PD Dr. Ingrid Hoffmann Cell Cycle Control and Carcinogenesis by steepslope9876

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									PD Dr. Ingrid Hoffmann
                          Cell Cycle Control and Carcinogenesis
                          German Cancer Research Center (DKFZ)
                          69120 Heidelberg, Germany


                          Phone: +49-(0)6221-42 4909
                          Fax: +49-(0)6221-42 4902
                          E-mail: ingrid.hoffmann@dkfz.de



25/06/1959, Merzig-Hilbringen


CURRICULUM VITAE

2000               Habilitation Ruprecht-Karls University of Heidelberg, venia legendi for cell
                   biology
1996 - present     Group leader at the German Cancer Reserach Center, Heidelberg
1991 - 1995        Post-doctoral DFG fellow, European Molecular Biology Laboratory,EMBL,
                   Heidelberg
1987 - 1990        Post-Doctoral fellow Research Institute of Molecular Pathology, IMP,
                   Vienna, Austria
1984 - 1987        PhD, University of Saarland, Saarbrücken
1984 - 1985        DAAD fellowship University of Lund, Sweden
1983 - 1984        Diploma Thesis, University of Saarland, Saarbrücken
1979 - 1984        Biology School, University of Saarland, Saarbrücken


COORDINATING FUNCTIONS

2006- present      Management board member of the German Society for Cell Biology
1998-2002          Coordinator of an EU-funded research network (Regulation of mitotic
                   events)


FIELDS OF INTEREST

Cell Biology, Cell cycle checkpoints, Centrosome function, polo-like kinases, protein kinases
and phosphatases as targets in cancer therapy


CURRENTLY FUNDED PROJECTS

Deutsche Krebshilfe (Cdc25 phosphatases as drug targets), BMFT (Regulation of centriole
duplication)
PUBLICATIONS (10 most important publications):

Cizmecioglu, O., Warnke, S., Duensing, S. and Hoffmann, I. (2007) Plk2/Snk regulated
      centriole duplication is polo-box dependent and mediated in cooperation with Plk4 and
      Cdk2 kinases, Mol Cell Biol in press

Volkening, M. and Hoffmann, I. (2005) Involvement of human MCM8 in pre-replication
       complex assembly by recruiting hcdc6 to chromatin Mol. Cell. Biol., 25, 1560-1568.

Warnke S., Kemmler S., Hames RS, Tsai HL, Hoffmann-Rohrer U., Fry AM, and Hoffmann I.
      (2004) The polo-like kinase-2 is required for centriole duplication in mammalian cells
      Curr Biol. 14, 1200-1207.

Hassepass, I.,, Voit, R. and Hoffmann, I. (2003) Phosphorylation at serine-75 is required for
      UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint
      J Biol. Chem.. 278, 29824-29829.

Katich, S., Zerfass-Thome, K. and Hoffmann, I. (2001) Regulation of the cell cycle
       phosphatase Cdc25A by the human papillomavirus type 16 E7 oncogene Oncogene
       20, 543-550

Blomberg, I and Hoffmann, I. (1999) Ectopic expression of Cdc25A accelerates the G1/S
      transition and leads to activation of cyclin E and cyclin A-dependent kinases Mol. Cell.
      Biol. 19, 6183-6194.

Lammer, Ch. Wagerer, D., Saffrich, R., Mertens, D., Ansorge, W. and Hoffmann, I. (1998)
     The Cdc25B phosphatase is essential for the G2/M transition in human cells J. Cell
     Sci. 111, 2445-2453.

Hoffmann, I., Draetta, G. and Karsenti, E. (1994) Activation of the phosphatase activity of
      human Cdc25A by a Cdk2-cyclin E dependent phosphorylation at the G1/S transition
      EMBO J. 13, 4302-4310.

Hoffmann, I., Clarke, P, Marcote, M.J., Karsenti, E. and Draetta, G. (1993) Activation of
      Cdc25 by phosphorylation at mitosis and its involvement in the self-amplification of
      MPF. EMBO J. 12, 53-63.

Hoffmann, I. and Birnstiel, M.L. (1990). The cell-cycle dependent regulation of histone
      precursor mRNA processing involves heat-labile factor modulation of U7 snRNA
      accessibility, Nature 346, 665-668
EXPERIENCE IN THE SUPERVISION OF DOCTORAL CANDIDATES

Member of numerous theses advisory committees
International reviewer of doctoral theses
Supervised 6 doctoral theses


SUPERVISED DISSERTATIONS (last 5 years)

Daniel Spengler (2006) Functional analysis of human Aurora-C kinase. University of
       Heidelberg
       Current occupation: Post-doctoral fellow Karolinska Institutet Stockholm

Silke Warnke (2004) Role of polo-like kinase-2 in centriole duplication. University of
       Heidelberg
       Current occupation: Post-doctoral fellow, University of Manchester, UK

Melanie Volkening (2004) Function of human MCM-8 in the initiation of DNA replication
      University of Heidelberg
      Current occupation: Post-doctoral fellow, DKFZ Heidelberg,

Ingo Hassepass (2003) Functional analysis of the human Cdc25A phosphatases at the G1/S
      phase transition in response to UV-induced DNA damage. University of Heidelberg
      Current occupation: Research Assistant Roche, Mannheim

								
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