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The effect of guarana versus caffeine on the resting metabolic

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					The effect of guarana versus caffeine on fat oxidation in healthy college students
Corrine A., Christine C., Veronica G., Jacqueline J., Lauren M., Emily S., & Tim W.

Guarana (Paullinia Cupana)

Background
Traditionally used as a tonic for:  Heat fatigue  Migraine  Diarrhea  Hypertension Currently used as a supplement for:  Stamina  General stimulant

Guaranine = Caffeine
 






Guaranine / Guarana Caffeine / Coffee Theine / Tea contains 5-10% naturally occurring caffeine guaranine is modified by other components of guarana

Guarana
 guarana

contains : threophylline & theobromine  guarana is rich in seed fiber, tannins and saponins  These compounds are said to be released slowly over 6 hours  Guarana toxic at doses @ 10 grams

Hypothesis
 Due

to the synergistic effect of guarana’s main constituents, we speculate that an equivalent dose of guaranine will fat oxidation for a longer amount of time than caffeine

Purpose
To determine if supplementation with guarana will increase fat oxidation for a greater amount of time than caffeine in healthy inviduals in a resting state.

Methods
 Controlled

clinical trial  Crossover design  6 subjects (1 male & 5 females)  Similar breakfast consumed before study  RER measured w/ Metabolic Cart  Baseline RER measured

Methods
 250

mg capsule of guarana (90 mg caffeine)  200 mg No Doz split in half (~90 mg caffeine)  RER measured every hour for 5 hours  No food or drink (except water)  Mean and standard deviation calculated

Results
The mean RER of Guarana and Caffeine during 5 hours of rest
Guarana
Hour Baseline 1 2 3 4 5 Mean 0.87 0.83 0.81 0.79 0.74 0.74 St Dev.  0.036  0.049  0.034  0.047  0.033  0.020

Caffeine
Mean 0.89 0.84 0.80 0.77 0.76 0.76 St Dev.  0.096  0.076  0.061  0.040  0.048  0.062

Results
The effect of guarana vs caffeine on RER over time
1 0.9 0.8 0.7 0.6 RER 0.5 0.4 0.3 0.2 0.1 0 0 1 2 3 4 5 Time (hours)

Guarana Caffeine

Discussion
4

out of the 6 subjects demonstrated the expected results, although to only a small degree  Insufficient evidence to conclude that guarana encourages fat metabolism for a longer time than caffeine  No difference between guarana & caffeine OR poor study design?

Limitations
 Small

sample size  Subjects not blinded  Study not long enough  Food as a confounder
– dinner the night before
– breakfast – fast

 Residual

caffeine from decaf coffee

Limitations
 Purity

of guarana capsule  Additives in No Doz  Menstrual cycle as possible confounder  Differences in lean body mass  Habitual caffeine use  Movie induced giggling / stress

Conclusions
A

large difference between guarana and caffeine was not observed  A more controlled trial could provide more reliable results  More time required to observe trends

Thank you!
Questions???


				
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posted:11/3/2009
language:English
pages:16