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Table S3 - Genetics

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Table S3 - Genetics Powered By Docstoc
					Table S3. Pleiotropic effects of P[GT1] -element insertions on multiple phenotypes.

                                                                                                                                            Effects on




                                                                       Alcohol sensitivity


                                                                                             Startle responsea
                                                                          (this study)




                                                                                                                            Olfactionc
                                                                                                                 b
                                                                                                                 Geotaxis
           Cytological




                                                                                                                                         resistanced
  Line                 P [GT1] insertion site      Nearest gene




                                                                                                                                                       Longevitye
                                                                                                                                         Starvation
            location



BG00003 32F3           no gene                  no gene                     ↑
BG00203                no sequence              no sequence                 ↑
                                                retinal degeneration
BG00291 12C1-12C4      200bp 5'
                                                B                           ↑
BG00293 68 C7          no gene                  no gene                     ↑                  ↓                 ↓                                      ↑
BG00294 68 C7          no gene                  no gene                     ↑                  ↓                 ↓
BG00297 75B7           no gene                  no gene                     ↑                                    ↓
                       400bp
BG00303 56D9           in(intron1)/430bp        meiotic W68/par-1
                       in(intron1)                                          ↑                                    ↓
BG00350 19 F4-5        268bp 5'/567bp 5'        tweety/flightless I         ↑                  ↓                 ↓
                                                Akt1/Myosin heavy
BG00351 89 B3          290bp 5'/1.3kb 5'
                                                chain-like                  ↑                  ↓
                                                Odorant-binding
BG00375 99B8           1.1kb 5'
                                                protein 99d                 ↑                                                                           ↓
BG00452   10 E3        1.6kb 5'                 Karl                        ↑                                                               ↓
BG00471   58 E4-8      48kb in(intron12)        plexus                      ↑                                                                           ↑
BG00524   87 F14       657bp 5'                 tal-1A/2A/3A/AA             ↑                  ↓
BG00528   83 E2        259bp 5'                 Osiris 9                    ↑                  ↓
BG00625   23 F3        421bp 5'                 Thor                        ↑                  ↓
BG00631   58 E4-8      48.1Kb in(intron7)       plexus                      ↑                  ↓
BG00640   32 F1-2      154bp 5' (intron2)       spalt major                 ↑                  ↓
BG00680   24 C5        58bp in(exon1)           lethal(2)k16918             ↑                  ↓
BG00683   96D2-96E1    50bp 5'/400bp 5'         Furin 1/CG5127              ↑                                    ↑
BG00685   24C5         100bp in(exon1)          lethal (2) k16918           ↑
BG00730   70E1-70E2    150bp 5'                 CG9238                      ↑
BG00756   56D15-56E1   800bp in(intron1)        smooth                      ↑
BG00882   37 B1        250bp 5'/700bp 3'        CG17323/CG17324             ↑                                    ↓
                                                Translocon-
BG00935 47 F7          267bp 5'
                                                associated protein d
                                                                            ↑                  ↓
BG00940 36 A10         8.7kb in(intron 1)       grapes                      ↑                  ↓
                                                daughterless/mitoch
                       100bp
BG00963 31D11-31E1                              ondrial ribosomal
                       in(exon1)/600bp 3'
                                                protein S7
                                                                            ↑
BG00990 35 A3-4       562bp 5'               wing blister         ↑   ↓
BG01037 39 A1         168bp in(exon1)        b[n] integrin        ↓   ↓
BG01075 67 E7         no gene                no gene              ↑   ↓
                                             Glutamate
                      150bp in(1st
BG01081 52E7-52E10                           oxaloacetate
                      intron)/300bp 3'
                                             transaminase 1       ↑
                       50kb
BG01109 51A6-51B4                            tout-velu/Lamin C
                      in(intron5)/1.1kb 5'                        ↑       ↓
BG01120 3A4-6         1.1kb 3'               CG13758              ↑   ↓
BG01127 54 B1-5       61bp 5'                muscleblind          ↑   ↓           ↓   ↓
                                             immune
                      1.6kb                  deficiency/Dodeca-
BG01213 55 C8
                      in(intron1)/53bp 5'    satellite-binding
                                             protein 1            ↑   ↓
BG01214 65D4-65D5     100bp 5'/350bp 3'      sugarless/CG10064
                                                                  ↑           ↑   ↓
BG01218 67C4-67C5     850bp in(intron1)      CG6767               ↑
BG01224 67C7-67C8     20bp in(exon1)         CG8177               ↑
BG01253 19 F1         no gene                no gene              ↑   ↓
                                             Trapped in
                                             endoderm-
BG01272 5A11-5A12     5bp 5'/750bp 5'
                                             1/Gustatory
                                             receptor 5a          ↑
                      500bp
BG01277 18F2-18F4                            CG11940/CG11943
                      in(exon1)/700bp 5'                          ↑               ↓
BG01301 39 D2         162bp in(exon1)        nervana 3            ↑   ↓
                      10bp
BG01339 57F4                                 cricklet
                      in(exon1)/300bp 3'                          ↑               ↓
BG01342 55 C4         no gene                no gene              ↑   ↓
BG01373 86 E11        85bp 5'                CG14709              ↑
                                             Laminin A/putative
BG01389 65 A8-9       156bp 5'               noncoding
                                             RNA008:3L
                                                                  ↑   ↓   ↓
BG01402 61 C7         3.9kb 5'               CG32345              ↑   ↓
                                             bicoid-interacting
BG01404 42A13-42A14 5.9kb in(intron1)
                                             protein 3            ↑
BG01491 100 D1        11.5kb in(intron1)     tramtrack            ↑   ↓               ↑
BG01536 17 C3-C4      58bp 5'                Beadex               ↑   ↓           ↓
BG01564 6 E4          672bp 5'               CG14430              ↑   ↓       ↑   ↓
                                             Secretory Pathway
BG01571 80A1-80A2     75bp in(exon1)
                                             Calcium atpase
                                                                  ↓               ↓
BG01607 35D4          20bp 5'                Gliotactin           ↑               ↓
BG01611 10A3          no gene                no gene              ↑               ↓
BG01636 36F5          4.3kb in(exon3)        CG12750              ↑       ↓
                      402bp in(exon2)/3bp
BG01661 9 E1-2                            raspberry/CG32676
                      in(exon1)
                                                                    ↑   ↓
BG01672 42 A8         25bp 3'/1kb 5'      CG14591/SCAP              ↑   ↓       ↑   ↓
BG01693 7 C3-4        15bp 5'/374bp 3'    CG10777/CG10778           ↓   ↓       ↑
BG01711 76A1          no gene                                       ↓   ↓
                      9bp in(exon1)/441bp
BG01713 95 E1                             4EHP/CG18428
                      5'                                            ↓   ↓
BG01722 102F8                             HeT-A                     ↑   ↓
                      593bp                  Calreticulin/Spermid
BG01724 85 E1
                      in(intron2)/1.4kb 5'   ine Synthase           ↑   ↓
BG01733 68 C1-2      3.1kb 5'                CG6175                 ↑   ↓
                     85bp in(exon1)/75bp
BG01735   30 F5                              CG13130/big brain
                     5'                                             ↑   ↓
BG01743   42 B3      265bp 5'                jing                   ↑   ↓   ↓
BG01744              no sequence             no sequence            ↑               ↓
BG01756   61B1       200bp 5'                Protein kinase 61C     ↑               ↓
BG01799   64A6-64A7 20bp 5'                  Chd64                  ↑               ↓   ↓
                     60bp                    Hormone receptor-
BG01818   39 B4-C1
                     in(exon1)/550bp 5'      like in 39/CG31626     ↑   ↓
BG01888   99 A1      1.7kb 5'/3kb 5'         mir-279/CG31044        ↑   ↓           ↓
                     96bp in(exon1)/1.1kb
BG01889   100 B7                             CG1746/CG12054
                     5'                                             ↑   ↓
                     161bp                   Splicing factor
BG01893   90 B4
                     in(exon1)/608bp5'       1/lethal(3)07882       ↑   ↓           ↓
                     16.5kb                  mastermind/CG304
BG01902   50C23-50D3
                     in(intron2)/1.7kb 5'    82                     ↑               ↓
                                             Ribosomal protein
BG01937 50 E4         1.45kb 5'/1.8kb 5'
                                             S23/CG8468             ↑
                      420bp                  Dek/Flap
BG01979 53D14
                      in(exon2)/1.3kb 5'     endonuclease 1         ↑               ↓
                      30bp
BG01989 67C5                                 visgun/SH3PX1
                      in(exon1)/550bp 5'                            ↑               ↓
BG02038 65 E4-5       84bp 5'                melted                 ↑   ↓               ↑
BG02128 12 E3-5       17.4kb in(intron2)     l(1)G0007              ↑   ↓
                                             High mobility group
BG02169 57 F10        700bp in (exon2)
                                             protein D              ↓   ↓       ↑       ↓
BG02180 70D3-70D4     14.5kb in(intron4)     nuclear fallout        ↑
                                             Glutamate
BG02181 95C13-95D1 100bp 5'/400bp 3'         dehydrogenase
                                             /CG12268               ↓           ↑
BG02207 23 C1-3       21.8kb in(intron2)     lilliputian            ↑   ↓
                                             lamina
                      550bp in(1st
BG02210 64C12-64C13                          ancestor/transfer
                      intron)/950bp 5'
                                             RNA:CR32420            ↓
BG02276 88C10         6kb in(intron1)        lethal (3) L1231       ↑
BG02287    100D3-100E1 57kb in(intron9)           hephaestus                ↑           ↓
BG02312    9D2-9D3     450bp 5'                   sprint                    ↑           ↑       ↓
BG02317    7A2-5       2kb in(intron1)            CG9650                    ↓
BG02365    64C12-64C13 2.5kb in(exon3)            Malic enzyme              ↑
BG02412    18C2        60bp 5'                    CG8062                    ↓
BG02415    70 A3-4     49bp in(exon1)             capricious                ↑       ↓   ↓
                          2.15kb
BG02420 68 E1                                     CG5946/CG11597
                          in(intron2)/250bp 5'
                                                                            ↑
BG02441 3 F1              51kb in(intron2)        Tousled-like kinase
                                                                            ↓       ↓
                          133bp                   CG8963/Apaf-1-
BG02470 53 E4
                          in(exon1)/720bp 5'      related-killer            ↑       ↓       ↑
BG02498 98 F1-2           3.3kb in(intron3)       Darkener of apricot
                                                                            ↓       ↓
                                                  Muscle-specific
BG02508 25C6-C10          648bp 5'
                                                  protein 300               ↑
BG02509 53 D11            1.4kb 3'                CG34460                   ↑       ↓
                                                  SRY interacting
BG02522 16 C8             27bp 5'
                                                  protein 1                 ↓       ↓       ↑   ↓
BG02524    85 F1-F4       34bp 5'                 CG34360                   ↑       ↓
BG02538    17 F3-18A2     44bp 5'                 CG32541                   ↓       ↓
BG02560    73 C4-D1       36bp 5'/694bp 5'        CG9674/nudC               ↓       ↓   ↓
BG02563    70 A3--4       249bp 5'                capricious                ↑       ↓
BG02588    99 F7-8        27.6kb in(intron2)      tropomodulin              ↑       ↓           ↓
BG02602    51E7-E10       489bp 5'                Follistatin               ↑                   ↓
BG02624    7A2-5          2.7kb in(intron1)       CG9650                    ↑       ↓           ↓
                          87bp                    Calreticulin/Spermid
BG02646 85 E1
                          in(exon1)/861bp 5'      ine Synthase              ↓       ↓
                                                  Ecdysone-induced
BG02657 78 C2-3           15.3kb in(intron3)
                                                  protein 78C               ↓       ↓
                                                  High mobility gourp
BG02724 57 F10            700bp in(exon2)
                                                  protein D                 ↓       ↓           ↓
BG02731 47 A11-13         1.6kb in(intron1)       longitudinals lacking
                                                                            ↑       ↓   ↓       ↓
BG02747 12F4              100bp 5'                rutabaga                  ↓           ↓       ↓
                          11.4kb
BG02777 6 E4                                      innexin 7/innexin 2
                          in(intron3)/182bp 5'
                                                                            ↑       ↓   ↓
BG02785 46 B1             156bp 5'                dacapo                    ↑       ↓   ↑
                                                  Lipid storage droplet-
BG02812 13 A8-9           238bp in(exon1)
                                                  2                         ↓       ↓
BG02818 47 A13-B1         6.5kb in(intron3)       pipsqueak                 ↓       ↓
BG02844 80 A4             1.5kb 5'                CG11226                   ↓       ↓

↑: effect increased relative to control; ↓: effect decreased relative to control.
a - Yamamoto et al . (2008), males only
b - unpublished data
c - Sambandan et al. (2006), males only
d - Harbison et al . (2004), males only
e- Magwire et al . (2010), males only
f - Edwards et al. (2009), males only
g - Norga et al. (2003). AB - abdominal bristle number, SP - sternopleural bristle number, males only
h - Harbison et al. (2008), males only
In bold indicated lines used for further analysis
                                                                    Effects on
                                                     f




                ↑
                                        Aggression
                                                          Bristle




    ↓
    ↑
            ↓
            ↓
                    ↓
                            ↓
                                ↑
                                    ↓
                                    ↓
                                           AB
                                                         number




↓
        ↑
            ↓
                        ↑
                                    ↑
                                           SP               g

                                        24h sleep
                                                       h
                                        24h sleep Sleep
                                          bouts
            ↑
            ↓




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