



Contributors IC



Contributor Contacts

Susan Weiss & Gaya Dowling & Genevieve deAlmeida-Morris (NIDA); Doug Hussey & John Grason (NINR); Kenneth Warren, Patricia Powell & Bridget Williams-Simmons (NIAAA)



Lead Budget Officer(s)

Chuck Willoughby JoAnne Wong Robert Feaga Van Nguyen



SRO-8.7 By 2012, identify Scientific Research Outcomes (SRO) 3 effective implementation strategies that enhance the uptake of research-tested Ken Ambrose interventions in service systems such as primary care, specialty care and community practice.



NIMH



Della Hann



NIDA, NINR, NIAAA



Ken Ambrose



SRO-8.8 By 2012, identify at least one candidate intervention that extends median lifespan in an animal model. SRO-9.1 By 2010, demonstrate through research a capacity to reduce the total years lost to disability (YLDs) in the United States by 10% by (1) developing treatment algorithms to improve the management of treatment-resistant and recurrent depression and (2) elucidating the mechanisms by which depression influences at least two comorbid physical illnesses (e.g., heart disease, cancer, Parkinson’s disease, or diabetes). SRO-9.2 By 2018, identify culturally appropriate, effective stroke prevention programs for nationwide implementation in minority communities. SRO-9.3 By 2011, characterize the progression of normal, healthy brain development in a nationally representative sample of children in the United States by creating a database of MRI and clinical/behavioral data and analytical software. SRO-9.4 By 2013, develop and evaluate the efficacy of neonatal screening for congenital cytomegalovirus (CMV) infection to permit identification of infants who will develop CMV-induced hearing loss in the first years of life. SRO-9.5 By 2014, assess the efficacy of long-term oxygen treatment in patients with COPD and moderate hypoxemia.



NIA



Kate Nagy



Jeannie Borger, Kathie Reed



Ken Ambrose



NIMH



Marina Volkov & Keisha Shropshire



Della Hann



NCI, NIAAA, NINDS



Margaret Ames & James Corrigan (NCI); Kenneth Warren, Patricia Powell & Bridget Williams-Simmons (NIAAA); Paul Scott & Rebecca Farkas (NINDS)



Chuck Willoughby JoAnne Wong



Deborah Duran



NINDS



Rebecca Farkas



Paul Scott Chanya Liv, Debbie Clay Buck (Baldwin) Wong Carl Roth



NHLBI, NINR, NCRR



Carl Roth, Melissa Antman & Stephanie Burrows (NHLBI); Doug Hussey & John Grason (NINR); Patricia Newman & Steve Seidel (NCRR) Paul Scott & Rebecca Farkas (NINDS); Susan Weiss & Gaya Dowling & Genevieve deAlmeida-Morris (NIDA); Della Hann, Marina Volkov & Keisha Shropshire (NIMH)



Ken Frushour Susan Free Nancy Parfitt Hondros



Ken Ambrose



NICHD



Mona Rowe



NINDS, NIDA, NIMH



Ken Ambrose



NIDCD



Laura Cole Melissa Antman Stephanie Burrows



None



Mimi Lee Catherine Langston Fred Wong Jimmy Do



Deborah Duran



NHLBI



None



Communication and Transfer of Results (CTR) CTR-1 By 2014, reduce the disparity between African American and white infants in back sleeping by 50% to further reduce the risk of sudden infant death syndrome (SIDS). CTR-6 By 2010, improve the efficiency and reduce the unit cost of producing authoritative serials cataloging records used to improve access to the biomedical literature in libraries worldwide. CTR-7 By 2010, establish the feasibility of sharing information from already-conducted scientific studies of warfarin (coumadinR) anti-coagulation, through the knowledge base PharmGKB. CTR-8 By 2012, increase communication efforts and enhance outreach strategies regarding extramural research funding policy, compliance and administration as demonstrated by the type and frequency of communications and related activities. Sarah Glavin, Shavon Artis Barbara Rapp John McGrath, Mona Rowe Susan Levine None



Ken Ambrose



NICHD



Nancy Parfitt Hondros Mitzi Allen Darlene Dodson Phyllis Frosst & Sanja Basaric Tony Moore Nancy Vess Megan Columbus



Evelyn Botchway



NLM



Evelyn Botchway



NIGMS



Juliana Blome



NHGRI



Evelyn Botchway



OER/OD



Megan Columbus



Neil Thakur



None



Capacity Building and Research Resources (CBRR) CBRR-1 By 2012, recruit, train, and retain a diverse population of highly trained scientists in biomedical, behavioral, and clinical research using research training grants, fellowships, career development awards, and student loan repayment programs. CBRR-2 Promote data sharing and provide information in real time by implementing and monitoring the NIH Business System. (By FY 2010, the NBS will be in an ongoing status). CBRR-4 By 2013, provide greater functionality and more streamlined processes in grants administration by continuing to develop NIH Electronic Research Administration (eRA). CBRR-6 By 2011, build capacity to conduct research by constructing or renovating extramural facilities to meet the biomedical and behavioral research, research training or research support needs. CBRR-7 By 2010, utilize enhanced ARIS database to more efficiently conduct portfolio analysis to invest in priority AIDS research. CBRR-8 By 2012, ensure that 100% of trainee appointment forms are processed electronically, to enhance program management. CBRR-9 By 2010, achieve cost savings of managing construction grants by expanding the use of electronic project management tools that enhance oversight and 20 year usage monitoring. CBRR-10 By 2013, make freely available to researchers the results of 300 high-throughput biological assays screened against a library of 300,000 unique compounds, and the detailed information on the molecular probes that are developed through that screening process.



Evelyn Botchway **



OEP/OER/O D



Jennifer Sutton



Neil Thakur, Sherry Mills



OIR/OLRS/OD



Stephen Boehlert



Joyce Rogers



Evelyn Botchway Evelyn Botchway ** Evelyn Botchway ** Evelyn Botchway ** Evelyn Botchway ** Evelyn Botchway **



OM/OD



Brian Frantz Donna Frahm Charles Saunders Amy Ngan Patricia Newman Christina Brackna Wendy Wertheimer Karin Lohman Jennifer Sutton



Charles Singleton



OM/OD



Janet Dudrick



Brian Frantz



OER/OD



Neil Thakur William Starr Kathy Hancock, Steve Seidel, Lori Mulligan Bob Eisinger



None



Donna Frahm Megan Columbus Terry Smith, Louis Frazier Fawn Friedman



NCRR



NIAID



Kevin Wright, Daphne Robinson, Jane Lockmuller



OAR



None



Donna Adderly



OER/OD



Neil Thakur Kathy Hancock, Steve Seidel, Lori Mulligan Della Hann



Jennifer Sutton Terry Smith, Louis Frazier Fawn Friedman JoAnne Wong?



NCRR



Patricia Newman



NIAID



Kevin Wright, Daphne Robinson, Jane Lockmuller



Ken Ambrose



NIMH



Keisha Shropshire Marina Volkov



RM (financial), NHGRI (sci/adm)



George Bramhall, Mary Perry & Betsy Wilder (Roadmap); Phyllis Frosst & Sanja Basaric (NHGRI)



Strategic Management of Human Capital (SMHC) SMHC-4 Ensure that NIH commercial functions are performed as efficiently and cost-effectively as possible by conducting competitive sourcing reviews on the required number of functions within the Agency’s commercial inventory. (Ongoing) Katy Finn Debra Wade Katy Perry Suzanne Servis Debra Wade Katy Perry



Evelyn Botchway



OM/OD



OM/OD



Janet Dudrick



3



Master File of Lead Contact, Lead cc, Contributor cc and Budget Officers (FY09 - FY11) - Performance Assessments Group

Perf. Contact



PERFORMANCE MEASURES and TARGETS



Lead IC



Lead Contact

Chien-ting Lin Rosa Perez Sharon Cunningham Chien-ting Lin Rosa Perez Sharon Cunningham Chien-ting Lin Rosa Perez Sharon Cunningham Chien-ting Lin Rosa Perez Sharon Cunningham



Lead cc

Evans Aine Dan Dupuis Erin Hooley Evans Aine Dan Dupuis



Contributors IC



Contributor Contacts



Lead Budget Officer(s)



Scientific Research Outcomes (SRO) SMHC-5 Improve and monitor the use of human resource services by providing real-time access to tools via the Evelyn

Botchway



NIH portal. (Ongoing)



OM/OD



OM/OD



Janet Dudrick



Connie Seminerio



Evelyn Botchway



SMHC-6 Provide opportunities for enhanced leadership skills to meet the challenges of workforce management and/or individual advancements. (Ongoing)



OM/OD



OM/OD



Janet Dudrick



Evans Aine Chien-ting Lin



Evelyn Botchway



SMHC-7 Address diverse workforce recruitment needs to ascertain highly qualified staff to conduct or support biomedical research. (Ongoing)



OM/OD



Evans Aine Dan Dupuis



OM/OD



Janet Dudrick



Evans Aine Chien-ting Lin



Evelyn Botchway



SMHC-8 Address areas to facilitate retention of highly qualified staff to conduct or support biomedical research. (Ongoing)



OM/OD



Evans Aine Dan Dupuis



OM/OD



Janet Dudrick



Evans Aine Chien-ting Lin



Program Oversight and Improvement (POI)

Evelyn Botchway Evelyn Botchway Evelyn Botchway ** Evelyn Botchway **



POI-2 Utilize Performance-Based Contracting (PBC). (Ongoing) POI-5 By 2010, enhance NIH's ability to demonstrate benefits for extramural research investments through changes to policy and information systems. POI-6 Provide responsible stewardship over existing federally owned real property assets. (Ongoing) POI-7 Manage design and construction of capital facility projects funded by the Building and Facilities Appropriation (B&F) so the HHS and congressionally approved scope of work is delivered within the approved budget. (Ongoing) POI-8 By 2010, protect NIH's interest in grant-supported real property supported under the extramural construction grant program by ensuring compliance with construction and 20 year usage requirements



OM/OD OER/OD



Derrick Montford Sherley Mizzell Megan Columbus Donna Frahm Charles Saunders Clarence Dukes



Diane Fraiser Neil Thakur Glen Stonebraker & Daniel Wheeland Farhad Memarzadeh & Daniel Wheeland Kathy Hancock, Steve Seidel, Lori Mulligan Richard Wyatt



OM/OD OER/OD



Janet Dudrick



Derrick Montford Shirley Mizzell Megan Columbus Donna Frahm



OM/OD



OM/OD



Janet Dudrick



Steven Berkowitz Victoria Davis Steven Berkowitz Victoria Davis



OM/OD



Clarence Dukes



OM/OD



Janet Dudrick Kevin Wright, Daphne Robinson, Jane Lockmuller (NIAID), Margaret Ames & Jim Corrigan (NCI), Carl Roth, Melissa Antman & Stephanie Burrows (NHLBI), Shefa Gordon & Richard Fisher (NEI), Susan Weiss & Gaya Dowling & Genevieve deAlmeida-Morris (NIDA)



Evelyn Botchway ** Evelyn Botchway **



NCRR



Patricia Newman



NIAID, NCI, NHLBI NEI, NIDA



Terry Smith, Louis Frazier Fawn Friedman



POI-9 By 2012, reallocation of laboratory resources based on external reviews by Boards of Scientific Counselors



OIR



Laurence (Larry) Chloupek



Laurence (Larry) Chloupek



** PART Measure



4



Scientific Research Outcomes (SRO) SRO-1.3 SRO-1.4



SRO-2.1



SRO-2.2



SRO-2.4



SRO-2.5



SRO-2.6



SRO-2.7



SRO-2.8



SRO-3.1 SRO-3.2



SRO-3.3



SRO-3.4



SRO-3.5



SRO-3.6



SRO-3.7



SRO-3.8



SRO-4.3



SRO-4.4



SRO-4.5



SRO-5.2



SRO-5.3



SRO-5.6



SRO-5.7 SRO-5.8



SRO-5.9



SRO-5.10



SRO-5.11



SRO-5.12



SRO-6.1



SRO-6.2



SRO-6.4



SRO-6.5



SRO-6.6



SRO-7.4



SRO-7.5



SRO-7.7



SRO-8.2



SRO-8.4



SRO-8.5



SRO-8.6



SRO-8.7



SRO-8.8



SRO-9.1



SRO-9.2



SRO-9.3



SRO-9.4



SRO-9.5 Communication and Transfer of Results (CTR)



CTR-1



CTR-6



CTR-7



CTR-8 Capacity Building and Research Resources (CBRR) CBRR-1



CBRR-2



CBRR-4



CBRR-6



CBRR-7



CBRR-8



CBRR-9



CBRR-10 Strategic Management of Human Capital (SMHC) SMHC-4



SMHC-5 SMHC-6 SMHC-7 SMHC-8 Program Oversight and Improvement (POI) POI-2 POI-5 POI-6



POI-7



POI-8



POI-9



Total Measures:



TOTAL: Total PART



TOTAL:



PERFORMANCE MEASURES (FY09 - FY11)



ntific Research Outcomes (SRO) By 2010, develop an experimental robotic exoskeleton that can be tested for clinical rehabilitation of upper extremity movement. By 2012, identify signatures of gene expression in peripheral tissues that are associated with alcoholinduced disorders. By 2015, evaluate islet transplantation in combination with immune modulation strategies for the treatment of type 1 diabetes in clinical trials. By 2009, evaluate the efficacy of two novel approaches to prevent weight gain and/or treat obesity in clinical trials in humans. By 2009, develop and test multidisciplinary biobehavioral interventions to prevent/attenuate diseaseand treatment-related symptoms such as pain, fatigue, and psychological distress to reduce related symptom burden and to increase functional status and quality of life. By 2011, identify and evaluate 5 novel molecular-targeted interventions for cancer, and determine suitability for use in early phase clinical trials. By 2011, develop one field deployable sensor device for use in human studies and develop one biomarker to characterize the impact of environmental exposures on biological pathways. By 2011, complete clinical testing of one candidate medical countermeasure that could be used to diagnose or treat victims of a chemical terrorist attack or accident, and complete preclinical testing for two others. By 2013, advance two emerging new strategies for treating muscular dystrophy to the point of preparedness for clinical trials. By 2013, identify at least one clinical intervention that will delay the progression, delay the onset, or prevent Alzheimer’s disease (AD). By 2010, develop one universal antibiotic effective against multiple classes of biological pathogens. By 2013, determine the efficacy of using salivary diagnostics to monitor health and diagnose at least one systemic disease.



By 2010, develop an HIV/AIDS vaccine. By 2013, identify and characterize at least 2 human candidate genes that have been shown to influence risk for substance use disorders and risk for psychiatric disorders using high-risk family, twin, and special population studies. By 2012, develop and apply clinically one new imaging technique to enable tracking the mobility of stem cells within cardiovascular tissues. By 2019, develop at least two novel therapies for immune-mediated disease. By 2016, determine the optimal tailored treatment regimen for patients with early stage breast cancer that maximizes the benefits of chemotherapy while minimizing the side-effects of unnecessary treatment. By 2009, evaluate the safety and efficacy of two new treatments for nonalcoholic steatohepatitis (NASH) in adults. By 2011, identify or study additional genes involved in communication disorders in humans and animal models. By 2011, identify genetic and environmental factors which predispose to three complex diseases. By 2009, determine the efficacy of statins in preventing the progression of atherosclerosis in children with systemic lupus erythematosus (SLE, or lupus). By 2009, expand the range of available methods used to create, analyze, and utilize chemical libraries, which can be used to discover new medications. Specifically, use these chemical libraries to discover 10 new and unique chemical structures that could serve as the starting point for new drugs. By 2009, identify 1 or 2 new medication candidates to further test and develop for the treatment of tobacco addiction. By 2010, validate and compare 3 imaging methods that could offer increased sensitivity over computed tomography (CT) as a means of assessing lung cancer response to therapy. By 2012, improve device(s) to measure hot flashes and test in clinical studies of hot flash therapies.



By 2010, establish the role of genetic factors in three major diseases for which health disparities are noted between populations. By 2011, conduct studies of girls aged 6 through 8 years to determine the associations between the age of onset of puberty and progression through puberty with 12 environmental exposures. By 2012, develop and test at least two behavioral strategies for the management of symptoms to reduce the effects of disease, disability, or psychological distress on quality of life and outcomes. By 2013, identify several potential targets and/or molecules that modulate or enhance the extinction of learned behaviors and conditioned associations supporting addiction, compulsion, or anxiety disorders. By 2012, identify the genes that control the risk of development of age-related macular degeneration (AMD) and glaucoma in humans. By 2011, assess the efficacy of at least three new treatment strategies to reduce cardiovascular morbidity/mortality in patients with type 2 diabetes and/or chronic kidney disease. By 2014, identify and characterize two molecular pathways of potential clinical significance to serve as the basis for discovering new medications for preventing and treating asthma exacerbations. By 2014, develop and evaluate two new interventions for the prevention and/or treatment of HIV disease utilizing the newly restructured HIV/AIDS clinical trials networks. By 2015, provide at least one new or significantly improved minimally-invasive treatment for patients using image-guided interventions. By 2009, create research resources to aid in the identification and evaluation of biomarkers as candidates for surrogate endpoints for osteoarthritis. By 2009, determine the feasibility of applying at least 2 tailored interventions designed to prevent dental caries in one or more underserved populations. By 2011, assess community-based methods for facilitating cancer research and providing patients access to optimal cancer care.



By 2009, identify and characterize two molecular interactions of potential clinical significance between bone-forming cells and components of bone. Such interactions are defined as those having significant impact on the accrual of bone mass or the actual mechanical performance of bone (i.e., fracture resistance) in laboratory animals. By 2009, assess the impact of two major Institutional Development Award (IDeA) Programs on the development of competitive investigators and their capacities to compete for NIH research funding. By 2009, develop an item bank and computerized adaptive testing system available to clinical researchers to improve assessment of non-specific symptoms (e.g., pain and fatigue) and other domains of health-related quality of life in chronic disease. By FY 2011, develop stable national estimates of vision impairment by extending the vision component of the National Health and Nutrition Examination Survey (NHANES). By 2012, identify 3 effective implementation strategies that enhance the uptake of research-tested interventions in service systems such as primary care, specialty care and community practice. By 2012, identify at least one candidate intervention that extends median lifespan in an animal model. By 2010, demonstrate through research a capacity to reduce the total years lost to disability (YLDs) in the United States by 10% by (1) developing treatment algorithms to improve the management of treatment-resistant and recurrent depression and (2) elucidating the mechanisms by which depression influences at least two comorbid physical illnesses (e.g., heart disease, cancer, Parkinson’s disease, or diabetes). By 2018, identify culturally appropriate, effective stroke prevention programs for nationwide implementation in minority communities. By 2011, characterize the progression of normal, healthy brain development in a nationally representative sample of children in the United States by creating a database of MRI and clinical/behavioral data and analytical software. By 2013, develop and evaluate the efficacy of neonatal screening for congenital cytomegalovirus (CMV) infection to permit identification of infants who will develop CMV-induced hearing loss in the first years of life. By 2014, assess the efficacy of long-term oxygen treatment in patients with COPD and moderate hypoxemia.



mmunication and Transfer of Results (CTR)



By 2014, reduce the disparity between African American and white infants in back sleeping by 50% to further reduce the risk of sudden infant death syndrome (SIDS). By 2010, improve the efficiency and reduce the unit cost of producing authoritative serials cataloging records used to improve access to the biomedical literature in libraries worldwide. By 2010, establish the feasibility of sharing information from already-conducted scientific studies of warfarin (coumadinR) anti-coagulation, through the knowledge base PharmGKB.



By 2012, increase communication efforts and enhance outreach strategies regarding extramural research funding policy, compliance and administration as demonstrated by the type and frequency of communications and related activities. pacity Building and Research Resources (CBRR) By 2012, recruit, train, and retain a diverse population of highly trained scientists in biomedical, behavioral, and clinical research using research training grants, fellowships, career development awards, and student loan repayment programs. Promote data sharing and provide information in real time by implementing and monitoring the NIH Business System. (By FY 2010, the NBS will be in an ongoing status). By 2013, provide greater functionality and more streamlined processes in grants administration by continuing to develop NIH Electronic Research Administration (eRA). By 2011, build capacity to conduct research by constructing or renovating extramural facilities to meet the biomedical and behavioral research, research training or research support needs. By 2010, utilize enhanced ARIS database to more efficiently conduct portfolio analysis to invest in priority AIDS research. By 2012, ensure that 100% of trainee appointment forms are processed electronically, to enhance program management. By 2010, achieve cost savings of managing construction grants by expanding the use of electronic project management tools that enhance oversight and 20 year usage monitoring. By 2013, make freely available to researchers the results of 300 high-throughput biological assays screened against a library of 300,000 unique compounds, and the detailed information on the molecular probes that are developed through that screening process.



ategic Management of Human Capital (SMHC) Ensure that NIH commercial functions are performed as efficiently and cost-effectively as possible by conducting competitive sourcing reviews on the required number of functions within the Agency’s commercial inventory. (Ongoing)



Improve and monitor the use of human resource services by providing real-time access to tools via the NIH portal. (Ongoing) Provide opportunities for enhanced leadership skills to meet the challenges of workforce management and/or individual advancements. (Ongoing) Address diverse workforce recruitment needs to ascertain highly qualified staff to conduct or support biomedical research. (Ongoing) Address areas to facilitate retention of highly qualified staff to conduct or support biomedical research. (Ongoing)



gram Oversight and Improvement (POI) Utilize Performance-Based Contracting (PBC). (Ongoing) By 2010, enhance NIH's ability to demonstrate benefits for extramural research investments through changes to policy and information systems. Provide responsible stewardship over existing federally owned real property assets. (Ongoing) Manage design and construction of capital facility projects funded by the Building and Facilities Appropriation (B&F) so the HHS and congressionally approved scope of work is delivered within the approved budget. (Ongoing) By 2010, protect NIH's interest in grant-supported real property supported under the extramural construction grant program by ensuring compliance with construction and 20 year usage requirements By 2012, reallocation of laboratory resources based on external reviews by Boards of Scientific Counselors



l Measures: SRO - 48 CTR - 4 CBRR - 8 SMHC -5 POI - 6 71 HIV/ AIDS Research (2005) Extramural Research (2006) Intramural Research (2007) Buildings & Facilities (2007) Research Training (2008) -- 2 -- 4 -- 3 -- 2 -- 2



Extramural Construction (2008) -- 3 = 16 (6 SRO, 6 CBRR, 4 POI)



PART Measure (Program & Yr.)



PART Extramural Research (2006)



PART HIV/AIDS Research (2005)



PART Intramural Research (2007)



PART Extramural Research (2006)



PART Intramural Research (2007)



PART Extramural Research (2006)



PART Research Training (2008)



PART Extramural Research (2006) PART Extramural Construction (2008) PART HIV/AIDS Research (2005) PART Research Training (2008) PART Extramural Construction (2008)



PART Buildings & Facilities (2007) PART Buildings & Facilities (2007) PART Extramural Construction (2008) PART Intramural Research (2007)




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