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the Gazette

VIEWS: 22 PAGES: 16

									the

Gazette
Issue nr. 1, April 2006, Guest editor: METU

Editorial: “the innovation resides on the integration”.................................................... 1 Learn more about the Middle East Technical University and the Software R&D Center)............................................................................................................................ 3 Interview with the boss .................................................................................................. 5 State of the art: Saphire in the world ............................................................................. 9 Cultural links................................................................................................................ 13

Editorial: “the innovation resides on the integration”
Dear friends, The Saphire proposal had been submitted by 2005, under the 4th Call Priority concerning strengthening the integration of the ICT research effort in an enlarged Europe, and with a focus on eHealth. The evaluators recognized that “given the topic of cardiac diseases and the addressed population, the potential impact could be strong, since such diseases in new member states are increasing and previous studies on monitoring patients give positive results”. As far as the proposed tools and technologies are concerned, these were found to be convincing, while our overall approach was found realistic as we intend to use existing sensor technologies. And I can only agree with the evaluators that expressed their agreement on the fact that “the innovation resides on the integration”. Not long time before, Forrester Research was identifying that “the integration market landscape is shifting” and that “Service-oriented architectures, business process management (BPM), composite applications, and other new application requirements have become the driving force in the market” (market overview of December 2004, “Integration Landscape 2005”). The picture is similarly positively assessed by Gartner as only “in 2004, the application integration, middleware and portal market in the EMEA region (Europe, Middle East and Africa) grew by 7.4 percent, reaching $2 billion”. (Gartner Inc., Market Trends: Application Integration, Middleware and Portal Software, EMEA, 2004-2009, December 2005) Our SAPHIRE project concerns the provision of an innovative infrastructure to support integration and service interoperability in the fields of intelligent healthcare monitoring and medical decision support.

It aims to develop such an infrastructure integrating the various wireless medical sensor data with hospital information systems. Our developments will be deployed in two pilot applications:  one for homecare monitoring of cardiovascular patients in Germany, and  one to monitor cardiovascular patients in a hospital in Romania. To subscribe to critical data delivery, clinicians will simply use a Web-based program indicating desired alerts, thresholds, delivery methods (sms/e-mail/Web/pager) or to build a patient coverage list. Once subscribed, clinicians will immediately receive clinical notifications and reminders. Creating such an information infrastructure requires safeguards to maintain security and privacy of patient data. In Saphire we propose such a comprehensive security and privacy mechanism to complement the infrastructure proposed. While providing these confidentiality and privacy facilities, the EU directives presenting the general principles of processing of personal data are taken into account. I shall refer to the same source of Forrester stating that “the ultimate goal of an integration strategy should still be to rationalize integration infrastructure to the smallest number of broad platforms that meet business requirements.” Resources are scarce and it is therefore that we need to provide the means for achieving excellence in well-selected areas. This principle holds for both the academia and the industry. In this respect my team at SRDC-METU has invested in developing a more-thansufficient know-how on what we broadly refer to as “semantic interoperability”. Medicine is one of the few domains to have some domain knowledge in a computable form and I consider this as an extremely attractive asset which we shall exploit in the Saphire project for defining the semantics of the different services. A last word for my User partners: I am extremely happy to have together with us on board two exceptionally good User partners, namely  the Schüchtermann-Schiller'sche Kliniken at Bad Rothenfelde in Germany which is a world-renowned specialized clinic for cardiovascular diseases, and  the Department of Internal Medicine and Cardiology of the Emergency Hospital of Bucharest that is an academic clinic of the “Carol Davila” University of Medicine and Pharmacy at Bucharest and also an emergency and tertiary center of Cardiology with an extremely high standard activity in clinical and academic work. Having User partners that are both motivated and well-positioned in their particular areas is a strong asset for our project and we are happy to collaborate with them. Both me personally and my SAPHIRE project team shall remain at your disposal for any information you might wish to have. Kind regards, Prof. Dr. Asuman Dogac

Director SRDC IST Project SAPHIRE Coordinator

Learn more about the Middle East Technical University and the Software R&D Center)
The Middle East Technical University (METU) (http://www.metu.edu.tr) is the leading technical university in Turkey. The Software Research and Development Center (SRDC) (http://www.srdc.metu.edu.tr) is established by the Scientific and Technical Research Council of Turkey (TUBITAK) in October 1991 and is operating under the Faculty of Engineering in METU. METU-SRDC is involved in a number of research and development projects supported by the government, industrial companies, international organizations and the European Commission. METU-SRDC has expertise on Semantic Web Technologies, Web Services, Ontologies, P2P networks, Agent Technologies, Semantic Interoperability, e-Health, Sensor Networks, GRID Systems. This research institute is formed with the following mission statement; “Our mission is to combine knowledge, hard work and enthusiasm in the areas of electronic business and Internet technologies to be able to contribute to the research and development activities in Turkey, and in EU by exploiting the outstanding young potential of Turkey.” For this aim, METU-SRDC is utilizing the great potential in METU, especially in the Information Technologies field. As METU-SRDC is operating with the Computer Engineering department, there is a great human resource potential both for part-time and full-time employees. With the provided summer practice options, students can have a chance to feel the R&D soul and the enthusiastic ones can continue as the part-time employees during their undergraduate studies. After finalizing the undergraduate studies, it is served an option as a full-time employment while continuing their graduate studies parallel with the research & development issues in the center. Graduate students can finalize their master thesis or PhD thesis with their research & development work in the METU-SRDC. It has been achieved over 75 master/PhD thesis in parallel with the researches in METU-SRDC. Furthermore, it has been published 98 articles about the research achieved in METU-SRDC since 1994.

METU-SRDC is also a great potential to provide the academy-industry collaboration. METU has a techno polis (http://www.metutech.metu.edu.tr/) in its campus with various IT companies and over 1400 employee power. METU-SRDC collaborates with industrial companies from this region in research projects to maximize the academy-industry collaborative work.

METU Techno Polis
R&D Projects in METU-SRDC METU-SRDC is involved in a number of research and development projects supported by the government, industrial companies, international organisations and the European Commission. Apart from the local projects supported by the Turkish State Planning Organisation, the Scientific and Technical Research Council of Turkey (TUBITAK) and by METU, METU-SRDC has:  realised a part of the prototype for AWACS Man-Machine Interface Prototype for NATO Mid-Term Modernisation Programme in co-operation with Gallium Software Inc. (Canada);  developed a health care information system which has been successfully commercialized in Turkey. METU-SRDC has experience in developing large scale software projects: METU Interoperable DBMS (MIND) Project is a multi-database system based on OMG's distributed object management architecture. METU Object-Oriented DBMS (MOOD) Project is an object-oriented DBMS prototype. METU-SRDC has successfully completed several European Commission supported projects, including, INCO-DC 97 2496 MARIFlow project (as a Scientific and Technical Coordinator of the project) and IST-1999-20216 LEVER (as a subcontractor), IST-2000-26429 HERMES project (as the scientific and technical coordinator), IST-2000-31050 Agent Academy (as a partner), and IST-2000-31046 HUMANTEC (as a partner), EUMEDIS MEDFORIST (as a partner). MARIFlow project has produced an inter enterprise workflow management system for data and control flow over the Internet. METU-SRDC has recently produced an ebXML compliant e-Business infrastructure prototype. Currently METU-SRDC is the coordinator of the following four projects in FP6 IST program:  IST-1-002104-STP SATINE: Semantic-based Interoperability Infrastructure for Integrating Web Service Platforms to Peer-to-Peer Networks

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IST-1-002103-STP ARTEMIS: A Semantic Web Service-based P2P Infrastructure for the Interoperability of Medical Information Systems IST-4-027074-STP SAPHIRE: Intelligent Healthcare Monitoring based on a Semantic Interoperability Platform IST-4-027065-CA RIDE: A Roadmap for Interoperability of eHealth Systems in Support of COM 356 with Special Emphasis on Semantic Interoperability

Additionally, METU-SRDC has partner roles on the following ongoing projects:  EUMEDIS DAEDALUS: Delivery of Mediterranean Destination Links in Unified Environments  IST-3-015871-SSA IST-BONUS: Identify and Support Research and Business Excellence to Enhance NMS - ACC Participation in the Development and Pilot Implementation-Demonstration of ICT Business Applications and Services  IST-4-027306-STP ABILITIES: Application Bus for InteroperabiLITy In enlarged Europe SMEs

Interview with the boss

Saphire Gazette: Prof. Dogac, looking at its title, Saphire is about “Intelligent Healthcare Monitoring based on a Semantic Interoperability Platform”. How should we understand this in some relation to our own lives and some practical situations? Prof Dogac: By intelligent healthcare monitoring we mean the patient follow-up and monitoring especially in remote locations through computerized decision support systems. With the aging society, the remote monitoring of patients becomes a must

both to decrease the cost, and the load of general practitioners and serve better healthcare services to the patients. The Saphire Project aims to monitor the vulnerable patients by specific guidelines. The wireless sensors which are gently located over the patient, measures the intended medical values; such as blood pressure, ECG, heart rate, oxygen saturation of blood. The clinical guidelines are executed through a clinical decision support system in a proactive manner for any abnormal case reported by the medical sensors. The decision support system also retrieves patient’s previous medical history from the hospitals where the patient has been previously hospitalized. If some abnormal situation is detected by the decision support system, the identified stakeholders who can be doctors, nurses or patient relatives are informed about the status of the patient immediately. Gazette: One of the points you raise in the description of the project is that “the medical practitioners at all levels are becoming more overloaded as the aging population of Europe increases”. What is your position? I.e. is this a social problem with economic implications and the Community should address it with an appropriate mix of services, technologies and infrastructures? And: how should we expect Saphire to contribute to the current situation? Dogac: The European population is getting older and the average life span is getting longer. It is a fact that while people getting older, the possibility to encounter chronic diseases increases. All of these facts directly affect the healthcare domain: the cost of treatment increases, and so does the load of general practitioners. Thus remote monitoring especially for the patients living at their homes has a key role to reduce the costs and to provide better services. Saphire enables to follow up the patients from their homes through wireless medical sensors and clinical decision support system which will lead to a reduction of medical costs by also cutting down rehospitalisation procedures in future. Gazette: In many cases, and not necessarily in the context of the new member countries, it is difficult to apply an advanced solution concept because of shortcomings in the underlying infrastructures and the people‟s and domain experts attitude. Is this holding also for the case of Saphire? Dogac: The infrastructure has an important role to apply and execute systems for remote healthcare monitoring because it is necessary to transmit sensor data between the remote points such as homes, and healthcare centres such as hospitals or clinics. The communication within the end points mainly between the sensors and interfaces for outer transmission can be handled with Bluetooth standard which is independent from the main public data infrastructure. For the data transmissions between the remote care endpoints and healthcare centres the basic internet infrastructure is enough which exists in all European Countries; such as cablenet, ADSL. Hence we do not think that the underlying infrastructure is an obstacle for Saphire. We aim to gain the support of domain experts through two pilot applications that will be realized in real life settings. We hope that through these pilot applications the healthcare practitioners will see the direct benefits of the Saphire System.

Gazette: There is a big number of projects that are lacking resources or willingness to make the extra mile which would bring them to a scientific breakthrough or a commercial success. Which are the envisaged goals from your side in Saphire? Dogac: Saphire project addresses a problem that has not yet been solved in healthcare domain: seamless integration of medical sensor data and electronic healthcare records of the patient for remote healthcare monitoring. We aim to publish the end results of Saphire through highly credible scientific journals to disseminate our results to the scientific community. Also through our pilot applications that will be realized in real life settings, we aim to attract industry, and increase our exploitation opportunities. Gazette: In the project you collaborate closely with medical doctors. For sure there might be some communication challenges as you don‟t have the same background and use different languages. Is this as difficult as it seems to be? How are you going to cope with this? Dogac: Medical doctors have a key role in the Saphire Project where they will shape the clinical guidelines to be used in the system. The effectiveness of clinical guidelines is vital for the general performance and efficiency of the Saphire System. These healthcare guidelines will be structured by the medical doctors and will be coded into the system by technical partners, so there is a high interaction and dependency between the medical doctors and the technical partners. However we hope that this issue will not create a problem, since the technical partners and the medical doctors will start studying together right in the beginning of the project through the requirements analysis and design phases of the Saphire System. Furthermore, the partners in the Saphire Project have expertise in eHealth domain with various projects. Gazette: Many projects solve a problem – but it is difficult to replicate the process and provide a solution either to the industry or to the end users. What is your view on this? How is Saphire going to cope with this matter? Dogac: We aim to base the Saphire architecture according to the requirements of our end users. Right from the beginning of the project we will do our best to create an infrastructure that can be used in real life settings, and will demonstrate the benefits of the system through real life pilot applications. We hope that this effort will increase the chance of an industry uptake. Gazette: In the project you take a dual approach by means of addressing the requirements of both an in-hospital solution to monitor cardiovascular patients in a hospital in Romania, and a second one for homecare monitoring of cardiovascular patients in Germany. Why? Do you see a potential in both cases, or is it part of some need to examine closer any deficiencies of the two approaches? Dogac: To prove the applicability of the solutions we have chosen two different settings: homecare and in-hospital monitoring. This is because that the requirements of these two settings are very different. Saphire architecture aims to cover both of these requirements, since it aims to provide a generic solution for remote intelligent healthcare monitoring.

Gazette: Let‟s talk about standards: in the last years you have personally participated in standardization activities and have personally contributed as author. On the other hand, you make use of existing de facto and industry standards in the area of Semantic Web and interoperability. What is the „perfect mix‟ for a company or an organization to cope with the issue of standards in the Saphire area? Dogac: Saphire project will built upon already existing standards in diverse domains in covers, such as OWL, GLIF, HL7 CDA, EHRCom, FIPA and so on. However we aim to contribute to these standards, by sharing our experiences in applying these standards to a specific healthcare problem: remote healthcare monitoring, and also to propose necessary extensions to these standards when necessary. Gazette: Currently, there are ongoing initiatives at the international level in the area of Saphire. Can you name some of them that you feel are interesting to watch or even to develop synergies with them? Dogac: Saphire Project is interested in some projects with similar objectives and with which synergies can be developed. The projects can be stated as followings; 1. MyHeart (IST 507816, http://www.extra.research.philips.com/euprojects/myheart/) which is an Integrated Project, funded by the IST programme. 2. The MobiHealth (IST-2001-36006, http://www.mobihealth.org/) which provides a Java service platform for mobile healthcare. 3. HEARTS (IST-2001-37403, http://heartsproject.datamat.it/hearts) project whose main aim is to develop techniques for early detection of myocardial ischaemia from the ECG signals. 4. The ARTEMIS (http://www.srdc.metu.edu.tr/webpage/projects/artemis) project which is currently developing a semantic Web services based interoperability framework for the healthcare domain. 5. U-R-SAFE (IST-2001-33352, http://ursafe.tesa.prd.fr/) project whose aim is to have the elderly person wear medical measuring devices, all connected via short range Wireless Personal Area Network (WPAN) to a central, portable electronic unit, the Personal Base Station. 6. CASCOM project whose aim is to implement, validate, and trial a value-added supportive infrastructure for Semantic Web based business application services across mobile and fixed networks. 7. SerAPI is a research and development project in Finland, which focuses on the utilisation of Service-oriented architecture and Web Service technologies for information system and application integration needs in healthcare. 8. AINGERU is a proposal for a new way of tele assistance for elderly people. Its goal is to overcome the weaknesses that present most of the teleassistance services offered nowadays. AINGERU takes benefit from the new advances in the areas of networking (wireless communications), mobile computing (Personal Digital Assistants) and semantic web and agent technologies to accomplish its goal. This project is been developed by the BDI Group (http://siul02.si.ehu.es/) and the work is mainly supported by the University of the Basque Country, Diputación Foral de Gipuzkoa (cosupported by the European Social Fund) and CICYT [TIN200407999-C02-00].

Gazette: Business process integration and service interoperability exhibit a ubiquity in terms that problems related to their lack appear in virtually any application domain. Why do you make an investment in terms of focusing to the area of e-Health? Dogac: You are right, business process integration and service interoperability can be applied in many domains, however each domain has its own specific problems to be addressed, and semantics is domain knowledge hence these research problems should be applied in a domain specific manner. Also healthcare domain is a very complex domain, where these technologies can help us to tackle some of the unsolved problems in healthcare domain. Gazette: You are also the Coordinator of another IST Project in the same area of eHealth. As we know, the ARTEMIS project is approaching its completion – do you consider that there is a bridge between these two projects that can exhibit some positive impact? Dogac: As you have stated, the Saphire Project is mainly built upon the results of a European commission funded project, IST-1-002103 Artemis. Artemis is developing a semantic web service-based P2P Infrastructure for the Interoperability of Medical Information Systems. Artemis project enables the Healthcare Institutes to exchange Electronic Healthcare Records in interoperable manner through semantically enriched web services and semantic mediation. The Saphire Project will exploit these results by integrating the patient data collected through wireless medical sensor devices with the hospital information systems. This infrastructure will constitute the interoperability base for the intelligent healthcare monitoring system.

State of the art: Saphire in the world
The SAPHIRE project mainly utilizes various current state-of-the-art technologies. Wireless medical sensor devices is one of them; by which it is possible to obtain measurements of heart rate, oxygen saturation, end-tidal CO2, and serum chemistries, including serum glucose, with small, non-invasive sensors. Companies such as Nonin (http://www.nonin.com/Products/products.html) and Numed (http://www.numed.on.ca/home.htm) have developed wireless vital sign sensors based on Bluetooth technology, while Radianse (http://www.radianse.com/) has developed an RF-based location-tracking system. Another important technology which is crucial for the SAPHIRE System is the Web Service. Web Services have been described as the third phase of the Internet. In the first phase communications over the Internet were mainly through static content. In the second phase there was a degree of dynamic content creation. In the third, Web services phase, Internet is becoming a global common platform where organizations and individuals communicate among each other to carry out various commercial activities and to provide value-added services. The dynamic enterprise and dynamic value chains become achievable and even mandatory for competitive advantage. Currently, describing the semantic of Web in general, and semantic of Web services in particular are very active research areas. World Wide Web Consortium has started the initiative to develop Semantic Web and a semantic markup language for

publishing and sharing ontologies, namely Web Ontology Language (OWL), is being developed for this purpose. OWL is derived from DAML+OIL (http://www.w3.org/2001/10/ daml+oil) by incorporating learnings from the design and application use of DAML+OIL. It builds upon the Resource Description Framework (http://www.w3.org/TR/PR-rdf-schema, http://www.w3.org/TR/REC-rdfsyntax). When healthcare information is transferred between two different Electronic Healthcare Record (EHR) systems, it is essential that the clinical meaning expressed by the original author within a set of record entries is faithfully preserved and presented by the receiving system, even though this may have internal system architecture different from that of the sending system. A number of EHR standards and frameworks have been developed to assist with the interoperability and integration of distributed EHR information. Ideally, all EHR systems would adopt common and systematized hierarchies of component names, use multi-lingual clinical coding systems with perfect cross-mappings and use identical reference models for measurements. However, this has not been realized yet. Not only do a number of international health information standards exist, such as CEN ENV 13606, HL7 and GEHR, but each country, state, division, hospital and vendor usually has their own “standard clinical data model”. Therefore the SAPHIRE Project is adopting the semantically enriched Web service approach to provide the interoperability of sensor systems and medical information systems. Another state of the art topic is the agent technology which is also mandatory for SAPHIRE Project. An agent is a software entity that can perform information-related tasks without ongoing human supervision. In the recent years, agent technology has found many interesting applications in decision support systems and internet applications. As the benefits of using agents in such applications become clear, numerous agent development platforms have emerged with various degrees of abstraction and completeness ranging from bare-bones API's to full-fledged but less flexible building packages. These frameworks all have their strong points and lacking features, the most important factors being compliance to a specification (e.g. FIPA), support for the mobility of the agents from host to host, support for lightweight agents, support for advanced planning-scheduling and combinations thereof. An Inference Engine is a software tool that emulates the human capability to arrive at a conclusion by reasoning and complements agent software. Due to the progress of the Information Society during the last couple of years the ability to easily gather and monitor personal data has improved dramatically. Several directives, recommendations, laws, and standards concerning these topics have been published at European level in recent years. These documents have in common that they are related to the protection of personal data against processing and that they formulate conditions and rules under which the processing is allowed and how

processing may be carried out. On the technological side, developing security and privacy mechanisms for sensor networks is still an active research area. Since sensor devices have limited computational and communications resources, it becomes impractical to use currently available security algorithms, since they were designed for powerful processors. Security and privacy mechanisms designed specifically for sensor data and network protocols are needed. Alternative cryptographic primitives and the security protocols in the sensor networks should be adapted. Security in sensor networks is mainly avoiding adversaries read and tamper sensor data. Basic wireless communication is also not secure. Because it is broadcast, any adversary can eavesdrop on traffic, inject new messages, and replay old messages. Hence, it is not possible to rely on trust assumptions on the communication infrastructure of wireless sensor networks. On the other hand, Security and Privacy standards for Web Services are now emerging based on the WS-Security roadmap (http://www106.ibm.com/developerworks/library/ws-secroad/). The key industry leaders such as IBM and Microsoft established a family of security specifications for web services. These specifications are designed to work together to provide a comprehensive and extensible web services security infrastructure. In addition to all, there are some wireless medical sensor based projects on the market which are;  Intel (http://www.intel.com/pressroom/archive/releases/20040316corp.htm) is investing in research and development of sensor networks, recognizing this technology as crucial to addressing the pending global age wave and public health crises. For this purpose, on March 16, 2004, Intel Corporation gave US government officials a first-hand look at future in-home healthcare applications at a technology demonstration hosted today by the Center for Aging Services Technologies (CAST).  Motorola and Partners Telemedicine, a service of Harvard Teaching Hospitals, on the 28th of September 2004, announced a collaboration to test MOTOHEALTH, a Motorola solution that uses mobile phones to help healthcare providers monitor chronically ill patients as they go about their normal daily routines. (http://www.motorola.com/mediacenter/news/detail/0,,4723_4023_23,00.html). It is stated that when MOTOHEALTH solution is implemented into a comprehensive healthcare program, can give healthcare providers useful, daily updates on a patient’s physiological levels such as blood pressure, glucose level, and weight. It is indicated that this will facilitate proactive treatment action, resulting in fewer hospitalizations and visits to emergency rooms, potentially lowering healthcare costs.  CodeBlue Project (http://www.eecs.harvard.edu/~mdw/proj/vitaldust/) is exploring applications of wireless sensor network technology to pre-hospital and in-hospital emergency care. It is designed to provide routing, naming, discovery, and security for wireless medical sensors, PDAs, PCs, and other devices that may be used to monitor and treat patients in a range of medical settings. CodeBlue

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scales across a wide range of network densities, ranging from sparse clinic and hospital deployments to very dense, ad hoc deployments at a mass casualty site. The US Military Operational Medicine Research Program, under its War Fighter Physiologic Status Monitoring – Initial Capability (WPSM-IC) program is developing what is essentially a wellness monitor for each soldier. This system is comprised of a medical hub which hosts a personal area network of physiologic and wireless medical sensors and a number of algorithms. The algorithms estimate the state of the war fighter in the following areas: Thermal, Hydration, Cognitive, Life Signs, and Wound Detection. CareMedia Project at Carnegie Mellon University http://www.informedia.cs.cmu.edu/caremedia/) uses computer vision techniques to track the progress of patients and staff at a skilled nursing facility for patients with advanced dementia. The shortage of geriatric care professionals, the growth of the elderly population, and the societal benefits of improving quality of life and care in skilled nursing facilities underscore the need for CareMedia: automated video and sensor analysis for geriatric care. Project Nightingale (http://www.supercomputingonline.com/print.php?sid=6748) at the University of Sydney, Australia, is aiming to develop a context-aware data management system across a suite of personal computing devices with an applied focus on applications that stimulate intellectual and social fitness in the elderly. The project's goal is to substitute the classic desktop interface with invisible and ambient interfaces that let individuals or groups engage in reminiscence-oriented group activities. The Smart Medical Home Research Laboratory (http://www.futurehealth.rochester.edu/ smart_home/) at the University of Rochester, USA, is aiming to develop an integrated Personal Health System, so all technologies are integrated and work seamlessly. This technology will allow consumers, in the privacy of their own homes, to maintain health, detect the onset of disease, and manage disease. The data collected 24/7 inside the home will augment the data collected by healthcare professionals and hospitals. The data collection modules in the home will start with the measurement of traditional vital signs (blood pressure, pulse, respiration).

There are also some other IST Projects which are in the European region and have similar field with SAPHIRE Project;  MyHeart (IST 507816, http://www.extra.research.philips.com/euprojects/myheart/), is an Integrated Project, funded by the IST programme. MyHeart aims fighting cardio-vascular diseases (CVD) by preventive lifestyle and early diagnosis. Its objective is to develop “functional clothes” together with integrated electronics which are considered as intelligent clothes. Intelligent clothes will contain novel sensors and electronics with intelligent algorithms that are integrated into the garments, allowing monitoring and evaluating the health status of a person and reacting on it.  The MobiHealth (IST-2001-36006, http://www.mobihealth.org/) provides a Java service platform for mobile healthcare. It enables remote monitoring of patients using 2.5/3G public wireless infrastructures. The major components of the MobiHealth system are the Body Area Network, the Back-end system and the end-user system. Patient data is collected using a Body Area Network (BAN). A healthcare practitioner can view and analyze the patient data from a remote

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location. The back-end system is the software system that registers the incoming signals and makes them available for further processing. MobiHeath project has focused on the infrastructure of the sensor network. AMON (IST-2000-25239, http://www.medictouch.net/AMON/index.htm) system is a wearable personal monitor medical device that evaluates human vital signs using advanced bio-sensors. The system gathers and analyzes the vital information and then transmits the data to a remote telemedicine centre, for further analysis and emergency care, using cellular infrastructure. AMON-WMD utilizes built-in medical algorithms for routine primary evaluation. The main objective of HEARTS (IST-2001-37403, http://heartsproject.datamat.it/hearts) project is to develop techniques for early detection of myocardial ischaemia from the ECG signals. The system has a decision support module which analyses data using neural network processing technology. It obtains anytime information about health status related to the specific subject and the specific context. The ARTEMIS project is currently developing a semantic Web services based interoperability framework for the healthcare domain. The aim of U-R-SAFE (IST-2001-33352, http://ursafe.tesa.prd.fr/) project is to have the elderly person wear medical measuring devices, all connected via short range Wireless Personal Area Network (WPAN) to a central, portable electronic unit, the Personal Base Station. Mobi-Dev project aims to allow clinical staff with portable devices (based on palm PCs) to wirelessly connect to different information databases, able to perform real time data management. The project uses the smart card technology to permit electronic signing of input data with legal validity all over Europe; Bluetooth connection to permit the use of Mobi-Dev inside the hospitals; GPRS/UMTS connection to permit the use of the system for transmitting large amounts of data and natural language understanding to allow the users to enter data into structured databases, simply speaking to the palm PC. In fact, Mobi-Dev project is using a palm PC to access the data in a Hospital Information System (HIS). Sensors and data coming from sensors are out of the scope of the project. The main objective of the CASCOM project is to implement, validate, and trial a value-added supportive infrastructure for Semantic Web based business application services across mobile and fixed networks. The primary field of validation of the project work is the telemedicine domain and the on-the-fly coordination of pervasive healthcare services.

Saphire project will built upon these state of the are technologies and research projects and provide an intelligent healthcare monitoring platform based on semantically enriched clinical guidelines, which has not been achieved yet.

Cultural links
The Official site of the Ministry of Tourism of Turkey ( click on the picture to activate the link)

Access to museums and cultural links in Turkey… ( click on the picture to activate the link)

Turkish cuisine and recipes ( click on the picture to activate the link)

Tourism in Turkey ( click on the picture to activate the link)

Impressum The Saphire Gazette is a quarterly publication of the Saphire project for dissemination purposes. Saphire is a Specific Targeted Research Project (STREP) co-financed by the European Commission and the Sixth Framework Programme, under Priority 2.4.13 for “Strengthening the Integration of the ICT research effort in an Enlarged Europe” Focus: eHealth. Project full title is: Intelligent Healthcare Monitoring based on a Semantic Interoperability

Platform. Contract no.: IST-27074. Project start: January 2006. Project duration: 30 months. Project web site: http://www.srdc.metu.edu.tr/webpage/projects/saphire


								
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